Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61278

- SMS_HUMAN

UniProt

P61278 - SMS_HUMAN

Protein

Somatostatin

Gene

SST

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Somatostatin inhibits the release of somatotropin.

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: UniProtKB
    2. cell surface receptor signaling pathway Source: UniProtKB
    3. digestion Source: UniProtKB
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. hormone-mediated apoptotic signaling pathway Source: UniProtKB
    6. hyperosmotic response Source: Ensembl
    7. negative regulation of cell proliferation Source: UniProtKB
    8. regulation of cell migration Source: Ensembl
    9. response to amino acid Source: Ensembl
    10. response to drug Source: Ensembl
    11. response to heat Source: Ensembl
    12. response to nutrient Source: UniProtKB
    13. response to steroid hormone Source: Ensembl
    14. synaptic transmission Source: UniProtKB

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin
    Alternative name(s):
    Growth hormone release-inhibiting factor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:SST
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11329. SST.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.

    Organism-specific databases

    PharmGKBiPA36153.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Propeptidei25 – 8864PRO_0000033086Add
    BLAST
    Peptidei89 – 11628Somatostatin-28PRO_0000033087Add
    BLAST
    Peptidei103 – 11614Somatostatin-14PRO_0000033088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi105 ↔ 116

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP61278.
    PeptideAtlasiP61278.
    PRIDEiP61278.

    Miscellaneous databases

    PMAP-CutDBP61278.

    Expressioni

    Gene expression databases

    BgeeiP61278.
    CleanExiHS_SST.
    GenevestigatoriP61278.

    Organism-specific databases

    HPAiCAB000075.
    HPA019472.

    Interactioni

    Protein-protein interaction databases

    BioGridi112628. 2 interactions.
    STRINGi9606.ENSP00000287641.

    Structurei

    Secondary structure

    1
    116
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi107 – 1148

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1P2Wmodel-A1-116[»]
    2MI1NMR-A103-116[»]
    ProteinModelPortaliP61278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatostatin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44503.
    HOGENOMiHOG000036630.
    HOVERGENiHBG017816.
    InParanoidiP61278.
    KOiK05237.
    OMAiTNSNPAM.
    OrthoDBiEOG7H4DXK.
    PhylomeDBiP61278.
    TreeFamiTF333185.

    Family and domain databases

    InterProiIPR004250. Somatostatin.
    IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view]
    PANTHERiPTHR10558. PTHR10558. 1 hit.
    PfamiPF03002. Somatostatin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001814. Somatostatin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61278-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK    50
    YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE 100
    RKAGCKNFFW KTFTSC 116
    Length:116
    Mass (Da):12,736
    Last modified:July 21, 1986 - v1
    Checksum:iAB49BB89DC9DD8DA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111A → V.
    Corresponds to variant rs35603672 [ dbSNP | Ensembl ].
    VAR_034499
    Natural varianti61 – 611N → T.
    Corresponds to variant rs33934967 [ dbSNP | Ensembl ].
    VAR_034500

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00306 Genomic DNA. Translation: AAA60566.1.
    AK312177 mRNA. Translation: BAG35110.1.
    CH471052 Genomic DNA. Translation: EAW78145.1.
    BC032625 mRNA. Translation: AAH32625.1.
    CCDSiCCDS3288.1.
    PIRiA43614. RIHUS1.
    RefSeqiNP_001039.1. NM_001048.3.
    UniGeneiHs.12409.

    Genome annotation databases

    EnsembliENST00000287641; ENSP00000287641; ENSG00000157005.
    GeneIDi6750.
    KEGGihsa:6750.
    UCSCiuc003frn.3. human.

    Polymorphism databases

    DMDMi47117741.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Somatostatin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00306 Genomic DNA. Translation: AAA60566.1 .
    AK312177 mRNA. Translation: BAG35110.1 .
    CH471052 Genomic DNA. Translation: EAW78145.1 .
    BC032625 mRNA. Translation: AAH32625.1 .
    CCDSi CCDS3288.1.
    PIRi A43614. RIHUS1.
    RefSeqi NP_001039.1. NM_001048.3.
    UniGenei Hs.12409.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1P2W model - A 1-116 [» ]
    2MI1 NMR - A 103-116 [» ]
    ProteinModelPortali P61278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112628. 2 interactions.
    STRINGi 9606.ENSP00000287641.

    Chemistry

    BindingDBi P61278.
    ChEMBLi CHEMBL1795130.
    DrugBanki DB01200. Bromocriptine.
    DB00847. Cysteamine.

    Polymorphism databases

    DMDMi 47117741.

    Proteomic databases

    PaxDbi P61278.
    PeptideAtlasi P61278.
    PRIDEi P61278.

    Protocols and materials databases

    DNASUi 6750.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287641 ; ENSP00000287641 ; ENSG00000157005 .
    GeneIDi 6750.
    KEGGi hsa:6750.
    UCSCi uc003frn.3. human.

    Organism-specific databases

    CTDi 6750.
    GeneCardsi GC03M187386.
    HGNCi HGNC:11329. SST.
    HPAi CAB000075.
    HPA019472.
    MIMi 182450. gene.
    neXtProti NX_P61278.
    PharmGKBi PA36153.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44503.
    HOGENOMi HOG000036630.
    HOVERGENi HBG017816.
    InParanoidi P61278.
    KOi K05237.
    OMAi TNSNPAM.
    OrthoDBi EOG7H4DXK.
    PhylomeDBi P61278.
    TreeFami TF333185.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi SST. human.
    GeneWikii Somatostatin.
    GenomeRNAii 6750.
    NextBioi 26332.
    PMAP-CutDB P61278.
    PROi P61278.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61278.
    CleanExi HS_SST.
    Genevestigatori P61278.

    Family and domain databases

    InterProi IPR004250. Somatostatin.
    IPR018142. Somatostatin/Cortistatin_C.
    [Graphical view ]
    PANTHERi PTHR10558. PTHR10558. 1 hit.
    Pfami PF03002. Somatostatin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001814. Somatostatin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence of the human somatostatin I gene."
      Shen L.-P., Rutter W.J.
      Science 224:168-171(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiSMS_HUMAN
    AccessioniPrimary (citable) accession number: P61278
    Secondary accession number(s): B2R5G3, P01166
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3