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Protein

ADP-ribosylation factor 1

Gene

Arf79F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development (PubMed:21976699). Required for cleavage furrow ingression in embryonic cells (PubMed:27535433).Curated2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • ARF protein signal transduction Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: UniProtKB
  • Golgi to plasma membrane protein transport Source: FlyBase
  • male meiosis cytokinesis Source: FlyBase
  • mitotic cleavage furrow ingression Source: UniProtKB
  • neurotransmitter secretion Source: FlyBase
  • positive regulation of endocytosis Source: FlyBase
  • positive regulation of neuron remodeling Source: FlyBase
  • post-Golgi vesicle-mediated transport Source: FlyBase
  • regulation of hematopoietic stem cell differentiation Source: FlyBase
  • regulation of lipid storage Source: FlyBase
  • synaptic vesicle endocytosis Source: FlyBase

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 1
Gene namesi
Name:Arf79F
Synonyms:ARF1
ORF Names:CG8385
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010348 Arf79F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Disruption phenotypei

Conditional RNAi-mediated knockdown in the eye results in aberrant compound eye morphogenesis (PubMed:21976699). Maternal RNAi-mediated knockdown results in abnormal aggregation of Golgi apparatus and disrupted cleavage furrow ingression in early embryos (PubMed:27535433).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46I → D: Abnormal aggregation of Golgi apparatus and disrupted cleavage furrow ingression in early embryos. May be insensitive to Asap activation. 1 Publication1
Mutagenesisi52N → A: No defect in Golgi apparatus and cleavage furrow ingression in early embryos. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074412 – 182ADP-ribosylation factor 1Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61209
PRIDEiP61209

Expressioni

Gene expression databases

BgeeiFBgn0010348
ExpressionAtlasiP61209 differential
GenevisibleiP61209 DM

Interactioni

Protein-protein interaction databases

BioGridi6573470 interactors.
IntActiP61209 11 interactors.
STRINGi7227.FBpp0289184

Structurei

3D structure databases

ProteinModelPortaliP61209
SMRiP61209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
InParanoidiP61209
KOiK07937
OMAiHYYSNTD
OrthoDBiEOG091G0S7S
PhylomeDBiP61209

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNVFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI
110 120 130 140 150
GEAREELMRM LAEDELRDAV LLIFANKQDL PNAMNAAEIT DKLGLHSLRN
160 170 180
RNWYIQATCA TSGDGLYEGL DWLSNQLKNA NR
Length:182
Mass (Da):20,688
Last modified:January 23, 2007 - v2
Checksum:i9E87E24DFAEA3674
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62079 Genomic DNA Translation: AAB27066.1
AE014296 Genomic DNA Translation: AAF51871.1
AE014296 Genomic DNA Translation: AAF51872.1
AE014296 Genomic DNA Translation: AAF51873.1
AE014296 Genomic DNA Translation: AAF51874.1
AE014296 Genomic DNA Translation: AAN12207.1
AE014296 Genomic DNA Translation: ABW08583.1
AE014296 Genomic DNA Translation: ABW08584.2
AY060375 mRNA Translation: AAL25414.1
PIRiA49520
RefSeqiNP_001097667.1, NM_001104197.3
NP_001097668.2, NM_001104198.2
NP_001262225.1, NM_001275296.1
NP_476955.1, NM_057607.6
NP_730757.1, NM_168970.4
NP_730758.1, NM_168971.4
NP_730759.1, NM_168972.5
NP_730760.1, NM_168973.3
UniGeneiDm.6446

Genome annotation databases

EnsemblMetazoaiFBtr0078571; FBpp0078222; FBgn0010348
FBtr0078573; FBpp0078224; FBgn0010348
FBtr0078574; FBpp0078225; FBgn0010348
FBtr0078575; FBpp0078226; FBgn0010348
FBtr0112858; FBpp0111771; FBgn0010348
FBtr0299906; FBpp0289184; FBgn0010348
FBtr0299907; FBpp0289185; FBgn0010348
FBtr0332054; FBpp0304364; FBgn0010348
GeneIDi40506
KEGGidme:Dmel_CG8385
UCSCiCG8385-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiARF1_DROME
AccessioniPrimary (citable) accession number: P61209
Secondary accession number(s): A4V2B1
, A8JNX4, P35676, Q9VNQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome