P61236 (YPEL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein yippee-like 3

Gene names

Name:	YPEL3
ORF Names:	FKSG5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in proliferation and apoptosis in myeloid precursor cells By similarity.
Subcellular location	Nucleus › nucleolus Ref.1.
Tissue specificity	Widely expressed. Ref.1
Post-translational modification	Probably ubiquitinated leading to its degradation by the proteasome By similarity.
Sequence similarities	Belongs to the yippee family.
Sequence caution	The sequence EAW79925.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P61236-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P61236-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein yippee-like 3		PRO_0000212389
Natural variations
	Alternative sequence	1	1	M → MCVAQVLTAHLLPPRQALGS LCSPWAAPRVGPLPPAPAM in isoform 2.		VSP_037276

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2004. Version 1. Checksum: A35E852DEB1FFBB4	FASTA	119	13,608
	10 20 30 40 50 60 MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL FNSVVNVGCG 70 80 90 100 110 PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY KEGKYIIELN HMIKDNGWD
	Isoform 2 [UniParc]. Checksum: DE3E720F14F48C09	FASTA	157	17,478
	10 20 30 40 50 60 MCVAQVLTAH LLPPRQALGS LCSPWAAPRV GPLPPAPAMV RISKPKTFQA YLDDCHRRYS 70 80 90 100 110 120 CAHCRAHLAN HDDLISKSFQ GSQGRAYLFN SVVNVGCGPA EERVLLTGLH AVADIHCENC 130 140 150 KTTLGWKYEQ AFESSQKYKE GKYIIELNHM IKDNGWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species." Hosono K., Sasaki T., Minoshima S., Shimizu N. Gene 340:31-43(2004) [PubMed: 15556292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Cloning and characterization of FKSG5, a novel gene related to DiGeorge syndrome." Wang Y.-G. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB098737 Genomic DNA. Translation: BAD51378.1. AF305622 mRNA. Translation: AAL09365.1. AC012645 Genomic DNA. No translation available. CH471238 Genomic DNA. Translation: EAW79925.1. Different initiation. BC005009 mRNA. Translation: AAH05009.3. BC050664 mRNA. Translation: AAH50664.2.
IPI	IPI00640143. IPI00873358.
RefSeq	NP_001138996.1. NM_001145524.1. NP_113665.3. NM_031477.4.
UniGene	Hs.513491.
3D structure databases
ProteinModelPortal	P61236.
ModBase	Search...
Polymorphism databases
DMDM	47117782.
Proteomic databases
PRIDE	P61236.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398838; ENSP00000381818; ENSG00000090238. ENST00000398841; ENSP00000381821; ENSG00000090238.
GeneID	83719.
KEGG	hsa:83719.
UCSC	uc002dwl.1. human.
Organism-specific databases
CTD	83719.
GeneCards	GC16M030103.
H-InvDB	HIX0012932.
HGNC	HGNC:18327. YPEL3.
HPA	HPA030501.
MIM	609724. gene.
neXtProt	NX_P61236.
PharmGKB	PA134985092.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04871.
GeneTree	ENSGT00390000008364.
HOGENOM	HBG524054.
HOVERGEN	HBG054215.
InParanoid	P61236.
OMA	QVLTAHL.
OrthoDB	EOG4HQDKR.
PhylomeDB	P61236.
Gene expression databases
ArrayExpress	P61236.
Bgee	P61236.
CleanEx	HS_YPEL3.
Genevestigator	P61236.
GermOnline	ENSG00000090238. Homo sapiens.
Family and domain databases
InterPro	IPR004910. Yippee. [Graphical view]
Pfam	PF03226. Yippee. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

YPEL3_HUMAN

Accession

Primary (citable) accession number: P61236
Secondary accession number(s): Q65Z99 , Q86VK6, Q9BSJ4, Q9CQB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.