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Protein

60S ribosomal protein L27

Gene

Rpl27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • response to aldosterone Source: RGD
  • rRNA processing Source: UniProtKB
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27
Gene namesi
Name:Rpl27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621192. Rpl27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260791 – 13660S ribosomal protein L27Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei93N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP61354.
PRIDEiP61354.

PTM databases

iPTMnetiP61354.
PhosphoSitePlusiP61354.
SwissPalmiP61354.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020674.
GenevisibleiP61354. RN.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi249021. 3 interactors.
IntActiP61354. 2 interactors.
MINTiMINT-4578026.
STRINGi10116.ENSRNOP00000028060.

Structurei

3D structure databases

ProteinModelPortaliP61354.
SMRiP61354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 40KOWAdd BLAST36

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3418. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000010721.
HOGENOMiHOG000210138.
HOVERGENiHBG050005.
InParanoidiP61354.
KOiK02901.
OMAiRYPRKVH.
OrthoDBiEOG091G0YBM.
PhylomeDBiP61354.
TreeFamiTF314648.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR10497. PTHR10497. 1 hit.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF01777. Ribosomal_L27e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009396. Ribosomal_L27e. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiView protein in PROSITE
PS01107. RIBOSOMAL_L27E. 1 hit.

Sequencei

Sequence statusi: Complete.

P61354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP
60 70 80 90 100
RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV
110 120 130
FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF
Length:136
Mass (Da):15,798
Last modified:January 23, 2007 - v2
Checksum:i73F4151495029A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07424 mRNA. Translation: CAA30313.1.
BC058474 mRNA. Translation: AAH58474.1.
BC091566 mRNA. Translation: AAH91566.1.
PIRiS00401. R5RT27.
RefSeqiNP_071959.1. NM_022514.1.
UniGeneiRn.1254.

Genome annotation databases

EnsembliENSRNOT00000028060; ENSRNOP00000028060; ENSRNOG00000020674.
GeneIDi64306.
KEGGirno:64306.
UCSCiRGD:621192. rat.

Similar proteinsi

Entry informationi

Entry nameiRL27_RAT
AccessioniPrimary (citable) accession number: P61354
Secondary accession number(s): P08526, Q5BJ97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families