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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.By similarity1 Publication

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL
  • receptor binding Source: ParkinsonsUK-UCL
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: ParkinsonsUK-UCL
  • intracellular protein transport Source: GO_Central
  • negative regulation of macropinocytosis Source: ParkinsonsUK-UCL
  • negative regulation of neuron projection development Source: ParkinsonsUK-UCL
  • negative regulation of synaptic vesicle recycling Source: ParkinsonsUK-UCL
  • positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
  • positive regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
  • positive regulation of spontaneous neurotransmitter secretion Source: ParkinsonsUK-UCL
  • regulation of gene expression Source: ParkinsonsUK-UCL
  • regulation of synaptic activity Source: ParkinsonsUK-UCL
  • regulation of synaptic vesicle priming Source: ParkinsonsUK-UCL
  • spontaneous neurotransmitter secretion Source: ParkinsonsUK-UCL
  • synaptic vesicle docking Source: ParkinsonsUK-UCL
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • vesicle docking involved in exocytosis Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Gene namesi
Name:Stx1b
Synonyms:Stx1b1, Stx1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930705. Stx1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264CytoplasmicSequence analysisAdd BLAST264
Transmembranei265 – 288Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • membrane Source: MGI
  • plasma membrane Source: ParkinsonsUK-UCL
  • presynapse Source: ParkinsonsUK-UCL
  • SNARE complex Source: GO_Central
  • synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101931 – 288Syntaxin-1BAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61264.
PaxDbiP61264.
PeptideAtlasiP61264.
PRIDEiP61264.

PTM databases

iPTMnetiP61264.
PhosphoSitePlusiP61264.
SwissPalmiP61264.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030806.
ExpressionAtlasiP61264. baseline and differential.
GenevisibleiP61264. MM.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.2 Publications

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL
  • receptor binding Source: ParkinsonsUK-UCL
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi207850. 3 interactors.
IntActiP61264. 6 interactors.
MINTiMINT-4135988.
STRINGi10090.ENSMUSP00000101874.

Structurei

3D structure databases

ProteinModelPortaliP61264.
SMRiP61264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 104Sequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61264.
KOiK08486.
OMAiEVMTENA.
OrthoDBiEOG091G0EUK.
PhylomeDBiP61264.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 10, 2004 - v1
Checksum:i2733497E02978BEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4DR → EW in BAA25986 (Ref. 1) Curated2
Sequence conflicti8L → R in BAA25986 (Ref. 1) Curated1
Sequence conflicti26D → A in BAA25986 (Ref. 1) Curated1
Sequence conflicti30D → A in BAA25986 (Ref. 1) Curated1
Sequence conflicti51 – 55EQVKK → GRVGG in BAA25986 (Ref. 1) Curated5
Sequence conflicti65N → K in BAA25986 (Ref. 1) Curated1
Sequence conflicti98S → G in BAA25986 (Ref. 1) Curated1
Sequence conflicti114 – 116IRK → YRT in BAA25986 (Ref. 1) Curated3
Sequence conflicti122L → V in BAA25986 (Ref. 1) Curated1
Sequence conflicti125K → N in BAA25986 (Ref. 1) Curated1
Sequence conflicti137Q → K in BAA25986 (Ref. 1) Curated1
Sequence conflicti148I → L in BAA25986 (Ref. 1) Curated1
Sequence conflicti191L → R in BAA25986 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSiCCDS40146.1.
RefSeqiNP_077725.1. NM_024414.2.
UniGeneiMm.439759.

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneIDi56216.
KEGGimmu:56216.
UCSCiuc009jwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSiCCDS40146.1.
RefSeqiNP_077725.1. NM_024414.2.
UniGeneiMm.439759.

3D structure databases

ProteinModelPortaliP61264.
SMRiP61264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207850. 3 interactors.
IntActiP61264. 6 interactors.
MINTiMINT-4135988.
STRINGi10090.ENSMUSP00000101874.

PTM databases

iPTMnetiP61264.
PhosphoSitePlusiP61264.
SwissPalmiP61264.

Proteomic databases

MaxQBiP61264.
PaxDbiP61264.
PeptideAtlasiP61264.
PRIDEiP61264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneIDi56216.
KEGGimmu:56216.
UCSCiuc009jwx.1. mouse.

Organism-specific databases

CTDi112755.
MGIiMGI:1930705. Stx1b.

Phylogenomic databases

eggNOGiKOG0810. Eukaryota.
COG5074. LUCA.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61264.
KOiK08486.
OMAiEVMTENA.
OrthoDBiEOG091G0EUK.
PhylomeDBiP61264.
TreeFamiTF313763.

Enzyme and pathway databases

ReactomeiR-MMU-5682910. LGI-ADAM interactions.

Miscellaneous databases

PROiP61264.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030806.
ExpressionAtlasiP61264. baseline and differential.
GenevisibleiP61264. MM.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX1B_MOUSE
AccessioniPrimary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.