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Protein

Somatostatin

Gene

SST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: UniProtKB
  • cell surface receptor signaling pathway Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • digestion Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • hormone-mediated apoptotic signaling pathway Source: UniProtKB
  • hyperosmotic response Source: Ensembl
  • negative regulation of cell proliferation Source: UniProtKB
  • regulation of cell migration Source: GO_Central
  • response to acidic pH Source: Ensembl
  • response to amino acid Source: Ensembl
  • response to drug Source: Ensembl
  • response to heat Source: Ensembl
  • response to nutrient Source: UniProtKB
  • response to steroid hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157005-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP61278.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Alternative name(s):
Growth hormone release-inhibiting factor
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11329. SST.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.

Organism-specific databases

DisGeNETi6750.
OpenTargetsiENSG00000157005.
PharmGKBiPA36153.

Chemistry databases

ChEMBLiCHEMBL1795130.
DrugBankiDB00847. Cysteamine.

Polymorphism and mutation databases

BioMutaiSST.
DMDMi47117741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
PropeptideiPRO_000003308625 – 88Add BLAST64
PeptideiPRO_000003308789 – 116Somatostatin-28Add BLAST28
PeptideiPRO_0000033088103 – 116Somatostatin-14Add BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116Combined sources

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP61278.
PeptideAtlasiP61278.
PRIDEiP61278.

PTM databases

PhosphoSitePlusiP61278.

Miscellaneous databases

PMAP-CutDBP61278.

Expressioni

Gene expression databases

BgeeiENSG00000157005.
CleanExiHS_SST.
GenevisibleiP61278. HS.

Organism-specific databases

HPAiCAB000075.
HPA019472.

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112628. 2 interactors.
STRINGi9606.ENSP00000287641.

Chemistry databases

BindingDBiP61278.

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi107 – 114Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P2Wmodel-A1-116[»]
2MI1NMR-A103-116[»]
ProteinModelPortaliP61278.
SMRiP61278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP61278.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.
PhylomeDBiP61278.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK
60 70 80 90 100
YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE
110
RKAGCKNFFW KTFTSC
Length:116
Mass (Da):12,736
Last modified:July 21, 1986 - v1
Checksum:iAB49BB89DC9DD8DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03449911A → V.Corresponds to variant rs35603672dbSNPEnsembl.1
Natural variantiVAR_03450061N → T.Corresponds to variant rs33934967dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00306 Genomic DNA. Translation: AAA60566.1.
AK312177 mRNA. Translation: BAG35110.1.
CH471052 Genomic DNA. Translation: EAW78145.1.
BC032625 mRNA. Translation: AAH32625.1.
CCDSiCCDS3288.1.
PIRiA43614. RIHUS1.
RefSeqiNP_001039.1. NM_001048.3.
UniGeneiHs.12409.

Genome annotation databases

EnsembliENST00000287641; ENSP00000287641; ENSG00000157005.
GeneIDi6750.
KEGGihsa:6750.
UCSCiuc003frn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Somatostatin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00306 Genomic DNA. Translation: AAA60566.1.
AK312177 mRNA. Translation: BAG35110.1.
CH471052 Genomic DNA. Translation: EAW78145.1.
BC032625 mRNA. Translation: AAH32625.1.
CCDSiCCDS3288.1.
PIRiA43614. RIHUS1.
RefSeqiNP_001039.1. NM_001048.3.
UniGeneiHs.12409.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P2Wmodel-A1-116[»]
2MI1NMR-A103-116[»]
ProteinModelPortaliP61278.
SMRiP61278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112628. 2 interactors.
STRINGi9606.ENSP00000287641.

Chemistry databases

BindingDBiP61278.
ChEMBLiCHEMBL1795130.
DrugBankiDB00847. Cysteamine.

PTM databases

PhosphoSitePlusiP61278.

Polymorphism and mutation databases

BioMutaiSST.
DMDMi47117741.

Proteomic databases

PaxDbiP61278.
PeptideAtlasiP61278.
PRIDEiP61278.

Protocols and materials databases

DNASUi6750.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287641; ENSP00000287641; ENSG00000157005.
GeneIDi6750.
KEGGihsa:6750.
UCSCiuc003frn.4. human.

Organism-specific databases

CTDi6750.
DisGeNETi6750.
GeneCardsiSST.
HGNCiHGNC:11329. SST.
HPAiCAB000075.
HPA019472.
MIMi182450. gene.
neXtProtiNX_P61278.
OpenTargetsiENSG00000157005.
PharmGKBiPA36153.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQ5. Eukaryota.
ENOG4111WUI. LUCA.
GeneTreeiENSGT00510000047914.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP61278.
KOiK05237.
OMAiAEQDDMR.
OrthoDBiEOG091G157X.
PhylomeDBiP61278.
TreeFamiTF333185.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157005-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP61278.

Miscellaneous databases

ChiTaRSiSST. human.
GeneWikiiSomatostatin.
GenomeRNAii6750.
PMAP-CutDBP61278.
PROiP61278.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157005.
CleanExiHS_SST.
GenevisibleiP61278. HS.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMS_HUMAN
AccessioniPrimary (citable) accession number: P61278
Secondary accession number(s): B2R5G3, P01166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.