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Protein

Osteocrin

Gene

OSTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782). Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hormone
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocrin1 Publication
Alternative name(s):
Musclin1 Publication
Cleaved into the following chain:
Processed OsteocrinBy similarity
Gene namesi
Name:OSTNImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29961. OSTN.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188729.
PharmGKBiPA134912892.

Polymorphism and mutation databases

BioMutaiOSTN.
DMDMi47117104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000043902928 – 133OsteocrinBy similarityAdd BLAST106
PeptideiPRO_000002196683 – 132Processed OsteocrinBy similarityAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132Arginine amideSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP61366.
PRIDEiP61366.

PTM databases

iPTMnetiP61366.
PhosphoSitePlusiP61366.

Expressioni

Tissue specificityi

Enriched in neocortical regions of the developing cerebral cortex (PubMed:27830782). Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum (PubMed:27830782). Also expressed in bone (PubMed:14523025). In developing neonatal rib bone, present at high level in osteoblasts on bone-forming surfaces, in newly incorporated osteocytes and in some late hypertrophic chondrocytes (at protein level) (PubMed:15923362). In adult bone, localizes specifically to osteoblasts and young osteocytes at bone-forming sites (at protein level) (PubMed:15923362).3 Publications

Developmental stagei

Expression in the developing cerebral cortex increases during the course of fetal development and peaks around the late-mid fetal stage, concurrent with the onset of synaptogenesis in the cortical plate (PubMed:27830782).1 Publication

Inductioni

Expression is induced in the developing cerebral cortex in response to neuronal activity in neurons: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).1 Publication

Gene expression databases

BgeeiENSG00000188729.
CleanExiHS_OSTN.
ExpressionAtlasiP61366. baseline and differential.

Organism-specific databases

HPAiCAB024997.
CAB025649.
HPA030878.

Interactioni

Subunit structurei

Interacts with NPR3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342356.

Structurei

3D structure databases

ProteinModelPortaliP61366.
SMRiP61366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Osteocrin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYXW. Eukaryota.
ENOG4112CN4. LUCA.
GeneTreeiENSGT00390000001750.
HOGENOMiHOG000115876.
HOVERGENiHBG049341.
InParanoidiP61366.
OMAiKVVDHPK.
OrthoDBiEOG091G0TUY.
PhylomeDBiP61366.
TreeFamiTF333399.

Family and domain databases

InterProiView protein in InterPro
IPR021088. Osteocrin.
PfamiView protein in Pfam
PF11037. Musclin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDWRLASAH FILAVTLTLW SSGKVLSVDV TTTEAFDSGV IDVQSTPTVR
60 70 80 90 100
EEKSATDLTA KLLLLDELVS LENDVIETKK KRSFSGFGSP LDRLSAGSVD
110 120 130
HKGKQRKVVD HPKRRFGIPM DRIGRNRLSN SRG
Length:133
Mass (Da):14,722
Last modified:May 10, 2004 - v1
Checksum:i00898A0B6BABFC5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398681 mRNA. Translation: AAQ94966.1.
AY573933 mRNA. Translation: AAS87599.1.
CH471052 Genomic DNA. Translation: EAW78095.1.
BC128106 mRNA. Translation: AAI28107.1.
BC128107 mRNA. Translation: AAI28108.1.
CCDSiCCDS3299.1.
RefSeqiNP_937827.1. NM_198184.2.
XP_016861792.1. XM_017006303.1.
UniGeneiHs.526794.

Genome annotation databases

EnsembliENST00000339051; ENSP00000342356; ENSG00000188729.
GeneIDi344901.
KEGGihsa:344901.
UCSCiuc011bsn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398681 mRNA. Translation: AAQ94966.1.
AY573933 mRNA. Translation: AAS87599.1.
CH471052 Genomic DNA. Translation: EAW78095.1.
BC128106 mRNA. Translation: AAI28107.1.
BC128107 mRNA. Translation: AAI28108.1.
CCDSiCCDS3299.1.
RefSeqiNP_937827.1. NM_198184.2.
XP_016861792.1. XM_017006303.1.
UniGeneiHs.526794.

3D structure databases

ProteinModelPortaliP61366.
SMRiP61366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342356.

PTM databases

iPTMnetiP61366.
PhosphoSitePlusiP61366.

Polymorphism and mutation databases

BioMutaiOSTN.
DMDMi47117104.

Proteomic databases

PaxDbiP61366.
PRIDEiP61366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339051; ENSP00000342356; ENSG00000188729.
GeneIDi344901.
KEGGihsa:344901.
UCSCiuc011bsn.2. human.

Organism-specific databases

CTDi344901.
GeneCardsiOSTN.
HGNCiHGNC:29961. OSTN.
HPAiCAB024997.
CAB025649.
HPA030878.
MIMi610280. gene.
neXtProtiNX_P61366.
OpenTargetsiENSG00000188729.
PharmGKBiPA134912892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYXW. Eukaryota.
ENOG4112CN4. LUCA.
GeneTreeiENSGT00390000001750.
HOGENOMiHOG000115876.
HOVERGENiHBG049341.
InParanoidiP61366.
OMAiKVVDHPK.
OrthoDBiEOG091G0TUY.
PhylomeDBiP61366.
TreeFamiTF333399.

Miscellaneous databases

GenomeRNAii344901.
PROiPR:P61366.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188729.
CleanExiHS_OSTN.
ExpressionAtlasiP61366. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR021088. Osteocrin.
PfamiView protein in Pfam
PF11037. Musclin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOSTN_HUMAN
AccessioniPrimary (citable) accession number: P61366
Secondary accession number(s): A1A4U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 10, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This protein-coding gene has been repurposed in primates, with the presence of a new enhancer sequence that drives expression in brain in response to sensory experience, leading to restrict dendritic growth in the developing cortex (PubMed:27830782).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.