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Protein

60S ribosomal protein L26

Gene

Rpl26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_292264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_302277. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_308559. Formation of a pool of free 40S subunits.
REACT_311765. Peptide chain elongation.
REACT_319670. Eukaryotic Translation Termination.
REACT_331340. SRP-dependent cotranslational protein targeting to membrane.
REACT_340387. L13a-mediated translational silencing of Ceruloplasmin expression.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26
Alternative name(s):
Silica-induced gene 20 protein
Short name:
SIG-20
Gene namesi
Name:Rpl26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106022. Rpl26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14514560S ribosomal protein L26PRO_0000130789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP61255.
PaxDbiP61255.
PRIDEiP61255.

PTM databases

PhosphoSiteiP61255.

Expressioni

Inductioni

Up-regulated in silica-treated macrophages.1 Publication

Gene expression databases

BgeeiP61255.
CleanExiMM_RPL26.
ExpressionAtlasiP61255. baseline and differential.
GenevisibleiP61255. MM.

Interactioni

Protein-protein interaction databases

BioGridi202973. 1 interaction.
IntActiP61255. 6 interactions.
MINTiMINT-1845853.
STRINGi10090.ENSMUSP00000073175.

Structurei

3D structure databases

ProteinModelPortaliP61255.
SMRiP61255. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

eggNOGiCOG0198.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiP61255.
KOiK02898.
OMAiHERRRIM.
OrthoDBiEOG76QFKH.
PhylomeDBiP61255.
TreeFamiTF300236.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
Length:145
Mass (Da):17,258
Last modified:May 10, 2004 - v1
Checksum:i049D53AB4E3F46B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80699 mRNA. Translation: CAA56716.1.
BC070397 mRNA. Translation: AAH70397.1.
CCDSiCCDS36187.1.
PIRiI48616. S48864.
RefSeqiNP_033106.1. NM_009080.2.
XP_011247131.1. XM_011248829.1.
UniGeneiMm.306548.
Mm.3229.

Genome annotation databases

EnsembliENSMUST00000073471; ENSMUSP00000073175; ENSMUSG00000060938.
ENSMUST00000167436; ENSMUSP00000129072; ENSMUSG00000060938.
GeneIDi19941.
KEGGimmu:19941.
UCSCiuc007joh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80699 mRNA. Translation: CAA56716.1.
BC070397 mRNA. Translation: AAH70397.1.
CCDSiCCDS36187.1.
PIRiI48616. S48864.
RefSeqiNP_033106.1. NM_009080.2.
XP_011247131.1. XM_011248829.1.
UniGeneiMm.306548.
Mm.3229.

3D structure databases

ProteinModelPortaliP61255.
SMRiP61255. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202973. 1 interaction.
IntActiP61255. 6 interactions.
MINTiMINT-1845853.
STRINGi10090.ENSMUSP00000073175.

PTM databases

PhosphoSiteiP61255.

Proteomic databases

MaxQBiP61255.
PaxDbiP61255.
PRIDEiP61255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073471; ENSMUSP00000073175; ENSMUSG00000060938.
ENSMUST00000167436; ENSMUSP00000129072; ENSMUSG00000060938.
GeneIDi19941.
KEGGimmu:19941.
UCSCiuc007joh.1. mouse.

Organism-specific databases

CTDi6154.
MGIiMGI:106022. Rpl26.

Phylogenomic databases

eggNOGiCOG0198.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiP61255.
KOiK02898.
OMAiHERRRIM.
OrthoDBiEOG76QFKH.
PhylomeDBiP61255.
TreeFamiTF300236.

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_292264. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_302277. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_308559. Formation of a pool of free 40S subunits.
REACT_311765. Peptide chain elongation.
REACT_319670. Eukaryotic Translation Termination.
REACT_331340. SRP-dependent cotranslational protein targeting to membrane.
REACT_340387. L13a-mediated translational silencing of Ceruloplasmin expression.

Miscellaneous databases

NextBioi297453.
PROiP61255.
SOURCEiSearch...

Gene expression databases

BgeeiP61255.
CleanExiMM_RPL26.
ExpressionAtlasiP61255. baseline and differential.
GenevisibleiP61255. MM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of nine gene sequences induced by silica in murine macrophages."
    Segade F., Claudio E., Wrobel K., Ramos S., Lazo P.S.
    J. Immunol. 154:2384-2392(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Tissue: Macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRL26_MOUSE
AccessioniPrimary (citable) accession number: P61255
Secondary accession number(s): Q02877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.