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Protein

Syntaxin-1B

Gene

STX1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
Synaptocanalin I
Syntaxin-1B2
Gene namesi
Name:STX1B
Synonyms:STX1B2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence analysisAdd
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1BPRO_0000210191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61267.
PRIDEiP61267.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002349.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022704.

Structurei

3D structure databases

ProteinModelPortaliP61267.
SMRiP61267. Positions 2-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61267.
KOiK08486.
OMAiCLQAKDS.
OrthoDBiEOG091G0EUK.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTTD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,275
Last modified:May 10, 2004 - v1
Checksum:iC66D4785F63C851F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791T → A AA sequence (PubMed:8455717).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14133 mRNA. Translation: BAA03188.1.
BC150124 mRNA. Translation: AAI50125.1.
PIRiJU0136.
RefSeqiNP_777043.1. NM_174618.2.
UniGeneiBt.4849.

Genome annotation databases

EnsembliENSBTAT00000022704; ENSBTAP00000022704; ENSBTAG00000002349.
GeneIDi282377.
KEGGibta:282377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14133 mRNA. Translation: BAA03188.1.
BC150124 mRNA. Translation: AAI50125.1.
PIRiJU0136.
RefSeqiNP_777043.1. NM_174618.2.
UniGeneiBt.4849.

3D structure databases

ProteinModelPortaliP61267.
SMRiP61267. Positions 2-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022704.

Proteomic databases

PaxDbiP61267.
PRIDEiP61267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022704; ENSBTAP00000022704; ENSBTAG00000002349.
GeneIDi282377.
KEGGibta:282377.

Organism-specific databases

CTDi112755.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61267.
KOiK08486.
OMAiCLQAKDS.
OrthoDBiEOG091G0EUK.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-BTA-5682910. LGI-ADAM interactions.

Gene expression databases

BgeeiENSBTAG00000002349.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX1B_BOVIN
AccessioniPrimary (citable) accession number: P61267
Secondary accession number(s): A6QR58, P41414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.