##gff-version 3 P61244 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:19413330,PMID:20068231,PMID:21406692 P61244 UniProtKB Chain 2 160 . . . ID=PRO_0000127269;Note=Protein max P61244 UniProtKB Domain 23 74 . . . Note=BHLH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00981 P61244 UniProtKB Region 1 40 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61244 UniProtKB Region 81 102 . . . Note=Leucine-zipper P61244 UniProtKB Region 103 160 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61244 UniProtKB Motif 152 156 . . . Note=Nuclear localization signal P61244 UniProtKB Compositional bias 13 40 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61244 UniProtKB Compositional bias 103 144 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61244 UniProtKB Compositional bias 145 160 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61244 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:19413330,PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 11 11 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 66 66 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Modified residue 107 107 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P61244 UniProtKB Modified residue 153 153 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Modified residue 154 154 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Alternative sequence 13 21 . . . ID=VSP_002117;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:2006410;Dbxref=PMID:14702039,PMID:15489334,PMID:2006410 P61244 UniProtKB Alternative sequence 58 160 . . . ID=VSP_043430;Note=In isoform 5. ASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS->LYFLFWKLCTPVLHRQSLMQKCHTFISSYQVHKKKECKI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P61244 UniProtKB Alternative sequence 58 160 . . . ID=VSP_047661;Note=In isoform 6. ASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS->GTKMKLTLPPVFPYEHLPFPTVFCHG;Ontology_term=ECO:0000305;evidence=ECO:0000305 P61244 UniProtKB Alternative sequence 99 160 . . . ID=VSP_002118;Note=In isoform 3. VRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS->GESES;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:1566084;Dbxref=PMID:14702039,PMID:1566084 P61244 UniProtKB Alternative sequence 99 160 . . . ID=VSP_043183;Note=In isoform 4. VRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS->GEHPSSWGSWPCCAPARSGFGTWACRVRASHGVCAQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P61244 UniProtKB Natural variant 9 9 . . . ID=VAR_079347;Note=In PCC%3B does not repress MYC transcriptional activity. V->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=dbSNP:rs201743423,PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 23 23 . . . ID=VAR_079348;Note=In PCC%3B uncertain significance%3B does not affect MYC transcriptional activity. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685915,ECO:0000269|PubMed:26070438;Dbxref=PMID:21685915,PMID:26070438 P61244 UniProtKB Natural variant 25 25 . . . ID=VAR_079349;Note=In PCC%3B does not repress MYC transcriptional activity. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 33 160 . . . ID=VAR_079350;Note=In PCC%3B does not repress MYC transcriptional activity. Missing;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685915,ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:21685915,PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 35 35 . . . ID=VAR_079351;Note=In PCC%3B does not repress MYC transcriptional activity. R->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 47 52 . . . ID=VAR_079352;Note=In PCC%3B uncertain significance%3B somatic mutation. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22452945;Dbxref=PMID:22452945 P61244 UniProtKB Natural variant 60 60 . . . ID=VAR_079353;Note=In PCC%3B does not repress MYC transcriptional activity. R->W;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=dbSNP:rs2063106124,PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 71 71 . . . ID=VAR_079354;Note=In PCC%3B does not repress MYC transcriptional activity. I->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 74 74 . . . ID=VAR_079355;Note=In PCC%3B does not repress MYC transcriptional activity. M->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 75 160 . . . ID=VAR_079356;Note=In PCC%3B uncertain significance. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685915,ECO:0000269|PubMed:22452945;Dbxref=PMID:21685915,PMID:22452945 P61244 UniProtKB Natural variant 82 160 . . . ID=VAR_079357;Note=In PCC%3B uncertain significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22452945;Dbxref=PMID:22452945 P61244 UniProtKB Natural variant 90 90 . . . ID=VAR_079358;Note=In PCC%3B does not repress MYC transcriptional activity. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 94 94 . . . ID=VAR_079359;Note=In PCC%3B does not repress MYC transcriptional activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685915,ECO:0000269|PubMed:26070438;Dbxref=PMID:21685915,PMID:26070438 P61244 UniProtKB Natural variant 102 102 . . . ID=VAR_079360;Note=In PCC%3B does not repress MYC transcriptional activity. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22452945,ECO:0000269|PubMed:26070438;Dbxref=PMID:22452945,PMID:26070438 P61244 UniProtKB Natural variant 114 114 . . . ID=VAR_079361;Note=Does not affect MYC transcriptional activity. N->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26070438;Dbxref=dbSNP:rs772912674,PMID:26070438 P61244 UniProtKB Natural variant 142 142 . . . ID=VAR_079362;Note=Does not affect MYC transcriptional activity. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21685915,ECO:0000269|PubMed:26070438;Dbxref=dbSNP:rs760147253,PMID:21685915,PMID:26070438 P61244 UniProtKB Mutagenesis 66 66 . . . Note=Kept nuclear localization. Loss of nuclear localization%3B when associated with Q-153 and Q-154. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Mutagenesis 66 66 . . . Note=Loss of acetylation%2C kept nuclear localization%3B when associated with R-153 and R-154. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Mutagenesis 153 153 . . . Note=Loss of nuclear localization%3B when associated with Q-66 and Q-154. Kept nuclear localization%3B when associated with Q-154. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Mutagenesis 153 153 . . . Note=Loss of acetylation%2C kept nuclear localization%3B when associated with R-66 and R-154. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Mutagenesis 154 154 . . . Note=Loss of nuclear localization%3B when associated with Q-66 and Q-153. Kept nuclear localization%3B when associated with Q-153. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Mutagenesis 154 154 . . . Note=Loss of acetylation%2C kept nuclear localization%3B when associated with R-66 and R-153. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17217336;Dbxref=PMID:17217336 P61244 UniProtKB Helix 5 9 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1HLO P61244 UniProtKB Helix 27 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6G6K P61244 UniProtKB Turn 51 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6G6K P61244 UniProtKB Helix 60 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6G6K P61244 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692;Dbxref=PMID:17081983,PMID:18691976,PMID:20068231,PMID:21406692 P61244 UniProtKB Modified residue 11 11 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231