P61205 (ARF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP-ribosylation factor 3

Gene names

Name:

Arf3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subunit structure	Interacts with PRKCABP By similarity. Interacts with PI4KB and NCS1/FREQ at the Golgi complex By similarity.
Subcellular location	Golgi apparatus By similarity. Cytoplasm › perinuclear region By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Cytoplasm Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Traceable author statement Ref.1. Source: MGI small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from direct assay Ref.1. Source: MGI perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Traceable author statement Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 181	180	ADP-ribosylation factor 3		PRO_0000207387
Regions
	Nucleotide binding	24 – 31	8	GTP By similarity
	Nucleotide binding	67 – 71	5	GTP By similarity
	Nucleotide binding	126 – 129	4	GTP By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential

Sequences

	Sequence		Length	Mass (Da)
	P61205 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D6FA234DFAED3E5F	FASTA	181	20,601
	10 20 30 40 50 60 MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 70 80 90 100 110 120 ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV 130 140 150 160 170 180 LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)." Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K. J. Biochem. 120:813-819(1996) [PubMed: 8947846] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D87900 mRNA. Translation: BAA13492.1. BC014778 mRNA. Translation: AAH14778.1. BC024935 mRNA. Translation: AAH24935.1.
IPI	IPI00221614.
PIR	JC4947.
RefSeq	NP_031504.1. NM_007478.3.
UniGene	Mm.221298.
3D structure databases
ProteinModelPortal	P61205.
SMR	P61205. Positions 18-177.
ModBase	Search...
Protein-protein interaction databases
IntAct	P61205. 2 interactions.
STRING	P61205.
PTM databases
PhosphoSite	P61205.
Proteomic databases
PRIDE	P61205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000053183; ENSMUSP00000050689; ENSMUSG00000051853.
GeneID	11842.
KEGG	mmu:11842.
Organism-specific databases
CTD	377.
MGI	MGI:99432. Arf3.
Phylogenomic databases
eggNOG	roNOG13910.
HOGENOM	HBG745225.
HOVERGEN	HBG002073.
InParanoid	P61205.
OMA	LWGKKEM.
OrthoDB	EOG4PZJ7Q.
PhylomeDB	P61205.
Gene expression databases
ArrayExpress	P61205.
Bgee	P61205.
CleanEx	MM_ARF3.
Genevestigator	P61205.
GermOnline	ENSMUSG00000051853. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view]
KO	K07938.
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. Small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279791.
SOURCE	Search...

Entry information

Entry name

ARF3_MOUSE

Accession

Primary (citable) accession number: P61205
Secondary accession number(s): P16587

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program