Syntaxin-1B - Mus musculus (Mouse)

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P61264 (STX1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 68. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Syntaxin-1B

Gene names

Name:	Stx1b
Synonyms:	Stx1b1, Stx1b2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potentially involved in docking of synaptic vesicles at presynaptic active zones By similarity. May mediate Ca²⁺-regulation of exocytosis acrosomal reaction in sperm. Ref.6
Subunit structure	Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca²⁺-dependent. Ref.6 Ref.8
Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Post-translational modification	Phosphorylated by CK2 By similarity. Ref.7 Ref.9
Sequence similarities	Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Neurotransmitter transport Transport
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro neurotransmitter transport Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Inferred from direct assay. Source: MGI
Molecular function	SNAP receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 288

288

Syntaxin-1B

PRO_0000210193

Regions

Topological domain

1 – 264

264

Cytoplasmic Potential

Transmembrane

265 – 288

Helical; Anchor for type IV membrane protein; Potential

Domain

191 – 253

t-SNARE coiled-coil homology

Coiled coil

29 – 104

Potential

Amino acid modifications

Modified residue

Phosphoserine Ref.7 Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

160

Phosphothreonine Ref.9

Experimental info

Sequence conflict

3 – 4

DR → EW in BAA25986. Ref.1

Sequence conflict

L → R in BAA25986. Ref.1

Sequence conflict

D → A in BAA25986. Ref.1

Sequence conflict

D → A in BAA25986. Ref.1

Sequence conflict

51 – 55

EQVKK → GRVGG in BAA25986. Ref.1

Sequence conflict

N → K in BAA25986. Ref.1

Sequence conflict

S → G in BAA25986. Ref.1

Sequence conflict

114 – 116

IRK → YRT in BAA25986. Ref.1

Sequence conflict

122

L → V in BAA25986. Ref.1

Sequence conflict

125

K → N in BAA25986. Ref.1

Sequence conflict

137

Q → K in BAA25986. Ref.1

Sequence conflict

148

I → L in BAA25986. Ref.1

Sequence conflict

191

L → R in BAA25986. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P61264 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 2733497E02978BEB
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FASTA

288

33,245

        10         20         30         40         50         60 
MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 

        70         80         90        100        110        120 
LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 

       130        140        150        160        170        180 
TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 

       190        200        210        220        230        240 
KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 

       250        260        270        280 
DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of the various species HPC-1/syntaxin cDNA." Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	Horikawa H.P. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 10-40; 46-69; 94-107; 125-139; 151-181; 189-197 AND 232-245, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[6]	"Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction." Hutt D.M., Baltz J.M., Ngsee J.K. J. Biol. Chem. 280:20197-20203(2005) [PubMed: 15774481] [Abstract] Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
[7]	"Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol." Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L., Hart G.W., Burlingame A.L. Proteomics 5:388-398(2005) [PubMed: 15648052] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[8]	"Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse." Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C. Cell 127:277-289(2006) [PubMed: 17055430] [Abstract] Cited for: INTERACTION WITH OTOF. Strain: BALB/c. Tissue: Cochlea.
[9]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-58 AND THR-160, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D45207 mRNA. Translation: BAA25986.1. D29743 mRNA. Translation: BAA06162.1. AC149222 Genomic DNA. No translation available. BC132042 mRNA. Translation: AAI32043.1. BC132068 mRNA. Translation: AAI32069.1.
IPI	IPI00113149.
RefSeq	NP_077725.1. NM_024414.2.
UniGene	Mm.439759.
3D structure databases
ProteinModelPortal	P61264.
SMR	P61264. Positions 2-284.
ModBase	Search...
Protein-protein interaction databases
IntAct	P61264. 2 interactions.
STRING	P61264.
PTM databases
PhosphoSite	P61264.
Proteomic databases
PRIDE	P61264.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000106267; ENSMUSP00000101874; ENSMUSG00000030806.
GeneID	56216.
KEGG	mmu:56216.
UCSC	uc009jwx.1. mouse.
Organism-specific databases
CTD	112755.
MGI	MGI:1930705. Stx1b.
Phylogenomic databases
eggNOG	roNOG14013.
GeneTree	ENSGT00550000074334.
HOGENOM	HBG717663.
HOVERGEN	HBG000497.
InParanoid	P61264.
OMA	NNIESHV.
OrthoDB	EOG4PC9SV.
PhylomeDB	P61264.
Gene expression databases
ArrayExpress	P61264.
Bgee	P61264.
Genevestigator	P61264.
GermOnline	ENSMUSG00000030806. Mus musculus.
Family and domain databases
InterPro	IPR015709. Syntaxin-1. IPR006012. Syntaxin/epimorphin_CS. IPR006011. Syntaxin_N. IPR010989. t-SNARE. IPR000727. T_SNARE_dom. [Graphical view]
KO	K08486.
PANTHER	PTHR19957:SF35. Syntaxin-1. 1 hit.
Pfam	PF05739. SNARE. 1 hit. PF00804. Syntaxin. 1 hit. [Graphical view]
SMART	SM00503. SynN. 1 hit. SM00397. t_SNARE. 1 hit. [Graphical view]
SUPFAM	SSF47661. t-snare. 1 hit.
PROSITE	PS00914. SYNTAXIN. 1 hit. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	312076.
SOURCE	Search...

Entry information

Entry name

STX1B_MOUSE

Accession

Primary (citable) accession number: P61264
Secondary accession number(s): A2RSB4, O35525, P32853

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents