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Protein

Transcription initiation factor TFIID subunit 13

Gene

Taf13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

TFIID beta-specific TAFII.By similarity

GO - Molecular functioni

  • DNA binding Source: MGI
  • protein C-terminus binding Source: MGI
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_282911. RNA Polymerase II Pre-transcription Events.
REACT_283211. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_329615. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_342690. RNA Polymerase II Transcription Initiation.
REACT_349121. RNA Polymerase II Promoter Escape.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 13
Alternative name(s):
Transcription initiation factor TFIID 18 kDa subunit
Short name:
TAF(II)18
Short name:
TAFII-18
Short name:
TAFII18
Gene namesi
Name:Taf13
Synonyms:Taf2k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913500. Taf13.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: MGI
  • nucleus Source: MGI
  • transcription factor TFIID complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Transcription initiation factor TFIID subunit 13PRO_0000118911Add
BLAST

Proteomic databases

PRIDEiP61216.

PTM databases

PhosphoSiteiP61216.

Expressioni

Gene expression databases

BgeeiP61216.
GenevisibleiP61216. MM.

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11 (By similarity).By similarity

Protein-protein interaction databases

BioGridi221311. 3 interactions.
IntActiP61216. 1 interaction.
STRINGi10090.ENSMUSP00000121346.

Structurei

3D structure databases

ProteinModelPortaliP61216.
SMRiP61216. Positions 31-75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The binding of TAF10 and TAF11 requires distinct domains of TAF13.By similarity

Sequence similaritiesi

Belongs to the TAF13 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

eggNOGiCOG5248.
GeneTreeiENSGT00390000012981.
HOGENOMiHOG000237827.
HOVERGENiHBG055385.
InParanoidiP61216.
KOiK03127.
OMAiEDIIFLV.
OrthoDBiEOG773XJ8.
PhylomeDBiP61216.
TreeFamiTF323609.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view]
PANTHERiPTHR11380. PTHR11380. 1 hit.
PfamiPF02269. TFIID-18kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

P61216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY
60 70 80 90 100
TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV
110 120
KDLLTMNEEL KRARKAFDEA NYGS
Length:124
Mass (Da):14,287
Last modified:May 10, 2004 - v1
Checksum:i98B62FF1BC8E7B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007339 mRNA. Translation: BAB24972.1.
AK076595 mRNA. Translation: BAC36408.1.
AK160171 mRNA. Translation: BAE35671.1.
BC021447 mRNA. Translation: AAH21447.1.
CCDSiCCDS17764.1.
RefSeqiNP_079720.1. NM_025444.2.
UniGeneiMm.24431.

Genome annotation databases

EnsembliENSMUST00000143054; ENSMUSP00000121346; ENSMUSG00000048100.
GeneIDi99730.
KEGGimmu:99730.
UCSCiuc008qzh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007339 mRNA. Translation: BAB24972.1.
AK076595 mRNA. Translation: BAC36408.1.
AK160171 mRNA. Translation: BAE35671.1.
BC021447 mRNA. Translation: AAH21447.1.
CCDSiCCDS17764.1.
RefSeqiNP_079720.1. NM_025444.2.
UniGeneiMm.24431.

3D structure databases

ProteinModelPortaliP61216.
SMRiP61216. Positions 31-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221311. 3 interactions.
IntActiP61216. 1 interaction.
STRINGi10090.ENSMUSP00000121346.

PTM databases

PhosphoSiteiP61216.

Proteomic databases

PRIDEiP61216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143054; ENSMUSP00000121346; ENSMUSG00000048100.
GeneIDi99730.
KEGGimmu:99730.
UCSCiuc008qzh.1. mouse.

Organism-specific databases

CTDi6884.
MGIiMGI:1913500. Taf13.

Phylogenomic databases

eggNOGiCOG5248.
GeneTreeiENSGT00390000012981.
HOGENOMiHOG000237827.
HOVERGENiHBG055385.
InParanoidiP61216.
KOiK03127.
OMAiEDIIFLV.
OrthoDBiEOG773XJ8.
PhylomeDBiP61216.
TreeFamiTF323609.

Enzyme and pathway databases

ReactomeiREACT_282911. RNA Polymerase II Pre-transcription Events.
REACT_283211. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_329615. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_342690. RNA Polymerase II Transcription Initiation.
REACT_349121. RNA Polymerase II Promoter Escape.

Miscellaneous databases

NextBioi354095.
PROiP61216.
SOURCEiSearch...

Gene expression databases

BgeeiP61216.
GenevisibleiP61216. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view]
PANTHERiPTHR11380. PTHR11380. 1 hit.
PfamiPF02269. TFIID-18kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas, Small intestine and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiTAF13_MOUSE
AccessioniPrimary (citable) accession number: P61216
Secondary accession number(s): Q3TVE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.