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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

  1. protein domain specific binding Source: RGD
  2. SNAP receptor activity Source: GO_Central
  3. SNARE binding Source: GO_Central

GO - Biological processi

  1. intracellular protein transport Source: GO_Central
  2. positive regulation of excitatory postsynaptic membrane potential Source: ParkinsonsUK-UCL
  3. positive regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
  4. protein transport Source: RGD
  5. regulation of exocytosis Source: RGD
  6. regulation of gene expression Source: ParkinsonsUK-UCL
  7. regulation of synaptic vesicle priming Source: ParkinsonsUK-UCL
  8. synaptic vesicle docking Source: ParkinsonsUK-UCL
  9. synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  10. vesicle docking Source: GO_Central
  11. vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
P35B
Syntaxin-1B2
Gene namesi
Name:Stx1b
Synonyms:Stx1b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3784. Stx1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endomembrane system Source: GO_Central
  2. integral component of membrane Source: GO_Central
  3. membrane Source: ParkinsonsUK-UCL
  4. plasma membrane Source: ParkinsonsUK-UCL
  5. SNARE complex Source: GO_Central
  6. synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1BPRO_0000210194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by CK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61265.
PRIDEiP61265.

PTM databases

PhosphoSiteiP61265.

Expressioni

Tissue specificityi

Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

Gene expression databases

GenevestigatoriP61265.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rnf40Q8CJB94EBI-2255905,EBI-6110162

Protein-protein interaction databases

BioGridi247029. 4 interactions.
IntActiP61265. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP61265.
SMRiP61265. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61265.
KOiK08486.
OMAiQVDRDHF.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61265.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95735 mRNA. Translation: AAA42197.1.
PIRiB48213.
RefSeqiNP_036832.1. NM_012700.2.
UniGeneiRn.98793.

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneIDi24923.
KEGGirno:24923.
UCSCiRGD:3784. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95735 mRNA. Translation: AAA42197.1.
PIRiB48213.
RefSeqiNP_036832.1. NM_012700.2.
UniGeneiRn.98793.

3D structure databases

ProteinModelPortaliP61265.
SMRiP61265. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247029. 4 interactions.
IntActiP61265. 1 interaction.

PTM databases

PhosphoSiteiP61265.

Proteomic databases

PaxDbiP61265.
PRIDEiP61265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneIDi24923.
KEGGirno:24923.
UCSCiRGD:3784. rat.

Organism-specific databases

CTDi112755.
RGDi3784. Stx1b.

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61265.
KOiK08486.
OMAiQVDRDHF.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61265.
TreeFamiTF313763.

Miscellaneous databases

NextBioi604871.
PROiP61265.

Gene expression databases

GenevestigatoriP61265.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones."
    Bennett M.K., Calakos N., Scheller R.H.
    Science 257:255-259(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-16 AND 31-55.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 189-197; 204-209 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "A method for the comprehensive proteomic analysis of membrane proteins."
    Wu C.C., MacCoss M.J., Howell K.E., Yates J.R. III
    Nat. Biotechnol. 21:532-538(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-14.

Entry informationi

Entry nameiSTX1B_RAT
AccessioniPrimary (citable) accession number: P61265
Secondary accession number(s): P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.