Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P61266

- STX1B_HUMAN

UniProt

P61266 - STX1B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Syntaxin-1B

Gene

STX1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

  1. protein kinase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. neurotransmitter transport Source: UniProtKB-KW
  3. regulation of exocytosis Source: Ensembl
  4. regulation of gene expression Source: ParkinsonsUK-UCL
  5. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
Syntaxin-1B1
Syntaxin-1B2
Gene namesi
Name:STX1B
Synonyms:STX1B1, STX1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18539. STX1B.

Subcellular locationi

Isoform 2 : Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
Note: Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
  5. plasma membrane Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1BPRO_0000210192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61266.
PaxDbiP61266.
PRIDEiP61266.

PTM databases

PhosphoSiteiP61266.

Expressioni

Gene expression databases

BgeeiP61266.
CleanExiHS_STX1B.
ExpressionAtlasiP61266. baseline and differential.
GenevestigatoriP61266.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

Protein-protein interaction databases

BioGridi125203. 13 interactions.
IntActiP61266. 1 interaction.
STRINGi9606.ENSP00000215095.

Structurei

3D structure databases

ProteinModelPortaliP61266.
SMRiP61266. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61266.
KOiK08486.
OMAiCREINEG.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61266.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61266-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO
Isoform 2 (identifier: P61266-2) [UniParc]FASTAAdd to Basket

Also known as: STX1B-DeltaTMD

The sequence of this isoform differs from the canonical sequence as follows:
     263-288: KKIMIIICCVVLGVVLASSIGGTLGL → VSGAGGLGVGGGAQG

Note: The glycine-rich C-terminus serves as an unconventional nuclear localization signal.

Show »
Length:277
Mass (Da):31,787
Checksum:i09B0ECE52474510C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 137ELRSAKD → VLRTRRN in BAA07152. 1 PublicationCurated
Sequence conflicti17 – 171E → K in BAA07152. 1 PublicationCurated
Sequence conflicti36 – 361V → E in BAA07152. 1 PublicationCurated
Sequence conflicti69 – 691K → R in BAA07152. 1 PublicationCurated
Sequence conflicti105 – 1117LNRSSAD → STAPRPI in BAA07152. 1 PublicationCurated
Sequence conflicti174 – 1741A → P in BAA07152. 1 PublicationCurated
Sequence conflicti266 – 2661M → I in BAA07152. 1 PublicationCurated
Sequence conflicti284 – 2841G → C in BAA07152. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 28826KKIMI…GTLGL → VSGAGGLGVGGGAQG in isoform 2. 1 PublicationVSP_047681Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY995211 mRNA. Translation: AAY45889.1.
D37933 mRNA. Translation: BAA07152.1.
AY028792 mRNA. Translation: AAK27267.1.
AC135048 Genomic DNA. No translation available.
AC135050 Genomic DNA. No translation available.
BC062298 mRNA. Translation: AAH62298.1.
CCDSiCCDS10699.1. [P61266-1]
RefSeqiNP_443106.1. NM_052874.3. [P61266-1]
UniGeneiHs.542230.

Genome annotation databases

EnsembliENST00000215095; ENSP00000215095; ENSG00000099365. [P61266-1]
ENST00000565419; ENSP00000455899; ENSG00000099365. [P61266-2]
GeneIDi112755.
KEGGihsa:112755.
UCSCiuc010cad.2. human. [P61266-1]

Polymorphism databases

DMDMi47117086.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY995211 mRNA. Translation: AAY45889.1 .
D37933 mRNA. Translation: BAA07152.1 .
AY028792 mRNA. Translation: AAK27267.1 .
AC135048 Genomic DNA. No translation available.
AC135050 Genomic DNA. No translation available.
BC062298 mRNA. Translation: AAH62298.1 .
CCDSi CCDS10699.1. [P61266-1 ]
RefSeqi NP_443106.1. NM_052874.3. [P61266-1 ]
UniGenei Hs.542230.

3D structure databases

ProteinModelPortali P61266.
SMRi P61266. Positions 25-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125203. 13 interactions.
IntActi P61266. 1 interaction.
STRINGi 9606.ENSP00000215095.

PTM databases

PhosphoSitei P61266.

Polymorphism databases

DMDMi 47117086.

Proteomic databases

MaxQBi P61266.
PaxDbi P61266.
PRIDEi P61266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215095 ; ENSP00000215095 ; ENSG00000099365 . [P61266-1 ]
ENST00000565419 ; ENSP00000455899 ; ENSG00000099365 . [P61266-2 ]
GeneIDi 112755.
KEGGi hsa:112755.
UCSCi uc010cad.2. human. [P61266-1 ]

Organism-specific databases

CTDi 112755.
GeneCardsi GC16M031000.
HGNCi HGNC:18539. STX1B.
MIMi 601485. gene.
neXtProti NX_P61266.
PharmGKBi PA38345.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00760000119200.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi P61266.
KOi K08486.
OMAi CREINEG.
OrthoDBi EOG7X9G7R.
PhylomeDBi P61266.
TreeFami TF313763.

Enzyme and pathway databases

Reactomei REACT_200658. Toxicity of botulinum toxin type C (BoNT/C).

Miscellaneous databases

ChiTaRSi STX1B. human.
GeneWikii STX1B.
GenomeRNAii 112755.
NextBioi 78657.
PROi P61266.
SOURCEi Search...

Gene expression databases

Bgeei P61266.
CleanExi HS_STX1B.
ExpressionAtlasi P61266. baseline and differential.
Genevestigatori P61266.

Family and domain databases

InterProi IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).
  2. Fujiwara T., Genda M., Akagawa K.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "STX1B2, a new member of the syntaxin gene family."
    Gastaldi M., Massacrier A., Pereira S., Roll P., Robaglia-Schlupp A., Cau P., Szepetowski P.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX1B_HUMAN
AccessioniPrimary (citable) accession number: P61266
Secondary accession number(s): Q15531, Q2VPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3