P61267 (STX1B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-1B

Alternative name(s):
Synaptocanalin I
Syntaxin-1B2

Gene names

Name:	STX1B
Synonyms:	STX1B2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.
Subunit structure	Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.
Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Post-translational modification	Phosphorylated by CK2 By similarity.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Neurotransmitter transport Transport
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro neurotransmitter transport Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Syntaxin-1B		PRO_0000210191
Regions
	Topological domain	1 – 264	264	Cytoplasmic Potential
	Transmembrane	265 – 288	24	Helical; Anchor for type IV membrane protein; Potential
	Domain	191 – 253	63	t-SNARE coiled-coil homology
	Coiled coil	29 – 104	76	Potential
Amino acid modifications
	Modified residue	14	1	Phosphoserine By similarity
	Modified residue	58	1	Phosphoserine By similarity
	Modified residue	160	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	79	1	T → A AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P61267 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: C66D4785F63C851F	FASTA	288	33,275
	10 20 30 40 50 60 MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 70 80 90 100 110 120 LAAPNPDEKT KQELEDLTTD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 130 140 150 160 170 180 TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 190 200 210 220 230 240 KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 250 260 270 280 DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Synaptocanalin I, a protein associated with brain omega-conotoxin-sensitive calcium channels." Morita T., Mori H., Sakimura K., Mishina M., Sekine Y., Tsugita A., Odani S., Horikawa H.P., Saisu H., Abe T. Biomed. Res. 13:357-364(1992) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.
[3]	"SNAP receptors implicated in vesicle targeting and fusion." Soellner T., Whiteheart S.W., Brunner M., Erdjument-Bromage H., Geromanos S., Tempst P., Rothman J.E. Nature 362:318-324(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 46-81; 125-137 AND 158-181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14133 mRNA. Translation: BAA03188.1. BC150124 mRNA. Translation: AAI50125.1.
IPI	IPI00701995.
PIR	JU0136.
RefSeq	NP_777043.1. NM_174618.2.
UniGene	Bt.4849.
3D structure databases
ProteinModelPortal	P61267.
SMR	P61267. Positions 2-247.
ModBase	Search...
Proteomic databases
PRIDE	P61267.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000022704; ENSBTAP00000022704; ENSBTAG00000002349.
GeneID	282377.
KEGG	bta:282377.
Organism-specific databases
CTD	112755.
Phylogenomic databases
eggNOG	COG5074.
GeneTree	ENSGT00550000074334.
HOGENOM	HOG000286023.
HOVERGEN	HBG000497.
InParanoid	P61267.
KO	K08486.
OMA	HEETKAV.
OrthoDB	EOG4PC9SV.
Family and domain databases
InterPro	IPR015709. Syntaxin-1. IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
PANTHER	PTHR19957:SF35. PTHR19957:SF35. 1 hit.
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806166.

Entry information

Entry name

STX1B_BOVIN

Accession

Primary (citable) accession number: P61267
Secondary accession number(s): A6QR58, P41414

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program