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P61247

- RS3A_HUMAN

UniProt

P61247 - RS3A_HUMAN

Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. RNA binding Source: UniProtKB
    4. structural constituent of ribosome Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cellular protein metabolic process Source: Reactome
    3. cytoplasmic translation Source: RefGenome
    4. gene expression Source: Reactome
    5. mRNA metabolic process Source: Reactome
    6. negative regulation of apoptotic process Source: UniProtKB
    7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    8. RNA metabolic process Source: Reactome
    9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    10. translation Source: UniProtKB
    11. translational elongation Source: Reactome
    12. translational initiation Source: UniProtKB
    13. translational termination Source: Reactome
    14. viral life cycle Source: Reactome
    15. viral process Source: Reactome
    16. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S3aUniRule annotation
    Alternative name(s):
    v-fos transformation effector protein
    Short name:
    Fte-1
    Gene namesi
    Name:RPS3AUniRule annotation
    Synonyms:FTE1, MFTL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10421. RPS3A.

    Subcellular locationi

    Cytoplasm 1 PublicationUniRule annotation. Nucleus UniRule annotation
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. nucleolus Source: UniProtKB
    6. nucleus Source: UniProtKB
    7. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 PublicationUniRule annotation
    Chaini2 – 26426340S ribosomal protein S3aPRO_0000153524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-acetyllysine1 Publication
    Modified residuei249 – 2491N6-acetyllysine1 Publication
    Modified residuei256 – 2561Phosphotyrosine1 Publication
    Modified residuei263 – 2631Phosphoserine6 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP61247.
    PaxDbiP61247.
    PRIDEiP61247.

    2D gel databases

    SWISS-2DPAGEP61247.

    PTM databases

    PhosphoSiteiP61247.

    Miscellaneous databases

    PMAP-CutDBP61247.

    Expressioni

    Gene expression databases

    BgeeiP61247.
    CleanExiHS_RPS3A.
    GenevestigatoriP61247.

    Organism-specific databases

    HPAiHPA047100.
    HPA053454.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.2 PublicationsUniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AA1P079002EBI-352378,EBI-296047

    Protein-protein interaction databases

    BioGridi112103. 160 interactions.
    DIPiDIP-29408N.
    IntActiP61247. 29 interactions.
    MINTiMINT-1160853.
    STRINGi9606.ENSP00000346050.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00B1-264[»]
    ProteinModelPortaliP61247.
    SMRiP61247. Positions 19-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S3Ae family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1890.
    HOGENOMiHOG000105220.
    HOVERGENiHBG000783.
    InParanoidiP61247.
    KOiK02984.
    OMAiVHKAKIL.
    OrthoDBiEOG7Q5HDW.
    PhylomeDBiP61247.
    TreeFamiTF300037.

    Family and domain databases

    HAMAPiMF_03122. Ribosomal_S3Ae_euk.
    InterProiIPR027500. Ribosomal_S1/3_euk.
    IPR001593. Ribosomal_S3Ae.
    IPR018281. Ribosomal_S3Ae_CS.
    [Graphical view]
    PfamiPF01015. Ribosomal_S3Ae. 1 hit.
    [Graphical view]
    PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT    50
    RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF 100
    HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI 150
    RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA 200
    CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV 250
    ERADGYEPPV QESV 264
    Length:264
    Mass (Da):29,945
    Last modified:January 23, 2007 - v2
    Checksum:i000037AE195F7A9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77234 mRNA. Translation: AAA60290.1.
    M84711 mRNA. Translation: AAA58487.1.
    L13802 mRNA. Translation: AAA35682.1.
    X87373 Genomic DNA. Translation: CAA60827.1.
    AC095055 Genomic DNA. No translation available.
    AK311788 mRNA. Translation: BAG34731.1.
    CH471056 Genomic DNA. Translation: EAX04991.1.
    CH471056 Genomic DNA. Translation: EAX04995.1.
    BC000204 mRNA. Translation: AAH00204.1.
    BC001708 mRNA. Translation: AAH01708.1.
    BC004981 mRNA. Translation: AAH04981.1.
    BC006298 mRNA. Translation: AAH06298.1.
    BC009219 mRNA. Translation: AAH09219.1.
    BC009404 mRNA. Translation: AAH09404.1.
    BC017123 mRNA. Translation: AAH17123.1.
    BC019072 mRNA. Translation: AAH19072.1.
    BC030161 mRNA. Translation: AAH30161.1.
    BC070211 mRNA. Translation: AAH70211.1.
    BC071916 mRNA. Translation: AAH71916.1.
    AB007148 Genomic DNA. Translation: BAA25814.1.
    CCDSiCCDS3775.1.
    PIRiJC4662.
    RefSeqiNP_000997.1. NM_001006.4.
    UniGeneiHs.356572.

    Genome annotation databases

    EnsembliENST00000274065; ENSP00000346050; ENSG00000145425.
    GeneIDi6189.
    KEGGihsa:6189.
    UCSCiuc003ilz.4. human.

    Polymorphism databases

    DMDMi47117764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77234 mRNA. Translation: AAA60290.1 .
    M84711 mRNA. Translation: AAA58487.1 .
    L13802 mRNA. Translation: AAA35682.1 .
    X87373 Genomic DNA. Translation: CAA60827.1 .
    AC095055 Genomic DNA. No translation available.
    AK311788 mRNA. Translation: BAG34731.1 .
    CH471056 Genomic DNA. Translation: EAX04991.1 .
    CH471056 Genomic DNA. Translation: EAX04995.1 .
    BC000204 mRNA. Translation: AAH00204.1 .
    BC001708 mRNA. Translation: AAH01708.1 .
    BC004981 mRNA. Translation: AAH04981.1 .
    BC006298 mRNA. Translation: AAH06298.1 .
    BC009219 mRNA. Translation: AAH09219.1 .
    BC009404 mRNA. Translation: AAH09404.1 .
    BC017123 mRNA. Translation: AAH17123.1 .
    BC019072 mRNA. Translation: AAH19072.1 .
    BC030161 mRNA. Translation: AAH30161.1 .
    BC070211 mRNA. Translation: AAH70211.1 .
    BC071916 mRNA. Translation: AAH71916.1 .
    AB007148 Genomic DNA. Translation: BAA25814.1 .
    CCDSi CCDS3775.1.
    PIRi JC4662.
    RefSeqi NP_000997.1. NM_001006.4.
    UniGenei Hs.356572.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 B 1-264 [» ]
    ProteinModelPortali P61247.
    SMRi P61247. Positions 19-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112103. 160 interactions.
    DIPi DIP-29408N.
    IntActi P61247. 29 interactions.
    MINTi MINT-1160853.
    STRINGi 9606.ENSP00000346050.

    PTM databases

    PhosphoSitei P61247.

    Polymorphism databases

    DMDMi 47117764.

    2D gel databases

    SWISS-2DPAGE P61247.

    Proteomic databases

    MaxQBi P61247.
    PaxDbi P61247.
    PRIDEi P61247.

    Protocols and materials databases

    DNASUi 6189.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274065 ; ENSP00000346050 ; ENSG00000145425 .
    GeneIDi 6189.
    KEGGi hsa:6189.
    UCSCi uc003ilz.4. human.

    Organism-specific databases

    CTDi 6189.
    GeneCardsi GC04P152020.
    HGNCi HGNC:10421. RPS3A.
    HPAi HPA047100.
    HPA053454.
    MIMi 180478. gene.
    neXtProti NX_P61247.
    PharmGKBi PA34830.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1890.
    HOGENOMi HOG000105220.
    HOVERGENi HBG000783.
    InParanoidi P61247.
    KOi K02984.
    OMAi VHKAKIL.
    OrthoDBi EOG7Q5HDW.
    PhylomeDBi P61247.
    TreeFami TF300037.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPS3A.
    GenomeRNAii 6189.
    NextBioi 24033.
    PMAP-CutDB P61247.
    PROi P61247.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61247.
    CleanExi HS_RPS3A.
    Genevestigatori P61247.

    Family and domain databases

    HAMAPi MF_03122. Ribosomal_S3Ae_euk.
    InterProi IPR027500. Ribosomal_S1/3_euk.
    IPR001593. Ribosomal_S3Ae.
    IPR018281. Ribosomal_S3Ae_CS.
    [Graphical view ]
    Pfami PF01015. Ribosomal_S3Ae. 1 hit.
    [Graphical view ]
    PROSITEi PS01191. RIBOSOMAL_S3AE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human ribosomal protein S3a: cloning of the cDNA and primary structure of the protein."
      Metspalu A., Rebane A., Hoth S., Pooga M., Stahl J., Kruppa J.
      Gene 119:313-316(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria."
      Kho C.J., Zarbl H.
      Proc. Natl. Acad. Sci. U.S.A. 89:2200-2204(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Bonaldo M., Soares M.B.
      Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "The human S3a ribosomal protein: sequence, location and cell-free transcription of the functional gene."
      Nolte D., Taimor G., Kalff-Suske M., Seifart K.H.
      Gene 169:179-185(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell, Eye, Muscle, Ovary, Skin and Uterus.
    9. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-13.
      Tissue: Placenta.
    10. "A map of 75 human ribosomal protein genes."
      Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
      Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-262.
    11. "The S3a ribosomal protein gene is identical to the Fte-1 (v-fos transformation effector) gene and the TNF-alpha-induced TU-11 gene, and its transcript level is altered in transformed and tumor cells."
      Lecomte F., Szpirer J., Szpirer C.
      Gene 186:271-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NOMENCLATURE.
    12. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
      Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
      EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IPO4.
    13. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34 AND LYS-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRS3A_HUMAN
    AccessioniPrimary (citable) accession number: P61247
    Secondary accession number(s): B2R4D4
    , D3DP05, P33443, P49241
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3