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P61255

- RL26_MOUSE

UniProt

P61255 - RL26_MOUSE

Protein

60S ribosomal protein L26

Gene

Rpl26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. ribosomal large subunit biogenesis Source: Ensembl
    2. rRNA processing Source: Ensembl
    3. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L26
    Alternative name(s):
    Silica-induced gene 20 protein
    Short name:
    SIG-20
    Gene namesi
    Name:Rpl26
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:106022. Rpl26.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14514560S ribosomal protein L26PRO_0000130789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP61255.
    PaxDbiP61255.
    PRIDEiP61255.

    PTM databases

    PhosphoSiteiP61255.

    Expressioni

    Inductioni

    Up-regulated in silica-treated macrophages.1 Publication

    Gene expression databases

    ArrayExpressiP61255.
    BgeeiP61255.
    CleanExiMM_RPL26.
    GenevestigatoriP61255.

    Interactioni

    Protein-protein interaction databases

    BioGridi202973. 1 interaction.
    IntActiP61255. 6 interactions.
    MINTiMINT-1845853.

    Structurei

    3D structure databases

    ProteinModelPortaliP61255.
    SMRiP61255. Positions 2-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24P family.Curated

    Phylogenomic databases

    eggNOGiCOG0198.
    HOGENOMiHOG000216571.
    HOVERGENiHBG017293.
    InParanoidiP61255.
    KOiK02898.
    OMAiHVERVTR.
    OrthoDBiEOG76QFKH.
    PhylomeDBiP61255.
    TreeFamiTF300236.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    HAMAPiMF_01326_A. Ribosomal_L24_A.
    InterProiIPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR005825. Ribosomal_L24/26_CS.
    IPR005756. Ribosomal_L26/L24P_euk/arc.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11143. PTHR11143. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    [Graphical view]
    SMARTiSM00739. KOW. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
    PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61255-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR    50
    KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH 100
    PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE 145
    Length:145
    Mass (Da):17,258
    Last modified:May 10, 2004 - v1
    Checksum:i049D53AB4E3F46B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80699 mRNA. Translation: CAA56716.1.
    BC070397 mRNA. Translation: AAH70397.1.
    CCDSiCCDS36187.1.
    PIRiI48616. S48864.
    RefSeqiNP_033106.1. NM_009080.2.
    UniGeneiMm.306548.
    Mm.3229.

    Genome annotation databases

    EnsembliENSMUST00000073471; ENSMUSP00000073175; ENSMUSG00000060938.
    ENSMUST00000167436; ENSMUSP00000129072; ENSMUSG00000060938.
    GeneIDi19941.
    KEGGimmu:19941.
    UCSCiuc007joh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80699 mRNA. Translation: CAA56716.1 .
    BC070397 mRNA. Translation: AAH70397.1 .
    CCDSi CCDS36187.1.
    PIRi I48616. S48864.
    RefSeqi NP_033106.1. NM_009080.2.
    UniGenei Mm.306548.
    Mm.3229.

    3D structure databases

    ProteinModelPortali P61255.
    SMRi P61255. Positions 2-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202973. 1 interaction.
    IntActi P61255. 6 interactions.
    MINTi MINT-1845853.

    PTM databases

    PhosphoSitei P61255.

    Proteomic databases

    MaxQBi P61255.
    PaxDbi P61255.
    PRIDEi P61255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073471 ; ENSMUSP00000073175 ; ENSMUSG00000060938 .
    ENSMUST00000167436 ; ENSMUSP00000129072 ; ENSMUSG00000060938 .
    GeneIDi 19941.
    KEGGi mmu:19941.
    UCSCi uc007joh.1. mouse.

    Organism-specific databases

    CTDi 6154.
    MGIi MGI:106022. Rpl26.

    Phylogenomic databases

    eggNOGi COG0198.
    HOGENOMi HOG000216571.
    HOVERGENi HBG017293.
    InParanoidi P61255.
    KOi K02898.
    OMAi HVERVTR.
    OrthoDBi EOG76QFKH.
    PhylomeDBi P61255.
    TreeFami TF300236.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 23899.
    PROi P61255.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61255.
    Bgeei P61255.
    CleanExi MM_RPL26.
    Genevestigatori P61255.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    HAMAPi MF_01326_A. Ribosomal_L24_A.
    InterProi IPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR005825. Ribosomal_L24/26_CS.
    IPR005756. Ribosomal_L26/L24P_euk/arc.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11143. PTHR11143. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    [Graphical view ]
    SMARTi SM00739. KOW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    TIGRFAMsi TIGR01080. rplX_A_E. 1 hit.
    PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of nine gene sequences induced by silica in murine macrophages."
      Segade F., Claudio E., Wrobel K., Ramos S., Lazo P.S.
      J. Immunol. 154:2384-2392(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Tissue: Macrophage.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiRL26_MOUSE
    AccessioniPrimary (citable) accession number: P61255
    Secondary accession number(s): Q02877
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3