UniProtKB - P61204 (ARF3_HUMAN)
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Protein
ADP-ribosylation factor 3
Gene
ARF3
Organism
Homo sapiens (Human)
Status
Functioni
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 24 – 31 | GTPBy similarity | 8 | |
Nucleotide bindingi | 67 – 71 | GTPBy similarity | 5 | |
Nucleotide bindingi | 126 – 129 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: ProtInc
- GTP binding Source: ProtInc
GO - Biological processi
- phosphatidylinositol biosynthetic process Source: Reactome
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to ER Source: WormBase
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-1660514. Synthesis of PIPs at the Golgi membrane. R-HSA-6807878. COPI-mediated anterograde transport. R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic. |
Names & Taxonomyi
Protein namesi | Recommended name: ADP-ribosylation factor 3 |
Gene namesi | Name:ARF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134287.9. |
HGNCi | HGNC:654. ARF3. |
MIMi | 103190. gene. |
neXtProti | NX_P61204. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 377. |
OpenTargetsi | ENSG00000134287. |
PharmGKBi | PA24936. |
Polymorphism and mutation databases
BioMutai | ARF3. |
DMDMi | 47117657. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedSequence analysis | |||
ChainiPRO_0000207386 | 2 – 181 | ADP-ribosylation factor 3Add BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineSequence analysis | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
EPDi | P61204. |
MaxQBi | P61204. |
PaxDbi | P61204. |
PeptideAtlasi | P61204. |
PRIDEi | P61204. |
TopDownProteomicsi | P61204-1. [P61204-1] |
2D gel databases
OGPi | P16587. |
PTM databases
iPTMneti | P61204. |
PhosphoSitePlusi | P61204. |
SwissPalmi | P61204. |
Expressioni
Gene expression databases
Bgeei | ENSG00000134287. |
CleanExi | HS_ARF3. |
ExpressionAtlasi | P61204. baseline and differential. |
Genevisiblei | P61204. HS. |
Interactioni
Subunit structurei
Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.2 Publications
Protein-protein interaction databases
BioGridi | 106872. 25 interactors. |
IntActi | P61204. 9 interactors. |
STRINGi | 9606.ENSP00000256682. |
Structurei
3D structure databases
ProteinModelPortali | P61204. |
SMRi | P61204. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0070. Eukaryota. COG1100. LUCA. |
GeneTreei | ENSGT00780000121855. |
HOGENOMi | HOG000163691. |
HOVERGENi | HBG002073. |
InParanoidi | P61204. |
KOi | K07938. |
OMAi | AMREMAN. |
OrthoDBi | EOG091G0S7S. |
PhylomeDBi | P61204. |
TreeFami | TF300808. |
Family and domain databases
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. |
Pfami | View protein in Pfam PF00025. Arf. 1 hit. |
PRINTSi | PR00328. SAR1GTPBP. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR00231. small_GTP. 1 hit. |
PROSITEi | View protein in PROSITE PS51417. ARF. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P61204-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG
60 70 80 90 100
FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV
110 120 130 140 150
NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH
160 170 180
RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056935 | 50 – 86 | Missing in isoform 2. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74493 Genomic DNA. Translation: AAA58359.1. M33384 mRNA. Translation: AAA83931.1. M74491 mRNA. Translation: AAB59425.1. AF493882 mRNA. Translation: AAM12596.1. BT006670 mRNA. Translation: AAP35316.1. AK291633 mRNA. Translation: BAF84322.1. AK316528 mRNA. Translation: BAH14899.1. AC073610 Genomic DNA. No translation available. CH471111 Genomic DNA. Translation: EAW58026.1. BC007647 mRNA. Translation: AAH07647.1. BC007762 mRNA. Translation: AAH07762.1. BC017565 mRNA. Translation: AAH17565.1. BC028402 mRNA. Translation: AAH28402.1. |
CCDSi | CCDS8774.1. [P61204-1] |
PIRi | A41570. |
RefSeqi | NP_001650.1. NM_001659.2. [P61204-1] XP_005268913.1. XM_005268856.1. [P61204-1] |
UniGenei | Hs.119177. |
Genome annotation databases
Ensembli | ENST00000256682; ENSP00000256682; ENSG00000134287. [P61204-1] ENST00000447318; ENSP00000395370; ENSG00000134287. [P61204-2] ENST00000541959; ENSP00000438510; ENSG00000134287. [P61204-1] |
GeneIDi | 377. |
KEGGi | hsa:377. |
UCSCi | uc001rsr.3. human. [P61204-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | ARF3_HUMAN | |
Accessioni | P61204Primary (citable) accession number: P61204 Secondary accession number(s): A8K6G8, B7ZB63, P16587 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |