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Protein

COP9 signalosome complex subunit 2

Gene

Cops2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 2
Short name:
SGN2
Short name:
Signalosome subunit 2
Alternative name(s):
Alien homolog
JAB1-containing signalosome subunit 2
Thyroid receptor-interacting protein 15
Short name:
TR-interacting protein 15
Short name:
TRIP-15
Gene namesi
Name:Cops2
Synonyms:Csn2, Trip15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi628791. Cops2.

Subcellular locationi

GO - Cellular componenti

  • COP9 signalosome Source: GO_Central
  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209701 – 443COP9 signalosome complex subunit 2Add BLAST443

Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP61203.
PeptideAtlasiP61203.
PRIDEiP61203.

PTM databases

iPTMnetiP61203.
PhosphoSitePlusiP61203.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

Regulated by thyroid hormone and TR.1 Publication

Gene expression databases

BgeeiENSRNOG00000008744.
GenevisibleiP61203. RN.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Interacts with CUL1 and CUL2. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (By similarity). Interacts with NIF3L1 (PubMed:12522100).By similarity1 Publication

Protein-protein interaction databases

BioGridi251749. 1 interactor.
STRINGi10116.ENSRNOP00000012287.

Structurei

3D structure databases

ProteinModelPortaliP61203.
SMRiP61203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 413PCIAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 275Mediates interaction with NIF3L11 PublicationAdd BLAST275

Sequence similaritiesi

Belongs to the CSN2 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG1464. Eukaryota.
COG5159. LUCA.
GeneTreeiENSGT00530000063301.
HOGENOMiHOG000194333.
HOVERGENiHBG003924.
InParanoidiP61203.
KOiK12176.
OMAiRNNIMDD.
OrthoDBiEOG091G07D9.
PhylomeDBiP61203.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48452. SSF48452. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P61203-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA
60 70 80 90 100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR
110 120 130 140 150
SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK
160 170 180 190 200
TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL
210 220 230 240 250
EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE
260 270 280 290 300
FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
310 320 330 340 350
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL
360 370 380 390 400
LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG
410 420 430 440
RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
Length:443
Mass (Da):51,597
Last modified:May 10, 2004 - v1
Checksum:i1DB6FA774C13BC59
GO
Isoform 2 (identifier: P61203-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-124: Q → QNSDFLCQ
     191-238: Missing.

Show »
Length:402
Mass (Da):46,914
Checksum:iCE81CE6A58C7CD89
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011886124Q → QNSDFLCQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_011887191 – 238Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081072 mRNA. Translation: BAC15575.1.
BC061864 mRNA. Translation: AAH61864.1.
RefSeqiNP_695209.1. NM_153297.1. [P61203-1]
XP_008760368.1. XM_008762146.2. [P61203-2]
UniGeneiRn.11556.

Genome annotation databases

EnsembliENSRNOT00000012287; ENSRNOP00000012287; ENSRNOG00000008744. [P61203-1]
ENSRNOT00000084154; ENSRNOP00000075473; ENSRNOG00000008744. [P61203-1]
GeneIDi261736.
KEGGirno:261736.
UCSCiRGD:628791. rat. [P61203-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081072 mRNA. Translation: BAC15575.1.
BC061864 mRNA. Translation: AAH61864.1.
RefSeqiNP_695209.1. NM_153297.1. [P61203-1]
XP_008760368.1. XM_008762146.2. [P61203-2]
UniGeneiRn.11556.

3D structure databases

ProteinModelPortaliP61203.
SMRiP61203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251749. 1 interactor.
STRINGi10116.ENSRNOP00000012287.

PTM databases

iPTMnetiP61203.
PhosphoSitePlusiP61203.

Proteomic databases

PaxDbiP61203.
PeptideAtlasiP61203.
PRIDEiP61203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012287; ENSRNOP00000012287; ENSRNOG00000008744. [P61203-1]
ENSRNOT00000084154; ENSRNOP00000075473; ENSRNOG00000008744. [P61203-1]
GeneIDi261736.
KEGGirno:261736.
UCSCiRGD:628791. rat. [P61203-1]

Organism-specific databases

CTDi9318.
RGDi628791. Cops2.

Phylogenomic databases

eggNOGiKOG1464. Eukaryota.
COG5159. LUCA.
GeneTreeiENSGT00530000063301.
HOGENOMiHOG000194333.
HOVERGENiHBG003924.
InParanoidiP61203.
KOiK12176.
OMAiRNNIMDD.
OrthoDBiEOG091G07D9.
PhylomeDBiP61203.

Enzyme and pathway databases

ReactomeiR-RNO-5696394. DNA Damage Recognition in GG-NER.
R-RNO-6781823. Formation of TC-NER Pre-Incision Complex.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiP61203.

Gene expression databases

BgeeiENSRNOG00000008744.
GenevisibleiP61203. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCSN2_RAT
AccessioniPrimary (citable) accession number: P61203
Secondary accession number(s): Q6P731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.