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P61266

- STX1B_HUMAN

UniProt

P61266 - STX1B_HUMAN

Protein

Syntaxin-1B

Gene

STX1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
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    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.By similarity

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: ProtInc
    2. extracellular ligand-gated ion channel activity Source: ProtInc
    3. protein kinase binding Source: ParkinsonsUK-UCL

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. ion transmembrane transport Source: GOC
    3. neurotransmitter transport Source: UniProtKB-KW
    4. regulation of exocytosis Source: Ensembl
    5. synaptic transmission Source: ProtInc
    6. transport Source: ProtInc
    7. vesicle-mediated transport Source: Ensembl

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-1B
    Alternative name(s):
    Syntaxin-1B1
    Syntaxin-1B2
    Gene namesi
    Name:STX1B
    Synonyms:STX1B1, STX1B2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18539. STX1B.

    Subcellular locationi

    Isoform 2 : Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
    Note: Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. integral component of plasma membrane Source: ProtInc
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell
    5. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Syntaxin-1BPRO_0000210192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by CK2.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP61266.
    PaxDbiP61266.
    PRIDEiP61266.

    PTM databases

    PhosphoSiteiP61266.

    Expressioni

    Gene expression databases

    ArrayExpressiP61266.
    BgeeiP61266.
    CleanExiHS_STX1B.
    GenevestigatoriP61266.

    Interactioni

    Subunit structurei

    Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125203. 8 interactions.
    IntActiP61266. 1 interaction.
    STRINGi9606.ENSP00000215095.

    Structurei

    3D structure databases

    ProteinModelPortaliP61266.
    SMRiP61266. Positions 25-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 10476Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiP61266.
    KOiK08486.
    OMAiCREINEG.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiP61266.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P61266-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV    50
    EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE 100
    QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR 150
    QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE 200
    IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT 250
    KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288
    Length:288
    Mass (Da):33,245
    Last modified:May 10, 2004 - v1
    Checksum:i2733497E02978BEB
    GO
    Isoform 2 (identifier: P61266-2) [UniParc]FASTAAdd to Basket

    Also known as: STX1B-DeltaTMD

    The sequence of this isoform differs from the canonical sequence as follows:
         263-288: KKIMIIICCVVLGVVLASSIGGTLGL → VSGAGGLGVGGGAQG

    Note: The glycine-rich C-terminus serves as an unconventional nuclear localization signal.

    Show »
    Length:277
    Mass (Da):31,787
    Checksum:i09B0ECE52474510C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 137ELRSAKD → VLRTRRN in BAA07152. 1 PublicationCurated
    Sequence conflicti17 – 171E → K in BAA07152. 1 PublicationCurated
    Sequence conflicti36 – 361V → E in BAA07152. 1 PublicationCurated
    Sequence conflicti69 – 691K → R in BAA07152. 1 PublicationCurated
    Sequence conflicti105 – 1117LNRSSAD → STAPRPI in BAA07152. 1 PublicationCurated
    Sequence conflicti174 – 1741A → P in BAA07152. 1 PublicationCurated
    Sequence conflicti266 – 2661M → I in BAA07152. 1 PublicationCurated
    Sequence conflicti284 – 2841G → C in BAA07152. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei263 – 28826KKIMI…GTLGL → VSGAGGLGVGGGAQG in isoform 2. 1 PublicationVSP_047681Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY995211 mRNA. Translation: AAY45889.1.
    D37933 mRNA. Translation: BAA07152.1.
    AY028792 mRNA. Translation: AAK27267.1.
    AC135048 Genomic DNA. No translation available.
    AC135050 Genomic DNA. No translation available.
    BC062298 mRNA. Translation: AAH62298.1.
    CCDSiCCDS10699.1. [P61266-1]
    RefSeqiNP_443106.1. NM_052874.3. [P61266-1]
    UniGeneiHs.542230.

    Genome annotation databases

    EnsembliENST00000215095; ENSP00000215095; ENSG00000099365. [P61266-1]
    ENST00000565419; ENSP00000455899; ENSG00000099365. [P61266-2]
    GeneIDi112755.
    KEGGihsa:112755.
    UCSCiuc010cad.2. human. [P61266-1]

    Polymorphism databases

    DMDMi47117086.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY995211 mRNA. Translation: AAY45889.1 .
    D37933 mRNA. Translation: BAA07152.1 .
    AY028792 mRNA. Translation: AAK27267.1 .
    AC135048 Genomic DNA. No translation available.
    AC135050 Genomic DNA. No translation available.
    BC062298 mRNA. Translation: AAH62298.1 .
    CCDSi CCDS10699.1. [P61266-1 ]
    RefSeqi NP_443106.1. NM_052874.3. [P61266-1 ]
    UniGenei Hs.542230.

    3D structure databases

    ProteinModelPortali P61266.
    SMRi P61266. Positions 25-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125203. 8 interactions.
    IntActi P61266. 1 interaction.
    STRINGi 9606.ENSP00000215095.

    PTM databases

    PhosphoSitei P61266.

    Polymorphism databases

    DMDMi 47117086.

    Proteomic databases

    MaxQBi P61266.
    PaxDbi P61266.
    PRIDEi P61266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215095 ; ENSP00000215095 ; ENSG00000099365 . [P61266-1 ]
    ENST00000565419 ; ENSP00000455899 ; ENSG00000099365 . [P61266-2 ]
    GeneIDi 112755.
    KEGGi hsa:112755.
    UCSCi uc010cad.2. human. [P61266-1 ]

    Organism-specific databases

    CTDi 112755.
    GeneCardsi GC16M031000.
    HGNCi HGNC:18539. STX1B.
    MIMi 601485. gene.
    neXtProti NX_P61266.
    PharmGKBi PA38345.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5074.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi P61266.
    KOi K08486.
    OMAi CREINEG.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi P61266.
    TreeFami TF313763.

    Enzyme and pathway databases

    Reactomei REACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

    Miscellaneous databases

    ChiTaRSi STX1B. human.
    GeneWikii STX1B.
    GenomeRNAii 112755.
    NextBioi 78657.
    PROi P61266.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61266.
    Bgeei P61266.
    CleanExi HS_STX1B.
    Genevestigatori P61266.

    Family and domain databases

    InterProi IPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).
    2. Fujiwara T., Genda M., Akagawa K.
      Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "STX1B2, a new member of the syntaxin gene family."
      Gastaldi M., Massacrier A., Pereira S., Roll P., Robaglia-Schlupp A., Cau P., Szepetowski P.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX1B_HUMAN
    AccessioniPrimary (citable) accession number: P61266
    Secondary accession number(s): Q15531, Q2VPS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3