P61276 (CATK_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin K
EC=3.4.22.38

Gene names

Name:

CTSK

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.
Catalytic activity	Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Propeptide	16 – 114	99	Activation peptide		PRO_0000026297
	Chain	115 – 329	215	Cathepsin K		PRO_0000026298
Sites
	Active site	139	1	By similarity
	Active site	276	1	By similarity
	Active site	296	1	By similarity
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Disulfide bond	136 ↔ 177		By similarity
	Disulfide bond	170 ↔ 210		By similarity
	Disulfide bond	269 ↔ 318		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61276 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: 652DD8DFC37FB984	FASTA	329	36,942
	10 20 30 40 50 60 MWGLKVLLLP VMSFALYPEE ILDTHWELWK KTHRKQYNSK VDEISRRLIW EKNLKYISIH 70 80 90 100 110 120 NLEASLGVHT YELAMNHLGD MTNEEVVQKM TGLKVPASHS RSNDTLYIPD WEGRAPDSVD 130 140 150 160 170 180 YRKKGYVTPV KNQGQCGSCW AFSSVGALEG QLKKKTGKLL NLSPQNLVDC VSENDGCGGG 190 200 210 220 230 240 YMTNAFQYVQ KNRGIDSEDA YPYVGQEESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA 250 260 270 280 290 300 RVGPVSVAID ASLTSFQFYS KGVYYDESCN SDNLNHAVLA VGYGIQKGNK HWIIKNSWGE 310 320 NWGNKGYILM ARNKNNACGI ANLASFPKM

References

[1]	Feild J.A., Brun K.A., McQueney M.S., Amegdazie B.Y. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF070927 mRNA. Translation: AAC23694.1.
3D structure databases
ProteinModelPortal	P61276.
SMR	P61276. Positions 16-329.
ModBase	Search...
Protein family/group databases
MEROPS	C01.036.
Proteomic databases
PRIDE	P61276.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG011513.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411:SF55. CathpsnK_like. 1 hit. PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATK_MACFA

Accession

Primary (citable) accession number: P61276
Secondary accession number(s): O77641

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program