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Protein

Syntaxin-1B

Gene

Stx1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.By similarity1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: ParkinsonsUK-UCL
  2. SNAP receptor activity Source: GO_Central
  3. SNARE binding Source: GO_Central

GO - Biological processi

  1. intracellular protein transport Source: GO_Central
  2. positive regulation of excitatory postsynaptic membrane potential Source: ParkinsonsUK-UCL
  3. positive regulation of neurotransmitter secretion Source: ParkinsonsUK-UCL
  4. regulation of gene expression Source: ParkinsonsUK-UCL
  5. regulation of synaptic vesicle priming Source: ParkinsonsUK-UCL
  6. synaptic vesicle docking Source: ParkinsonsUK-UCL
  7. synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  8. vesicle docking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1B
Gene namesi
Name:Stx1b
Synonyms:Stx1b1, Stx1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930705. Stx1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 264264CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28824Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endomembrane system Source: GO_Central
  2. integral component of membrane Source: GO_Central
  3. membrane Source: MGI
  4. plasma membrane Source: ParkinsonsUK-UCL
  5. SNARE complex Source: GO_Central
  6. synaptic vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1BPRO_0000210193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by CK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61264.
PaxDbiP61264.
PRIDEiP61264.

PTM databases

PhosphoSiteiP61264.

Expressioni

Gene expression databases

BgeeiP61264.
GenevestigatoriP61264.

Interactioni

Subunit structurei

Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.2 Publications

Protein-protein interaction databases

BioGridi207850. 3 interactions.
IntActiP61264. 6 interactions.
MINTiMINT-4135988.

Structurei

3D structure databases

ProteinModelPortaliP61264.
SMRiP61264. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 25363t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 10476Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61264.
KOiK08486.
OMAiMDTIMEI.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61264.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV
60 70 80 90 100
EQVKKQHSAI LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE
110 120 130 140 150
QEEGLNRSSA DLRIRKTQHS TLSRKFVEVM TEYNATQSKY RDRCKDRIQR
160 170 180 190 200
QLEITGRTTT NEELEDMLES GKLAIFTDDI KMDSQMTKQA LNEIETRHNE
210 220 230 240 250
IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV DYVERAVSDT
260 270 280
KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL
Length:288
Mass (Da):33,245
Last modified:May 9, 2004 - v1
Checksum:i2733497E02978BEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42DR → EW in BAA25986 (Ref. 1) Curated
Sequence conflicti8 – 81L → R in BAA25986 (Ref. 1) Curated
Sequence conflicti26 – 261D → A in BAA25986 (Ref. 1) Curated
Sequence conflicti30 – 301D → A in BAA25986 (Ref. 1) Curated
Sequence conflicti51 – 555EQVKK → GRVGG in BAA25986 (Ref. 1) Curated
Sequence conflicti65 – 651N → K in BAA25986 (Ref. 1) Curated
Sequence conflicti98 – 981S → G in BAA25986 (Ref. 1) Curated
Sequence conflicti114 – 1163IRK → YRT in BAA25986 (Ref. 1) Curated
Sequence conflicti122 – 1221L → V in BAA25986 (Ref. 1) Curated
Sequence conflicti125 – 1251K → N in BAA25986 (Ref. 1) Curated
Sequence conflicti137 – 1371Q → K in BAA25986 (Ref. 1) Curated
Sequence conflicti148 – 1481I → L in BAA25986 (Ref. 1) Curated
Sequence conflicti191 – 1911L → R in BAA25986 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSiCCDS40146.1.
RefSeqiNP_077725.1. NM_024414.2.
UniGeneiMm.439759.

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneIDi56216.
KEGGimmu:56216.
UCSCiuc009jwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45207 mRNA. Translation: BAA25986.1.
D29743 mRNA. Translation: BAA06162.1.
AC149222 Genomic DNA. No translation available.
BC132042 mRNA. Translation: AAI32043.1.
BC132068 mRNA. Translation: AAI32069.1.
CCDSiCCDS40146.1.
RefSeqiNP_077725.1. NM_024414.2.
UniGeneiMm.439759.

3D structure databases

ProteinModelPortaliP61264.
SMRiP61264. Positions 25-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207850. 3 interactions.
IntActiP61264. 6 interactions.
MINTiMINT-4135988.

PTM databases

PhosphoSiteiP61264.

Proteomic databases

MaxQBiP61264.
PaxDbiP61264.
PRIDEiP61264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneIDi56216.
KEGGimmu:56216.
UCSCiuc009jwx.1. mouse.

Organism-specific databases

CTDi112755.
MGIiMGI:1930705. Stx1b.

Phylogenomic databases

eggNOGiCOG5074.
GeneTreeiENSGT00760000119200.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP61264.
KOiK08486.
OMAiMDTIMEI.
OrthoDBiEOG7X9G7R.
PhylomeDBiP61264.
TreeFamiTF313763.

Miscellaneous databases

NextBioi312076.
PROiP61264.
SOURCEiSearch...

Gene expression databases

BgeeiP61264.
GenevestigatoriP61264.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF76. PTHR19957:SF76. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the various species HPC-1/syntaxin cDNA."
    Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Horikawa H.P.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-40; 46-69; 94-107; 125-139; 151-181; 189-197 AND 232-245, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
    Hutt D.M., Baltz J.M., Ngsee J.K.
    J. Biol. Chem. 280:20197-20203(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
  7. "Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse."
    Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C.
    Cell 127:277-289(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OTOF.
    Strain: BALB/c.
    Tissue: Cochlea.
  8. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSTX1B_MOUSE
AccessioniPrimary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2004
Last sequence update: May 9, 2004
Last modified: March 31, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.