Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61254

- RL26_HUMAN

UniProt

P61254 - RL26_HUMAN

Protein

60S ribosomal protein L26

Gene

RPL26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: ProtInc
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. ribosomal large subunit biogenesis Source: UniProtKB
    6. RNA metabolic process Source: Reactome
    7. rRNA processing Source: UniProtKB
    8. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    9. translation Source: UniProtKB
    10. translational elongation Source: Reactome
    11. translational initiation Source: Reactome
    12. translational termination Source: Reactome
    13. viral life cycle Source: Reactome
    14. viral process Source: Reactome
    15. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L26
    Gene namesi
    Name:RPL26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10327. RPL26.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. membrane Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    Diamond-Blackfan anemia 11 (DBA11) [MIM:614900]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Diamond-Blackfan anemia

    Organism-specific databases

    MIMi614900. phenotype.
    Orphaneti124. Blackfan-Diamond anemia.
    PharmGKBiPA34705.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14514560S ribosomal protein L26PRO_0000130787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP61254.
    PaxDbiP61254.
    PRIDEiP61254.

    PTM databases

    PhosphoSiteiP61254.

    Expressioni

    Gene expression databases

    BgeeiP61254.
    CleanExiHS_RPL26.
    GenevestigatoriP61254.

    Organism-specific databases

    HPAiHPA030449.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX56Q9NY931EBI-352405,EBI-372376
    MAGEB2O154791EBI-352405,EBI-1057615
    PSTPIP1O435861EBI-352405,EBI-1050964

    Protein-protein interaction databases

    BioGridi112073. 45 interactions.
    IntActiP61254. 27 interactions.
    MINTiMINT-1427663.
    STRINGi9606.ENSP00000293842.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00Y1-145[»]
    ProteinModelPortaliP61254.
    SMRiP61254. Positions 2-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24P family.Curated

    Phylogenomic databases

    eggNOGiCOG0198.
    HOGENOMiHOG000216571.
    HOVERGENiHBG017293.
    KOiK02898.
    OMAiHVERVTR.
    PhylomeDBiP61254.
    TreeFamiTF300236.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    HAMAPiMF_01326_A. Ribosomal_L24_A.
    InterProiIPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR005825. Ribosomal_L24/26_CS.
    IPR005756. Ribosomal_L26/L24P_euk/arc.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11143. PTHR11143. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    [Graphical view]
    SMARTiSM00739. KOW. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
    PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61254-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR    50
    KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH 100
    PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE 145
    Length:145
    Mass (Da):17,258
    Last modified:May 10, 2004 - v1
    Checksum:i049D53AB4E3F46B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331G → S in AAA60279. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69392 mRNA. Translation: CAA49189.1.
    L07287 Genomic DNA. Translation: AAA60279.1.
    AB061829 Genomic DNA. Translation: BAB79467.1.
    AK311804 mRNA. Translation: BAG34747.1.
    CH471108 Genomic DNA. Translation: EAW90053.1.
    CH471108 Genomic DNA. Translation: EAW90054.1.
    CH471108 Genomic DNA. Translation: EAW90057.1.
    BC071664 mRNA. Translation: AAH71664.1.
    CCDSiCCDS11142.1.
    PIRiS33713.
    RefSeqiNP_000978.1. NM_000987.3.
    XP_005256806.1. XM_005256749.1.
    XP_005256807.1. XM_005256750.1.
    UniGeneiHs.482144.
    Hs.644794.
    Hs.744896.

    Genome annotation databases

    EnsembliENST00000293842; ENSP00000293842; ENSG00000161970.
    ENST00000582556; ENSP00000463470; ENSG00000161970.
    ENST00000583011; ENSP00000462322; ENSG00000161970.
    ENST00000584164; ENSP00000463784; ENSG00000161970.
    GeneIDi6154.
    KEGGihsa:6154.
    UCSCiuc002glh.1. human.

    Polymorphism databases

    DMDMi47117765.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69392 mRNA. Translation: CAA49189.1 .
    L07287 Genomic DNA. Translation: AAA60279.1 .
    AB061829 Genomic DNA. Translation: BAB79467.1 .
    AK311804 mRNA. Translation: BAG34747.1 .
    CH471108 Genomic DNA. Translation: EAW90053.1 .
    CH471108 Genomic DNA. Translation: EAW90054.1 .
    CH471108 Genomic DNA. Translation: EAW90057.1 .
    BC071664 mRNA. Translation: AAH71664.1 .
    CCDSi CCDS11142.1.
    PIRi S33713.
    RefSeqi NP_000978.1. NM_000987.3.
    XP_005256806.1. XM_005256749.1.
    XP_005256807.1. XM_005256750.1.
    UniGenei Hs.482144.
    Hs.644794.
    Hs.744896.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 Y 1-145 [» ]
    ProteinModelPortali P61254.
    SMRi P61254. Positions 2-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112073. 45 interactions.
    IntActi P61254. 27 interactions.
    MINTi MINT-1427663.
    STRINGi 9606.ENSP00000293842.

    PTM databases

    PhosphoSitei P61254.

    Polymorphism databases

    DMDMi 47117765.

    Proteomic databases

    MaxQBi P61254.
    PaxDbi P61254.
    PRIDEi P61254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293842 ; ENSP00000293842 ; ENSG00000161970 .
    ENST00000582556 ; ENSP00000463470 ; ENSG00000161970 .
    ENST00000583011 ; ENSP00000462322 ; ENSG00000161970 .
    ENST00000584164 ; ENSP00000463784 ; ENSG00000161970 .
    GeneIDi 6154.
    KEGGi hsa:6154.
    UCSCi uc002glh.1. human.

    Organism-specific databases

    CTDi 6154.
    GeneCardsi GC17M008280.
    GeneReviewsi RPL26.
    HGNCi HGNC:10327. RPL26.
    HPAi HPA030449.
    MIMi 603704. gene.
    614900. phenotype.
    neXtProti NX_P61254.
    Orphaneti 124. Blackfan-Diamond anemia.
    PharmGKBi PA34705.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0198.
    HOGENOMi HOG000216571.
    HOVERGENi HBG017293.
    KOi K02898.
    OMAi HVERVTR.
    PhylomeDBi P61254.
    TreeFami TF300236.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPL26.
    GenomeRNAii 6154.
    NextBioi 23899.
    PROi P61254.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61254.
    CleanExi HS_RPL26.
    Genevestigatori P61254.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    HAMAPi MF_01326_A. Ribosomal_L24_A.
    InterProi IPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR005825. Ribosomal_L24/26_CS.
    IPR005756. Ribosomal_L26/L24P_euk/arc.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11143. PTHR11143. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    [Graphical view ]
    SMARTi SM00739. KOW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    TIGRFAMsi TIGR01080. rplX_A_E. 1 hit.
    PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6."
      Zaman G.J.R.
      Nucleic Acids Res. 21:1673-1673(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the human homologue to rat ribosomal protein L26 from HL60 cells."
      Butterfield L.H., Stephen K., Snyder C., Winston S.
      Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia."
      Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A., Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C., Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E., Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E., Beggs A.H.
      Hum. Mutat. 33:1037-1044(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN DBA11.
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL26_HUMAN
    AccessioniPrimary (citable) accession number: P61254
    Secondary accession number(s): B2R4F0
    , D3DTR8, Q02877, Q6IPY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3