Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61249

- CNCG_MOUSE

UniProt

P61249 - CNCG_MOUSE

Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

Pde6h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: MGI
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:Pde6h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1925850. Pde6h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166121Add
    BLAST

    Proteomic databases

    PRIDEiP61249.

    PTM databases

    PhosphoSiteiP61249.

    Expressioni

    Gene expression databases

    ArrayExpressiP61249.
    CleanExiMM_PDE6H.
    GenevestigatoriP61249.

    Interactioni

    Subunit structurei

    Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

    Structurei

    3D structure databases

    ProteinModelPortaliP61249.
    SMRiP61249. Positions 15-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    The C-terminal region is important in conferring inhibition.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiP61249.
    KOiK13760.
    OMAiTSNQGPT.
    OrthoDBiEOG7SN8FW.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P61249-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSPSLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI   50
    PGMEGLGTDI TVICPWEAFS HLELHELAQF GII 83
    Length:83
    Mass (Da):9,028
    Last modified:October 3, 2012 - v2
    Checksum:iC5E47E0839BC70AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61S → C in AAG17170. (PubMed:11944991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190929 mRNA. Translation: AAG17170.1.
    AK020922 mRNA. Translation: BAB32255.1.
    AC125341 Genomic DNA. No translation available.
    CH466572 Genomic DNA. Translation: EDL10581.1.
    BC115671 mRNA. Translation: AAI15672.1.
    BC115672 mRNA. Translation: AAI15673.1.
    CCDSiCCDS39686.1.
    RefSeqiNP_076387.2. NM_023898.4.
    XP_006506836.1. XM_006506773.1.
    XP_006506837.1. XM_006506774.1.
    UniGeneiMm.290622.

    Genome annotation databases

    EnsembliENSMUST00000137768; ENSMUSP00000119246; ENSMUSG00000064330.
    GeneIDi78600.
    KEGGimmu:78600.
    UCSCiuc009emq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190929 mRNA. Translation: AAG17170.1 .
    AK020922 mRNA. Translation: BAB32255.1 .
    AC125341 Genomic DNA. No translation available.
    CH466572 Genomic DNA. Translation: EDL10581.1 .
    BC115671 mRNA. Translation: AAI15672.1 .
    BC115672 mRNA. Translation: AAI15673.1 .
    CCDSi CCDS39686.1.
    RefSeqi NP_076387.2. NM_023898.4.
    XP_006506836.1. XM_006506773.1.
    XP_006506837.1. XM_006506774.1.
    UniGenei Mm.290622.

    3D structure databases

    ProteinModelPortali P61249.
    SMRi P61249. Positions 15-83.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P61249.

    Proteomic databases

    PRIDEi P61249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000137768 ; ENSMUSP00000119246 ; ENSMUSG00000064330 .
    GeneIDi 78600.
    KEGGi mmu:78600.
    UCSCi uc009emq.1. mouse.

    Organism-specific databases

    CTDi 5149.
    MGIi MGI:1925850. Pde6h.

    Phylogenomic databases

    eggNOGi NOG44345.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi P61249.
    KOi K13760.
    OMAi TSNQGPT.
    OrthoDBi EOG7SN8FW.
    TreeFami TF333297.

    Miscellaneous databases

    NextBioi 349167.
    PROi P61249.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61249.
    CleanExi MM_PDE6H.
    Genevestigatori P61249.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts."
      Tate R.J., Arshavsky V.Y., Pyne N.J.
      Genomics 79:582-586(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCNCG_MOUSE
    AccessioniPrimary (citable) accession number: P61249
    Secondary accession number(s): Q14BP9, Q9D1Y6, Q9EP63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3