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Protein

60S ribosomal protein L35a

Gene

RPL35A

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35a
Gene namesi
Name:RPL35A
ORF Names:QnpA-15663
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001927971 – 11060S ribosomal protein L35aAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei63N6-acetyllysine; alternateBy similarity1
Modified residuei63N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP61272.

Structurei

3D structure databases

ProteinModelPortaliP61272.
SMRiP61272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L35Ae family.Curated

Phylogenomic databases

HOVERGENiHBG054581.
KOiK02917.

Family and domain databases

InterProiView protein in InterPro
IPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiView protein in Pfam
PF01247. Ribosomal_L35Ae. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670. Ribosomal_L35Ae. 1 hit.
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiView protein in PROSITE
PS01105. RIBOSOMAL_L35AE. 1 hit.

Sequencei

Sequence statusi: Complete.

P61272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRLWSKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV
60 70 80 90 100
YKAKNNTVTP GGKPNKTRVI WGKVTRAHGN SGMVRAKFRS NLPAKAIGHR
110
IRVMLYPSRI
Length:110
Mass (Da):12,538
Last modified:May 10, 2004 - v1
Checksum:iF32E4A26A25E79E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093673 mRNA. Translation: BAC21647.1.
RefSeqiNP_001270366.1. NM_001283437.1.
XP_015300053.1. XM_015444567.1.
UniGeneiMfa.8218.

Genome annotation databases

GeneIDi102120755.
KEGGimcf:102120755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093673 mRNA. Translation: BAC21647.1.
RefSeqiNP_001270366.1. NM_001283437.1.
XP_015300053.1. XM_015444567.1.
UniGeneiMfa.8218.

3D structure databases

ProteinModelPortaliP61272.
SMRiP61272.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP61272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102120755.
KEGGimcf:102120755.

Organism-specific databases

CTDi6165.

Phylogenomic databases

HOVERGENiHBG054581.
KOiK02917.

Family and domain databases

InterProiView protein in InterPro
IPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiView protein in Pfam
PF01247. Ribosomal_L35Ae. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012670. Ribosomal_L35Ae. 1 hit.
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiView protein in PROSITE
PS01105. RIBOSOMAL_L35AE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL35A_MACFA
AccessioniPrimary (citable) accession number: P61272
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: February 15, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.