P61353 (RL27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L27

Gene names

Name:

RPL27

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L27e family. Contains 1 KOW domain.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 136	136	60S ribosomal protein L27		PRO_0000126077
Regions
	Domain	5 – 40	36	KOW
Amino acid modifications
	Modified residue	27	1	N6-acetyllysine Ref.5
	Modified residue	93	1	N6-acetyllysine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P61353 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 73F4151495029A32	FASTA	136	15,798
	10 20 30 40 50 60 MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK 70 80 90 100 110 120 KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE 130 RYKTGKNKWF FQKLRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney." Gallagher R.A., McClean P.M., Malik A.N. Biochim. Biophys. Acta 1217:329-332(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Bhat K.S. Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood, Brain, Eye and Skin.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-93, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L19527 mRNA. Translation: AAA19815.1. AB061851 Genomic DNA. Translation: BAB79492.1. L05094 mRNA. Translation: AAC15857.1. BC001700 mRNA. Translation: AAH01700.1. BC002588 mRNA. Translation: AAH02588.1. BC007273 mRNA. Translation: AAH07273.1. BC010026 mRNA. Translation: AAH10026.1. BC098560 mRNA. Translation: AAH98560.1.
IPI	IPI00219155.
PIR	S43505.
RefSeq	NP_000979.1. NM_000988.3.
UniGene	Hs.514196. Hs.660076.
3D structure databases
ProteinModelPortal	P61353.
ModBase	Search...
Protein-protein interaction databases
IntAct	P61353. 11 interactions.
MINT	MINT-1145695.
STRING	9606.ENSP00000253788.
PTM databases
PhosphoSite	P61353.
Polymorphism databases
DMDM	47117772.
2D gel databases
SWISS-2DPAGE	P61353.
Proteomic databases
PaxDb	P61353.
PRIDE	P61353.
Protocols and materials databases
DNASU	6155.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253788; ENSP00000253788; ENSG00000131469. ENST00000589037; ENSP00000467587; ENSG00000131469. ENST00000589913; ENSP00000464813; ENSG00000131469.
GeneID	6155.
KEGG	hsa:6155.
UCSC	uc002icj.3. human.
Organism-specific databases
CTD	6155.
GeneCards	GC17P041150.
HGNC	HGNC:10328. RPL27.
HPA	HPA002649.
MIM	607526. gene.
neXtProt	NX_P61353.
PharmGKB	PA34707.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2163.
HOGENOM	HOG000210138.
HOVERGEN	HBG050005.
InParanoid	P61353.
KO	K02901.
OMA	FNYNHLM.
OrthoDB	EOG48SGVG.
PhylomeDB	P61353.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P61353.
Bgee	P61353.
CleanEx	HS_RPL27.
Genevestigator	P61353.
GermOnline	ENSG00000131469. Homo sapiens.
Family and domain databases
Gene3D	2.30.30.30. 1 hit.
InterPro	IPR005824. KOW. IPR014722. Rib_L2_dom2. IPR001141. Ribosomal_L27e. IPR018262. Ribosomal_L27e_CS. [Graphical view]
PANTHER	PTHR10497. PTHR10497. 1 hit.
Pfam	PF00467. KOW. 1 hit. PF01777. Ribosomal_L27e. 1 hit. [Graphical view]
ProDom	PD009396. Ribosomal_L27e. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00739. KOW. 1 hit. [Graphical view]
PROSITE	PS01107. RIBOSOMAL_L27E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL27. human.
GenomeRNAi	6155.
NextBio	23903.
SOURCE	Search...

Entry information

Entry name

RL27_HUMAN

Accession

Primary (citable) accession number: P61353
Secondary accession number(s): P08526, Q4G0A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.