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P61250

- CNCG_RAT

UniProt

P61250 - CNCG_RAT

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Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6h

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (By similarity).By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  4. response to stimulus Source: UniProtKB-KW
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:Pde6h
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi70933. Pde6h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166122Add
BLAST

Proteomic databases

PaxDbiP61250.

PTM databases

PhosphoSiteiP61250.

Expressioni

Gene expression databases

GenevestigatoriP61250.

Interactioni

Subunit structurei

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Structurei

3D structure databases

ProteinModelPortaliP61250.
SMRiP61250. Positions 15-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
BLAST

Domaini

The C-terminal region is important in conferring inhibition.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44509.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP61250.
KOiK13760.
OMAiNETHICV.
OrthoDBiEOG7SN8FW.
PhylomeDBiP61250.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P61250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI
60 70 80
PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
Length:83
Mass (Da):9,044
Last modified:May 10, 2004 - v1
Checksum:iD84EC90839A834FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169390 mRNA. Translation: AAG43400.1.
RefSeqiNP_446140.1. NM_053688.2.
XP_006237620.1. XM_006237558.2.
UniGeneiRn.21249.

Genome annotation databases

EnsembliENSRNOT00000007905; ENSRNOP00000007905; ENSRNOG00000005947.
GeneIDi114248.
KEGGirno:114248.
UCSCiRGD:70933. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169390 mRNA. Translation: AAG43400.1 .
RefSeqi NP_446140.1. NM_053688.2.
XP_006237620.1. XM_006237558.2.
UniGenei Rn.21249.

3D structure databases

ProteinModelPortali P61250.
SMRi P61250. Positions 15-83.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P61250.

Proteomic databases

PaxDbi P61250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007905 ; ENSRNOP00000007905 ; ENSRNOG00000005947 .
GeneIDi 114248.
KEGGi rno:114248.
UCSCi RGD:70933. rat.

Organism-specific databases

CTDi 5149.
RGDi 70933. Pde6h.

Phylogenomic databases

eggNOGi NOG44509.
GeneTreei ENSGT00390000013260.
HOGENOMi HOG000261673.
HOVERGENi HBG000447.
InParanoidi P61250.
KOi K13760.
OMAi NETHICV.
OrthoDBi EOG7SN8FW.
PhylomeDBi P61250.
TreeFami TF333297.

Miscellaneous databases

NextBioi 349167.

Gene expression databases

Genevestigatori P61250.

Family and domain databases

Gene3Di 4.10.1120.10. 1 hit.
InterProi IPR006952. PDE6_gamma.
[Graphical view ]
PANTHERi PTHR12122. PTHR12122. 1 hit.
Pfami PF04868. PDE6_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a cone-like phosphodiesterase 6 gamma in rat testis."
    Tate R.J., Pyne N.J.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCNCG_RAT
AccessioniPrimary (citable) accession number: P61250
Secondary accession number(s): Q9D1Y6, Q9EP63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3