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Protein

Protein yippee-like 3

Gene

Ypel3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in proliferation and apoptosis in myeloid precursor cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi79ZincPROSITE-ProRule annotation1
Metal bindingi82ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 3
Alternative name(s):
Small ubiquitinated apoptotic protein
Gene namesi
Name:Ypel3
Synonyms:Suap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913340. Ypel3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123901 – 119Protein yippee-like 3Add BLAST119

Post-translational modificationi

Probably ubiquitinated leading to its degradation by the proteasome.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP61237.
PRIDEiP61237.

Expressioni

Tissue specificityi

Widely expressed. Strongly expressed in heart, brain, testis, lung, spleen, liver, kidney and myeloid cells.2 Publications

Inductioni

Up-regulated after the removal of interleukin 3 and exposure to granulocyte colony stimulating factor.1 Publication

Gene expression databases

BgeeiENSMUSG00000042675.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Interactioni

Protein-protein interaction databases

BioGridi211207. 1 interactor.
STRINGi10090.ENSMUSP00000037332.

Structurei

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 116YippeePROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the yippee family.Curated

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiADIHCES.
OrthoDBiEOG091G0XLE.
PhylomeDBiP61237.
TreeFamiTF313936.

Family and domain databases

InterProiView protein in InterPro
IPR034751. Yippee.
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51792. YIPPEE. 1 hit.

Sequencei

Sequence statusi: Complete.

P61237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY
110
KEGKYIIELN HMIKDNGWD
Length:119
Mass (Da):13,608
Last modified:May 10, 2004 - v1
Checksum:iA35E852DEB1FFBB4
GO

Sequence cautioni

The sequence AAH09171 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16D → N in BAB23301 (PubMed:12566317).Curated1
Sequence conflicti25H → Q in BAB23301 (PubMed:12566317).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211207. 1 interactor.
STRINGi10090.ENSMUSP00000037332.

Proteomic databases

PaxDbiP61237.
PRIDEiP61237.

Protocols and materials databases

DNASUi66090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Organism-specific databases

CTDi83719.
MGIiMGI:1913340. Ypel3.

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiADIHCES.
OrthoDBiEOG091G0XLE.
PhylomeDBiP61237.
TreeFamiTF313936.

Miscellaneous databases

PROiPR:P61237.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042675.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Family and domain databases

InterProiView protein in InterPro
IPR034751. Yippee.
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51792. YIPPEE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYPEL3_MOUSE
AccessioniPrimary (citable) accession number: P61237
Secondary accession number(s): Q71E85
, Q9BSJ4, Q9CQB6, Q9D0U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.