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P61250

- CNCG_RAT

UniProt

P61250 - CNCG_RAT

Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6h

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:Pde6h
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi70933. Pde6h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166122Add
    BLAST

    Proteomic databases

    PaxDbiP61250.

    PTM databases

    PhosphoSiteiP61250.

    Expressioni

    Gene expression databases

    GenevestigatoriP61250.

    Interactioni

    Subunit structurei

    Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

    Structurei

    3D structure databases

    ProteinModelPortaliP61250.
    SMRiP61250. Positions 15-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    The C-terminal region is important in conferring inhibition.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44509.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiP61250.
    KOiK13760.
    OMAiNETHICV.
    OrthoDBiEOG7SN8FW.
    PhylomeDBiP61250.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P61250-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI   50
    PGMEGLGTDI TVICPWEAFS HLELHELAQF GII 83
    Length:83
    Mass (Da):9,044
    Last modified:May 10, 2004 - v1
    Checksum:iD84EC90839A834FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169390 mRNA. Translation: AAG43400.1.
    RefSeqiNP_446140.1. NM_053688.2.
    XP_006237619.1. XM_006237557.1.
    XP_006237620.1. XM_006237558.1.
    XP_006237621.1. XM_006237559.1.
    UniGeneiRn.21249.

    Genome annotation databases

    EnsembliENSRNOT00000007905; ENSRNOP00000007905; ENSRNOG00000005947.
    GeneIDi114248.
    KEGGirno:114248.
    UCSCiRGD:70933. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169390 mRNA. Translation: AAG43400.1 .
    RefSeqi NP_446140.1. NM_053688.2.
    XP_006237619.1. XM_006237557.1.
    XP_006237620.1. XM_006237558.1.
    XP_006237621.1. XM_006237559.1.
    UniGenei Rn.21249.

    3D structure databases

    ProteinModelPortali P61250.
    SMRi P61250. Positions 15-83.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P61250.

    Proteomic databases

    PaxDbi P61250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007905 ; ENSRNOP00000007905 ; ENSRNOG00000005947 .
    GeneIDi 114248.
    KEGGi rno:114248.
    UCSCi RGD:70933. rat.

    Organism-specific databases

    CTDi 5149.
    RGDi 70933. Pde6h.

    Phylogenomic databases

    eggNOGi NOG44509.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi P61250.
    KOi K13760.
    OMAi NETHICV.
    OrthoDBi EOG7SN8FW.
    PhylomeDBi P61250.
    TreeFami TF333297.

    Miscellaneous databases

    NextBioi 349167.

    Gene expression databases

    Genevestigatori P61250.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a cone-like phosphodiesterase 6 gamma in rat testis."
      Tate R.J., Pyne N.J.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCNCG_RAT
    AccessioniPrimary (citable) accession number: P61250
    Secondary accession number(s): Q9D1Y6, Q9EP63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3