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P61265

- STX1B_RAT

UniProt

P61265 - STX1B_RAT

Protein

Syntaxin-1B

Gene

Stx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
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    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein domain specific binding Source: RGD

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. neurotransmitter transport Source: UniProtKB-KW
    3. protein transport Source: RGD
    4. regulation of exocytosis Source: RGD
    5. vesicle-mediated transport Source: RGD

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-1B
    Alternative name(s):
    P35B
    Syntaxin-1B2
    Gene namesi
    Name:Stx1b
    Synonyms:Stx1b2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3784. Stx1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Syntaxin-1BPRO_0000210194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by CK2.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP61265.
    PRIDEiP61265.

    PTM databases

    PhosphoSiteiP61265.

    Expressioni

    Tissue specificityi

    Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

    Gene expression databases

    GenevestigatoriP61265.

    Interactioni

    Subunit structurei

    Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Rnf40Q8CJB94EBI-2255905,EBI-6110162

    Protein-protein interaction databases

    BioGridi247029. 4 interactions.
    IntActiP61265. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP61265.
    SMRiP61265. Positions 25-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 10476Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110552.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiP61265.
    KOiK08486.
    OMAiCREINEG.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiP61265.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV    50
    EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE 100
    QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR 150
    QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE 200
    IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT 250
    KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288
    Length:288
    Mass (Da):33,245
    Last modified:May 10, 2004 - v1
    Checksum:i2733497E02978BEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95735 mRNA. Translation: AAA42197.1.
    PIRiB48213.
    RefSeqiNP_036832.1. NM_012700.2.
    UniGeneiRn.98793.

    Genome annotation databases

    EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
    GeneIDi24923.
    KEGGirno:24923.
    UCSCiRGD:3784. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95735 mRNA. Translation: AAA42197.1 .
    PIRi B48213.
    RefSeqi NP_036832.1. NM_012700.2.
    UniGenei Rn.98793.

    3D structure databases

    ProteinModelPortali P61265.
    SMRi P61265. Positions 25-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247029. 4 interactions.
    IntActi P61265. 1 interaction.

    PTM databases

    PhosphoSitei P61265.

    Proteomic databases

    PaxDbi P61265.
    PRIDEi P61265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026063 ; ENSRNOP00000026063 ; ENSRNOG00000019193 .
    GeneIDi 24923.
    KEGGi rno:24923.
    UCSCi RGD:3784. rat.

    Organism-specific databases

    CTDi 112755.
    RGDi 3784. Stx1b.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110552.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi P61265.
    KOi K08486.
    OMAi CREINEG.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi P61265.
    TreeFami TF313763.

    Miscellaneous databases

    NextBioi 604871.
    PROi P61265.

    Gene expression databases

    Genevestigatori P61265.

    Family and domain databases

    InterProi IPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones."
      Bennett M.K., Calakos N., Scheller R.H.
      Science 257:255-259(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-16 AND 31-55.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 189-197; 204-209 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    4. "A method for the comprehensive proteomic analysis of membrane proteins."
      Wu C.C., MacCoss M.J., Howell K.E., Yates J.R. III
      Nat. Biotechnol. 21:532-538(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-14.

    Entry informationi

    Entry nameiSTX1B_RAT
    AccessioniPrimary (citable) accession number: P61265
    Secondary accession number(s): P32853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3