Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P61250 (CNCG_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:Pde6h
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length83 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Domain

The C-terminal region is important in conferring inhibition By similarity.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166122

Regions

Compositional bias20 – 4122Arg/Lys-rich (basic)

Sequences

Sequence LengthMass (Da)Tools
P61250 [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: D84EC90839A834FF

FASTA839,044
        10         20         30         40         50         60 
MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 

        70         80 
TVICPWEAFS HLELHELAQF GII 

« Hide

References

[1]"Molecular cloning and characterization of a cone-like phosphodiesterase 6 gamma in rat testis."
Tate R.J., Pyne N.J.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169390 mRNA. Translation: AAG43400.1.
RefSeqNP_446140.1. NM_053688.2.
XP_006237619.1. XM_006237557.1.
XP_006237620.1. XM_006237558.1.
XP_006237621.1. XM_006237559.1.
UniGeneRn.21249.

3D structure databases

ProteinModelPortalP61250.
SMRP61250. Positions 15-83.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP61250.

Proteomic databases

PaxDbP61250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007905; ENSRNOP00000007905; ENSRNOG00000005947.
GeneID114248.
KEGGrno:114248.
UCSCRGD:70933. rat.

Organism-specific databases

CTD5149.
RGD70933. Pde6h.

Phylogenomic databases

eggNOGNOG44509.
GeneTreeENSGT00390000013260.
HOGENOMHOG000261673.
HOVERGENHBG000447.
InParanoidP61250.
KOK13760.
OMATSNQGPT.
OrthoDBEOG7SN8FW.
PhylomeDBP61250.
TreeFamTF333297.

Gene expression databases

GenevestigatorP61250.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Other

NextBio349167.

Entry information

Entry nameCNCG_RAT
AccessionPrimary (citable) accession number: P61250
Secondary accession number(s): Q9D1Y6, Q9EP63
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families