Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-binding cassette sub-family E member 1

Gene

Abce1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway (By similarity).By similarity1 Publication

Miscellaneous

The ABC transporter domains seem not to be functional.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 117ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi379 – 386ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family E member 1
Alternative name(s):
RNase L inhibitor
Ribonuclease 4 inhibitor
Short name:
RNS4I
Gene namesi
Name:Abce1
Synonyms:Rli
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1195458 Abce1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933171 – 599ATP-binding cassette sub-family E member 1Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei417PhosphoserineBy similarity1
Modified residuei550PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61222
PaxDbiP61222
PeptideAtlasiP61222
PRIDEiP61222

PTM databases

iPTMnetiP61222
PhosphoSitePlusiP61222
SwissPalmiP61222

Expressioni

Gene expression databases

BgeeiENSMUSG00000058355
ExpressionAtlasiP61222 baseline and differential
GenevisibleiP61222 MM

Interactioni

Subunit structurei

Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.By similarity

Protein-protein interaction databases

BioGridi204855, 2 interactors
IntActiP61222, 2 interactors
MINTiP61222
STRINGi10090.ENSMUSP00000079379

Structurei

3D structure databases

ProteinModelPortaliP61222
SMRiP61222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 374Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini46 – 754Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30
Domaini79 – 315ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini342 – 562ABC transporter 2PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0063 Eukaryota
COG1245 LUCA
GeneTreeiENSGT00390000015089
HOVERGENiHBG050439
InParanoidiP61222
KOiK06174
OMAiTGCNTFL
OrthoDBiEOG091G038V
PhylomeDBiP61222
TreeFamiTF105206

Family and domain databases

CDDicd03236 ABC_RNaseL_inhibitor_domain1, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR013283 RLI1
IPR034348 RLI_dom_1
IPR007209 RNaseL-inhib_metal-bd_dom
PANTHERiPTHR19248 PTHR19248, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF00037 Fer4, 1 hit
PF04068 RLI, 1 hit
PRINTSiPR01868 ABCEFAMILY
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P61222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI
60 70 80 90 100
SETLCIGCGI CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP
110 120 130 140 150
RPGEVLGLVG TNGIGKSTAL KILAGKQKPN LGKYDDPPDW QEILTYFRGS
160 170 180 190 200
ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA KGTVGSILDR KDETKTQAIV
210 220 230 240 250
CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF DEPSSYLDVK
260 270 280 290 300
QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
310 320 330 340 350
MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY
360 370 380 390 400
PGMKKKMGEF ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE
410 420 430 440 450
GGEVPVLNVS YKPQKISPKS TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ
460 470 480 490 500
IENIIDQEVQ TLSGGELQRV ALALCLGKPA DVYLIDEPSA YLDSEQRLMA
510 520 530 540 550
ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS KNTVANSPQT
560 570 580 590
LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
Length:599
Mass (Da):67,314
Last modified:May 10, 2004 - v1
Checksum:i5D582B62E95BC7A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153Q → K in AAC24730 (PubMed:9524254).Curated1
Sequence conflicti158K → T in AAC24730 (PubMed:9524254).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90446 mRNA Translation: AAC24730.1
BC005422 mRNA Translation: AAH05422.1
CCDSiCCDS22438.1
PIRiJC6555
RefSeqiNP_056566.2, NM_015751.2
UniGeneiMm.5831

Genome annotation databases

EnsembliENSMUST00000080536; ENSMUSP00000079379; ENSMUSG00000058355
GeneIDi24015
KEGGimmu:24015
UCSCiuc009mit.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCE1_MOUSE
AccessioniPrimary (citable) accession number: P61222
Secondary accession number(s): O88793
, Q13181, Q13864, Q96AL0, Q96B10, Q99K66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health