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P61265 (STX1B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-1B
Alternative name(s):
P35B
Syntaxin-1B2
Gene names
Name:Stx1b
Synonyms:Stx1b2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.

Subunit structure

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Tissue specificity

Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

Post-translational modification

Phosphorylated by CK2. Ref.4

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Rnf40Q8CJB94EBI-2255905,EBI-6110162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Syntaxin-1B
PRO_0000210194

Regions

Topological domain1 – 264264Cytoplasmic Potential
Transmembrane265 – 28824Helical; Anchor for type IV membrane protein; Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil29 – 10476 Potential

Amino acid modifications

Modified residue141Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P61265 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 2733497E02978BEB

FASTA28833,245
        10         20         30         40         50         60 
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 

        70         80         90        100        110        120 
LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 

       130        140        150        160        170        180 
TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 

       190        200        210        220        230        240 
KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 

       250        260        270        280 
DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 

« Hide

References

[1]"Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones."
Bennett M.K., Calakos N., Scheller R.H.
Science 257:255-259(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-16 AND 31-55.
Tissue: Brain.
[2]"The syntaxin family of vesicular transport receptors."
Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K.E., Fleming A.M., Hazuka C.D., Scheller R.H.
Cell 74:863-873(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 189-197; 204-209 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
[4]"A method for the comprehensive proteomic analysis of membrane proteins."
Wu C.C., MacCoss M.J., Howell K.E., Yates J.R. III
Nat. Biotechnol. 21:532-538(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-14.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95735 mRNA. Translation: AAA42197.1.
PIRB48213.
RefSeqNP_036832.1. NM_012700.2.
UniGeneRn.98793.

3D structure databases

ProteinModelPortalP61265.
SMRP61265. Positions 25-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247029. 4 interactions.
IntActP61265. 1 interaction.

PTM databases

PhosphoSiteP61265.

Proteomic databases

PaxDbP61265.
PRIDEP61265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneID24923.
KEGGrno:24923.
UCSCRGD:3784. rat.

Organism-specific databases

CTD112755.
RGD3784. Stx1b.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00730000110552.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidP61265.
KOK08486.
OMACREINEG.
OrthoDBEOG7X9G7R.
PhylomeDBP61265.
TreeFamTF313763.

Gene expression databases

GenevestigatorP61265.

Family and domain databases

InterProIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604871.
PROP61265.

Entry information

Entry nameSTX1B_RAT
AccessionPrimary (citable) accession number: P61265
Secondary accession number(s): P32853
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families