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P61266 (STX1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-1B
Alternative name(s):
Syntaxin-1B1
Syntaxin-1B2
Gene names
Name:STX1B
Synonyms:STX1B1, STX1B2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.

Subunit structure

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.

Subcellular location

Isoform 1: Membrane; Single-pass type IV membrane protein Potential Ref.1.

Isoform 2: Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle. Note: Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells. Ref.1

Post-translational modification

Phosphorylated by CK2 By similarity.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processNeurotransmitter transport
Transport
   Cellular componentCytoplasm
Cytoskeleton
Membrane
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

ion transmembrane transport

Traceable author statement PubMed 8105537. Source: GOC

neurotransmitter transport

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of exocytosis

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement PubMed 8105537. Source: ProtInc

transport

Traceable author statement PubMed 8105537. Source: ProtInc

vesicle-mediated transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

integral component of plasma membrane

Traceable author statement PubMed 8105537. Source: ProtInc

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

spindle

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionextracellular ligand-gated ion channel activity

Traceable author statement PubMed 8105537. Source: ProtInc

extracellular-glutamate-gated ion channel activity

Traceable author statement PubMed 8105537. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P61266-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P61266-2)

Also known as: STX1B-DeltaTMD;

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKIMIIICCVVLGVVLASSIGGTLGL → VSGAGGLGVGGGAQG
Note: The glycine-rich C-terminus serves as an unconventional nuclear localization signal.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Syntaxin-1B
PRO_0000210192

Regions

Topological domain1 – 264264Cytoplasmic Potential
Transmembrane265 – 28824Helical; Anchor for type IV membrane protein; Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil29 – 10476 Potential

Amino acid modifications

Modified residue141Phosphoserine Ref.6

Natural variations

Alternative sequence263 – 28826KKIMI…GTLGL → VSGAGGLGVGGGAQG in isoform 2.
VSP_047681

Experimental info

Sequence conflict7 – 137ELRSAKD → VLRTRRN in BAA07152. Ref.2
Sequence conflict171E → K in BAA07152. Ref.2
Sequence conflict361V → E in BAA07152. Ref.2
Sequence conflict691K → R in BAA07152. Ref.2
Sequence conflict105 – 1117LNRSSAD → STAPRPI in BAA07152. Ref.2
Sequence conflict1741A → P in BAA07152. Ref.2
Sequence conflict2661M → I in BAA07152. Ref.2
Sequence conflict2841G → C in BAA07152. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 2733497E02978BEB

FASTA28833,245
        10         20         30         40         50         60 
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 

        70         80         90        100        110        120 
LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 

       130        140        150        160        170        180 
TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 

       190        200        210        220        230        240 
KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 

       250        260        270        280 
DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 

« Hide

Isoform 2 (STX1B-DeltaTMD) [UniParc].

Checksum: 09B0ECE52474510C
Show »

FASTA27731,787

References

« Hide 'large scale' references
[1]"Nuclear localization of a novel human syntaxin 1B isoform."
Pereira S., Massacrier A., Roll P., Verine A., Etienne-Grimaldi M.C., Poitelon Y., Robaglia-Schlupp A., Jamali S., Roeckel-Trevisiol N., Royer B., Pontarotti P., Leveque C., Seagar M., Levy N., Cau P., Szepetowski P.
Gene 423:160-171(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).
[2]Fujiwara T., Genda M., Akagawa K.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"STX1B2, a new member of the syntaxin gene family."
Gastaldi M., Massacrier A., Pereira S., Roll P., Robaglia-Schlupp A., Cau P., Szepetowski P.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY995211 mRNA. Translation: AAY45889.1.
D37933 mRNA. Translation: BAA07152.1.
AY028792 mRNA. Translation: AAK27267.1.
AC135048 Genomic DNA. No translation available.
AC135050 Genomic DNA. No translation available.
BC062298 mRNA. Translation: AAH62298.1.
RefSeqNP_443106.1. NM_052874.3.
UniGeneHs.542230.

3D structure databases

ProteinModelPortalP61266.
SMRP61266. Positions 25-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125203. 8 interactions.
IntActP61266. 1 interaction.
STRING9606.ENSP00000215095.

PTM databases

PhosphoSiteP61266.

Polymorphism databases

DMDM47117086.

Proteomic databases

PaxDbP61266.
PRIDEP61266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000215095; ENSP00000215095; ENSG00000099365. [P61266-1]
ENST00000565419; ENSP00000455899; ENSG00000099365. [P61266-2]
GeneID112755.
KEGGhsa:112755.
UCSCuc010cad.2. human. [P61266-1]

Organism-specific databases

CTD112755.
GeneCardsGC16M031000.
HGNCHGNC:18539. STX1B.
MIM601485. gene.
neXtProtNX_P61266.
PharmGKBPA38345.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5074.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidP61266.
KOK08486.
OMARMIQQRT.
OrthoDBEOG7X9G7R.
PhylomeDBP61266.
TreeFamTF313763.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_13685. Neuronal System.

Gene expression databases

ArrayExpressP61266.
BgeeP61266.
CleanExHS_STX1B.
GenevestigatorP61266.

Family and domain databases

InterProIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF33. PTHR19957:SF33. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTX1B. human.
GeneWikiSTX1B.
GenomeRNAi112755.
NextBio78657.
PROP61266.
SOURCESearch...

Entry information

Entry nameSTX1B_HUMAN
AccessionPrimary (citable) accession number: P61266
Secondary accession number(s): Q15531, Q2VPS2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM