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Protein

ADP-ribosylation factor-like protein 4C

Gene

Arl4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 4C
Alternative name(s):
ADP-ribosylation factor-like 7
Gene namesi
Name:Arl4c
Synonyms:Arl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2445172 Arl4c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074632 – 192ADP-ribosylation factor-like protein 4CAdd BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP61208
MaxQBiP61208
PaxDbiP61208
PeptideAtlasiP61208
PRIDEiP61208

PTM databases

PhosphoSitePlusiP61208

Expressioni

Gene expression databases

BgeeiENSMUSG00000049866
CleanExiMM_ARL4C
GenevisibleiP61208 MM

Interactioni

Subunit structurei

Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057085

Structurei

3D structure databases

ProteinModelPortaliP61208
SMRiP61208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOVERGENiHBG002073
InParanoidiP61208
KOiK07945
OMAiRVQPACA
OrthoDBiEOG091G0LK5
TreeFamiTF105464

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNISSNISA FQSLHIVMLG LDSAGKTTVL YRLKFNEFVN TVPTIGFNTE
60 70 80 90 100
KIKLSNGTAK GISCHFWDVG GQEKLRPLWK SYSRCTDGII YVVDSVDVDR
110 120 130 140 150
LEEAKTELHK VTKFAENQGT PLLVIANKQD LPKSLPVAEI EKQLALHELI
160 170 180 190
PATTYHVQPA CAIIGEGLTE GMDKLYEMIL KRRKSLKQKK KR
Length:192
Mass (Da):21,487
Last modified:May 10, 2004 - v1
Checksum:i389BD49CF9E6D10D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ623276 Genomic DNA Translation: CAF22225.1
AK080335 mRNA Translation: BAC37882.1
AK080380 mRNA Translation: BAC37900.1
BC055769 mRNA Translation: AAH55769.1
CCDSiCCDS15146.1
RefSeqiNP_796279.2, NM_177305.4
UniGeneiMm.27968
Mm.477970

Genome annotation databases

EnsembliENSMUST00000051236; ENSMUSP00000057085; ENSMUSG00000049866
ENSMUST00000159814; ENSMUSP00000124344; ENSMUSG00000049866
ENSMUST00000187810; ENSMUSP00000139499; ENSMUSG00000049866
GeneIDi320982
KEGGimmu:320982
UCSCiuc007byt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARL4C_MOUSE
AccessioniPrimary (citable) accession number: P61208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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