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P61278

- SMS_HUMAN

UniProt

P61278 - SMS_HUMAN

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Protein
Somatostatin
Gene
SST
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Somatostatin inhibits the release of somatotropin.

GO - Molecular functioni

  1. hormone activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. cell surface receptor signaling pathway Source: UniProtKB
  3. cell-cell signaling Source: UniProtKB
  4. digestion Source: UniProtKB
  5. hormone-mediated apoptotic signaling pathway Source: UniProtKB
  6. hyperosmotic response Source: Ensembl
  7. negative regulation of cell proliferation Source: UniProtKB
  8. regulation of cell migration Source: Ensembl
  9. response to amino acid Source: Ensembl
  10. response to drug Source: Ensembl
  11. response to heat Source: Ensembl
  12. response to nutrient Source: UniProtKB
  13. response to steroid hormone Source: Ensembl
  14. synaptic transmission Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin
Alternative name(s):
Growth hormone release-inhibiting factor
Cleaved into the following 2 chains:
Gene namesi
Name:SST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11329. SST.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.

Organism-specific databases

PharmGKBiPA36153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424
Add
BLAST
Propeptidei25 – 8864
PRO_0000033086Add
BLAST
Peptidei89 – 11628Somatostatin-28
PRO_0000033087Add
BLAST
Peptidei103 – 11614Somatostatin-14
PRO_0000033088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 116

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP61278.
PeptideAtlasiP61278.
PRIDEiP61278.

Miscellaneous databases

PMAP-CutDBP61278.

Expressioni

Gene expression databases

BgeeiP61278.
CleanExiHS_SST.
GenevestigatoriP61278.

Organism-specific databases

HPAiCAB000075.
HPA019472.

Interactioni

Protein-protein interaction databases

BioGridi112628. 2 interactions.
STRINGi9606.ENSP00000287641.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi107 – 1148

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P2Wmodel-A1-116[»]
2MI1NMR-A103-116[»]
ProteinModelPortaliP61278.

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44503.
HOGENOMiHOG000036630.
HOVERGENiHBG017816.
InParanoidiP61278.
KOiK05237.
OMAiTNSNPAM.
OrthoDBiEOG7H4DXK.
PhylomeDBiP61278.
TreeFamiTF333185.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PANTHERiPTHR10558. PTHR10558. 1 hit.
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61278-1 [UniParc]FASTAAdd to Basket

« Hide

MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK    50
YFLAELLSEP NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE 100
RKAGCKNFFW KTFTSC 116
Length:116
Mass (Da):12,736
Last modified:July 21, 1986 - v1
Checksum:iAB49BB89DC9DD8DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111A → V.
Corresponds to variant rs35603672 [ dbSNP | Ensembl ].
VAR_034499
Natural varianti61 – 611N → T.
Corresponds to variant rs33934967 [ dbSNP | Ensembl ].
VAR_034500

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00306 Genomic DNA. Translation: AAA60566.1.
AK312177 mRNA. Translation: BAG35110.1.
CH471052 Genomic DNA. Translation: EAW78145.1.
BC032625 mRNA. Translation: AAH32625.1.
CCDSiCCDS3288.1.
PIRiA43614. RIHUS1.
RefSeqiNP_001039.1. NM_001048.3.
UniGeneiHs.12409.

Genome annotation databases

EnsembliENST00000287641; ENSP00000287641; ENSG00000157005.
GeneIDi6750.
KEGGihsa:6750.
UCSCiuc003frn.3. human.

Polymorphism databases

DMDMi47117741.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Somatostatin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00306 Genomic DNA. Translation: AAA60566.1 .
AK312177 mRNA. Translation: BAG35110.1 .
CH471052 Genomic DNA. Translation: EAW78145.1 .
BC032625 mRNA. Translation: AAH32625.1 .
CCDSi CCDS3288.1.
PIRi A43614. RIHUS1.
RefSeqi NP_001039.1. NM_001048.3.
UniGenei Hs.12409.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1P2W model - A 1-116 [» ]
2MI1 NMR - A 103-116 [» ]
ProteinModelPortali P61278.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112628. 2 interactions.
STRINGi 9606.ENSP00000287641.

Chemistry

BindingDBi P61278.
ChEMBLi CHEMBL1795130.
DrugBanki DB01200. Bromocriptine.
DB00847. Cysteamine.

Polymorphism databases

DMDMi 47117741.

Proteomic databases

PaxDbi P61278.
PeptideAtlasi P61278.
PRIDEi P61278.

Protocols and materials databases

DNASUi 6750.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287641 ; ENSP00000287641 ; ENSG00000157005 .
GeneIDi 6750.
KEGGi hsa:6750.
UCSCi uc003frn.3. human.

Organism-specific databases

CTDi 6750.
GeneCardsi GC03M187386.
HGNCi HGNC:11329. SST.
HPAi CAB000075.
HPA019472.
MIMi 182450. gene.
neXtProti NX_P61278.
PharmGKBi PA36153.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44503.
HOGENOMi HOG000036630.
HOVERGENi HBG017816.
InParanoidi P61278.
KOi K05237.
OMAi TNSNPAM.
OrthoDBi EOG7H4DXK.
PhylomeDBi P61278.
TreeFami TF333185.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi SST. human.
GeneWikii Somatostatin.
GenomeRNAii 6750.
NextBioi 26332.
PMAP-CutDB P61278.
PROi P61278.
SOURCEi Search...

Gene expression databases

Bgeei P61278.
CleanExi HS_SST.
Genevestigatori P61278.

Family and domain databases

InterProi IPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view ]
PANTHERi PTHR10558. PTHR10558. 1 hit.
Pfami PF03002. Somatostatin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001814. Somatostatin. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence of the human somatostatin I gene."
    Shen L.-P., Rutter W.J.
    Science 224:168-171(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.

Entry informationi

Entry nameiSMS_HUMAN
AccessioniPrimary (citable) accession number: P61278
Secondary accession number(s): B2R5G3, P01166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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