UniProtKB - P61201 (CSN2_HUMAN)
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Protein
COP9 signalosome complex subunit 2
Gene
COPS2
Organism
Homo sapiens (Human)
Status
Functioni
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.5 Publications
GO - Molecular functioni
- signal transducer activity Source: UniProtKB
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- cell proliferation Source: Ensembl
- negative regulation of nucleic acid-templated transcription Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neurogenesis Source: GO_Central
- neuron differentiation Source: Ensembl
- nucleotide-excision repair, DNA damage recognition Source: Reactome
- post-translational protein modification Source: Reactome
- protein deneddylation Source: UniProtKB
- signal transduction Source: UniProtKB
- skeletal muscle cell differentiation Source: Ensembl
- transcription by RNA polymerase II Source: UniProtKB
- transcription-coupled nucleotide-excision repair Source: Reactome
Enzyme and pathway databases
Reactomei | R-HSA-5696394. DNA Damage Recognition in GG-NER. R-HSA-6781823. Formation of TC-NER Pre-Incision Complex. R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis. R-HSA-8951664. Neddylation. |
SignaLinki | P61201. |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 2Short name: SGN2 Short name: Signalosome subunit 2 Alternative name(s): Alien homolog JAB1-containing signalosome subunit 2 Thyroid receptor-interacting protein 15 Short name: TR-interacting protein 15 Short name: TRIP-15 |
Gene namesi | Name:COPS2 Synonyms:CSN2, TRIP15 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166200.14. |
HGNCi | HGNC:30747. COPS2. |
MIMi | 604508. gene. |
neXtProti | NX_P61201. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9318. |
OpenTargetsi | ENSG00000166200. |
PharmGKBi | PA134952445. |
Polymorphism and mutation databases
BioMutai | COPS2. |
DMDMi | 47117681. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120968 | 1 – 443 | COP9 signalosome complex subunit 2Add BLAST | 443 |
Post-translational modificationi
Phosphorylated by CK2 and PKD kinases.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P61201. |
MaxQBi | P61201. |
PaxDbi | P61201. |
PeptideAtlasi | P61201. |
PRIDEi | P61201. |
PTM databases
iPTMneti | P61201. |
PhosphoSitePlusi | P61201. |
SwissPalmi | P61201. |
Expressioni
Gene expression databases
Bgeei | ENSG00000166200. |
CleanExi | HS_COPS2. HS_CSN2. |
ExpressionAtlasi | P61201. baseline and differential. |
Genevisiblei | P61201. HS. |
Organism-specific databases
HPAi | HPA016867. HPA018271. HPA061071. |
Interactioni
Subunit structurei
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:11337588, PubMed:18850735). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with CUL1 and CUL2 (PubMed:11337588). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (PubMed:10207062, PubMed:10713076, PubMed:10991940). Interacts with NIF3L1 (By similarity).By similarity6 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 114729. 128 interactors. |
CORUMi | P61201. |
DIPi | DIP-42076N. |
IntActi | P61201. 37 interactors. |
MINTi | P61201. |
STRINGi | 9606.ENSP00000299259. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4D10 | X-ray | 3.80 | B/J | 1-443 | [»] | |
4D18 | X-ray | 4.08 | B/J | 1-443 | [»] | |
4WSN | X-ray | 5.50 | B/J/R/Z/h/p | 1-443 | [»] | |
ProteinModelPortali | P61201. | |||||
SMRi | P61201. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 254 – 416 | PCIPROSITE-ProRule annotationAdd BLAST | 163 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 275 | Mediates interaction with NIF3L1By similarityAdd BLAST | 275 |
Sequence similaritiesi
Belongs to the CSN2 family.Curated
Phylogenomic databases
eggNOGi | KOG1464. Eukaryota. COG5159. LUCA. |
GeneTreei | ENSGT00530000063301. |
HOVERGENi | HBG003924. |
InParanoidi | P61201. |
KOi | K12176. |
OMAi | EDYGFDY. |
OrthoDBi | EOG091G07D9. |
PhylomeDBi | P61201. |
TreeFami | TF105738. |
Family and domain databases
InterProi | View protein in InterPro IPR000717. PCI_dom. IPR011990. TPR-like_helical_dom_sf. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF01399. PCI. 1 hit. |
SMARTi | View protein in SMART SM00088. PINT. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. SSF48452. SSF48452. 2 hits. |
PROSITEi | View protein in PROSITE PS50250. PCI. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P61201-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA
60 70 80 90 100
LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR
110 120 130 140 150
SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK
160 170 180 190 200
TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL
210 220 230 240 250
EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE
260 270 280 290 300
FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
310 320 330 340 350
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL
360 370 380 390 400
LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG
410 420 430 440
RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 | Y → N in CAG46860 (Ref. 3) Curated | 1 | |
Sequence conflicti | 151 | T → A in AAD43026 (PubMed:10931946).Curated | 1 | |
Sequence conflicti | 211 | N → T in CAG46860 (Ref. 3) Curated | 1 | |
Sequence conflicti | 352 | R → Q (PubMed:10207062).Curated | 1 | |
Sequence conflicti | 392 | C → S (PubMed:10207062).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011884 | 124 | Q → QNSDFLCQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF084260 mRNA. Translation: AAC34122.1. AF100762 mRNA. Translation: AAD43026.1. AF212227 mRNA. Translation: AAK26250.1. CR542063 mRNA. Translation: CAG46860.1. BC012629 mRNA. Translation: AAH12629.1. L40388 mRNA. Translation: AAC41734.1. AF120268 mRNA. Translation: AAD30269.1. Frameshift. |
CCDSi | CCDS32235.1. [P61201-1] CCDS45257.1. [P61201-2] |
RefSeqi | NP_001137359.1. NM_001143887.1. [P61201-2] NP_004227.1. NM_004236.3. [P61201-1] |
UniGenei | Hs.369614. |
Genome annotation databases
Ensembli | ENST00000299259; ENSP00000299259; ENSG00000166200. [P61201-2] ENST00000388901; ENSP00000373553; ENSG00000166200. [P61201-1] |
GeneIDi | 9318. |
KEGGi | hsa:9318. |
UCSCi | uc001zxf.4. human. [P61201-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | CSN2_HUMAN | |
Accessioni | P61201Primary (citable) accession number: P61201 Secondary accession number(s): O88950 Q9UNQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | March 28, 2018 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |