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P61248

- CNRG_FELCA

UniProt

P61248 - CNRG_FELCA

Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:PDE6G
    Synonyms:PDEG
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome E1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.By similarity

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000011984.

    Structurei

    3D structure databases

    ProteinModelPortaliP61248.
    SMRiP61248. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    KOiK13759.
    OMAiTRVMGGP.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P61248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
    GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
    Length:87
    Mass (Da):9,651
    Last modified:May 10, 2004 - v1
    Checksum:i8EA7C7A1D7D14B9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417434 Genomic DNA. Translation: CAD10146.1.
    RefSeqiXP_003997317.1. XM_003997268.2.

    Genome annotation databases

    EnsembliENSFCAT00000012926; ENSFCAP00000011984; ENSFCAG00000012923.
    GeneIDi101088443.
    KEGGifca:101088443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417434 Genomic DNA. Translation: CAD10146.1 .
    RefSeqi XP_003997317.1. XM_003997268.2.

    3D structure databases

    ProteinModelPortali P61248.
    SMRi P61248. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000011984.

    Chemistry

    BindingDBi P61248.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000012926 ; ENSFCAP00000011984 ; ENSFCAG00000012923 .
    GeneIDi 101088443.
    KEGGi fca:101088443.

    Organism-specific databases

    CTDi 5148.

    Phylogenomic databases

    eggNOGi NOG44345.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    KOi K13759.
    OMAi TRVMGGP.
    TreeFami TF333297.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic investigations into the inherited progressive retinal degenerations of dogs and cats."
      Gould D.J.
      Thesis (1997), University of Cambridge, United Kingdom
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCNRG_FELCA
    AccessioniPrimary (citable) accession number: P61248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3