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P61278 (SMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin
Alternative name(s):
Growth hormone release-inhibiting factor

Cleaved into the following 2 chains:

  1. Somatostatin-28
  2. Somatostatin-14
Gene names
Name:SST
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Somatostatin inhibits the release of somatotropin.

Subcellular location

Secreted.

Pharmaceutical use

A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.

Sequence similarities

Belongs to the somatostatin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical term3D-structure
Complete proteome
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 8405411. Source: UniProtKB

cell surface receptor signaling pathway

Traceable author statement PubMed 9437026. Source: UniProtKB

cell-cell signaling

Traceable author statement PubMed 6145156. Source: UniProtKB

digestion

Traceable author statement PubMed 6145156. Source: UniProtKB

hormone-mediated apoptotic signaling pathway

Traceable author statement PubMed 8961277. Source: UniProtKB

hyperosmotic response

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Traceable author statement PubMed 9886848. Source: UniProtKB

regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Traceable author statement PubMed 6145156. Source: UniProtKB

response to steroid hormone

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement PubMed 9437026. Source: UniProtKB

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Traceable author statement PubMed 9437026. Source: UniProtKB

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhormone activity

Traceable author statement PubMed 9886848. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Propeptide25 – 8864
PRO_0000033086
Peptide89 – 11628Somatostatin-28
PRO_0000033087
Peptide103 – 11614Somatostatin-14
PRO_0000033088

Amino acid modifications

Disulfide bond105 ↔ 116

Natural variations

Natural variant111A → V.
Corresponds to variant rs35603672 [ dbSNP | Ensembl ].
VAR_034499
Natural variant611N → T.
Corresponds to variant rs33934967 [ dbSNP | Ensembl ].
VAR_034500

Secondary structure

.................. 116
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P61278 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: AB49BB89DC9DD8DA

FASTA11612,736
        10         20         30         40         50         60 
MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK YFLAELLSEP 

        70         80         90        100        110 
NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE RKAGCKNFFW KTFTSC 

« Hide

References

« Hide 'large scale' references
[1]"Human somatostatin I: sequence of the cDNA."
Shen L.-P., Pictet R.L., Rutter W.J.
Proc. Natl. Acad. Sci. U.S.A. 79:4575-4579(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence of the human somatostatin I gene."
Shen L.-P., Rutter W.J.
Science 224:168-171(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
+Additional computationally mapped references.

Web resources

Wikipedia

Somatostatin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00306 Genomic DNA. Translation: AAA60566.1.
AK312177 mRNA. Translation: BAG35110.1.
CH471052 Genomic DNA. Translation: EAW78145.1.
BC032625 mRNA. Translation: AAH32625.1.
PIRRIHUS1. A43614.
RefSeqNP_001039.1. NM_001048.3.
UniGeneHs.12409.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1P2Wmodel-A1-116[»]
ProteinModelPortalP61278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112628. 2 interactions.
STRING9606.ENSP00000287641.

Chemistry

BindingDBP61278.
ChEMBLCHEMBL1795130.
DrugBankDB01200. Bromocriptine.
DB00847. Cysteamine.

Polymorphism databases

DMDM47117741.

Proteomic databases

PaxDbP61278.
PeptideAtlasP61278.
PRIDEP61278.

Protocols and materials databases

DNASU6750.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287641; ENSP00000287641; ENSG00000157005.
GeneID6750.
KEGGhsa:6750.
UCSCuc003frn.3. human.

Organism-specific databases

CTD6750.
GeneCardsGC03M187386.
HGNCHGNC:11329. SST.
HPACAB000075.
HPA019472.
MIM182450. gene.
neXtProtNX_P61278.
PharmGKBPA36153.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44503.
HOGENOMHOG000036630.
HOVERGENHBG017816.
InParanoidP61278.
KOK05237.
OMARMELQRS.
OrthoDBEOG7H4DXK.
PhylomeDBP61278.
TreeFamTF333185.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP61278.
CleanExHS_SST.
GenevestigatorP61278.

Family and domain databases

InterProIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERPTHR10558. PTHR10558. 1 hit.
PfamPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFPIRSF001814. Somatostatin. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSST. human.
GeneWikiSomatostatin.
GenomeRNAi6750.
NextBio26332.
PMAP-CutDBP61278.
PROP61278.
SOURCESearch...

Entry information

Entry nameSMS_HUMAN
AccessionPrimary (citable) accession number: P61278
Secondary accession number(s): B2R5G3, P01166
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM