Reviewed,
UniProtKB/Swiss-Prot P61313 (RL15_HUMAN)
Last modified
June 16, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60S ribosomal protein L15 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the ribosomal protein L15e family. |
| Sequence caution | The sequence AAA36583.1 differs from that shown. Reason: Frameshift at position 199. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | translational elongation Inferred from Experiment. Source: Reactome |
| Cellular component | cytosol Inferred from Experiment. Source: Reactome ribosomeTraceable author statement. Source: ProtInc |
| Molecular function | RNA binding Traceable author statement. Source: ProtInc structural constituent of ribosomeTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 204 | 203 | 60S ribosomal protein L15 | PRO_0000127527 | |||||
Amino acid modifications | |||||||||
| Modified residue | 34 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 97 | 1 | Phosphoserine Ref.8 | ||||||
Experimental info | |||||||||
| Sequence conflict | 101 | 1 | V → L in AAG44837. Ref.5 | ||||||
| Sequence conflict | 129 | 1 | F → A Ref.1 | ||||||
| Sequence conflict | 129 | 1 | F → A Ref.4 | ||||||
| Sequence conflict | 155 | 1 | V → D in AAA36583. Ref.1 | ||||||
| Sequence conflict | 180 | 1 | F → S in AAH14837. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA encoding the human homologue of yeast ribosomal protein YL10." Herzog H. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning and characterization of EC45 gene, encoding human ribosomal protein L15 and overexpressing in esophageal cancer." Wang Q., Yang C., Zhou J., Liu Z., Wang X., Zhou C., Wu M. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Structures of 69 human ribosomal protein genes: cloning, sequencing, and comparative analysis." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Tanaka T., Shimizu N., Kenmochi N. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Cloning of a new isoform of ribosomal protein L15 in testis." Lu L., Huang X.Y., Xu M., Yin L.L., Li J.M., Zhou Z.M., Sha J.H. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [5] | "Pediatric leukemia cDNA sequencing project." Villalon D.K., Luna R.A., Margolin J.K., Tsang Y.T.M., Hale S.M., Mei G., Bouck J., Gibbs R.A. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Leukemia. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone, Brain, Cervix and Skin. |
| [7] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L25899 mRNA. Translation: AAA36583.1. Frameshift. AF279903 mRNA. Translation: AAG44837.1. AB061823 Genomic DNA. Translation: BAB79461.1. AY347528 mRNA. Translation: AAQ24859.1. AF283772 mRNA. Translation: AAG15591.1. BC014837 mRNA. Translation: AAH14837.1. BC068198 mRNA. Translation: AAH68198.1. BC070328 mRNA. Translation: AAH70328.1. BC071672 mRNA. Translation: AAH71672.1. | |
| IPI | IPI00470528. |
| RefSeq | NP_002939.2. |
| UniGene | Hs.381219 Hs.695621 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P61313. 4 interactions. |
PTM databases | |
| PhosphoSite | P61313. |
2-D gel databases | |
| SWISS-2DPAGE | P61313. |
Proteomic databases | |
| PRIDE | P61313. |
Genome annotation databases | |
| Ensembl | ENSG00000174748. Homo sapiens. [Contig view] |
| GeneID | 6138. |
| KEGG | hsa:6138. |
Organism-specific databases | |
| GeneCards | GC03P023933. GC06P012625. |
| HGNC | HGNC:10306. RPL15. |
| MIM | 604174. gene. |
| PharmGKB | PA30944. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P61313. |
| OMA | P61313. MEVLNSY. |
Enzyme and pathway databases | |
| Reactome | REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression. |
Gene expression databases | |
| ArrayExpress | P61313. |
| Bgee | P61313. |
| CleanEx | HS_RPL15. |
| GermOnline | ENSG00000174748. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000439. Ribosomal_L15e. [Graphical view] |
| PANTHER | PTHR11847. Ribosomal_L15e. 1 hit. |
| Pfam | PF00827. Ribosomal_L15e. 1 hit. [Graphical view] |
| PROSITE | PS01194. RIBOSOMAL_L15E. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 23845. |
| SOURCE | Search... |
Entry information
| Entry name | RL15_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P61313 Secondary accession number(s): P39030 Q9H2E5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


