Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 (By similarity).By similarity

GO - Biological processi

  1. astrocyte cell migration Source: Ensembl
  2. cellular response to fibroblast growth factor stimulus Source: Ensembl
  3. cellular response to interferon-gamma Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to organic cyclic compound Source: Ensembl
  6. cellular response to tumor necrosis factor Source: Ensembl
  7. cytokine-mediated signaling pathway Source: Ensembl
  8. cytoskeleton organization Source: Ensembl
  9. helper T cell extravasation Source: Ensembl
  10. inflammatory response Source: UniProtKB-KW
  11. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  12. macrophage chemotaxis Source: Ensembl
  13. MAPK cascade Source: Ensembl
  14. monocyte chemotaxis Source: Ensembl
  15. negative regulation of angiogenesis Source: Ensembl
  16. negative regulation of glial cell apoptotic process Source: Ensembl
  17. negative regulation of natural killer cell chemotaxis Source: Ensembl
  18. negative regulation of neuron apoptotic process Source: Ensembl
  19. positive regulation of apoptotic cell clearance Source: Ensembl
  20. positive regulation of calcium ion import Source: Ensembl
  21. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  22. positive regulation of macrophage chemotaxis Source: Ensembl
  23. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  24. positive regulation of T cell activation Source: Ensembl
  25. protein kinase B signaling Source: Ensembl
  26. regulation of cell shape Source: Ensembl
  27. regulation of vascular endothelial growth factor production Source: Ensembl
  28. response to wounding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

ExpressionAtlasiP61275. baseline.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Structurei

3D structure databases

SMRiP61275. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP61275.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS
60 70 80 90
YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQIQTPKP
Length:99
Mass (Da):11,007
Last modified:May 10, 2004 - v1
Checksum:i433CB88C64EE7A4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255343 mRNA. Translation: AAF67756.1.
RefSeqiNP_001027993.1. NM_001032821.1.
UniGeneiMmu.3491.

Genome annotation databases

EnsembliENSMMUT00000000422; ENSMMUP00000000391; ENSMMUG00000000288.
GeneIDi574138.
KEGGimcc:574138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255343 mRNA. Translation: AAF67756.1.
RefSeqiNP_001027993.1. NM_001032821.1.
UniGeneiMmu.3491.

3D structure databases

SMRiP61275. Positions 24-93.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000000422; ENSMMUP00000000391; ENSMMUG00000000288.
GeneIDi574138.
KEGGimcc:574138.

Organism-specific databases

CTDi6347.

Phylogenomic databases

eggNOGiNOG46819.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP61275.
KOiK14624.
OMAiNKEICAD.
OrthoDBiEOG7C5MC2.
TreeFamiTF334888.

Miscellaneous databases

NextBioi19974150.

Gene expression databases

ExpressionAtlasiP61275. baseline.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of rhesus monkey monocyte chemoattractant protein-1."
    Studer C., Urfer R.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL2_MACMU
AccessioniPrimary (citable) accession number: P61275
Secondary accession number(s): Q9MYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 1, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.