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Protein

Osteocrin

Gene

OSTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hormone

Keywords - Biological processi

Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocrin
Alternative name(s):
Musclin
Gene namesi
Name:OSTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29961. OSTN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912892.

Polymorphism and mutation databases

BioMutaiOSTN.
DMDMi47117104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 7851Sequence analysisPRO_0000021965Add
BLAST
Peptidei83 – 13250OsteocrinPRO_0000021966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321Arginine amideSequence analysis

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1162CleavageSequence analysis

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP61366.
PRIDEiP61366.

PTM databases

iPTMnetiP61366.

Expressioni

Tissue specificityi

Expressed in bone.

Gene expression databases

BgeeiP61366.
CleanExiHS_OSTN.
ExpressionAtlasiP61366. baseline and differential.

Organism-specific databases

HPAiCAB024997.
CAB025649.
HPA030878.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342356.

Structurei

3D structure databases

ProteinModelPortaliP61366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYXW. Eukaryota.
ENOG4112CN4. LUCA.
GeneTreeiENSGT00390000001750.
HOGENOMiHOG000115876.
HOVERGENiHBG049341.
InParanoidiP61366.
OMAiKVVDHPK.
PhylomeDBiP61366.
TreeFamiTF333399.

Family and domain databases

InterProiIPR021088. Osteocrin.
[Graphical view]
PfamiPF11037. Musclin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDWRLASAH FILAVTLTLW SSGKVLSVDV TTTEAFDSGV IDVQSTPTVR
60 70 80 90 100
EEKSATDLTA KLLLLDELVS LENDVIETKK KRSFSGFGSP LDRLSAGSVD
110 120 130
HKGKQRKVVD HPKRRFGIPM DRIGRNRLSN SRG
Length:133
Mass (Da):14,722
Last modified:May 10, 2004 - v1
Checksum:i00898A0B6BABFC5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398681 mRNA. Translation: AAQ94966.1.
AY573933 mRNA. Translation: AAS87599.1.
CH471052 Genomic DNA. Translation: EAW78095.1.
BC128106 mRNA. Translation: AAI28107.1.
BC128107 mRNA. Translation: AAI28108.1.
CCDSiCCDS3299.1.
RefSeqiNP_937827.1. NM_198184.1.
XP_005247485.1. XM_005247428.3.
UniGeneiHs.526794.

Genome annotation databases

EnsembliENST00000339051; ENSP00000342356; ENSG00000188729.
GeneIDi344901.
KEGGihsa:344901.
UCSCiuc011bsn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398681 mRNA. Translation: AAQ94966.1.
AY573933 mRNA. Translation: AAS87599.1.
CH471052 Genomic DNA. Translation: EAW78095.1.
BC128106 mRNA. Translation: AAI28107.1.
BC128107 mRNA. Translation: AAI28108.1.
CCDSiCCDS3299.1.
RefSeqiNP_937827.1. NM_198184.1.
XP_005247485.1. XM_005247428.3.
UniGeneiHs.526794.

3D structure databases

ProteinModelPortaliP61366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342356.

PTM databases

iPTMnetiP61366.

Polymorphism and mutation databases

BioMutaiOSTN.
DMDMi47117104.

Proteomic databases

PaxDbiP61366.
PRIDEiP61366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339051; ENSP00000342356; ENSG00000188729.
GeneIDi344901.
KEGGihsa:344901.
UCSCiuc011bsn.2. human.

Organism-specific databases

CTDi344901.
GeneCardsiOSTN.
HGNCiHGNC:29961. OSTN.
HPAiCAB024997.
CAB025649.
HPA030878.
MIMi610280. gene.
neXtProtiNX_P61366.
PharmGKBiPA134912892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYXW. Eukaryota.
ENOG4112CN4. LUCA.
GeneTreeiENSGT00390000001750.
HOGENOMiHOG000115876.
HOVERGENiHBG049341.
InParanoidiP61366.
OMAiKVVDHPK.
PhylomeDBiP61366.
TreeFamiTF333399.

Miscellaneous databases

GenomeRNAii344901.
PROiP61366.
SOURCEiSearch...

Gene expression databases

BgeeiP61366.
CleanExiHS_OSTN.
ExpressionAtlasiP61366. baseline and differential.

Family and domain databases

InterProiIPR021088. Osteocrin.
[Graphical view]
PfamiPF11037. Musclin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype."
    Thomas G., Moffatt P., Salois P., Gaumond M.-H., Gingras R., Godin E., Miao D., Goltzman D., Lanctot C.
    J. Biol. Chem. 278:50563-50571(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOSTN_HUMAN
AccessioniPrimary (citable) accession number: P61366
Secondary accession number(s): A1A4U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.