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P61264

- STX1B_MOUSE

UniProt

P61264 - STX1B_MOUSE

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Protein
Syntaxin-1B
Gene
Stx1b, Stx1b1, Stx1b2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones By similarity. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. neurotransmitter transport Source: UniProtKB-KW
  3. regulation of exocytosis Source: Ensembl
  4. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Gene namesi
Name:Stx1b
Synonyms:Stx1b1, Stx1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1930705. Stx1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1B
PRO_0000210193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by CK2 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61264.
PaxDbiP61264.
PRIDEiP61264.

PTM databases

PhosphoSiteiP61264.

Expressioni

Gene expression databases

BgeeiP61264.
GenevestigatoriP61264.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.2 Publications

Protein-protein interaction databases

BioGridi207850. 1 interaction.
IntActiP61264. 6 interactions.
MINTiMINT-4135988.

Structurei

3D structure databases

ProteinModelPortaliP61264.
SMRiP61264. Positions 25-284.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00730000110552.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61264.
KOiK08486.
OMAiPWKNKSA.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61264.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61264-1 [UniParc]FASTAAdd to Basket

« Hide

MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV    50
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE 100
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR 150
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE 200
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT 250
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL 288
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42DR → EW in BAA25986. 1 Publication
Sequence conflicti8 – 81L → R in BAA25986. 1 Publication
Sequence conflicti26 – 261D → A in BAA25986. 1 Publication
Sequence conflicti30 – 301D → A in BAA25986. 1 Publication
Sequence conflicti51 – 555EQVKK → GRVGG in BAA25986. 1 Publication
Sequence conflicti65 – 651N → K in BAA25986. 1 Publication
Sequence conflicti98 – 981S → G in BAA25986. 1 Publication
Sequence conflicti114 – 1163IRK → YRT in BAA25986. 1 Publication
Sequence conflicti122 – 1221L → V in BAA25986. 1 Publication
Sequence conflicti125 – 1251K → N in BAA25986. 1 Publication
Sequence conflicti137 – 1371Q → K in BAA25986. 1 Publication
Sequence conflicti148 – 1481I → L in BAA25986. 1 Publication
Sequence conflicti191 – 1911L → R in BAA25986. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSiCCDS40146.1.
RefSeqiNP_077725.1. NM_024414.2.
UniGeneiMm.439759.

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneIDi56216.
KEGGimmu:56216.
UCSCiuc009jwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45207 mRNA. Translation: BAA25986.1 .
D29743 mRNA. Translation: BAA06162.1 .
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1 .
BC132068 mRNA. Translation: AAI32069.1 .
CCDSi CCDS40146.1.
RefSeqi NP_077725.1. NM_024414.2.
UniGenei Mm.439759.

3D structure databases

ProteinModelPortali P61264.
SMRi P61264. Positions 25-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207850. 1 interaction.
IntActi P61264. 6 interactions.
MINTi MINT-4135988.

PTM databases

PhosphoSitei P61264.

Proteomic databases

MaxQBi P61264.
PaxDbi P61264.
PRIDEi P61264.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106267 ; ENSMUSP00000101874 ; ENSMUSG00000030806 .
GeneIDi 56216.
KEGGi mmu:56216.
UCSCi uc009jwx.1. mouse.

Organism-specific databases

CTDi 112755.
MGIi MGI:1930705. Stx1b.

Phylogenomic databases

eggNOGi COG5074.
GeneTreei ENSGT00730000110552.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi P61264.
KOi K08486.
OMAi PWKNKSA.
OrthoDBi EOG7X9G7R.
PhylomeDBi P61264.
TreeFami TF313763.

Miscellaneous databases

NextBioi 312076.
PROi P61264.
SOURCEi Search...

Gene expression databases

Bgeei P61264.
Genevestigatori P61264.

Family and domain databases

InterProi IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF76. PTHR19957:SF76. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the various species HPC-1/syntaxin cDNA."
    Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Horikawa H.P.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-40; 46-69; 94-107; 125-139; 151-181; 189-197 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
    Hutt D.M., Baltz J.M., Ngsee J.K.
    J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
  7. "Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse."
    Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C.
    Cell 127:277-289(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OTOF.
    Strain: BALB/c.
    Tissue: Cochlea.
  8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSTX1B_MOUSE
AccessioniPrimary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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