Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-like protein 1

Gene

Arl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi31 – 311MagnesiumBy similarity
Metal bindingi48 – 481MagnesiumBy similarity
Binding sitei70 – 701GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi45 – 484GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity
Nucleotide bindingi160 – 1612GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 1
Gene namesi
Name:Arl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:99436. Arl1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: GOC
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 181180ADP-ribosylation factor-like protein 1PRO_0000207451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP61211.
PaxDbiP61211.
PeptideAtlasiP61211.
PRIDEiP61211.
TopDownProteomicsiP61211.

PTM databases

iPTMnetiP61211.
PhosphoSiteiP61211.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060904.
CleanExiMM_ARL1.
ExpressionAtlasiP61211. baseline and differential.
GenevisibleiP61211. MM.

Interactioni

Subunit structurei

The GTP-bound form interacts with GOLGA1, GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to an increase in the amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222534. 2 interactions.
IntActiP61211. 1 interaction.
MINTiMINT-1864152.
STRINGi10090.ENSMUSP00000111942.

Structurei

3D structure databases

ProteinModelPortaliP61211.
SMRiP61211. Positions 16-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61211.
KOiK07942.
OMAiDMEGCMS.
OrthoDBiEOG091G0MRS.
PhylomeDBiP61211.
TreeFamiTF105461.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG
60 70 80 90 100
FNVETVTYKN LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI
110 120 130 140 150
GISKSELVAM LEEEELRKAI LVVFANKQDM EQAMTPSEMA NALGLPALKD
160 170 180
RKWQIFKTSA TKGTGLDEAM EWLVETLKSR Q
Length:181
Mass (Da):20,412
Last modified:May 10, 2004 - v1
Checksum:i3DFC4CC8ED632FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010732 mRNA. Translation: BAB27148.1.
AK018138 mRNA. Translation: BAB31089.1.
AK088330 mRNA. Translation: BAC40286.1.
CCDSiCCDS36025.1.
RefSeqiNP_080135.2. NM_025859.3.
UniGeneiMm.291247.

Genome annotation databases

EnsembliENSMUST00000116234; ENSMUSP00000111942; ENSMUSG00000060904.
GeneIDi104303.
KEGGimmu:104303.
UCSCiuc007grw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010732 mRNA. Translation: BAB27148.1.
AK018138 mRNA. Translation: BAB31089.1.
AK088330 mRNA. Translation: BAC40286.1.
CCDSiCCDS36025.1.
RefSeqiNP_080135.2. NM_025859.3.
UniGeneiMm.291247.

3D structure databases

ProteinModelPortaliP61211.
SMRiP61211. Positions 16-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222534. 2 interactions.
IntActiP61211. 1 interaction.
MINTiMINT-1864152.
STRINGi10090.ENSMUSP00000111942.

PTM databases

iPTMnetiP61211.
PhosphoSiteiP61211.

Proteomic databases

EPDiP61211.
PaxDbiP61211.
PeptideAtlasiP61211.
PRIDEiP61211.
TopDownProteomicsiP61211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116234; ENSMUSP00000111942; ENSMUSG00000060904.
GeneIDi104303.
KEGGimmu:104303.
UCSCiuc007grw.1. mouse.

Organism-specific databases

CTDi400.
MGIiMGI:99436. Arl1.

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61211.
KOiK07942.
OMAiDMEGCMS.
OrthoDBiEOG091G0MRS.
PhylomeDBiP61211.
TreeFamiTF105461.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiP61211.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060904.
CleanExiMM_ARL1.
ExpressionAtlasiP61211. baseline and differential.
GenevisibleiP61211. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL1_MOUSE
AccessioniPrimary (citable) accession number: P61211
Secondary accession number(s): P41276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.