P61248 (CNRG_FELCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Short name=GMP-PDE gamma
EC=3.1.4.35

Gene names

Name:	PDE6G
Synonyms:	PDEG

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones By similarity.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain By similarity.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166116
Regions
	Compositional bias	24 – 45	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P61248 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: 8EA7C7A1D7D14B9E	FASTA	87	9,651
	10 20 30 40 50 60 MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 70 80 GTDITVICPW EAFNHLELHE LAQYGII

References

[1]	"Molecular genetic investigations into the inherited progressive retinal degenerations of dogs and cats." Gould D.J. Thesis (1997), University of Cambridge, United Kingdom Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ417434 Genomic DNA. Translation: CAD10146.1.
3D structure databases
ProteinModelPortal	P61248.
SMR	P61248. Positions 1-87.
ModBase	Search...
Protein-protein interaction databases
STRING	P61248.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSFCAT00000012926; ENSFCAP00000011984; ENSFCAG00000012923.
Phylogenomic databases
eggNOG	maNOG20541.
GeneTree	ENSGT00390000013260.
HOVERGEN	HBG000447.
OrthoDB	EOG43210Q.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...
Other
BindingDB	P61248.

Entry information

Entry name

CNRG_FELCA

Accession

Primary (citable) accession number: P61248

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	May 31, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program