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Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
  • positive regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  • response to stimulus Source: UniProtKB-KW
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:Pde6h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1925850. Pde6h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166121Add
BLAST

Proteomic databases

PaxDbiP61249.
PRIDEiP61249.

PTM databases

iPTMnetiP61249.
PhosphoSiteiP61249.

Expressioni

Gene expression databases

BgeeiENSMUSG00000064330.
CleanExiMM_PDE6H.
ExpressionAtlasiP61249. baseline and differential.
GenevisibleiP61249. MM.

Interactioni

Subunit structurei

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119246.

Structurei

3D structure databases

ProteinModelPortaliP61249.
SMRiP61249. Positions 15-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
BLAST

Domaini

The C-terminal region is important in conferring inhibition.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP61249.
KOiK13760.
OMAiNDIPLME.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P61249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSPSLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI
60 70 80
PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
Length:83
Mass (Da):9,028
Last modified:October 3, 2012 - v2
Checksum:iC5E47E0839BC70AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61S → C in AAG17170 (PubMed:11944991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190929 mRNA. Translation: AAG17170.1.
AK020922 mRNA. Translation: BAB32255.1.
AC125341 Genomic DNA. No translation available.
CH466572 Genomic DNA. Translation: EDL10581.1.
BC115671 mRNA. Translation: AAI15672.1.
BC115672 mRNA. Translation: AAI15673.1.
CCDSiCCDS39686.1.
RefSeqiNP_076387.2. NM_023898.4.
XP_006506836.1. XM_006506773.2.
XP_006506837.1. XM_006506774.1.
UniGeneiMm.290622.

Genome annotation databases

EnsembliENSMUST00000137768; ENSMUSP00000119246; ENSMUSG00000064330.
GeneIDi78600.
KEGGimmu:78600.
UCSCiuc009emq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190929 mRNA. Translation: AAG17170.1.
AK020922 mRNA. Translation: BAB32255.1.
AC125341 Genomic DNA. No translation available.
CH466572 Genomic DNA. Translation: EDL10581.1.
BC115671 mRNA. Translation: AAI15672.1.
BC115672 mRNA. Translation: AAI15673.1.
CCDSiCCDS39686.1.
RefSeqiNP_076387.2. NM_023898.4.
XP_006506836.1. XM_006506773.2.
XP_006506837.1. XM_006506774.1.
UniGeneiMm.290622.

3D structure databases

ProteinModelPortaliP61249.
SMRiP61249. Positions 15-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119246.

PTM databases

iPTMnetiP61249.
PhosphoSiteiP61249.

Proteomic databases

PaxDbiP61249.
PRIDEiP61249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000137768; ENSMUSP00000119246; ENSMUSG00000064330.
GeneIDi78600.
KEGGimmu:78600.
UCSCiuc009emq.1. mouse.

Organism-specific databases

CTDi5149.
MGIiMGI:1925850. Pde6h.

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP61249.
KOiK13760.
OMAiNDIPLME.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Miscellaneous databases

PROiP61249.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064330.
CleanExiMM_PDE6H.
ExpressionAtlasiP61249. baseline and differential.
GenevisibleiP61249. MM.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCNCG_MOUSE
AccessioniPrimary (citable) accession number: P61249
Secondary accession number(s): Q14BP9, Q9D1Y6, Q9EP63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.