P61250 (CNCG_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Short name=GMP-PDE gamma
EC=3.1.4.35

Gene names

Name:

Pde6h

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
Domain	The C-terminal region is important in conferring inhibition By similarity.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara positive regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of epidermal growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166122
Regions
	Compositional bias	20 – 41	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P61250 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: D84EC90839A834FF	FASTA	83	9,044
	10 20 30 40 50 60 MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 70 80 TVICPWEAFS HLELHELAQF GII

References

[1]	"Molecular cloning and characterization of a cone-like phosphodiesterase 6 gamma in rat testis." Tate R.J., Pyne N.J. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF169390 mRNA. Translation: AAG43400.1.
IPI	IPI00188696.
RefSeq	NP_446140.1. NM_053688.2.
UniGene	Rn.21249.
3D structure databases
ProteinModelPortal	P61250.
SMR	P61250. Positions 15-83.
ModBase	Search...
PTM databases
PhosphoSite	P61250.
Proteomic databases
PaxDb	P61250.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000007905; ENSRNOP00000007905; ENSRNOG00000005947.
GeneID	114248.
KEGG	rno:114248.
UCSC	RGD:70933. rat.
Organism-specific databases
CTD	5149.
RGD	70933. Pde6h.
Phylogenomic databases
eggNOG	NOG44509.
GeneTree	ENSGT00390000013260.
HOGENOM	HOG000261673.
HOVERGEN	HBG000447.
InParanoid	P61250.
KO	K13760.
OMA	TSNQGPT.
OrthoDB	EOG43210Q.
Gene expression databases
ArrayExpress	P61250.
Genevestigator	P61250.
GermOnline	ENSRNOG00000005947. Rattus norvegicus.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
PANTHER	PTHR12122. PTHR12122. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL4988.
NextBio	349167.

Entry information

Entry name

CNCG_RAT

Accession

Primary (citable) accession number: P61250
Secondary accession number(s): Q9D1Y6, Q9EP63

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program