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Protein

ADP-ribosylation factor 1

Gene

Arf79F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: FlyBase

GO - Biological processi

  • ARF protein signal transduction Source: FlyBase
  • cell adhesion Source: FlyBase
  • compound eye development Source: FlyBase
  • endosomal transport Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • positive regulation of endocytosis Source: FlyBase
  • post-Golgi vesicle-mediated transport Source: FlyBase
  • protein ADP-ribosylation Source: FlyBase
  • protein transport Source: UniProtKB-KW
  • regulation of cell shape Source: FlyBase
  • regulation of hematopoietic stem cell differentiation Source: FlyBase
  • regulation of lipid storage Source: FlyBase
  • synaptic vesicle endocytosis Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1660514. Synthesis of PIPs at the Golgi membrane.
R-DME-199997. COPI Mediated Transport.
R-DME-421837. Clathrin derived vesicle budding.
R-DME-432720. Lysosome Vesicle Biogenesis.
R-DME-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 1
Gene namesi
Name:Arf79F
Synonyms:ARF1
ORF Names:CG8385
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010348. Arf79F.

Subcellular locationi

GO - Cellular componenti

  • cleavage furrow Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • Golgi stack Source: FlyBase
  • presynapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 182181ADP-ribosylation factor 1PRO_0000207441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61209.
PRIDEiP61209.

Expressioni

Gene expression databases

BgeeiP61209.
ExpressionAtlasiP61209. differential.
GenevisibleiP61209. DM.

Interactioni

Protein-protein interaction databases

BioGridi65734. 47 interactions.
IntActiP61209. 8 interactions.
MINTiMINT-970074.
STRINGi7227.FBpp0289184.

Structurei

3D structure databases

ProteinModelPortaliP61209.
SMRiP61209. Positions 18-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiP61209.
KOiK07937.
OMAiNDNERVS.
OrthoDBiEOG77WWDV.
PhylomeDBiP61209.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNVFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI
110 120 130 140 150
GEAREELMRM LAEDELRDAV LLIFANKQDL PNAMNAAEIT DKLGLHSLRN
160 170 180
RNWYIQATCA TSGDGLYEGL DWLSNQLKNA NR
Length:182
Mass (Da):20,688
Last modified:January 23, 2007 - v2
Checksum:i9E87E24DFAEA3674
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62079 Genomic DNA. Translation: AAB27066.1.
AE014296 Genomic DNA. Translation: AAF51871.1.
AE014296 Genomic DNA. Translation: AAF51872.1.
AE014296 Genomic DNA. Translation: AAF51873.1.
AE014296 Genomic DNA. Translation: AAF51874.1.
AE014296 Genomic DNA. Translation: AAN12207.1.
AE014296 Genomic DNA. Translation: ABW08583.1.
AE014296 Genomic DNA. Translation: ABW08584.2.
AY060375 mRNA. Translation: AAL25414.1.
PIRiA49520.
RefSeqiNP_001097667.1. NM_001104197.3.
NP_001097668.2. NM_001104198.2.
NP_001262225.1. NM_001275296.1.
NP_476955.1. NM_057607.6.
NP_730757.1. NM_168970.4.
NP_730758.1. NM_168971.4.
NP_730759.1. NM_168972.5.
NP_730760.1. NM_168973.3.
UniGeneiDm.6446.

Genome annotation databases

EnsemblMetazoaiFBtr0078571; FBpp0078222; FBgn0010348.
FBtr0078573; FBpp0078224; FBgn0010348.
FBtr0078574; FBpp0078225; FBgn0010348.
FBtr0078575; FBpp0078226; FBgn0010348.
FBtr0112858; FBpp0111771; FBgn0010348.
FBtr0299906; FBpp0289184; FBgn0010348.
FBtr0299907; FBpp0289185; FBgn0010348.
FBtr0332054; FBpp0304364; FBgn0010348.
GeneIDi40506.
KEGGidme:Dmel_CG8385.
UCSCiCG8385-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62079 Genomic DNA. Translation: AAB27066.1.
AE014296 Genomic DNA. Translation: AAF51871.1.
AE014296 Genomic DNA. Translation: AAF51872.1.
AE014296 Genomic DNA. Translation: AAF51873.1.
AE014296 Genomic DNA. Translation: AAF51874.1.
AE014296 Genomic DNA. Translation: AAN12207.1.
AE014296 Genomic DNA. Translation: ABW08583.1.
AE014296 Genomic DNA. Translation: ABW08584.2.
AY060375 mRNA. Translation: AAL25414.1.
PIRiA49520.
RefSeqiNP_001097667.1. NM_001104197.3.
NP_001097668.2. NM_001104198.2.
NP_001262225.1. NM_001275296.1.
NP_476955.1. NM_057607.6.
NP_730757.1. NM_168970.4.
NP_730758.1. NM_168971.4.
NP_730759.1. NM_168972.5.
NP_730760.1. NM_168973.3.
UniGeneiDm.6446.

3D structure databases

ProteinModelPortaliP61209.
SMRiP61209. Positions 18-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65734. 47 interactions.
IntActiP61209. 8 interactions.
MINTiMINT-970074.
STRINGi7227.FBpp0289184.

Proteomic databases

PaxDbiP61209.
PRIDEiP61209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078571; FBpp0078222; FBgn0010348.
FBtr0078573; FBpp0078224; FBgn0010348.
FBtr0078574; FBpp0078225; FBgn0010348.
FBtr0078575; FBpp0078226; FBgn0010348.
FBtr0112858; FBpp0111771; FBgn0010348.
FBtr0299906; FBpp0289184; FBgn0010348.
FBtr0299907; FBpp0289185; FBgn0010348.
FBtr0332054; FBpp0304364; FBgn0010348.
GeneIDi40506.
KEGGidme:Dmel_CG8385.
UCSCiCG8385-RB. d. melanogaster.

Organism-specific databases

CTDi40506.
FlyBaseiFBgn0010348. Arf79F.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiP61209.
KOiK07937.
OMAiNDNERVS.
OrthoDBiEOG77WWDV.
PhylomeDBiP61209.

Enzyme and pathway databases

ReactomeiR-DME-1660514. Synthesis of PIPs at the Golgi membrane.
R-DME-199997. COPI Mediated Transport.
R-DME-421837. Clathrin derived vesicle budding.
R-DME-432720. Lysosome Vesicle Biogenesis.
R-DME-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiArf79F. fly.
GenomeRNAii40506.
NextBioi819087.
PROiP61209.

Gene expression databases

BgeeiP61209.
ExpressionAtlasiP61209. differential.
GenevisibleiP61209. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster."
    Murtagh J.J. Jr., Lee F.-J.S., Deak P., Hall L.M., Monaco L., Lee C.M., Stevens L.A., Moss J., Vaughan M.
    Biochemistry 32:6011-6018(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiARF1_DROME
AccessioniPrimary (citable) accession number: P61209
Secondary accession number(s): A4V2B1
, A8JNX4, P35676, Q9VNQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.