P61266 (STX1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Syntaxin-1B

Alternative name(s):
Syntaxin-1B1
Syntaxin-1B2

Gene names

Name:	STX1B
Synonyms:	STX1B1, STX1B2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.
Subunit structure	Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.
Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Post-translational modification	Phosphorylated by CK2 By similarity.
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Neurotransmitter transport Transport
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro neurotransmitter transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement PubMed 8105537. Source: ProtInc vesicle-mediated transport Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement PubMed 8105537. Source: ProtInc
Molecular_function	extracellular-glutamate-gated ion channel activity Traceable author statement PubMed 8105537. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Syntaxin-1B		PRO_0000210192
Regions
	Topological domain	1 – 264	264	Cytoplasmic Potential
	Transmembrane	265 – 288	24	Helical; Anchor for type IV membrane protein; Potential
	Domain	191 – 253	63	t-SNARE coiled-coil homology
	Coiled coil	29 – 104	76	Potential
Amino acid modifications
	Modified residue	14	1	Phosphoserine Ref.4
	Modified residue	58	1	Phosphoserine By similarity
	Modified residue	160	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	7 – 13	7	ELRSAKD → VLRTRRN in BAA07152. Ref.1
	Sequence conflict	17	1	E → K in BAA07152. Ref.1
	Sequence conflict	36	1	V → E in BAA07152. Ref.1
	Sequence conflict	69	1	K → R in BAA07152. Ref.1
	Sequence conflict	105 – 111	7	LNRSSAD → STAPRPI in BAA07152. Ref.1
	Sequence conflict	174	1	A → P in BAA07152. Ref.1
	Sequence conflict	266	1	M → I in BAA07152. Ref.1
	Sequence conflict	284	1	G → C in BAA07152. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P61266 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: 2733497E02978BEB	FASTA	288	33,245
	10 20 30 40 50 60 MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 70 80 90 100 110 120 LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 130 140 150 160 170 180 TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 190 200 210 220 230 240 KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 250 260 270 280 DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Fujiwara T., Genda M., Akagawa K. Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"STX1B2, a new member of the syntaxin gene family." Gastaldi M., Massacrier A., Pereira S., Roll P., Robaglia-Schlupp A., Cau P., Szepetowski P. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D37933 mRNA. Translation: BAA07152.1. AY028792 mRNA. Translation: AAK27267.1. BC062298 mRNA. Translation: AAH62298.1.
IPI	IPI00410675.
RefSeq	NP_443106.1. NM_052874.3.
UniGene	Hs.542230.
3D structure databases
ProteinModelPortal	P61266.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000215095.
PTM databases
PhosphoSite	P61266.
Polymorphism databases
DMDM	47117086.
Proteomic databases
PaxDb	P61266.
PRIDE	P61266.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000215095; ENSP00000215095; ENSG00000099365.
GeneID	112755.
KEGG	hsa:112755.
UCSC	uc010cad.2. human.
Organism-specific databases
CTD	112755.
GeneCards	GC16M031000.
HGNC	HGNC:18539. STX1B.
MIM	601485. gene.
neXtProt	NX_P61266.
PharmGKB	PA38345.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5074.
HOGENOM	HOG000286023.
HOVERGEN	HBG000497.
InParanoid	P61266.
KO	K08486.
OMA	HEETKAV.
OrthoDB	EOG4PC9SV.
PhylomeDB	P61266.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	P61266.
Bgee	P61266.
CleanEx	HS_STX1B.
Genevestigator	P61266.
Family and domain databases
InterPro	IPR015709. Syntaxin-1. IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
PANTHER	PTHR19957:SF35. PTHR19957:SF35. 1 hit.
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STX1B. human.
GenomeRNAi	112755.
NextBio	78657.
SOURCE	Search...

Entry information

Entry name

STX1B_HUMAN

Accession

Primary (citable) accession number: P61266
Secondary accession number(s): Q15531

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.