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Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cytoplasmic translation Source: GO_Central
  • negative regulation of apoptotic process Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: UniProtKB
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Alternative name(s):
Small ribosomal subunit protein eS11 Publication
v-fos transformation effector protein
Short name:
Fte-1
Gene namesi
Name:RPS3AUniRule annotation
Synonyms:FTE1, MFTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10421. RPS3A.

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Nucleus UniRule annotation

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: HPA
  • cytosolic small ribosomal subunit Source: UniProtKB
  • endoplasmic reticulum Source: HPA
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6189.
OpenTargetsiENSG00000145425.
PharmGKBiPA34830.

Polymorphism and mutation databases

BioMutaiRPS3A.
DMDMi47117764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation1 Publication
ChainiPRO_00001535242 – 26440S ribosomal protein S3aAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysine; alternateCombined sources1
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei249N6-acetyllysine; alternateCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei256PhosphotyrosineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP61247.
MaxQBiP61247.
PaxDbiP61247.
PeptideAtlasiP61247.
PRIDEiP61247.
TopDownProteomicsiP61247.

2D gel databases

SWISS-2DPAGEiP61247.

PTM databases

iPTMnetiP61247.
PhosphoSitePlusiP61247.
SwissPalmiP61247.

Miscellaneous databases

PMAP-CutDBiP61247.

Expressioni

Gene expression databases

BgeeiENSG00000145425.
CleanExiHS_RPS3A.
ExpressionAtlasiP61247. baseline and differential.
GenevisibleiP61247. HS.

Organism-specific databases

HPAiHPA047100.
HPA053454.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AA1P079003EBI-352378,EBI-296047

Protein-protein interaction databases

BioGridi112103. 246 interactors.
DIPiDIP-29408N.
IntActiP61247. 47 interactors.
MINTiMINT-1160853.
STRINGi9606.ENSP00000346050.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SB1-264[»]
4V6Xelectron microscopy5.00AB1-264[»]
5A2Qelectron microscopy3.90B1-264[»]
5AJ0electron microscopy3.50BB1-264[»]
5FLXelectron microscopy3.90B1-264[»]
5LKSelectron microscopy3.60SB1-264[»]
5T2Celectron microscopy3.60Ap1-264[»]
ProteinModelPortaliP61247.
SMRiP61247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
GeneTreeiENSGT00390000018433.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.
InParanoidiP61247.
KOiK02984.
OMAiMFEIMTR.
OrthoDBiEOG091G0HTU.
PhylomeDBiP61247.
TreeFamiTF300037.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiView protein in InterPro
IPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
PANTHERiPTHR11830:SF11. PTHR11830:SF11. 1 hit.
PfamiView protein in Pfam
PF01015. Ribosomal_S3Ae. 1 hit.
SMARTiView protein in SMART
SM01397. Ribosomal_S3Ae. 1 hit.
PROSITEiView protein in PROSITE
PS01191. RIBOSOMAL_S3AE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,945
Last modified:January 23, 2007 - v2
Checksum:i000037AE195F7A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77234 mRNA. Translation: AAA60290.1.
M84711 mRNA. Translation: AAA58487.1.
L13802 mRNA. Translation: AAA35682.1.
X87373 Genomic DNA. Translation: CAA60827.1.
AC095055 Genomic DNA. No translation available.
AK311788 mRNA. Translation: BAG34731.1.
CH471056 Genomic DNA. Translation: EAX04991.1.
CH471056 Genomic DNA. Translation: EAX04995.1.
BC000204 mRNA. Translation: AAH00204.1.
BC001708 mRNA. Translation: AAH01708.1.
BC004981 mRNA. Translation: AAH04981.1.
BC006298 mRNA. Translation: AAH06298.1.
BC009219 mRNA. Translation: AAH09219.1.
BC009404 mRNA. Translation: AAH09404.1.
BC017123 mRNA. Translation: AAH17123.1.
BC019072 mRNA. Translation: AAH19072.1.
BC030161 mRNA. Translation: AAH30161.1.
BC070211 mRNA. Translation: AAH70211.1.
BC071916 mRNA. Translation: AAH71916.1.
AB007148 Genomic DNA. Translation: BAA25814.1.
CCDSiCCDS3775.1.
PIRiJC4662.
RefSeqiNP_000997.1. NM_001006.4.
UniGeneiHs.356572.

Genome annotation databases

EnsembliENST00000274065; ENSP00000346050; ENSG00000145425.
GeneIDi6189.
KEGGihsa:6189.
UCSCiuc003ilz.4. human.

Similar proteinsi

Entry informationi

Entry nameiRS3A_HUMAN
AccessioniPrimary (citable) accession number: P61247
Secondary accession number(s): B2R4D4
, D3DP05, P33443, P49241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families