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P61275 (CCL2_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 2
Alternative name(s):
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name=MCP-1
Small-inducible cytokine A2
Gene names
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Binds to CCR2 and CCR4 By similarity.

Subunit structure

Monomer or homodimer; in equilibrium By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

astrocyte cell migration

Inferred from electronic annotation. Source: Ensembl

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

helper T cell extravasation

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of glial cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of natural killer cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

regulation of vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9976C-C motif chemokine 2
PRO_0000005148

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Glycosylation371N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
P61275 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 433CB88C64EE7A4F

FASTA9911,007
        10         20         30         40         50         60 
MKVSAALLCL LLIAATFSPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS YRRITSSKCP 

        70         80         90 
KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQIQTPKP 

« Hide

References

[1]"Cloning and expression of rhesus monkey monocyte chemoattractant protein-1."
Studer C., Urfer R.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255343 mRNA. Translation: AAF67756.1.
RefSeqNP_001027993.1. NM_001032821.1.
UniGeneMmu.3491.

3D structure databases

ProteinModelPortalP61275.
SMRP61275. Positions 24-93.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000000422; ENSMMUP00000000391; ENSMMUG00000000288.
GeneID574138.
KEGGmcc:574138.

Organism-specific databases

CTD6347.

Phylogenomic databases

eggNOGNOG46819.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP61275.
KOK14624.
OMANKEICAD.
OrthoDBEOG7C5MC2.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19974150.

Entry information

Entry nameCCL2_MACMU
AccessionPrimary (citable) accession number: P61275
Secondary accession number(s): Q9MYN4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families