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P61264 (STX1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-1B
Gene names
Name:Stx1b
Synonyms:Stx1b1, Stx1b2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones By similarity. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm. Ref.6

Subunit structure

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent. Ref.6 Ref.7

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Post-translational modification

Phosphorylated by CK2 By similarity.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Syntaxin-1B
PRO_0000210193

Regions

Topological domain1 – 264264Cytoplasmic Potential
Transmembrane265 – 28824Helical; Anchor for type IV membrane protein; Potential
Domain191 – 25363t-SNARE coiled-coil homology
Coiled coil29 – 10476 Potential

Amino acid modifications

Modified residue141Phosphoserine By similarity

Experimental info

Sequence conflict3 – 42DR → EW in BAA25986. Ref.1
Sequence conflict81L → R in BAA25986. Ref.1
Sequence conflict261D → A in BAA25986. Ref.1
Sequence conflict301D → A in BAA25986. Ref.1
Sequence conflict51 – 555EQVKK → GRVGG in BAA25986. Ref.1
Sequence conflict651N → K in BAA25986. Ref.1
Sequence conflict981S → G in BAA25986. Ref.1
Sequence conflict114 – 1163IRK → YRT in BAA25986. Ref.1
Sequence conflict1221L → V in BAA25986. Ref.1
Sequence conflict1251K → N in BAA25986. Ref.1
Sequence conflict1371Q → K in BAA25986. Ref.1
Sequence conflict1481I → L in BAA25986. Ref.1
Sequence conflict1911L → R in BAA25986. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P61264 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 2733497E02978BEB

FASTA28833,245
        10         20         30         40         50         60 
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 

        70         80         90        100        110        120 
LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 

       130        140        150        160        170        180 
TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 

       190        200        210        220        230        240 
KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 

       250        260        270        280 
DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of the various species HPC-1/syntaxin cDNA."
Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Horikawa H.P.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 10-40; 46-69; 94-107; 125-139; 151-181; 189-197 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[6]"Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
Hutt D.M., Baltz J.M., Ngsee J.K.
J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
[7]"Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse."
Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C.
Cell 127:277-289(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH OTOF.
Strain: BALB/c.
Tissue: Cochlea.
[8]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSCCDS40146.1.
RefSeqNP_077725.1. NM_024414.2.
UniGeneMm.439759.

3D structure databases

ProteinModelPortalP61264.
SMRP61264. Positions 25-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207850. 1 interaction.
IntActP61264. 6 interactions.
MINTMINT-4135988.

PTM databases

PhosphoSiteP61264.

Proteomic databases

MaxQBP61264.
PaxDbP61264.
PRIDEP61264.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneID56216.
KEGGmmu:56216.
UCSCuc009jwx.1. mouse.

Organism-specific databases

CTD112755.
MGIMGI:1930705. Stx1b.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00730000110552.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidP61264.
KOK08486.
OMAPWKNKSA.
OrthoDBEOG7X9G7R.
PhylomeDBP61264.
TreeFamTF313763.

Gene expression databases

BgeeP61264.
GenevestigatorP61264.

Family and domain databases

InterProIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. SSF47661. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312076.
PROP61264.
SOURCESearch...

Entry information

Entry nameSTX1B_MOUSE
AccessionPrimary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot