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Protein

Protein yippee-like 3

Gene

Ypel3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in proliferation and apoptosis in myeloid precursor cells.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231ZincPROSITE-ProRule annotation
Metal bindingi26 – 261ZincPROSITE-ProRule annotation
Metal bindingi79 – 791ZincPROSITE-ProRule annotation
Metal bindingi82 – 821ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 3
Alternative name(s):
Small ubiquitinated apoptotic protein
Gene namesi
Name:Ypel3
Synonyms:Suap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913340. Ypel3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Protein yippee-like 3PRO_0000212390Add
BLAST

Post-translational modificationi

Probably ubiquitinated leading to its degradation by the proteasome.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP61237.
PaxDbiP61237.
PRIDEiP61237.

Expressioni

Tissue specificityi

Widely expressed. Strongly expressed in heart, brain, testis, lung, spleen, liver, kidney and myeloid cells.2 Publications

Inductioni

Up-regulated after the removal of interleukin 3 and exposure to granulocyte colony stimulating factor.1 Publication

Gene expression databases

BgeeiP61237.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Interactioni

Protein-protein interaction databases

BioGridi211207. 1 interaction.
STRINGi10090.ENSMUSP00000037332.

Structurei

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 11698YippeePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the yippee family.Curated
Contains 1 Yippee domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiCALCATH.
OrthoDBiEOG7TXKJJ.
PhylomeDBiP61237.
TreeFamiTF313936.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY
110
KEGKYIIELN HMIKDNGWD
Length:119
Mass (Da):13,608
Last modified:May 10, 2004 - v1
Checksum:iA35E852DEB1FFBB4
GO

Sequence cautioni

The sequence AAH09171.4 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161D → N in BAB23301 (PubMed:12566317).Curated
Sequence conflicti25 – 251H → Q in BAB23301 (PubMed:12566317).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523353 mRNA. Translation: AAO85716.1.
AB098742 mRNA. Translation: BAD51383.1.
AK002925 mRNA. Translation: BAB22461.1.
AK003371 mRNA. Translation: BAB22745.1.
AK004431 mRNA. Translation: BAB23301.1.
CH466531 Genomic DNA. Translation: EDL17433.1.
CH466531 Genomic DNA. Translation: EDL17435.1.
BC009171 mRNA. Translation: AAH09171.4. Different initiation.
CCDSiCCDS21842.1.
RefSeqiNP_079623.1. NM_025347.2.
NP_081151.2. NM_026875.2.
UniGeneiMm.27114.

3D structure databases

ProteinModelPortaliP61237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211207. 1 interaction.
STRINGi10090.ENSMUSP00000037332.

Proteomic databases

MaxQBiP61237.
PaxDbiP61237.
PRIDEiP61237.

Protocols and materials databases

DNASUi66090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038614; ENSMUSP00000037332; ENSMUSG00000042675.
ENSMUST00000106356; ENSMUSP00000101963; ENSMUSG00000042675.
ENSMUST00000106357; ENSMUSP00000101964; ENSMUSG00000042675.
ENSMUST00000170882; ENSMUSP00000128753; ENSMUSG00000042675.
GeneIDi66090.
KEGGimmu:66090.
UCSCiuc009jsp.1. mouse.

Organism-specific databases

CTDi83719.
MGIiMGI:1913340. Ypel3.

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP61237.
OMAiCALCATH.
OrthoDBiEOG7TXKJJ.
PhylomeDBiP61237.
TreeFamiTF313936.

Miscellaneous databases

NextBioi320600.
PROiP61237.
SOURCEiSearch...

Gene expression databases

BgeeiP61237.
CleanExiMM_YPEL3.
ExpressionAtlasiP61237. baseline and differential.
GenevisibleiP61237. MM.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Small unstable apoptotic protein, an apoptosis-associated protein, suppresses proliferation of myeloid cells."
    Baker S.J.
    Cancer Res. 63:705-712(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROBABLE UBIQUITINATION, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Bone marrow.
  2. "Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species."
    Hosono K., Sasaki T., Minoshima S., Shimizu N.
    Gene 340:31-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiYPEL3_MOUSE
AccessioniPrimary (citable) accession number: P61237
Secondary accession number(s): Q71E85
, Q9BSJ4, Q9CQB6, Q9D0U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.