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P61371

- ISL1_HUMAN

UniProt

P61371 - ISL1_HUMAN

Protein

Insulin gene enhancer protein ISL-1

Gene

ISL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (24 May 2004)
      Previous versions | rss
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    Functioni

    Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi181 – 24060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. bHLH transcription factor binding Source: BHF-UCL
    2. chromatin binding Source: Ensembl
    3. enhancer sequence-specific DNA binding Source: BHF-UCL
    4. estrogen receptor binding Source: BHF-UCL
    5. ligand-dependent nuclear receptor binding Source: BHF-UCL
    6. RNA polymerase II activating transcription factor binding Source: BHF-UCL
    7. RNA polymerase II transcription coactivator activity Source: BHF-UCL
    8. sequence-specific DNA binding transcription factor activity Source: InterPro
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. atrial septum morphogenesis Source: BHF-UCL
    2. axon regeneration Source: Ensembl
    3. cardiac cell fate determination Source: BHF-UCL
    4. cardiac muscle cell myoblast differentiation Source: Ensembl
    5. cardiac right ventricle morphogenesis Source: BHF-UCL
    6. cellular response to glucocorticoid stimulus Source: BHF-UCL
    7. endocardial cushion morphogenesis Source: BHF-UCL
    8. innervation Source: BHF-UCL
    9. mesenchymal cell differentiation Source: BHF-UCL
    10. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    11. negative regulation of inflammatory response Source: BHF-UCL
    12. negative regulation of intracellular estrogen receptor signaling pathway Source: BHF-UCL
    13. negative regulation of neuron apoptotic process Source: BHF-UCL
    14. negative regulation of neuron differentiation Source: Ensembl
    15. negative regulation of protein homodimerization activity Source: BHF-UCL
    16. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    17. neural crest cell migration Source: Ensembl
    18. neuron fate specification Source: BHF-UCL
    19. outflow tract morphogenesis Source: BHF-UCL
    20. outflow tract septum morphogenesis Source: BHF-UCL
    21. pancreas development Source: BHF-UCL
    22. peripheral nervous system neuron axonogenesis Source: BHF-UCL
    23. pharyngeal system development Source: BHF-UCL
    24. pituitary gland development Source: Ensembl
    25. positive regulation of angiogenesis Source: BHF-UCL
    26. positive regulation of cell proliferation Source: Ensembl
    27. positive regulation of DNA binding Source: Ensembl
    28. positive regulation of granulocyte colony-stimulating factor production Source: BHF-UCL
    29. positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
    30. positive regulation of insulin secretion Source: BHF-UCL
    31. positive regulation of interferon-gamma production Source: BHF-UCL
    32. positive regulation of interleukin-12 production Source: BHF-UCL
    33. positive regulation of interleukin-1 alpha production Source: BHF-UCL
    34. positive regulation of interleukin-1 beta production Source: BHF-UCL
    35. positive regulation of interleukin-6 production Source: BHF-UCL
    36. positive regulation of macrophage colony-stimulating factor production Source: BHF-UCL
    37. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    38. positive regulation of tumor necrosis factor production Source: BHF-UCL
    39. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    40. positive regulation vascular endothelial growth factor production Source: BHF-UCL
    41. regulation of secondary heart field cardioblast proliferation Source: Ensembl
    42. retinal ganglion cell axon guidance Source: Ensembl
    43. secondary heart field specification Source: BHF-UCL
    44. sensory system development Source: BHF-UCL
    45. spinal cord motor neuron cell fate specification Source: Ensembl
    46. spinal cord motor neuron differentiation Source: BHF-UCL
    47. trigeminal nerve development Source: BHF-UCL
    48. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
    49. visceral motor neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin gene enhancer protein ISL-1
    Short name:
    Islet-1
    Gene namesi
    Name:ISL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6132. ISL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29932.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Insulin gene enhancer protein ISL-1PRO_0000075746Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP61371.
    PRIDEiP61371.

    PTM databases

    PhosphoSiteiP61371.

    Expressioni

    Tissue specificityi

    Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

    Gene expression databases

    ArrayExpressiP61371.
    BgeeiP61371.
    CleanExiHS_ISL1.
    GenevestigatoriP61371.

    Organism-specific databases

    HPAiHPA057416.

    Interactioni

    Subunit structurei

    At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1.By similarity

    Protein-protein interaction databases

    BioGridi109877. 18 interactions.
    IntActiP61371. 5 interactions.
    MINTiMINT-3022667.
    STRINGi9606.ENSP00000230658.

    Structurei

    3D structure databases

    ProteinModelPortaliP61371.
    SMRiP61371. Positions 13-168, 180-244, 254-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 7054LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini79 – 13355LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni262 – 29130LIM-binding domain (LID)By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi241 – 349109Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiCOG5576.
    HOGENOMiHOG000236304.
    HOVERGENiHBG004671.
    InParanoidiP61371.
    KOiK09370.
    OMAiTDMGDMG.
    OrthoDBiEOG7JQBPW.
    PhylomeDBiP61371.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ    50
    YLDESCTCFV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY 100
    HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL 150
    HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTCY 200
    AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ 250
    PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 300
    SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA 349
    Length:349
    Mass (Da):39,036
    Last modified:May 24, 2004 - v1
    Checksum:i4DB82FD09154F404
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70721 mRNA. Translation: AAD14064.1.
    U07559 mRNA. Translation: AAA81946.1.
    BC031213 mRNA. Translation: AAH31213.1.
    CCDSiCCDS43314.1.
    PIRiI53277.
    RefSeqiNP_002193.2. NM_002202.2.
    UniGeneiHs.505.

    Genome annotation databases

    EnsembliENST00000230658; ENSP00000230658; ENSG00000016082.
    GeneIDi3670.
    KEGGihsa:3670.
    UCSCiuc003jor.3. human.

    Polymorphism databases

    DMDMi47606423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70721 mRNA. Translation: AAD14064.1 .
    U07559 mRNA. Translation: AAA81946.1 .
    BC031213 mRNA. Translation: AAH31213.1 .
    CCDSi CCDS43314.1.
    PIRi I53277.
    RefSeqi NP_002193.2. NM_002202.2.
    UniGenei Hs.505.

    3D structure databases

    ProteinModelPortali P61371.
    SMRi P61371. Positions 13-168, 180-244, 254-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109877. 18 interactions.
    IntActi P61371. 5 interactions.
    MINTi MINT-3022667.
    STRINGi 9606.ENSP00000230658.

    PTM databases

    PhosphoSitei P61371.

    Polymorphism databases

    DMDMi 47606423.

    Proteomic databases

    PaxDbi P61371.
    PRIDEi P61371.

    Protocols and materials databases

    DNASUi 3670.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230658 ; ENSP00000230658 ; ENSG00000016082 .
    GeneIDi 3670.
    KEGGi hsa:3670.
    UCSCi uc003jor.3. human.

    Organism-specific databases

    CTDi 3670.
    GeneCardsi GC05P050714.
    HGNCi HGNC:6132. ISL1.
    HPAi HPA057416.
    MIMi 600366. gene.
    neXtProti NX_P61371.
    PharmGKBi PA29932.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5576.
    HOGENOMi HOG000236304.
    HOVERGENi HBG004671.
    InParanoidi P61371.
    KOi K09370.
    OMAi TDMGDMG.
    OrthoDBi EOG7JQBPW.
    PhylomeDBi P61371.
    TreeFami TF315442.

    Enzyme and pathway databases

    Reactomei REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

    Miscellaneous databases

    GeneWikii ISL1.
    GenomeRNAii 3670.
    NextBioi 14363.
    PROi P61371.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61371.
    Bgeei P61371.
    CleanExi HS_ISL1.
    Genevestigatori P61371.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage."
      Wang M., Drucker D.J.
      Endocrinology 134:1416-1422(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism."
      Tanizawa Y., Riggs A.C., Dagogo-Jack S., Vaxillaire M., Froguel P., Liu L., Donis-Keller H., Permutt M.A.
      Diabetes 43:935-941(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-349.
      Tissue: Pancreatic islet.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.

    Entry informationi

    Entry nameiISL1_HUMAN
    AccessioniPrimary (citable) accession number: P61371
    Secondary accession number(s): P20663, P47894
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3