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Protein

Fibroblast growth factor 12

Gene

FGF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

  • growth factor activity Source: ProtInc
  • heparin binding Source: MGI
  • ion channel binding Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • cardiac muscle cell action potential involved in contraction Source: BHF-UCL
  • cell-cell signaling Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • heart development Source: ProtInc
  • JNK cascade Source: MGI
  • negative regulation of cation channel activity Source: Ensembl
  • nervous system development Source: ProtInc
  • neuromuscular process Source: Ensembl
  • positive regulation of sodium ion transport Source: Ensembl
  • regulation of membrane depolarization Source: Ensembl
  • regulation of sodium ion transmembrane transport Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
  • signal transduction Source: ProtInc
  • synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 12
Short name:
FGF-12
Alternative name(s):
Fibroblast growth factor homologous factor 1
Short name:
FHF-1
Myocyte-activating factor
Gene namesi
Name:FGF12
Synonyms:FGF12B, FHF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3668. FGF12.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
  • intracellular Source: GOC
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28108.

Polymorphism and mutation databases

BioMutaiFGF12.
DMDMi47117683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Fibroblast growth factor 12PRO_0000147604Add
BLAST

Proteomic databases

PaxDbiP61328.
PRIDEiP61328.

PTM databases

PhosphoSiteiP61328.

Expressioni

Tissue specificityi

Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.

Gene expression databases

BgeeiP61328.
CleanExiHS_FGF12.
ExpressionAtlasiP61328. baseline and differential.
GenevisibleiP61328. HS.

Interactioni

Subunit structurei

Interacts with the C-terminal region of SCN9A.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
COILP384323EBI-6657662,EBI-945751
DACH1Q9UI36-23EBI-6657662,EBI-10186082
DCTDP323213EBI-6657662,EBI-739870
IKZF1Q134223EBI-6657662,EBI-745305
LZTS2Q9BRK43EBI-6657662,EBI-741037
ZNF460Q145923EBI-6657662,EBI-2555738

Protein-protein interaction databases

BioGridi108548. 14 interactions.
DIPiDIP-59850N.
IntActiP61328. 10 interactions.
STRINGi9606.ENSP00000413496.

Structurei

Secondary structure

1
243
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi73 – 797Combined sources
Turni80 – 823Combined sources
Beta strandi83 – 875Combined sources
Beta strandi93 – 975Combined sources
Helixi102 – 1043Combined sources
Beta strandi106 – 1127Combined sources
Beta strandi115 – 1206Combined sources
Turni121 – 1233Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi135 – 1406Combined sources
Helixi143 – 1453Combined sources
Beta strandi147 – 1526Combined sources
Turni153 – 1553Combined sources
Beta strandi156 – 16510Combined sources
Turni167 – 1693Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi181 – 1833Combined sources
Helixi186 – 1883Combined sources
Helixi194 – 1963Combined sources
Beta strandi198 – 2025Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1UX-ray1.70A67-206[»]
4JQ0X-ray3.84A1-243[»]
ProteinModelPortaliP61328.
SMRiP61328. Positions 68-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61328.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 3828Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG275698.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
InParanoidiP61328.
KOiK04358.
OMAiYIGMNGE.
OrthoDBiEOG7J447D.
PhylomeDBiP61328.
TreeFamiTF330751.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028254. FGF12.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF17. PTHR11486:SF17. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P61328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS
60 70 80 90 100
KVRFCSGRKR PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN
110 120 130 140 150
SDYTLFNLIP VGLRVVAIQG VKASLYVAMN GEGYLYSSDV FTPECKFKES
160 170 180 190 200
VFENYYVIYS STLYRQQESG RAWFLGLNKE GQIMKGNRVK KTKPSSHFVP
210 220 230 240
KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ DST
Length:243
Mass (Da):27,399
Last modified:May 10, 2004 - v1
Checksum:i773ED10B5BDD033C
GO
Isoform 2 (identifier: P61328-2) [UniParc]FASTAAdd to basket

Also known as: FGF-12B

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRP → MESK

Show »
Length:181
Mass (Da):20,424
Checksum:iE150D8758875C8B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901K → E in AAB18786 (PubMed:10049777).Curated
Sequence conflicti211 – 2111P → Q in AAH22524 (PubMed:15489334).Curated
Sequence conflicti229 – 24315TPTMN…NQDST → HHHDGGKL in AAB18786 (PubMed:10049777).CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666MAAAI…VRRRP → MESK in isoform 2. 3 PublicationsVSP_010222Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66197 mRNA. Translation: AAB18913.1.
U76381 mRNA. Translation: AAB18786.3.
AK125307 mRNA. Translation: BAG54181.1.
AK313671 mRNA. Translation: BAG36423.1.
AK312513 mRNA. Translation: BAG35414.1.
CH471052 Genomic DNA. Translation: EAW78084.1.
BC022524 mRNA. Translation: AAH22524.1.
CCDSiCCDS3301.1. [P61328-1]
CCDS46983.1. [P61328-2]
PIRiJG0184.
RefSeqiNP_004104.3. NM_004113.5. [P61328-2]
NP_066360.1. NM_021032.4. [P61328-1]
UniGeneiHs.390250.

Genome annotation databases

EnsembliENST00000445105; ENSP00000393686; ENSG00000114279. [P61328-2]
ENST00000450716; ENSP00000397635; ENSG00000114279. [P61328-2]
ENST00000454309; ENSP00000413496; ENSG00000114279. [P61328-1]
GeneIDi2257.
KEGGihsa:2257.
UCSCiuc003fsx.3. human. [P61328-1]
uc003fsy.3. human. [P61328-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66197 mRNA. Translation: AAB18913.1.
U76381 mRNA. Translation: AAB18786.3.
AK125307 mRNA. Translation: BAG54181.1.
AK313671 mRNA. Translation: BAG36423.1.
AK312513 mRNA. Translation: BAG35414.1.
CH471052 Genomic DNA. Translation: EAW78084.1.
BC022524 mRNA. Translation: AAH22524.1.
CCDSiCCDS3301.1. [P61328-1]
CCDS46983.1. [P61328-2]
PIRiJG0184.
RefSeqiNP_004104.3. NM_004113.5. [P61328-2]
NP_066360.1. NM_021032.4. [P61328-1]
UniGeneiHs.390250.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1UX-ray1.70A67-206[»]
4JQ0X-ray3.84A1-243[»]
ProteinModelPortaliP61328.
SMRiP61328. Positions 68-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108548. 14 interactions.
DIPiDIP-59850N.
IntActiP61328. 10 interactions.
STRINGi9606.ENSP00000413496.

PTM databases

PhosphoSiteiP61328.

Polymorphism and mutation databases

BioMutaiFGF12.
DMDMi47117683.

Proteomic databases

PaxDbiP61328.
PRIDEiP61328.

Protocols and materials databases

DNASUi2257.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445105; ENSP00000393686; ENSG00000114279. [P61328-2]
ENST00000450716; ENSP00000397635; ENSG00000114279. [P61328-2]
ENST00000454309; ENSP00000413496; ENSG00000114279. [P61328-1]
GeneIDi2257.
KEGGihsa:2257.
UCSCiuc003fsx.3. human. [P61328-1]
uc003fsy.3. human. [P61328-2]

Organism-specific databases

CTDi2257.
GeneCardsiGC03M191859.
HGNCiHGNC:3668. FGF12.
MIMi601513. gene.
neXtProtiNX_P61328.
PharmGKBiPA28108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275698.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
InParanoidiP61328.
KOiK04358.
OMAiYIGMNGE.
OrthoDBiEOG7J447D.
PhylomeDBiP61328.
TreeFamiTF330751.

Miscellaneous databases

ChiTaRSiFGF12. human.
EvolutionaryTraceiP61328.
GeneWikiiFGF12.
GenomeRNAii2257.
NextBioi9143.
PROiP61328.
SOURCEiSearch...

Gene expression databases

BgeeiP61328.
CleanExiHS_FGF12.
ExpressionAtlasiP61328. baseline and differential.
GenevisibleiP61328. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028254. FGF12.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF17. PTHR11486:SF17. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
    Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart."
    Kok L.D.S., Tsui S.K.W., Waye M.M.Y., Liew C.C., Lee C.-Y., Fung K.-P.
    Biochem. Biophys. Res. Commun. 255:717-721(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hippocampus and Thalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiFGF12_HUMAN
AccessioniPrimary (citable) accession number: P61328
Secondary accession number(s): B2R6B7
, B2R976, O35339, P70376, Q8TBG5, Q92912, Q93001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.