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Protein

Syntaxin-1B

Gene

STX1B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
Synaptocanalin I
Syntaxin-1B2
Gene namesi
Name:STX1B
Synonyms:STX1B2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101911 – 288Syntaxin-1BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61267.
PRIDEiP61267.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002349.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP61267.
STRINGi9913.ENSBTAP00000022704.

Structurei

3D structure databases

ProteinModelPortaliP61267.
SMRiP61267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 104Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61267.
KOiK08486.
OMAiGEHPDEE.
OrthoDBiEOG091G0EUK.
TreeFamiTF313763.

Family and domain databases

InterProiView protein in InterPro
IPR010989. SNARE.
IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR000727. T_SNARE_dom.
PANTHERiPTHR19957:SF141. PTHR19957:SF141. 1 hit.
PfamiView protein in Pfam
PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
SMARTiView protein in SMART
SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

P61267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTTD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,275
Last modified:May 10, 2004 - v1
Checksum:iC66D4785F63C851F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79T → A AA sequence (PubMed:8455717).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14133 mRNA. Translation: BAA03188.1.
BC150124 mRNA. Translation: AAI50125.1.
PIRiJU0136.
RefSeqiNP_777043.1. NM_174618.2.
UniGeneiBt.4849.

Genome annotation databases

EnsembliENSBTAT00000022704; ENSBTAP00000022704; ENSBTAG00000002349.
GeneIDi282377.
KEGGibta:282377.

Similar proteinsi

Entry informationi

Entry nameiSTX1B_BOVIN
AccessioniPrimary (citable) accession number: P61267
Secondary accession number(s): A6QR58, P41414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families