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Protein

ADP-ribosylation factor 3

Gene

Arf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660514. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 3
Gene namesi
Name:Arf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99432. Arf3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 181180ADP-ribosylation factor 3PRO_0000207387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP61205.
PaxDbiP61205.
PeptideAtlasiP61205.
PRIDEiP61205.
TopDownProteomicsiP61205.

PTM databases

iPTMnetiP61205.
PhosphoSiteiP61205.
SwissPalmiP61205.

Expressioni

Gene expression databases

BgeeiP61205.
CleanExiMM_ARF3.
ExpressionAtlasiP61205. baseline and differential.
GenevisibleiP61205. MM.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.By similarity

Protein-protein interaction databases

BioGridi198186. 2 interactions.
IntActiP61205. 3 interactions.
MINTiMINT-4088218.
STRINGi10090.ENSMUSP00000050689.

Structurei

3D structure databases

ProteinModelPortaliP61205.
SMRiP61205. Positions 18-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61205.
KOiK07938.
OMAiQTTCATS.
OrthoDBiEOG77WWDV.
PhylomeDBiP61205.
TreeFamiTF300808.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
160 170 180
RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
Length:181
Mass (Da):20,601
Last modified:January 23, 2007 - v2
Checksum:iD6FA234DFAED3E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87900 mRNA. Translation: BAA13492.1.
BC014778 mRNA. Translation: AAH14778.1.
BC024935 mRNA. Translation: AAH24935.1.
CCDSiCCDS27804.1.
PIRiJC4947.
RefSeqiNP_031504.1. NM_007478.3.
XP_011243747.1. XM_011245445.1.
UniGeneiMm.221298.

Genome annotation databases

EnsembliENSMUST00000053183; ENSMUSP00000050689; ENSMUSG00000051853.
GeneIDi11842.
KEGGimmu:11842.
UCSCiuc007xnp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87900 mRNA. Translation: BAA13492.1.
BC014778 mRNA. Translation: AAH14778.1.
BC024935 mRNA. Translation: AAH24935.1.
CCDSiCCDS27804.1.
PIRiJC4947.
RefSeqiNP_031504.1. NM_007478.3.
XP_011243747.1. XM_011245445.1.
UniGeneiMm.221298.

3D structure databases

ProteinModelPortaliP61205.
SMRiP61205. Positions 18-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198186. 2 interactions.
IntActiP61205. 3 interactions.
MINTiMINT-4088218.
STRINGi10090.ENSMUSP00000050689.

PTM databases

iPTMnetiP61205.
PhosphoSiteiP61205.
SwissPalmiP61205.

Proteomic databases

EPDiP61205.
PaxDbiP61205.
PeptideAtlasiP61205.
PRIDEiP61205.
TopDownProteomicsiP61205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053183; ENSMUSP00000050689; ENSMUSG00000051853.
GeneIDi11842.
KEGGimmu:11842.
UCSCiuc007xnp.1. mouse.

Organism-specific databases

CTDi377.
MGIiMGI:99432. Arf3.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiP61205.
KOiK07938.
OMAiQTTCATS.
OrthoDBiEOG77WWDV.
PhylomeDBiP61205.
TreeFamiTF300808.

Enzyme and pathway databases

ReactomeiR-MMU-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

ChiTaRSiArf3. mouse.
PROiP61205.
SOURCEiSearch...

Gene expression databases

BgeeiP61205.
CleanExiMM_ARF3.
ExpressionAtlasiP61205. baseline and differential.
GenevisibleiP61205. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)."
    Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.
    J. Biochem. 120:813-819(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiARF3_MOUSE
AccessioniPrimary (citable) accession number: P61205
Secondary accession number(s): P16587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.