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Protein

Dynein light chain 1, cytoplasmic

Gene

DYNLL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).By similarity
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.By similarity
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Motor protein

Keywords - Biological processi

Apoptosis, Host-virus interaction, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

ReactomeiR-BTA-111446. Activation of BIM and translocation to mitochondria.
R-BTA-1632852. Macroautophagy.
R-BTA-2132295. MHC class II antigen presentation.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-380259. Loss of Nlp from mitotic centrosomes.
R-BTA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-BTA-5620912. Anchoring of the basal body to the plasma membrane.
R-BTA-5620924. Intraflagellar transport.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-BTA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
Dynein light chain LC8-type 1
Gene namesi
Name:DYNLL1
Synonyms:DNCL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 17, Chromosome 20, Chromosome 6

Subcellular locationi

GO - Cellular componenti

  • cilium Source: Ensembl
  • cytoplasmic dynein complex Source: UniProtKB
  • cytosol Source: Ensembl
  • kinetochore Source: UniProtKB
  • membrane Source: Ensembl
  • microtubule Source: UniProtKB-KW
  • mitochondrion Source: UniProtKB-SubCell
  • mitotic spindle Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Dynein light chain 1, cytoplasmicPRO_0000195124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361N6-acetyllysineBy similarity
Modified residuei88 – 881PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-88 appears to control the dimer-monomer transition.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61285.
PeptideAtlasiP61285.
PRIDEiP61285.

Expressioni

Gene expression databases

BgeeiENSBTAG00000024605.

Interactioni

Subunit structurei

Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 (By similarity). Interacts with bovine immunodeficiency virus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport. Interacts with MYZAP (By similarity). Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2 (By similarity). Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944') (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056381.

Structurei

3D structure databases

ProteinModelPortaliP61285.
SMRiP61285. Positions 5-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 8923Interaction with ESR1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiP61285.
KOiK10418.
OMAiAIECATQ.
OrthoDBiEOG091G15JY.
TreeFamiTF300264.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,366
Last modified:May 10, 2004 - v1
Checksum:iF5E7647D092BEB3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099086 mRNA. Translation: BAC56576.1.
AY675078 mRNA. Translation: AAT84371.1.
BT021030 mRNA. Translation: AAX09047.1.
BC102872 mRNA. Translation: AAI02873.1.
RefSeqiNP_001003901.1. NM_001003901.1.
XP_010796262.1. XM_010797960.2.
XP_010804565.1. XM_010806263.2.
XP_010815015.1. XM_010816713.1.
XP_015323821.1. XM_015468335.1.
UniGeneiBt.2307.
Bt.51760.

Genome annotation databases

EnsembliENSBTAT00000034274; ENSBTAP00000034172; ENSBTAG00000024605.
ENSBTAT00000045443; ENSBTAP00000056381; ENSBTAG00000032034.
ENSBTAT00000064169; ENSBTAP00000053982; ENSBTAG00000034170.
GeneIDi404151.
783613.
784058.
KEGGibta:404151.
bta:783613.
bta:784058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099086 mRNA. Translation: BAC56576.1.
AY675078 mRNA. Translation: AAT84371.1.
BT021030 mRNA. Translation: AAX09047.1.
BC102872 mRNA. Translation: AAI02873.1.
RefSeqiNP_001003901.1. NM_001003901.1.
XP_010796262.1. XM_010797960.2.
XP_010804565.1. XM_010806263.2.
XP_010815015.1. XM_010816713.1.
XP_015323821.1. XM_015468335.1.
UniGeneiBt.2307.
Bt.51760.

3D structure databases

ProteinModelPortaliP61285.
SMRiP61285. Positions 5-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056381.

Proteomic databases

PaxDbiP61285.
PeptideAtlasiP61285.
PRIDEiP61285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000034274; ENSBTAP00000034172; ENSBTAG00000024605.
ENSBTAT00000045443; ENSBTAP00000056381; ENSBTAG00000032034.
ENSBTAT00000064169; ENSBTAP00000053982; ENSBTAG00000034170.
GeneIDi404151.
783613.
784058.
KEGGibta:404151.
bta:783613.
bta:784058.

Organism-specific databases

CTDi8655.

Phylogenomic databases

eggNOGiKOG3430. Eukaryota.
ENOG4111NK2. LUCA.
GeneTreeiENSGT00390000000378.
HOVERGENiHBG002133.
InParanoidiP61285.
KOiK10418.
OMAiAIECATQ.
OrthoDBiEOG091G15JY.
TreeFamiTF300264.

Enzyme and pathway databases

ReactomeiR-BTA-111446. Activation of BIM and translocation to mitochondria.
R-BTA-1632852. Macroautophagy.
R-BTA-2132295. MHC class II antigen presentation.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-380259. Loss of Nlp from mitotic centrosomes.
R-BTA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-BTA-5620912. Anchoring of the basal body to the plasma membrane.
R-BTA-5620924. Intraflagellar transport.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-BTA-8854518. AURKA Activation by TPX2.

Gene expression databases

BgeeiENSBTAG00000024605.

Family and domain databases

Gene3Di3.30.740.10. 1 hit.
InterProiIPR019763. Dynein_light_1/2_CS.
IPR001372. Dynein_light_chain_typ-1/2.
[Graphical view]
PfamiPF01221. Dynein_light. 1 hit.
[Graphical view]
SMARTiSM01375. Dynein_light. 1 hit.
[Graphical view]
PROSITEiPS01239. DYNEIN_LIGHT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYL1_BOVIN
AccessioniPrimary (citable) accession number: P61285
Secondary accession number(s): Q6B859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.