Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P61265

- STX1B_RAT

UniProt

P61265 - STX1B_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Syntaxin-1B

Gene

Stx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

  1. protein domain specific binding Source: RGD

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. neurotransmitter transport Source: UniProtKB-KW
  3. protein transport Source: RGD
  4. regulation of exocytosis Source: RGD
  5. regulation of gene expression Source: ParkinsonsUK-UCL
  6. vesicle-mediated transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
P35B
Syntaxin-1B2
Gene namesi
Name:Stx1b
Synonyms:Stx1b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3784. Stx1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1BPRO_0000210194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by CK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61265.
PRIDEiP61265.

PTM databases

PhosphoSiteiP61265.

Expressioni

Tissue specificityi

Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

Gene expression databases

GenevestigatoriP61265.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rnf40Q8CJB94EBI-2255905,EBI-6110162

Protein-protein interaction databases

BioGridi247029. 4 interactions.
IntActiP61265. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP61265.
SMRiP61265. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61265.
KOiK08486.
OMAiCREINEG.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61265.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61265-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95735 mRNA. Translation: AAA42197.1.
PIRiB48213.
RefSeqiNP_036832.1. NM_012700.2.
UniGeneiRn.98793.

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneIDi24923.
KEGGirno:24923.
UCSCiRGD:3784. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95735 mRNA. Translation: AAA42197.1 .
PIRi B48213.
RefSeqi NP_036832.1. NM_012700.2.
UniGenei Rn.98793.

3D structure databases

ProteinModelPortali P61265.
SMRi P61265. Positions 25-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247029. 4 interactions.
IntActi P61265. 1 interaction.

PTM databases

PhosphoSitei P61265.

Proteomic databases

PaxDbi P61265.
PRIDEi P61265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026063 ; ENSRNOP00000026063 ; ENSRNOG00000019193 .
GeneIDi 24923.
KEGGi rno:24923.
UCSCi RGD:3784. rat.

Organism-specific databases

CTDi 112755.
RGDi 3784. Stx1b.

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00760000119200.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi P61265.
KOi K08486.
OMAi CREINEG.
OrthoDBi EOG7X9G7R.
PhylomeDBi P61265.
TreeFami TF313763.

Miscellaneous databases

NextBioi 604871.
PROi P61265.

Gene expression databases

Genevestigatori P61265.

Family and domain databases

InterProi IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones."
    Bennett M.K., Calakos N., Scheller R.H.
    Science 257:255-259(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-16 AND 31-55.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 189-197; 204-209 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "A method for the comprehensive proteomic analysis of membrane proteins."
    Wu C.C., MacCoss M.J., Howell K.E., Yates J.R. III
    Nat. Biotechnol. 21:532-538(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-14.

Entry informationi

Entry nameiSTX1B_RAT
AccessioniPrimary (citable) accession number: P61265
Secondary accession number(s): P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3