ID CNCG_RAT Reviewed; 83 AA. AC P61250; Q9D1Y6; Q9EP63; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2004, sequence version 1. DT 24-JAN-2024, entry version 115. DE RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; DE Short=GMP-PDE gamma; DE EC=3.1.4.35; GN Name=Pde6h; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RA Tate R.J., Pyne N.J.; RT "Molecular cloning and characterization of a cone-like phosphodiesterase 6 RT gamma in rat testis."; RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Participates in processes of transmission and amplification CC of the visual signal. cGMP-PDEs are the effector molecules in G- CC protein-mediated phototransduction in vertebrate rods and cones (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746, CC ChEBI:CHEBI:58115; EC=3.1.4.35; CC -!- SUBUNIT: Tetramer composed of two catalytic chains (alpha and beta), CC and two inhibitory chains (gamma). CC -!- DOMAIN: The C-terminal region is important in conferring inhibition. CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF169390; AAG43400.1; -; mRNA. DR RefSeq; NP_446140.1; NM_053688.2. DR RefSeq; XP_006237620.1; XM_006237558.3. DR RefSeq; XP_017447868.1; XM_017592379.1. DR RefSeq; XP_017447869.1; XM_017592380.1. DR AlphaFoldDB; P61250; -. DR SMR; P61250; -. DR STRING; 10116.ENSRNOP00000007905; -. DR PhosphoSitePlus; P61250; -. DR PaxDb; 10116-ENSRNOP00000007905; -. DR Ensembl; ENSRNOT00000007905.4; ENSRNOP00000007905.2; ENSRNOG00000005947.5. DR Ensembl; ENSRNOT00055044612; ENSRNOP00055036517; ENSRNOG00055025860. DR Ensembl; ENSRNOT00060015441; ENSRNOP00060012043; ENSRNOG00060009170. DR Ensembl; ENSRNOT00065019235; ENSRNOP00065014708; ENSRNOG00065011843. DR GeneID; 114248; -. DR KEGG; rno:114248; -. DR UCSC; RGD:70933; rat. DR AGR; RGD:70933; -. DR CTD; 5149; -. DR RGD; 70933; Pde6h. DR eggNOG; ENOG502S4P1; Eukaryota. DR GeneTree; ENSGT00390000013260; -. DR HOGENOM; CLU_170469_0_0_1; -. DR InParanoid; P61250; -. DR OMA; FNVICPW; -. DR OrthoDB; 5320589at2759; -. DR PhylomeDB; P61250; -. DR TreeFam; TF333297; -. DR PRO; PR:P61250; -. DR Proteomes; UP000002494; Chromosome 4. DR Bgee; ENSRNOG00000005947; Expressed in spleen and 13 other cell types or tissues. DR GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central. DR GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0030553; F:cGMP binding; IEA:InterPro. DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; ISO:RGD. DR GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; ISO:RGD. DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD. DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW. DR Gene3D; 4.10.1120.10; Retinal cGMP phosphodiesterase, gamma subunit; 1. DR InterPro; IPR006952; PDE6_gamma. DR InterPro; IPR037030; PDE6_gamma_sf. DR PANTHER; PTHR12122; RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT-RELATED; 1. DR PANTHER; PTHR12122:SF5; RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA; 1. DR Pfam; PF04868; PDE6_gamma; 1. DR PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1. DR Genevisible; P61250; RN. PE 3: Inferred from homology; KW cGMP; Hydrolase; Reference proteome; Sensory transduction; Vision. FT CHAIN 1..83 FT /note="Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic FT phosphodiesterase subunit gamma" FT /id="PRO_0000166122" FT REGION 1..51 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 25..39 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 83 AA; 9044 MW; D84EC90839A834FF CRC64; MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI TVICPWEAFS HLELHELAQF GII //