P61249 (CNCG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Short name=GMP-PDE gamma
EC=3.1.4.35

Gene names

Name:

Pde6h

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
Domain	The C-terminal region is important in conferring inhibition By similarity.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of MAPK activity Inferred from direct assay. Source: MGI positive regulation of G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: MGI positive regulation of epidermal growth factor receptor signaling pathway Inferred from direct assay. Source: MGI visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166121
Regions
	Compositional bias	20 – 41	22	Arg/Lys-rich (basic)
Experimental info
	Sequence conflict	6	1	C → S in BAB32255. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P61249 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: D84EC90839A834FF	FASTA	83	9,044
	10 20 30 40 50 60 MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 70 80 TVICPWEAFS HLELHELAQF GII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts." Tate R.J., Arshavsky V.Y., Pyne N.J. Genomics 79:582-586(2002) [PubMed: 11944991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190929 mRNA. Translation: AAG17170.1. AK020922 mRNA. Translation: BAB32255.1.
IPI	IPI00138443.
RefSeq	NP_076387.2. NM_023898.4.
UniGene	Mm.290622.
3D structure databases
ProteinModelPortal	P61249.
SMR	P61249. Positions 15-83.
ModBase	Search...
Protein-protein interaction databases
STRING	P61249.
PTM databases
PhosphoSite	P61249.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	78600.
KEGG	mmu:78600.
Organism-specific databases
CTD	5149.
MGI	MGI:1925850. Pde6h.
Phylogenomic databases
eggNOG	roNOG17001.
HOGENOM	HBG278334.
HOVERGEN	HBG000447.
InParanoid	P61249.
OrthoDB	EOG43210Q.
Gene expression databases
ArrayExpress	P61249.
Bgee	P61249.
CleanEx	MM_PDE6H.
Genevestigator	P61249.
GermOnline	ENSMUSG00000064330. Mus musculus.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
KO	K13760.
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...
Other
NextBio	349167.
SOURCE	Search...

Entry information

Entry name

CNCG_MOUSE

Accession

Primary (citable) accession number: P61249
Secondary accession number(s): Q9D1Y6, Q9EP63

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program