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Protein

60S ribosomal protein L26

Gene

RPL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • cytoplasmic translation Source: GO_Central
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26
Gene namesi
Name:RPL26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10327. RPL26.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 11 (DBA11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:614900

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

MalaCardsiRPL26.
MIMi614900. phenotype.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34705.

Polymorphism and mutation databases

BioMutaiRPL26.
DMDMi47117765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14514560S ribosomal protein L26PRO_0000130787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki136 – 136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei139 – 1391PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP61254.
MaxQBiP61254.
PaxDbiP61254.
PeptideAtlasiP61254.
PRIDEiP61254.
TopDownProteomicsiP61254.

PTM databases

iPTMnetiP61254.
PhosphoSiteiP61254.

Expressioni

Gene expression databases

BgeeiENSG00000161970.
CleanExiHS_RPL26.
ExpressionAtlasiP61254. baseline and differential.

Organism-specific databases

HPAiCAB037301.
HPA030449.

Interactioni

Protein-protein interaction databases

BioGridi112073. 98 interactions.
DIPiDIP-33198N.
IntActiP61254. 33 interactions.
MINTiMINT-1427663.
STRINGi9606.ENSP00000293842.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LY1-145[»]
4V6Xelectron microscopy5.00CY1-145[»]
5AJ0electron microscopy3.50AY1-145[»]
ProteinModelPortaliP61254.
SMRiP61254. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

eggNOGiKOG3401. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiP61254.
KOiK02898.
OMAiCYRKKFV.
OrthoDBiEOG091G0TZX.
PhylomeDBiP61254.
TreeFamiTF300236.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
Length:145
Mass (Da):17,258
Last modified:May 10, 2004 - v1
Checksum:i049D53AB4E3F46B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331G → S in AAA60279 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69392 mRNA. Translation: CAA49189.1.
L07287 Genomic DNA. Translation: AAA60279.1.
AB061829 Genomic DNA. Translation: BAB79467.1.
AK311804 mRNA. Translation: BAG34747.1.
CH471108 Genomic DNA. Translation: EAW90053.1.
CH471108 Genomic DNA. Translation: EAW90054.1.
CH471108 Genomic DNA. Translation: EAW90057.1.
BC071664 mRNA. Translation: AAH71664.1.
CCDSiCCDS11142.1.
PIRiS33713.
RefSeqiNP_000978.1. NM_000987.3.
NP_001302459.1. NM_001315530.1.
NP_001302460.1. NM_001315531.1.
UniGeneiHs.482144.
Hs.644794.
Hs.744896.

Genome annotation databases

EnsembliENST00000293842; ENSP00000293842; ENSG00000161970.
ENST00000582556; ENSP00000463470; ENSG00000161970.
ENST00000583011; ENSP00000462322; ENSG00000161970.
ENST00000584164; ENSP00000463784; ENSG00000161970.
GeneIDi6154.
KEGGihsa:6154.
UCSCiuc002glh.2. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69392 mRNA. Translation: CAA49189.1.
L07287 Genomic DNA. Translation: AAA60279.1.
AB061829 Genomic DNA. Translation: BAB79467.1.
AK311804 mRNA. Translation: BAG34747.1.
CH471108 Genomic DNA. Translation: EAW90053.1.
CH471108 Genomic DNA. Translation: EAW90054.1.
CH471108 Genomic DNA. Translation: EAW90057.1.
BC071664 mRNA. Translation: AAH71664.1.
CCDSiCCDS11142.1.
PIRiS33713.
RefSeqiNP_000978.1. NM_000987.3.
NP_001302459.1. NM_001315530.1.
NP_001302460.1. NM_001315531.1.
UniGeneiHs.482144.
Hs.644794.
Hs.744896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LY1-145[»]
4V6Xelectron microscopy5.00CY1-145[»]
5AJ0electron microscopy3.50AY1-145[»]
ProteinModelPortaliP61254.
SMRiP61254. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112073. 98 interactions.
DIPiDIP-33198N.
IntActiP61254. 33 interactions.
MINTiMINT-1427663.
STRINGi9606.ENSP00000293842.

PTM databases

iPTMnetiP61254.
PhosphoSiteiP61254.

Polymorphism and mutation databases

BioMutaiRPL26.
DMDMi47117765.

Proteomic databases

EPDiP61254.
MaxQBiP61254.
PaxDbiP61254.
PeptideAtlasiP61254.
PRIDEiP61254.
TopDownProteomicsiP61254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293842; ENSP00000293842; ENSG00000161970.
ENST00000582556; ENSP00000463470; ENSG00000161970.
ENST00000583011; ENSP00000462322; ENSG00000161970.
ENST00000584164; ENSP00000463784; ENSG00000161970.
GeneIDi6154.
KEGGihsa:6154.
UCSCiuc002glh.2. human.

Organism-specific databases

CTDi6154.
GeneCardsiRPL26.
GeneReviewsiRPL26.
HGNCiHGNC:10327. RPL26.
HPAiCAB037301.
HPA030449.
MalaCardsiRPL26.
MIMi603704. gene.
614900. phenotype.
neXtProtiNX_P61254.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34705.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3401. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiP61254.
KOiK02898.
OMAiCYRKKFV.
OrthoDBiEOG091G0TZX.
PhylomeDBiP61254.
TreeFamiTF300236.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL26. human.
GeneWikiiRPL26.
GenomeRNAii6154.
PROiP61254.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161970.
CleanExiHS_RPL26.
ExpressionAtlasiP61254. baseline and differential.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL26_HUMAN
AccessioniPrimary (citable) accession number: P61254
Secondary accession number(s): B2R4F0
, D3DTR8, Q02877, Q6IPY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.