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Protein

60S ribosomal protein L27

Gene

Rpl27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_232342. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_233747. Peptide chain elongation.
REACT_242264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_255492. Formation of a pool of free 40S subunits.
REACT_258344. SRP-dependent cotranslational protein targeting to membrane.
REACT_259632. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_263136. Eukaryotic Translation Termination.
REACT_82530. L13a-mediated translational silencing of Ceruloplasmin expression.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27
Gene namesi
Name:Rpl27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi621192. Rpl27.

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13613660S ribosomal protein L27PRO_0000126079Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysineBy similarity
Modified residuei93 – 931N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP61354.
PRIDEiP61354.

Expressioni

Gene expression databases

GenevestigatoriP61354.

Interactioni

Protein-protein interaction databases

BioGridi249021. 3 interactions.
IntActiP61354. 1 interaction.
MINTiMINT-4578026.
STRINGi10116.ENSRNOP00000028060.

Structurei

3D structure databases

ProteinModelPortaliP61354.
SMRiP61354. Positions 2-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 4036KOWAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein L27e family.Curated
Contains 1 KOW domain.Curated

Phylogenomic databases

eggNOGiCOG2163.
GeneTreeiENSGT00390000010721.
HOGENOMiHOG000210138.
HOVERGENiHBG050005.
InParanoidiP61354.
KOiK02901.
OMAiKIYKPGK.
OrthoDBiEOG7J181Z.
PhylomeDBiP61354.
TreeFamiTF314648.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10497. PTHR10497. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF01777. Ribosomal_L27e. 1 hit.
[Graphical view]
ProDomiPD009396. Ribosomal_L27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01107. RIBOSOMAL_L27E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61354-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP
60 70 80 90 100
RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV
110 120 130
FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF
Length:136
Mass (Da):15,798
Last modified:January 23, 2007 - v2
Checksum:i73F4151495029A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07424 mRNA. Translation: CAA30313.1.
BC058474 mRNA. Translation: AAH58474.1.
BC091566 mRNA. Translation: AAH91566.1.
PIRiS00401. R5RT27.
RefSeqiNP_071959.1. NM_022514.1.
UniGeneiRn.1254.

Genome annotation databases

EnsembliENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674.
GeneIDi64306.
KEGGirno:64306.
UCSCiRGD:621192. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07424 mRNA. Translation: CAA30313.1.
BC058474 mRNA. Translation: AAH58474.1.
BC091566 mRNA. Translation: AAH91566.1.
PIRiS00401. R5RT27.
RefSeqiNP_071959.1. NM_022514.1.
UniGeneiRn.1254.

3D structure databases

ProteinModelPortaliP61354.
SMRiP61354. Positions 2-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249021. 3 interactions.
IntActiP61354. 1 interaction.
MINTiMINT-4578026.
STRINGi10116.ENSRNOP00000028060.

Proteomic databases

PaxDbiP61354.
PRIDEiP61354.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674.
GeneIDi64306.
KEGGirno:64306.
UCSCiRGD:621192. rat.

Organism-specific databases

CTDi6155.
RGDi621192. Rpl27.

Phylogenomic databases

eggNOGiCOG2163.
GeneTreeiENSGT00390000010721.
HOGENOMiHOG000210138.
HOVERGENiHBG050005.
InParanoidiP61354.
KOiK02901.
OMAiKIYKPGK.
OrthoDBiEOG7J181Z.
PhylomeDBiP61354.
TreeFamiTF314648.

Enzyme and pathway databases

ReactomeiREACT_232342. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_233747. Peptide chain elongation.
REACT_242264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_255492. Formation of a pool of free 40S subunits.
REACT_258344. SRP-dependent cotranslational protein targeting to membrane.
REACT_259632. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_263136. Eukaryotic Translation Termination.
REACT_82530. L13a-mediated translational silencing of Ceruloplasmin expression.

Miscellaneous databases

NextBioi612950.
PROiP61354.

Gene expression databases

GenevestigatoriP61354.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10497. PTHR10497. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF01777. Ribosomal_L27e. 1 hit.
[Graphical view]
ProDomiPD009396. Ribosomal_L27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01107. RIBOSOMAL_L27E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cloned cDNA specific for rat ribosomal protein L27."
    Tanaka T., Kuwano Y., Ishikawa K., Ogata K.
    Eur. J. Biochem. 173:53-56(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary and Thymus.

Entry informationi

Entry nameiRL27_RAT
AccessioniPrimary (citable) accession number: P61354
Secondary accession number(s): P08526, Q5BJ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.