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P61248

- CNRG_FELCA

UniProt

P61248 - CNRG_FELCA

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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene
PDE6G, PDEG
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  4. response to stimulus Source: UniProtKB-KW
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6G
Synonyms:PDEG
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome E1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain By similarity.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011984.

Structurei

3D structure databases

ProteinModelPortaliP61248.
SMRiP61248. Positions 1-87.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44345.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
KOiK13759.
OMAiTRVMGGP.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P61248-1 [UniParc]FASTAAdd to Basket

« Hide

MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
Length:87
Mass (Da):9,651
Last modified:May 10, 2004 - v1
Checksum:i8EA7C7A1D7D14B9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ417434 Genomic DNA. Translation: CAD10146.1.
RefSeqiXP_003997317.1. XM_003997268.2.

Genome annotation databases

EnsembliENSFCAT00000012926; ENSFCAP00000011984; ENSFCAG00000012923.
GeneIDi101088443.
KEGGifca:101088443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ417434 Genomic DNA. Translation: CAD10146.1 .
RefSeqi XP_003997317.1. XM_003997268.2.

3D structure databases

ProteinModelPortali P61248.
SMRi P61248. Positions 1-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000011984.

Chemistry

BindingDBi P61248.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000012926 ; ENSFCAP00000011984 ; ENSFCAG00000012923 .
GeneIDi 101088443.
KEGGi fca:101088443.

Organism-specific databases

CTDi 5148.

Phylogenomic databases

eggNOGi NOG44345.
GeneTreei ENSGT00390000013260.
HOGENOMi HOG000261673.
HOVERGENi HBG000447.
KOi K13759.
OMAi TRVMGGP.
TreeFami TF333297.

Family and domain databases

Gene3Di 4.10.1120.10. 1 hit.
InterProi IPR006952. PDE6_gamma.
[Graphical view ]
PANTHERi PTHR12122. PTHR12122. 1 hit.
Pfami PF04868. PDE6_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic investigations into the inherited progressive retinal degenerations of dogs and cats."
    Gould D.J.
    Thesis (1997), University of Cambridge, United Kingdom
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCNRG_FELCA
AccessioniPrimary (citable) accession number: P61248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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