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Protein

ADP-ribosylation factor-like protein 1

Gene

Arl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi31MagnesiumBy similarity1
Metal bindingi48MagnesiumBy similarity1
Binding sitei70GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi45 – 48GTPBy similarity4
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi160 – 161GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 1
Gene namesi
Name:Arl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:99436. Arl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002074512 – 181ADP-ribosylation factor-like protein 1Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP61211.
PaxDbiP61211.
PeptideAtlasiP61211.
PRIDEiP61211.
TopDownProteomicsiP61211.

PTM databases

iPTMnetiP61211.
PhosphoSitePlusiP61211.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060904.
CleanExiMM_ARL1.
ExpressionAtlasiP61211. baseline and differential.
GenevisibleiP61211. MM.

Interactioni

Subunit structurei

The GTP-bound form interacts with GOLGA1, GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to an increase in the amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222534. 2 interactors.
IntActiP61211. 1 interactor.
MINTiMINT-1864152.
STRINGi10090.ENSMUSP00000111942.

Structurei

3D structure databases

ProteinModelPortaliP61211.
SMRiP61211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0072. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00890000139352.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61211.
KOiK07942.
OMAiWSKDQDV.
OrthoDBiEOG091G0MRS.
PhylomeDBiP61211.
TreeFamiTF105461.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG
60 70 80 90 100
FNVETVTYKN LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI
110 120 130 140 150
GISKSELVAM LEEEELRKAI LVVFANKQDM EQAMTPSEMA NALGLPALKD
160 170 180
RKWQIFKTSA TKGTGLDEAM EWLVETLKSR Q
Length:181
Mass (Da):20,412
Last modified:May 10, 2004 - v1
Checksum:i3DFC4CC8ED632FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010732 mRNA. Translation: BAB27148.1.
AK018138 mRNA. Translation: BAB31089.1.
AK088330 mRNA. Translation: BAC40286.1.
CCDSiCCDS36025.1.
RefSeqiNP_080135.2. NM_025859.3.
UniGeneiMm.291247.

Genome annotation databases

EnsembliENSMUST00000116234; ENSMUSP00000111942; ENSMUSG00000060904.
GeneIDi104303.
KEGGimmu:104303.
UCSCiuc007grw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARL1_MOUSE
AccessioniPrimary (citable) accession number: P61211
Secondary accession number(s): P41276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: August 30, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families