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Protein

ADM2

Gene

Adm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.1 Publication

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • angiogenesis Source: Ensembl
  • digestion Source: RGD
  • feeding behavior Source: RGD
  • negative regulation of blood pressure Source: RGD
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of gene expression Source: Ensembl
  • protein phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM2
Alternative name(s):
Intermedin
Cleaved into the following 2 chains:
Adrenomedullin-2
Short name:
AM2
Alternative name(s):
Intermedin-long
Short name:
IMDL
Intermedin-short
Short name:
IMDS
Gene namesi
Name:Adm2
Synonyms:Am2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1302971. Adm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 9671By similarityPRO_0000000983Add
BLAST
Peptidei99 – 14547Adrenomedullin-2By similarityPRO_0000000984Add
BLAST
Peptidei106 – 14540Intermedin-shortSequence analysisPRO_0000000985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 113By similarity
Modified residuei145 – 1451Tyrosine amideCurated

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP61312.
PRIDEiP61312.

Expressioni

Tissue specificityi

Expression was restricted to the intermediate and anterior lobes of the pituitary.1 Publication

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051266.

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3UK. Eukaryota.
ENOG410Z5UT. LUCA.
GeneTreeiENSGT00530000064523.
HOGENOMiHOG000033820.
HOVERGENiHBG048691.
InParanoidiP61312.
OMAiPAMGHPL.
OrthoDBiEOG74N5JJ.

Family and domain databases

InterProiIPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLLMVTVT FGCISLLYLL PGTLSGSLGK GLRPREPPAK IPSSGPQPGH
60 70 80 90 100
PSLRPVVWKP PHALQPQGRG NPALATVHLP QGGGSRHPGP QRHVGSRRPH
110 120 130 140
AQLLRVGCVL GTCQVQNLSH RLWQLVRPSG RRDSAPVDPS SPHSYG
Length:146
Mass (Da):15,572
Last modified:May 10, 2004 - v1
Checksum:iC87043237AD29DDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121036 mRNA. Translation: BAD07413.1.
AB181297 mRNA. Translation: BAD22678.1.
AY590103 mRNA. Translation: AAT01302.1.
RefSeqiNP_958829.1. NM_201426.1.
UniGeneiRn.145378.

Genome annotation databases

EnsembliENSRNOT00000044854; ENSRNOP00000051266; ENSRNOG00000029830.
GeneIDi399475.
KEGGirno:399475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB121036 mRNA. Translation: BAD07413.1.
AB181297 mRNA. Translation: BAD22678.1.
AY590103 mRNA. Translation: AAT01302.1.
RefSeqiNP_958829.1. NM_201426.1.
UniGeneiRn.145378.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051266.

Proteomic databases

PaxDbiP61312.
PRIDEiP61312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044854; ENSRNOP00000051266; ENSRNOG00000029830.
GeneIDi399475.
KEGGirno:399475.

Organism-specific databases

CTDi79924.
RGDi1302971. Adm2.

Phylogenomic databases

eggNOGiENOG410J3UK. Eukaryota.
ENOG410Z5UT. LUCA.
GeneTreeiENSGT00530000064523.
HOGENOMiHOG000033820.
HOVERGENiHBG048691.
InParanoidiP61312.
OMAiPAMGHPL.
OrthoDBiEOG74N5JJ.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi692730.
PROiP61312.

Family and domain databases

InterProiIPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator."
    Takei Y., Inoue K., Ogoshi M., Kawahara T., Bannai H., Miyano S.
    FEBS Lett. 556:53-58(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "cDNA for the precursor of rat adrenomedullin 2."
    Inoue K., Takei Y.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Rat IMD sequence."
    Chang C.L., Roh J., Hsu S.Y.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  4. "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes."
    Roh J., Chang C.L., Bhalla A., Klein C., Hsu S.Y.T.
    J. Biol. Chem. 279:7264-7274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADM2_RAT
AccessioniPrimary (citable) accession number: P61312
Secondary accession number(s): Q6L5N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 11, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.