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P61275

- CCL2_MACMU

UniProt

P61275 - CCL2_MACMU

Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 By similarity.By similarity

    GO - Biological processi

    1. astrocyte cell migration Source: Ensembl
    2. cellular response to fibroblast growth factor stimulus Source: Ensembl
    3. cellular response to interferon-gamma Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to organic cyclic compound Source: Ensembl
    6. cellular response to tumor necrosis factor Source: Ensembl
    7. cytokine-mediated signaling pathway Source: Ensembl
    8. cytoskeleton organization Source: Ensembl
    9. helper T cell extravasation Source: Ensembl
    10. inflammatory response Source: UniProtKB-KW
    11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    12. macrophage chemotaxis Source: Ensembl
    13. MAPK cascade Source: Ensembl
    14. monocyte chemotaxis Source: Ensembl
    15. negative regulation of angiogenesis Source: Ensembl
    16. negative regulation of glial cell apoptotic process Source: Ensembl
    17. negative regulation of natural killer cell chemotaxis Source: Ensembl
    18. negative regulation of neuron apoptotic process Source: Ensembl
    19. positive regulation of apoptotic cell clearance Source: Ensembl
    20. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
    21. positive regulation of macrophage chemotaxis Source: Ensembl
    22. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    23. positive regulation of T cell activation Source: Ensembl
    24. protein kinase B signaling Source: Ensembl
    25. regulation of cell shape Source: Ensembl
    26. regulation of vascular endothelial growth factor production Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:CCL2
    Synonyms:MCP1, SCYA2
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 16

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9976C-C motif chemokine 2PRO_0000005148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP61275.
    SMRiP61275. Positions 24-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP61275.
    KOiK14624.
    OMAiNKEICAD.
    OrthoDBiEOG7C5MC2.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61275-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS   50
    YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQIQTPKP 99
    Length:99
    Mass (Da):11,007
    Last modified:May 10, 2004 - v1
    Checksum:i433CB88C64EE7A4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255343 mRNA. Translation: AAF67756.1.
    RefSeqiNP_001027993.1. NM_001032821.1.
    UniGeneiMmu.3491.

    Genome annotation databases

    EnsembliENSMMUT00000000422; ENSMMUP00000000391; ENSMMUG00000000288.
    GeneIDi574138.
    KEGGimcc:574138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255343 mRNA. Translation: AAF67756.1 .
    RefSeqi NP_001027993.1. NM_001032821.1.
    UniGenei Mmu.3491.

    3D structure databases

    ProteinModelPortali P61275.
    SMRi P61275. Positions 24-93.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000000422 ; ENSMMUP00000000391 ; ENSMMUG00000000288 .
    GeneIDi 574138.
    KEGGi mcc:574138.

    Organism-specific databases

    CTDi 6347.

    Phylogenomic databases

    eggNOGi NOG46819.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P61275.
    KOi K14624.
    OMAi NKEICAD.
    OrthoDBi EOG7C5MC2.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 19974150.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of rhesus monkey monocyte chemoattractant protein-1."
      Studer C., Urfer R.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL2_MACMU
    AccessioniPrimary (citable) accession number: P61275
    Secondary accession number(s): Q9MYN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3