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Protein

ADP-ribosylation factor 3

Gene

Arf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 3
Alternative name(s):
Liver regeneration-related protein LRRG202
Gene namesi
Name:Arf3
ORF Names:Ac1-253
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621273. Arf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002073892 – 181ADP-ribosylation factor 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61206.
PRIDEiP61206.

2D gel databases

World-2DPAGE0004:P61206.

PTM databases

iPTMnetiP61206.
PhosphoSitePlusiP61206.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033155.
ExpressionAtlasiP61206. baseline.
GenevisibleiP61206. RN.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.By similarity

Protein-protein interaction databases

IntActiP61206. 1 interactor.
MINTiMINT-1775307.
STRINGi10116.ENSRNOP00000047811.

Structurei

3D structure databases

ProteinModelPortaliP61206.
SMRiP61206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61206.
KOiK07938.
PhylomeDBiP61206.
TreeFamiTF300808.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
160 170 180
RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
Length:181
Mass (Da):20,601
Last modified:January 23, 2007 - v2
Checksum:iD6FA234DFAED3E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12382 mRNA. Translation: AAA40687.1.
AY325223 mRNA. Translation: AAP92624.1.
BC088865 mRNA. Translation: AAH88865.1.
RefSeqiNP_543180.1. NM_080904.2.
XP_006257382.1. XM_006257320.3.
XP_017450124.1. XM_017594635.1.
XP_017450125.1. XM_017594636.1.
UniGeneiRn.106440.

Genome annotation databases

EnsembliENSRNOT00000077884; ENSRNOP00000069538; ENSRNOG00000054775.
GeneIDi140940.
KEGGirno:140940.
UCSCiRGD:621273. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12382 mRNA. Translation: AAA40687.1.
AY325223 mRNA. Translation: AAP92624.1.
BC088865 mRNA. Translation: AAH88865.1.
RefSeqiNP_543180.1. NM_080904.2.
XP_006257382.1. XM_006257320.3.
XP_017450124.1. XM_017594635.1.
XP_017450125.1. XM_017594636.1.
UniGeneiRn.106440.

3D structure databases

ProteinModelPortaliP61206.
SMRiP61206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61206. 1 interactor.
MINTiMINT-1775307.
STRINGi10116.ENSRNOP00000047811.

PTM databases

iPTMnetiP61206.
PhosphoSitePlusiP61206.

2D gel databases

World-2DPAGE0004:P61206.

Proteomic databases

PaxDbiP61206.
PRIDEiP61206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077884; ENSRNOP00000069538; ENSRNOG00000054775.
GeneIDi140940.
KEGGirno:140940.
UCSCiRGD:621273. rat.

Organism-specific databases

CTDi377.
RGDi621273. Arf3.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61206.
KOiK07938.
PhylomeDBiP61206.
TreeFamiTF300808.

Miscellaneous databases

PROiP61206.

Gene expression databases

BgeeiENSRNOG00000033155.
ExpressionAtlasiP61206. baseline.
GenevisibleiP61206. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARF3_RAT
AccessioniPrimary (citable) accession number: P61206
Secondary accession number(s): P16587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.