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Reviewed, UniProtKB/Swiss-Prot P61328 (FGF12_HUMAN)

Last modified November 4, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fibroblast growth factor 12
      Short name=FGF-12
Alternative name(s):
    Fibroblast growth factor homologous factor 1
      Short name=FHF-1
    Myocyte-activating factor
Gene names
Name: FGF12
Synonyms: FGF12B, FHF1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Probably involved in nervous system development and function.

Subunit structure

Interacts with the C-terminal region of SCN9A By similarity.

Subcellular location

NucleusProbable.

Tissue specificity

Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords

   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Molecular functionGrowth factor
   Technical term3D-structure

Gene Ontology (GO)

   Biological processcell-cell signaling Ref.1 Ref.2

Traceable author statement. Source: ProtInc

heart development Ref.2

Traceable author statement. Source: ProtInc

nervous system development Ref.1

Traceable author statement. Source: ProtInc

signal transduction Ref.1 Ref.2

Traceable author statement. Source: ProtInc

   Cellular componentextracellular space Ref.2

Traceable author statement. Source: ProtInc

nucleus Ref.1

Inferred from direct assay. Source: MGI

   Molecular functiongrowth factor activity Ref.1 Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P61328-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P61328-2)

Also known as: FGF-12B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRP → MESK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Fibroblast growth factor 12
PRO_0000147604

Regions

Motif11 – 3828Bipartite nuclear localization signal Potential

Natural variations

Alternative sequence1 – 6666MAAAI…VRRRP → MESK in isoform 2.
VSP_010222

Experimental info

Sequence conflict1901K → E in AAB18786. Ref.2
Sequence conflict2111P → Q in AAH22524. Ref.3
Sequence conflict229 – 24315TPTMN…NQDST → HHHDGGKL Ref.2

Secondary structure

.................................... 243
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 773ED10B5BDD033C

FASTA24327,399
        10         20         30         40         50         60 
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR 

        70         80         90        100        110        120 
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 

       130        140        150        160        170        180 
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 

       190        200        210        220        230        240 
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 


DST 

« Hide

Isoform 2 (FGF-12B) [UniParc].

Checksum: E150D8758875C8B7
Show »

18120,424

References

« Hide 'large scale' references
[1]"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed: 8790420] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retina.
[2]"Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart."
Kok L.D.S., Tsui S.K.W., Waye M.M.Y., Liew C.C., Lee C.-Y., Fung K.-P.
Biochem. Biophys. Res. Commun. 255:717-721(1999) [PubMed: 10049777] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

U66197 mRNA. Translation: AAB18913.1.
U76381 mRNA. Translation: AAB18786.3.
BC022524 mRNA. Translation: AAH22524.1.
PIRJG0184.
RefSeqNP_066360.1.
UniGeneHs.584758

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1UX-ray1.70A67-205[»]
ModBaseSearch...

PTM databases

PhosphoSiteP61328.

Genome annotation databases

EnsemblENSG00000114279. Homo sapiens. [Contig view]
GeneID2257.
KEGGhsa:2257.

Organism-specific databases

H-InvDBHIX0003950.
HGNCHGNC:3668. FGF12.
MIM601513. gene.
PharmGKBPA28108.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP61328.
HOVERGENP61328.

Gene expression databases

ArrayExpressP61328.
CleanExHS_FGF12.
GermOnlineENSG00000114279. Homo sapiens.

Family and domain databases

InterProIPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio9143.
SOURCESearch...

Entry information

Entry nameFGF12_HUMAN
AccessionPrimary (citable) accession number: P61328
Secondary accession number(s): O35339 expand/collapse secondary AC list , P70376, Q8TBG5, Q92912, Q93001
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents