SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P61266

- STX1B_HUMAN

UniProt

P61266 - STX1B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Syntaxin-1B
Gene
STX1B, STX1B1, STX1B2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.

GO - Molecular functioni

  1. extracellular ligand-gated ion channel activity Source: ProtInc
  2. extracellular-glutamate-gated ion channel activity Source: ProtInc
  3. protein kinase binding Source: ParkinsonsUK-UCL
Complete GO annotation...

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. ion transmembrane transport Source: GOC
  3. neurotransmitter transport Source: UniProtKB-KW
  4. regulation of exocytosis Source: Ensembl
  5. synaptic transmission Source: ProtInc
  6. transport Source: ProtInc
  7. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
Syntaxin-1B1
Syntaxin-1B2
Gene namesi
Name:STX1B
Synonyms:STX1B1, STX1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18539. STX1B.

Subcellular locationi

Isoform 1 : Membrane; Single-pass type IV membrane protein Reviewed prediction 1 Publication
Isoform 2 : Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle
Note: Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. microtubule organizing center Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB-SubCell
  5. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1B
PRO_0000210192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by CK2 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61266.
PaxDbiP61266.
PRIDEiP61266.

PTM databases

PhosphoSiteiP61266.

Expressioni

Gene expression databases

ArrayExpressiP61266.
BgeeiP61266.
CleanExiHS_STX1B.
GenevestigatoriP61266.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.

Protein-protein interaction databases

BioGridi125203. 8 interactions.
IntActiP61266. 1 interaction.
STRINGi9606.ENSP00000215095.

Structurei

3D structure databases

ProteinModelPortaliP61266.
SMRiP61266. Positions 25-284.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61266.
KOiK08486.
OMAiCREINEG.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61266.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61266-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV    50
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE 100
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR 150
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE 200
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT 250
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO
Isoform 2 (identifier: P61266-2) [UniParc]FASTAAdd to Basket

Also known as: STX1B-DeltaTMD

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKIMIIICCVVLGVVLASSIGGTLGL → VSGAGGLGVGGGAQG

Note: The glycine-rich C-terminus serves as an unconventional nuclear localization signal.

Show »
Length:277
Mass (Da):31,787
Checksum:i09B0ECE52474510C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 28826KKIMI…GTLGL → VSGAGGLGVGGGAQG in isoform 2.
VSP_047681Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 137ELRSAKD → VLRTRRN in BAA07152. 1 Publication
Sequence conflicti17 – 171E → K in BAA07152. 1 Publication
Sequence conflicti36 – 361V → E in BAA07152. 1 Publication
Sequence conflicti69 – 691K → R in BAA07152. 1 Publication
Sequence conflicti105 – 1117LNRSSAD → STAPRPI in BAA07152. 1 Publication
Sequence conflicti174 – 1741A → P in BAA07152. 1 Publication
Sequence conflicti266 – 2661M → I in BAA07152. 1 Publication
Sequence conflicti284 – 2841G → C in BAA07152. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY995211 mRNA. Translation: AAY45889.1.
D37933 mRNA. Translation: BAA07152.1.
AY028792 mRNA. Translation: AAK27267.1.
AC135048 Genomic DNA. No translation available.
AC135050 Genomic DNA. No translation available.
BC062298 mRNA. Translation: AAH62298.1.
CCDSiCCDS10699.1. [P61266-1]
RefSeqiNP_443106.1. NM_052874.3. [P61266-1]
UniGeneiHs.542230.

Genome annotation databases

EnsembliENST00000215095; ENSP00000215095; ENSG00000099365. [P61266-1]
ENST00000565419; ENSP00000455899; ENSG00000099365. [P61266-2]
GeneIDi112755.
KEGGihsa:112755.
UCSCiuc010cad.2. human. [P61266-1]

Polymorphism databases

DMDMi47117086.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY995211 mRNA. Translation: AAY45889.1 .
D37933 mRNA. Translation: BAA07152.1 .
AY028792 mRNA. Translation: AAK27267.1 .
AC135048 Genomic DNA. No translation available.
AC135050 Genomic DNA. No translation available.
BC062298 mRNA. Translation: AAH62298.1 .
CCDSi CCDS10699.1. [P61266-1 ]
RefSeqi NP_443106.1. NM_052874.3. [P61266-1 ]
UniGenei Hs.542230.

3D structure databases

ProteinModelPortali P61266.
SMRi P61266. Positions 25-284.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125203. 8 interactions.
IntActi P61266. 1 interaction.
STRINGi 9606.ENSP00000215095.

PTM databases

PhosphoSitei P61266.

Polymorphism databases

DMDMi 47117086.

Proteomic databases

MaxQBi P61266.
PaxDbi P61266.
PRIDEi P61266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215095 ; ENSP00000215095 ; ENSG00000099365 . [P61266-1 ]
ENST00000565419 ; ENSP00000455899 ; ENSG00000099365 . [P61266-2 ]
GeneIDi 112755.
KEGGi hsa:112755.
UCSCi uc010cad.2. human. [P61266-1 ]

Organism-specific databases

CTDi 112755.
GeneCardsi GC16M031000.
HGNCi HGNC:18539. STX1B.
MIMi 601485. gene.
neXtProti NX_P61266.
PharmGKBi PA38345.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5074.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi P61266.
KOi K08486.
OMAi CREINEG.
OrthoDBi EOG7X9G7R.
PhylomeDBi P61266.
TreeFami TF313763.

Enzyme and pathway databases

Reactomei REACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

Miscellaneous databases

ChiTaRSi STX1B. human.
GeneWikii STX1B.
GenomeRNAii 112755.
NextBioi 78657.
PROi P61266.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61266.
Bgeei P61266.
CleanExi HS_STX1B.
Genevestigatori P61266.

Family and domain databases

InterProi IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).
  2. Fujiwara T., Genda M., Akagawa K.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "STX1B2, a new member of the syntaxin gene family."
    Gastaldi M., Massacrier A., Pereira S., Roll P., Robaglia-Schlupp A., Cau P., Szepetowski P.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX1B_HUMAN
AccessioniPrimary (citable) accession number: P61266
Secondary accession number(s): Q15531, Q2VPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi