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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • receptor binding Source: ParkinsonsUK-UCL
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Alternative name(s):
P35B
Syntaxin-1B2
Gene namesi
Name:Stx1b
Synonyms:Stx1b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3784. Stx1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101941 – 288Syntaxin-1BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei14PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Phosphorylated by CK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61265.
PRIDEiP61265.

PTM databases

iPTMnetiP61265.
PhosphoSitePlusiP61265.
SwissPalmiP61265.

Expressioni

Tissue specificityi

Cerebral cortex, hippocampus, cerebellum, and adrenal medulla.

Gene expression databases

BgeeiENSRNOG00000019193.
GenevisibleiP61265. RN.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rnf40Q8CJB94EBI-2255905,EBI-6110162

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • receptor binding Source: ParkinsonsUK-UCL
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi247029. 4 interactors.
IntActiP61265. 1 interactor.
STRINGi10116.ENSRNOP00000026063.

Structurei

3D structure databases

ProteinModelPortaliP61265.
SMRiP61265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 104Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61265.
KOiK08486.
OMAiCLQAKDS.
OrthoDBiEOG091G0EUK.
PhylomeDBiP61265.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95735 mRNA. Translation: AAA42197.1.
PIRiB48213.
RefSeqiNP_036832.1. NM_012700.2.
UniGeneiRn.98793.

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneIDi24923.
KEGGirno:24923.
UCSCiRGD:3784. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95735 mRNA. Translation: AAA42197.1.
PIRiB48213.
RefSeqiNP_036832.1. NM_012700.2.
UniGeneiRn.98793.

3D structure databases

ProteinModelPortaliP61265.
SMRiP61265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247029. 4 interactors.
IntActiP61265. 1 interactor.
STRINGi10116.ENSRNOP00000026063.

PTM databases

iPTMnetiP61265.
PhosphoSitePlusiP61265.
SwissPalmiP61265.

Proteomic databases

PaxDbiP61265.
PRIDEiP61265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026063; ENSRNOP00000026063; ENSRNOG00000019193.
GeneIDi24923.
KEGGirno:24923.
UCSCiRGD:3784. rat.

Organism-specific databases

CTDi112755.
RGDi3784. Stx1b.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61265.
KOiK08486.
OMAiCLQAKDS.
OrthoDBiEOG091G0EUK.
PhylomeDBiP61265.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-RNO-5682910. LGI-ADAM interactions.

Miscellaneous databases

PROiP61265.

Gene expression databases

BgeeiENSRNOG00000019193.
GenevisibleiP61265. RN.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX1B_RAT
AccessioniPrimary (citable) accession number: P61265
Secondary accession number(s): P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.