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P61191

- GMSS_TREDE

UniProt

P61191 - GMSS_TREDE

Protein

Glutamate mutase sigma subunit

Gene

glmS

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).UniRule annotation

    Catalytic activityi

    L-threo-3-methylaspartate = L-glutamate.UniRule annotation

    Cofactori

    Adenosylcobalamin.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Cobalt (cobalamin axial ligand)UniRule annotation

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methylaspartate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. anaerobic glutamate catabolic process Source: UniProtKB-HAMAP
    2. glutamate catabolic process via L-citramalate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Cobalamin, Cobalt, Metal-binding

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-1037-MONOMER.
    UniPathwayiUPA00561; UER00617.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate mutase sigma subunitUniRule annotation (EC:5.4.99.1UniRule annotation)
    Alternative name(s):
    Glutamate mutase S chainUniRule annotation
    Glutamate mutase small subunitUniRule annotation
    Methylaspartate mutaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Synonyms:mamA
    Ordered Locus Names:TDE_1023
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Glutamate mutase sigma subunitPRO_0000216448Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243275.TDE1023.

    Structurei

    3D structure databases

    ProteinModelPortaliP61191.
    SMRiP61191. Positions 4-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 139136B12-bindingUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 185Adenosylcobalamin bindingUniRule annotation
    Regioni62 – 643Adenosylcobalamin bindingUniRule annotation
    Regioni94 – 985Adenosylcobalamin bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the methylaspartate mutase GlmS subunit family.UniRule annotation
    Contains 1 B12-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2185.
    KOiK01846.
    OMAiLNGHAYE.
    OrthoDBiEOG6CP428.

    Family and domain databases

    Gene3Di3.40.50.280. 1 hit.
    HAMAPiMF_00526. Me_Asp_mutase_S.
    InterProiIPR006159. Acid_CoA_mut_C.
    IPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF52242. SSF52242. 1 hit.
    TIGRFAMsiTIGR00640. acid_CoA_mut_C. 1 hit.
    TIGR01501. MthylAspMutase. 1 hit.
    PROSITEiPS51332. B12_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKIKLVLG VIGSDCHAVG NKILDYSLTE AGFEVTNIGV LSPQEDFINA    50
    ALETNADAIL VSSLYGQGEL DCKGLREKCD EAGLKGIKLF VGGNIVVGKQ 100
    NFDEVHKRFT AMGFDHVYPP GTPVETTIKD LHADFPDHA 139
    Length:139
    Mass (Da):14,988
    Last modified:May 10, 2004 - v1
    Checksum:iD43FFA8217AA6F15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11512.1.
    RefSeqiNP_971631.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS11512; AAS11512; TDE_1023.
    GeneIDi2741502.
    KEGGitde:TDE1023.
    PATRICi20524254. VBITreDen445_0985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS11512.1 .
    RefSeqi NP_971631.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali P61191.
    SMRi P61191. Positions 4-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE1023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS11512 ; AAS11512 ; TDE_1023 .
    GeneIDi 2741502.
    KEGGi tde:TDE1023.
    PATRICi 20524254. VBITreDen445_0985.

    Phylogenomic databases

    eggNOGi COG2185.
    KOi K01846.
    OMAi LNGHAYE.
    OrthoDBi EOG6CP428.

    Enzyme and pathway databases

    UniPathwayi UPA00561 ; UER00617 .
    BioCyci TDEN243275:GJ7G-1037-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.280. 1 hit.
    HAMAPi MF_00526. Me_Asp_mutase_S.
    InterProi IPR006159. Acid_CoA_mut_C.
    IPR006158. Cobalamin-bd.
    IPR006394. Me_Asp_mutase.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52242. SSF52242. 1 hit.
    TIGRFAMsi TIGR00640. acid_CoA_mut_C. 1 hit.
    TIGR01501. MthylAspMutase. 1 hit.
    PROSITEi PS51332. B12_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiGMSS_TREDE
    AccessioniPrimary (citable) accession number: P61191
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3