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Protein

LIM/homeobox protein Lhx5

Gene

Lhx5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: MGI
  • cell proliferation in forebrain Source: MGI
  • cerebellar Purkinje cell differentiation Source: MGI
  • cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Source: MGI
  • cerebellum development Source: MGI
  • forebrain neuron differentiation Source: MGI
  • hippocampus development Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of cell proliferation Source: MGI
  • spinal cord association neuron differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx5
Short name:
LIM homeobox protein 5
Gene namesi
Name:Lhx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107792. Lhx5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402LIM/homeobox protein Lhx5PRO_0000075790Add
BLAST

Proteomic databases

PaxDbiP61375.
PRIDEiP61375.

PTM databases

iPTMnetiP61375.
PhosphoSiteiP61375.

Expressioni

Gene expression databases

BgeeiP61375.
CleanExiMM_LHX5.
ExpressionAtlasiP61375. baseline and differential.
GenevisibleiP61375. MM.

Interactioni

Protein-protein interaction databases

BioGridi201158. 2 interactions.
STRINGi10090.ENSMUSP00000031591.

Structurei

3D structure databases

ProteinModelPortaliP61375.
SMRiP61375. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6159LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini62 – 12564LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiP61375.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiP61375.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL
60 70 80 90 100
YCKNDFFRRF GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS
110 120 130 140 150
TGEELYVIDE NKFVCKDDYL SSSSLKEGSL NSVSSCTDRS LSPDLQDPLQ
160 170 180 190 200
DDPKETDNST SSDKETANNE NEEQNSGTKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQSDYYAPG GNYDFFAHGP
310 320 330 340 350
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHGADNPR FTDMISHPDT
360 370 380 390 400
PSPEPGLPGA LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA

VW
Length:402
Mass (Da):44,388
Last modified:May 24, 2004 - v1
Checksum:i8F2DBBF1C6237227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61155 mRNA. Translation: AAC52842.1.
BC057585 mRNA. Translation: AAH57585.1.
CCDSiCCDS19617.1.
RefSeqiNP_032525.1. NM_008499.5.
UniGeneiMm.5151.

Genome annotation databases

EnsembliENSMUST00000031591; ENSMUSP00000031591; ENSMUSG00000029595.
GeneIDi16873.
KEGGimmu:16873.
UCSCiuc012ecn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61155 mRNA. Translation: AAC52842.1.
BC057585 mRNA. Translation: AAH57585.1.
CCDSiCCDS19617.1.
RefSeqiNP_032525.1. NM_008499.5.
UniGeneiMm.5151.

3D structure databases

ProteinModelPortaliP61375.
SMRiP61375. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201158. 2 interactions.
STRINGi10090.ENSMUSP00000031591.

PTM databases

iPTMnetiP61375.
PhosphoSiteiP61375.

Proteomic databases

PaxDbiP61375.
PRIDEiP61375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031591; ENSMUSP00000031591; ENSMUSG00000029595.
GeneIDi16873.
KEGGimmu:16873.
UCSCiuc012ecn.1. mouse.

Organism-specific databases

CTDi64211.
MGIiMGI:107792. Lhx5.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiP61375.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiP61375.
TreeFamiTF315442.

Miscellaneous databases

NextBioi290846.
PROiP61375.
SOURCEiSearch...

Gene expression databases

BgeeiP61375.
CleanExiMM_LHX5.
ExpressionAtlasiP61375. baseline and differential.
GenevisibleiP61375. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5."
    Bertuzzi S., Sheng H.Z., Copeland N.G., Gilbert D.J., Jenkins N.A., Taira M., Dawid I.B., Westphal H.
    Genomics 36:234-239(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiLHX5_MOUSE
AccessioniPrimary (citable) accession number: P61375
Secondary accession number(s): P50459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.