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Protein

Protein yippee-like 3

Gene

Ypel3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in proliferation and apoptosis in myeloid precursor cells.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231ZincPROSITE-ProRule annotation
Metal bindingi26 – 261ZincPROSITE-ProRule annotation
Metal bindingi79 – 791ZincPROSITE-ProRule annotation
Metal bindingi82 – 821ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 3
Alternative name(s):
Small ubiquitinated apoptotic protein
Gene namesi
Name:Ypel3
Synonyms:Suap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913340. Ypel3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Protein yippee-like 3PRO_0000212390Add
BLAST

Post-translational modificationi

Probably ubiquitinated leading to its degradation by the proteasome.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP61237.
PaxDbiP61237.
PRIDEiP61237.

Expressioni

Tissue specificityi

Widely expressed. Strongly expressed in heart, brain, testis, lung, spleen, liver, kidney and myeloid cells.2 Publications

Inductioni

Up-regulated after the removal of interleukin 3 and exposure to granulocyte colony stimulating factor.1 Publication

Gene expression databases

BgeeiENSMUSG00000042675.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Interactioni

Protein-protein interaction databases

BioGridi211207. 1 interaction.
STRINGi10090.ENSMUSP00000037332.

Structurei

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 11698YippeePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the yippee family.Curated
Contains 1 Yippee domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiVGWRYEA.
OrthoDBiEOG091G0XLE.
PhylomeDBiP61237.
TreeFamiTF313936.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY
110
KEGKYIIELN HMIKDNGWD
Length:119
Mass (Da):13,608
Last modified:May 10, 2004 - v1
Checksum:iA35E852DEB1FFBB4
GO

Sequence cautioni

The sequence AAH09171 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161D → N in BAB23301 (PubMed:12566317).Curated
Sequence conflicti25 – 251H → Q in BAB23301 (PubMed:12566317).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211207. 1 interaction.
STRINGi10090.ENSMUSP00000037332.

Proteomic databases

MaxQBiP61237.
PaxDbiP61237.
PRIDEiP61237.

Protocols and materials databases

DNASUi66090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Organism-specific databases

CTDi83719.
MGIiMGI:1913340. Ypel3.

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiVGWRYEA.
OrthoDBiEOG091G0XLE.
PhylomeDBiP61237.
TreeFamiTF313936.

Miscellaneous databases

PROiP61237.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042675.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPEL3_MOUSE
AccessioniPrimary (citable) accession number: P61237
Secondary accession number(s): Q71E85
, Q9BSJ4, Q9CQB6, Q9D0U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.