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Protein

60S ribosomal protein L27

Gene

RPL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit (PubMed:12962325). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902).1 Publication1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L27
Alternative name(s):
Large ribosomal subunit protein eL271 Publication
Gene namesi
Name:RPL27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131469.12.
HGNCiHGNC:10328. RPL27.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 16 (DBA16)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:617408

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6155.
MIMi617408. phenotype.
OpenTargetsiENSG00000131469.
PharmGKBiPA34707.

Polymorphism and mutation databases

BioMutaiRPL27.
DMDMi47117772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001260772 – 13660S ribosomal protein L27Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysineCombined sources1
Modified residuei93N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61353.
MaxQBiP61353.
PaxDbiP61353.
PeptideAtlasiP61353.
PRIDEiP61353.
TopDownProteomicsiP61353.

2D gel databases

SWISS-2DPAGEiP61353.

PTM databases

iPTMnetiP61353.
PhosphoSitePlusiP61353.
SwissPalmiP61353.

Expressioni

Gene expression databases

BgeeiENSG00000131469.
CleanExiHS_RPL27.
ExpressionAtlasiP61353. baseline and differential.
GenevisibleiP61353. HS.

Organism-specific databases

HPAiHPA002649.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

Protein-protein interaction databases

BioGridi112074. 145 interactors.
CORUMiP61353.
IntActiP61353. 31 interactors.
MINTiMINT-1145695.
STRINGi9606.ENSP00000253788.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LZ1-136[»]
4V6Xelectron microscopy5.00CZ1-136[»]
5AJ0electron microscopy3.50AZ1-136[»]
5LKSelectron microscopy3.60LZ1-136[»]
5T2Celectron microscopy3.60T1-136[»]
ProteinModelPortaliP61353.
SMRiP61353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 40KOWAdd BLAST36

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3418. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000010721.
HOGENOMiHOG000210138.
HOVERGENiHBG050005.
InParanoidiP61353.
KOiK02901.
OMAiRYPRKVH.
PhylomeDBiP61353.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR001141. Ribosomal_L27e.
IPR018262. Ribosomal_L27e_CS.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR10497. PTHR10497. 1 hit.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF01777. Ribosomal_L27e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009396. Ribosomal_L27e. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiView protein in PROSITE
PS01107. RIBOSOMAL_L27E. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP
60 70 80 90 100
RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV
110 120 130
FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF
Length:136
Mass (Da):15,798
Last modified:January 23, 2007 - v2
Checksum:i73F4151495029A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19527 mRNA. Translation: AAA19815.1.
AB061851 Genomic DNA. Translation: BAB79492.1.
L05094 mRNA. Translation: AAC15857.1.
BC001700 mRNA. Translation: AAH01700.1.
BC002588 mRNA. Translation: AAH02588.1.
BC007273 mRNA. Translation: AAH07273.1.
BC010026 mRNA. Translation: AAH10026.1.
BC098560 mRNA. Translation: AAH98560.1.
CCDSiCCDS11449.1.
PIRiS43505.
RefSeqiNP_000979.1. NM_000988.3.
UniGeneiHs.514196.
Hs.660076.
Hs.731595.

Genome annotation databases

EnsembliENST00000253788; ENSP00000253788; ENSG00000131469.
ENST00000589037; ENSP00000467587; ENSG00000131469.
ENST00000589913; ENSP00000464813; ENSG00000131469.
GeneIDi6155.
KEGGihsa:6155.
UCSCiuc002icj.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL27_HUMAN
AccessioniPrimary (citable) accession number: P61353
Secondary accession number(s): P08526, Q4G0A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families