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Protein

ADP-ribosylation factor-like protein 4A

Gene

Arl4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348GTPBy similarity
Nucleotide bindingi75 – 795GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4A
Gene namesi
Name:Arl4a
Synonyms:Arl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:99437. Arl4a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 200199ADP-ribosylation factor-like protein 4APRO_0000207460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Post-translational modificationi

Myristoylated.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP61213.
PaxDbiP61213.
PRIDEiP61213.

PTM databases

PhosphoSiteiP61213.

Expressioni

Tissue specificityi

Expressed strongly in testis and liver. Expressed slightly in heart, spleen, lung and kidney.1 Publication

Developmental stagei

Expressed strongly in embryo at 7 dpc. Expressed slightly in embryo at 11, 15 and 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000047446.
CleanExiMM_ARL4A.
ExpressionAtlasiP61213. baseline and differential.
GenevisibleiP61213. MM.

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099013.

Structurei

3D structure databases

ProteinModelPortaliP61213.
SMRiP61213. Positions 23-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61213.
KOiK07945.
OMAiCFHIVIL.
OrthoDBiEOG091G0LK5.
PhylomeDBiP61213.
TreeFamiTF105464.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGLSDQTS ILSSLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP
60 70 80 90 100
TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV
110 120 130 140 150
DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL
160 170 180 190 200
LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR
Length:200
Mass (Da):22,588
Last modified:May 10, 2004 - v1
Checksum:i8D82542D0F5CEA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76546 mRNA. Translation: AAB18812.1.
AK006286 mRNA. Translation: BAB24505.1.
AK048606 mRNA. Translation: BAC33388.1.
AK168618 mRNA. Translation: BAE40483.1.
BC029234 mRNA. Translation: AAH29234.1.
CCDSiCCDS25890.1.
RefSeqiNP_001034604.1. NM_001039515.1.
NP_031513.1. NM_007487.3.
UniGeneiMm.12723.

Genome annotation databases

EnsembliENSMUST00000101472; ENSMUSP00000099013; ENSMUSG00000047446.
ENSMUST00000146905; ENSMUSP00000114458; ENSMUSG00000047446.
GeneIDi11861.
KEGGimmu:11861.
UCSCiuc007nks.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76546 mRNA. Translation: AAB18812.1.
AK006286 mRNA. Translation: BAB24505.1.
AK048606 mRNA. Translation: BAC33388.1.
AK168618 mRNA. Translation: BAE40483.1.
BC029234 mRNA. Translation: AAH29234.1.
CCDSiCCDS25890.1.
RefSeqiNP_001034604.1. NM_001039515.1.
NP_031513.1. NM_007487.3.
UniGeneiMm.12723.

3D structure databases

ProteinModelPortaliP61213.
SMRiP61213. Positions 23-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099013.

PTM databases

PhosphoSiteiP61213.

Proteomic databases

MaxQBiP61213.
PaxDbiP61213.
PRIDEiP61213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101472; ENSMUSP00000099013; ENSMUSG00000047446.
ENSMUST00000146905; ENSMUSP00000114458; ENSMUSG00000047446.
GeneIDi11861.
KEGGimmu:11861.
UCSCiuc007nks.1. mouse.

Organism-specific databases

CTDi10124.
MGIiMGI:99437. Arl4a.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61213.
KOiK07945.
OMAiCFHIVIL.
OrthoDBiEOG091G0LK5.
PhylomeDBiP61213.
TreeFamiTF105464.

Miscellaneous databases

PROiP61213.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047446.
CleanExiMM_ARL4A.
ExpressionAtlasiP61213. baseline and differential.
GenevisibleiP61213. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL4A_MOUSE
AccessioniPrimary (citable) accession number: P61213
Secondary accession number(s): P41275, Q3TGR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.