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P61275

- CCL2_MACMU

UniProt

P61275 - CCL2_MACMU

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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 By similarity.By similarity

GO - Biological processi

  1. astrocyte cell migration Source: Ensembl
  2. cellular response to fibroblast growth factor stimulus Source: Ensembl
  3. cellular response to interferon-gamma Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to organic cyclic compound Source: Ensembl
  6. cellular response to tumor necrosis factor Source: Ensembl
  7. cytokine-mediated signaling pathway Source: Ensembl
  8. cytoskeleton organization Source: Ensembl
  9. helper T cell extravasation Source: Ensembl
  10. inflammatory response Source: UniProtKB-KW
  11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  12. macrophage chemotaxis Source: Ensembl
  13. MAPK cascade Source: Ensembl
  14. monocyte chemotaxis Source: Ensembl
  15. negative regulation of angiogenesis Source: Ensembl
  16. negative regulation of glial cell apoptotic process Source: Ensembl
  17. negative regulation of natural killer cell chemotaxis Source: Ensembl
  18. negative regulation of neuron apoptotic process Source: Ensembl
  19. positive regulation of apoptotic cell clearance Source: Ensembl
  20. positive regulation of calcium ion import Source: Ensembl
  21. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  22. positive regulation of macrophage chemotaxis Source: Ensembl
  23. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  24. positive regulation of T cell activation Source: Ensembl
  25. protein kinase B signaling Source: Ensembl
  26. regulation of cell shape Source: Ensembl
  27. regulation of vascular endothelial growth factor production Source: Ensembl
  28. response to wounding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 16

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

ExpressionAtlasiP61275. baseline.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61275.
SMRiP61275. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP61275.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61275-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS
60 70 80 90
YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQIQTPKP
Length:99
Mass (Da):11,007
Last modified:May 10, 2004 - v1
Checksum:i433CB88C64EE7A4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255343 mRNA. Translation: AAF67756.1.
RefSeqiNP_001027993.1. NM_001032821.1.
UniGeneiMmu.3491.

Genome annotation databases

EnsembliENSMMUT00000000422; ENSMMUP00000000391; ENSMMUG00000000288.
GeneIDi574138.
KEGGimcc:574138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255343 mRNA. Translation: AAF67756.1 .
RefSeqi NP_001027993.1. NM_001032821.1.
UniGenei Mmu.3491.

3D structure databases

ProteinModelPortali P61275.
SMRi P61275. Positions 24-93.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000000422 ; ENSMMUP00000000391 ; ENSMMUG00000000288 .
GeneIDi 574138.
KEGGi mcc:574138.

Organism-specific databases

CTDi 6347.

Phylogenomic databases

eggNOGi NOG46819.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P61275.
KOi K14624.
OMAi NKEICAD.
OrthoDBi EOG7C5MC2.
TreeFami TF334888.

Miscellaneous databases

NextBioi 19974150.

Gene expression databases

ExpressionAtlasi P61275. baseline.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of rhesus monkey monocyte chemoattractant protein-1."
    Studer C., Urfer R.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL2_MACMU
AccessioniPrimary (citable) accession number: P61275
Secondary accession number(s): Q9MYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3