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Protein

ADP-ribosylation factor 3

Gene

Arf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: MGI

GO - Biological processi

  • protein transport Source: MGI
  • retrograde vesicle-mediated transport, Golgi to ER Source: MGI

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660514 Synthesis of PIPs at the Golgi membrane
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor 3
Gene namesi
Name:Arf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99432 Arf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002073872 – 181ADP-ribosylation factor 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP61205
PeptideAtlasiP61205
PRIDEiP61205
TopDownProteomicsiP61205

PTM databases

iPTMnetiP61205
PhosphoSitePlusiP61205
SwissPalmiP61205

Expressioni

Gene expression databases

BgeeiENSMUSG00000051853
CleanExiMM_ARF3
ExpressionAtlasiP61205 baseline and differential
GenevisibleiP61205 MM

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.By similarity

Protein-protein interaction databases

BioGridi198186, 8 interactors
IntActiP61205, 8 interactors
MINTiP61205
STRINGi10090.ENSMUSP00000050689

Structurei

3D structure databases

ProteinModelPortaliP61205
SMRiP61205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00780000121855
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiP61205
KOiK07938
OMAiAMREMAN
OrthoDBiEOG091G0S7S
PhylomeDBiP61205
TreeFamiTF300808

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
160 170 180
RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
Length:181
Mass (Da):20,601
Last modified:January 23, 2007 - v2
Checksum:iD6FA234DFAED3E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87900 mRNA Translation: BAA13492.1
BC014778 mRNA Translation: AAH14778.1
BC024935 mRNA Translation: AAH24935.1
CCDSiCCDS27804.1
PIRiJC4947
RefSeqiNP_031504.1, NM_007478.3
XP_011243747.1, XM_011245445.1
UniGeneiMm.221298

Genome annotation databases

EnsembliENSMUST00000053183; ENSMUSP00000050689; ENSMUSG00000051853
GeneIDi11842
KEGGimmu:11842
UCSCiuc007xnp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiARF3_MOUSE
AccessioniPrimary (citable) accession number: P61205
Secondary accession number(s): P16587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health