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P61371

- ISL1_HUMAN

UniProt

P61371 - ISL1_HUMAN

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Protein

Insulin gene enhancer protein ISL-1

Gene
ISL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi181 – 24060HomeoboxAdd
BLAST

GO - Molecular functioni

  1. bHLH transcription factor binding Source: BHF-UCL
  2. chromatin binding Source: Ensembl
  3. enhancer sequence-specific DNA binding Source: BHF-UCL
  4. estrogen receptor binding Source: BHF-UCL
  5. ligand-dependent nuclear receptor binding Source: BHF-UCL
  6. RNA polymerase II activating transcription factor binding Source: BHF-UCL
  7. RNA polymerase II transcription coactivator activity Source: BHF-UCL
  8. sequence-specific DNA binding transcription factor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. atrial septum morphogenesis Source: BHF-UCL
  2. axon regeneration Source: Ensembl
  3. cardiac cell fate determination Source: BHF-UCL
  4. cardiac muscle cell myoblast differentiation Source: Ensembl
  5. cardiac right ventricle morphogenesis Source: BHF-UCL
  6. cellular response to glucocorticoid stimulus Source: BHF-UCL
  7. endocardial cushion morphogenesis Source: BHF-UCL
  8. innervation Source: BHF-UCL
  9. mesenchymal cell differentiation Source: BHF-UCL
  10. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  11. negative regulation of inflammatory response Source: BHF-UCL
  12. negative regulation of intracellular estrogen receptor signaling pathway Source: BHF-UCL
  13. negative regulation of neuron apoptotic process Source: BHF-UCL
  14. negative regulation of neuron differentiation Source: Ensembl
  15. negative regulation of protein homodimerization activity Source: BHF-UCL
  16. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  17. neural crest cell migration Source: Ensembl
  18. neuron fate specification Source: BHF-UCL
  19. outflow tract morphogenesis Source: BHF-UCL
  20. outflow tract septum morphogenesis Source: BHF-UCL
  21. pancreas development Source: BHF-UCL
  22. peripheral nervous system neuron axonogenesis Source: BHF-UCL
  23. pharyngeal system development Source: BHF-UCL
  24. pituitary gland development Source: Ensembl
  25. positive regulation of angiogenesis Source: BHF-UCL
  26. positive regulation of cell proliferation Source: Ensembl
  27. positive regulation of DNA binding Source: Ensembl
  28. positive regulation of granulocyte colony-stimulating factor production Source: BHF-UCL
  29. positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  30. positive regulation of insulin secretion Source: BHF-UCL
  31. positive regulation of interferon-gamma production Source: BHF-UCL
  32. positive regulation of interleukin-12 production Source: BHF-UCL
  33. positive regulation of interleukin-1 alpha production Source: BHF-UCL
  34. positive regulation of interleukin-1 beta production Source: BHF-UCL
  35. positive regulation of interleukin-6 production Source: BHF-UCL
  36. positive regulation of macrophage colony-stimulating factor production Source: BHF-UCL
  37. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  38. positive regulation of tumor necrosis factor production Source: BHF-UCL
  39. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  40. positive regulation vascular endothelial growth factor production Source: BHF-UCL
  41. regulation of secondary heart field cardioblast proliferation Source: Ensembl
  42. retinal ganglion cell axon guidance Source: Ensembl
  43. secondary heart field specification Source: BHF-UCL
  44. sensory system development Source: BHF-UCL
  45. spinal cord motor neuron cell fate specification Source: Ensembl
  46. spinal cord motor neuron differentiation Source: BHF-UCL
  47. trigeminal nerve development Source: BHF-UCL
  48. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  49. visceral motor neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin gene enhancer protein ISL-1
Short name:
Islet-1
Gene namesi
Name:ISL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6132. ISL1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Insulin gene enhancer protein ISL-1PRO_0000075746Add
BLAST

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61371.
PRIDEiP61371.

PTM databases

PhosphoSiteiP61371.

Expressioni

Tissue specificityi

Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

Gene expression databases

ArrayExpressiP61371.
BgeeiP61371.
CleanExiHS_ISL1.
GenevestigatoriP61371.

Organism-specific databases

HPAiHPA057416.

Interactioni

Subunit structurei

At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1 By similarity.

Protein-protein interaction databases

BioGridi109877. 18 interactions.
IntActiP61371. 5 interactions.
MINTiMINT-3022667.
STRINGi9606.ENSP00000230658.

Structurei

3D structure databases

ProteinModelPortaliP61371.
SMRiP61371. Positions 13-168, 180-244, 254-288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 7054LIM zinc-binding 1Add
BLAST
Domaini79 – 13355LIM zinc-binding 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 29130LIM-binding domain (LID) By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 349109Gln-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiCOG5576.
HOGENOMiHOG000236304.
HOVERGENiHBG004671.
InParanoidiP61371.
KOiK09370.
OMAiTDMGDMG.
OrthoDBiEOG7JQBPW.
PhylomeDBiP61371.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61371-1 [UniParc]FASTAAdd to Basket

« Hide

MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ    50
YLDESCTCFV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY 100
HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL 150
HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTCY 200
AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ 250
PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 300
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA 349
Length:349
Mass (Da):39,036
Last modified:May 24, 2004 - v1
Checksum:i4DB82FD09154F404
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70721 mRNA. Translation: AAD14064.1.
U07559 mRNA. Translation: AAA81946.1.
BC031213 mRNA. Translation: AAH31213.1.
CCDSiCCDS43314.1.
PIRiI53277.
RefSeqiNP_002193.2. NM_002202.2.
UniGeneiHs.505.

Genome annotation databases

EnsembliENST00000230658; ENSP00000230658; ENSG00000016082.
GeneIDi3670.
KEGGihsa:3670.
UCSCiuc003jor.3. human.

Polymorphism databases

DMDMi47606423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70721 mRNA. Translation: AAD14064.1 .
U07559 mRNA. Translation: AAA81946.1 .
BC031213 mRNA. Translation: AAH31213.1 .
CCDSi CCDS43314.1.
PIRi I53277.
RefSeqi NP_002193.2. NM_002202.2.
UniGenei Hs.505.

3D structure databases

ProteinModelPortali P61371.
SMRi P61371. Positions 13-168, 180-244, 254-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109877. 18 interactions.
IntActi P61371. 5 interactions.
MINTi MINT-3022667.
STRINGi 9606.ENSP00000230658.

PTM databases

PhosphoSitei P61371.

Polymorphism databases

DMDMi 47606423.

Proteomic databases

PaxDbi P61371.
PRIDEi P61371.

Protocols and materials databases

DNASUi 3670.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230658 ; ENSP00000230658 ; ENSG00000016082 .
GeneIDi 3670.
KEGGi hsa:3670.
UCSCi uc003jor.3. human.

Organism-specific databases

CTDi 3670.
GeneCardsi GC05P050714.
HGNCi HGNC:6132. ISL1.
HPAi HPA057416.
MIMi 600366. gene.
neXtProti NX_P61371.
PharmGKBi PA29932.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5576.
HOGENOMi HOG000236304.
HOVERGENi HBG004671.
InParanoidi P61371.
KOi K09370.
OMAi TDMGDMG.
OrthoDBi EOG7JQBPW.
PhylomeDBi P61371.
TreeFami TF315442.

Enzyme and pathway databases

Reactomei REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Miscellaneous databases

GeneWikii ISL1.
GenomeRNAii 3670.
NextBioi 14363.
PROi P61371.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61371.
Bgeei P61371.
CleanExi HS_ISL1.
Genevestigatori P61371.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage."
    Wang M., Drucker D.J.
    Endocrinology 134:1416-1422(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism."
    Tanizawa Y., Riggs A.C., Dagogo-Jack S., Vaxillaire M., Froguel P., Liu L., Donis-Keller H., Permutt M.A.
    Diabetes 43:935-941(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-349.
    Tissue: Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiISL1_HUMAN
AccessioniPrimary (citable) accession number: P61371
Secondary accession number(s): P20663, P47894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi