Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61264

- STX1B_MOUSE

UniProt

P61264 - STX1B_MOUSE

Protein

Syntaxin-1B

Gene

Stx1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potentially involved in docking of synaptic vesicles at presynaptic active zones By similarity. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: ParkinsonsUK-UCL

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. neurotransmitter transport Source: UniProtKB-KW
    3. regulation of exocytosis Source: Ensembl
    4. vesicle-mediated transport Source: Ensembl

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-1B
    Gene namesi
    Name:Stx1b
    Synonyms:Stx1b1, Stx1b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1930705. Stx1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Syntaxin-1BPRO_0000210193Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by CK2.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP61264.
    PaxDbiP61264.
    PRIDEiP61264.

    PTM databases

    PhosphoSiteiP61264.

    Expressioni

    Gene expression databases

    BgeeiP61264.
    GenevestigatoriP61264.

    Interactioni

    Subunit structurei

    Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.2 Publications

    Protein-protein interaction databases

    BioGridi207850. 1 interaction.
    IntActiP61264. 6 interactions.
    MINTiMINT-4135988.

    Structurei

    3D structure databases

    ProteinModelPortaliP61264.
    SMRiP61264. Positions 25-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 10476Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110552.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiP61264.
    KOiK08486.
    OMAiPWKNKSA.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiP61264.
    TreeFamiTF313763.

    Family and domain databases

    InterProiIPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61264-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV    50
    EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE 100
    QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR 150
    QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE 200
    IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT 250
    KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288
    Length:288
    Mass (Da):33,245
    Last modified:May 10, 2004 - v1
    Checksum:i2733497E02978BEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 42DR → EW in BAA25986. 1 PublicationCurated
    Sequence conflicti8 – 81L → R in BAA25986. 1 PublicationCurated
    Sequence conflicti26 – 261D → A in BAA25986. 1 PublicationCurated
    Sequence conflicti30 – 301D → A in BAA25986. 1 PublicationCurated
    Sequence conflicti51 – 555EQVKK → GRVGG in BAA25986. 1 PublicationCurated
    Sequence conflicti65 – 651N → K in BAA25986. 1 PublicationCurated
    Sequence conflicti98 – 981S → G in BAA25986. 1 PublicationCurated
    Sequence conflicti114 – 1163IRK → YRT in BAA25986. 1 PublicationCurated
    Sequence conflicti122 – 1221L → V in BAA25986. 1 PublicationCurated
    Sequence conflicti125 – 1251K → N in BAA25986. 1 PublicationCurated
    Sequence conflicti137 – 1371Q → K in BAA25986. 1 PublicationCurated
    Sequence conflicti148 – 1481I → L in BAA25986. 1 PublicationCurated
    Sequence conflicti191 – 1911L → R in BAA25986. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45207 mRNA. Translation: BAA25986.1.
    D29743 mRNA. Translation: BAA06162.1.
    AC149222 Genomic DNA. No translation available.
    BC132042 mRNA. Translation: AAI32043.1.
    BC132068 mRNA. Translation: AAI32069.1.
    CCDSiCCDS40146.1.
    RefSeqiNP_077725.1. NM_024414.2.
    UniGeneiMm.439759.

    Genome annotation databases

    EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
    GeneIDi56216.
    KEGGimmu:56216.
    UCSCiuc009jwx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45207 mRNA. Translation: BAA25986.1 .
    D29743 mRNA. Translation: BAA06162.1 .
    AC149222 Genomic DNA. No translation available.
    BC132042 mRNA. Translation: AAI32043.1 .
    BC132068 mRNA. Translation: AAI32069.1 .
    CCDSi CCDS40146.1.
    RefSeqi NP_077725.1. NM_024414.2.
    UniGenei Mm.439759.

    3D structure databases

    ProteinModelPortali P61264.
    SMRi P61264. Positions 25-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207850. 1 interaction.
    IntActi P61264. 6 interactions.
    MINTi MINT-4135988.

    PTM databases

    PhosphoSitei P61264.

    Proteomic databases

    MaxQBi P61264.
    PaxDbi P61264.
    PRIDEi P61264.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106267 ; ENSMUSP00000101874 ; ENSMUSG00000030806 .
    GeneIDi 56216.
    KEGGi mmu:56216.
    UCSCi uc009jwx.1. mouse.

    Organism-specific databases

    CTDi 112755.
    MGIi MGI:1930705. Stx1b.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110552.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi P61264.
    KOi K08486.
    OMAi PWKNKSA.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi P61264.
    TreeFami TF313763.

    Miscellaneous databases

    NextBioi 312076.
    PROi P61264.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61264.
    Genevestigatori P61264.

    Family and domain databases

    InterProi IPR028669. STX1A/1B.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the various species HPC-1/syntaxin cDNA."
      Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Horikawa H.P.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 10-40; 46-69; 94-107; 125-139; 151-181; 189-197 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
      Hutt D.M., Baltz J.M., Ngsee J.K.
      J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
    7. "Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse."
      Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C.
      Cell 127:277-289(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OTOF.
      Strain: BALB/c.
      Tissue: Cochlea.
    8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiSTX1B_MOUSE
    AccessioniPrimary (citable) accession number: P61264
    Secondary accession number(s): A2RSB4, O35525, P32853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3