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P61169 (DRD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
Gene names
Name:Drd2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Subunit structure

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling By similarity. Interacts with HTR2A, GNAI1, CADPS and CADPS2 By similarity. Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2. Ref.10 Ref.11 Ref.12 Ref.13

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor internalization

Inferred from direct assay PubMed 14617818. Source: RGD

Wnt signaling pathway

Inferred from direct assay PubMed 17472703. Source: RGD

acid secretion

Inferred from direct assay PubMed 8302280. Source: BHF-UCL

activation of protein kinase activity

Inferred from direct assay PubMed 12086672. Source: RGD

adenohypophysis development

Inferred from electronic annotation. Source: Ensembl

adenylate cyclase-inhibiting dopamine receptor signaling pathway

Inferred from direct assay PubMed 2410769. Source: BHF-UCL

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 12086672. Source: RGD

adult walking behavior

Inferred from electronic annotation. Source: Ensembl

arachidonic acid secretion

Inferred from electronic annotation. Source: Ensembl

auditory behavior

Inferred from mutant phenotype PubMed 17142301. Source: RGD

axonogenesis

Inferred from electronic annotation. Source: Ensembl

behavioral response to cocaine

Inferred from electronic annotation. Source: Ensembl

behavioral response to ethanol

Inferred from electronic annotation. Source: Ensembl

branching morphogenesis of a nerve

Inferred from electronic annotation. Source: Ensembl

cellular potassium ion homeostasis

Inferred by curator PubMed 2162345. Source: BHF-UCL

cerebral cortex GABAergic interneuron migration

Inferred from electronic annotation. Source: Ensembl

circadian regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

dopamine metabolic process

Inferred from electronic annotation. Source: Ensembl

dopamine receptor signaling pathway

Inferred from direct assay PubMed 12121979PubMed 17314300. Source: RGD

feeding behavior

Inferred from electronic annotation. Source: Ensembl

forebrain development

Inferred from mutant phenotype PubMed 17175142. Source: RGD

grooming behavior

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from mutant phenotype PubMed 16530737. Source: RGD

long-term memory

Inferred from mutant phenotype PubMed 17118678. Source: RGD

negative regulation of adenylate cyclase activity

Inferred from direct assay PubMed 2410769. Source: BHF-UCL

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of circadian sleep/wake cycle, sleep

Inferred from direct assay PubMed 12944496. Source: RGD

negative regulation of cytosolic calcium ion concentration

Inferred from mutant phenotype PubMed 15681393. Source: RGD

negative regulation of dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of dopamine secretion

Inferred from mutant phenotype PubMed 16490190. Source: RGD

negative regulation of insulin secretion

Inferred from mutant phenotype PubMed 18216393. Source: RGD

negative regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

negative regulation of voltage-gated calcium channel activity

Inferred from direct assay PubMed 2162345. Source: BHF-UCL

neurological system process involved in regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

orbitofrontal cortex development

Inferred from expression pattern PubMed 22015925. Source: RGD

peristalsis

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol metabolic process

Inferred from direct assay PubMed 2162345. Source: BHF-UCL

phospholipase C-activating dopamine receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

pigmentation

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 18809670. Source: RGD

positive regulation of G-protein coupled receptor protein signaling pathway

Inferred from mutant phenotype PubMed 18809670. Source: RGD

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of dopamine uptake involved in synaptic transmission

Inferred from electronic annotation. Source: Ensembl

positive regulation of growth hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of long-term synaptic potentiation

Inferred from mutant phenotype PubMed 20377617. Source: RGD

positive regulation of mitosis

Traceable author statement PubMed 8302280. Source: BHF-UCL

positive regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor internalization

Inferred from mutant phenotype PubMed 18809670. Source: RGD

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12388421. Source: RGD

positive regulation of urine volume

Inferred from electronic annotation. Source: Ensembl

prepulse inhibition

Inferred from electronic annotation. Source: Ensembl

protein localization

Inferred from electronic annotation. Source: Ensembl

regulation of MAPK cascade

Inferred from direct assay PubMed 12121979. Source: RGD

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

regulation of locomotion involved in locomotory behavior

Inferred from mutant phenotype PubMed 22394078. Source: RGD

regulation of long-term neuronal synaptic plasticity

Inferred from electronic annotation. Source: Ensembl

regulation of phosphoprotein phosphatase activity

Inferred from mutant phenotype PubMed 12435803. Source: RGD

regulation of potassium ion transport

Inferred from direct assay PubMed 2162345PubMed 8371717. Source: BHF-UCL

regulation of sodium ion transport

Inferred from electronic annotation. Source: Ensembl

regulation of synapse structural plasticity

Inferred from direct assay PubMed 22216301. Source: RGD

regulation of synaptic transmission

Inferred from direct assay PubMed 17314300. Source: RGD

regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Ensembl

release of sequestered calcium ion into cytosol

Inferred from mutant phenotype PubMed 8371717. Source: BHF-UCL

response to amphetamine

Inferred from expression pattern PubMed 19145071. Source: RGD

response to axon injury

Inferred from expression pattern PubMed 19500946. Source: RGD

response to drug

Inferred from direct assay PubMed 1975644. Source: BHF-UCL

response to ethanol

Inferred from expression pattern PubMed 18536982. Source: RGD

response to histamine

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from mutant phenotype PubMed 15681393. Source: RGD

response to inactivity

Inferred from expression pattern PubMed 17511973. Source: RGD

response to iron ion

Inferred from expression pattern PubMed 19022977. Source: RGD

response to morphine

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from expression pattern PubMed 19406037. Source: RGD

response to toxic substance

Inferred from expression pattern PubMed 19576243. Source: RGD

sensory perception of smell

Inferred from electronic annotation. Source: Ensembl

striatum development

Inferred from expression pattern PubMed 22015925. Source: RGD

synapse assembly

Inferred from expression pattern PubMed 10051231. Source: BHF-UCL

synaptic transmission, dopaminergic

Inferred from direct assay PubMed 17314300. Source: RGD

temperature homeostasis

Inferred from electronic annotation. Source: Ensembl

visual learning

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentacrosomal vesicle

Inferred from direct assay PubMed 16924680. Source: RGD

axon

Inferred from direct assay PubMed 12965226. Source: RGD

axon terminus

Inferred from direct assay PubMed 7623147. Source: RGD

cytoplasmic vesicle

Inferred from direct assay PubMed 17593530. Source: RGD

dendrite

Inferred from direct assay PubMed 12965226PubMed 15224400. Source: RGD

dendritic spine

Inferred from direct assay PubMed 7623147. Source: RGD

endocytic vesicle

Inferred from direct assay PubMed 14617818. Source: RGD

integral component of plasma membrane

Inferred from electronic annotation. Source: InterPro

lateral plasma membrane

Inferred from direct assay Ref.10. Source: RGD

membrane

Inferred from direct assay PubMed 8302280. Source: BHF-UCL

perikaryon

Inferred from direct assay PubMed 12965226. Source: RGD

plasma membrane

Inferred from direct assay Ref.11. Source: RGD

postsynaptic density

Inferred from direct assay PubMed 17145509. Source: RGD

sperm flagellum

Inferred from direct assay PubMed 16924680. Source: RGD

synaptic vesicle membrane

Inferred from direct assay PubMed 7623147. Source: RGD

   Molecular_functionadrenergic receptor activity

Inferred from electronic annotation. Source: InterPro

dopamine binding

Inferred from mutant phenotype PubMed 17174299. Source: RGD

dopamine neurotransmitter receptor activity

Inferred from mutant phenotype PubMed 16490190. Source: RGD

dopamine neurotransmitter receptor activity, coupled via Gi/Go

Inferred from direct assay PubMed 8302280. Source: BHF-UCL

drug binding

Inferred from direct assay PubMed 1975644. Source: BHF-UCL

ionotropic glutamate receptor binding

Inferred from physical interaction PubMed 17145509. Source: RGD

protein heterodimerization activity

Inferred from physical interaction PubMed 22986162. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 20813060. Source: RGD

receptor binding

Inferred from physical interaction PubMed 17145509. Source: RGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Ppp1r9bO352742EBI-80012,EBI-80022

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P61169-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P61169-2)

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444D(2) dopamine receptor
PRO_0000069390

Regions

Topological domain1 – 3737Extracellular By similarity
Transmembrane38 – 6023Helical; Name=1; By similarity
Topological domain61 – 7010Cytoplasmic By similarity
Transmembrane71 – 9323Helical; Name=2; By similarity
Topological domain94 – 10815Extracellular By similarity
Transmembrane109 – 13022Helical; Name=3; By similarity
Topological domain131 – 15121Cytoplasmic By similarity
Transmembrane152 – 17221Helical; Name=4; By similarity
Topological domain173 – 18816Extracellular By similarity
Transmembrane189 – 21325Helical; Name=5; By similarity
Topological domain214 – 374161Cytoplasmic By similarity
Transmembrane375 – 39622Helical; Name=6; By similarity
Topological domain397 – 41014Extracellular By similarity
Transmembrane411 – 43222Helical; Name=7; By similarity
Topological domain433 – 44412Cytoplasmic By similarity
Region190 – 1978Agonist binding By similarity
Region211 – 374164Interaction with PPP1R9B
Region387 – 3959Agonist binding By similarity

Sites

Binding site1141Agonist By similarity
Site1941Important for receptor activation
Site1971Important for receptor activation

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 182 By similarity
Disulfide bond400 ↔ 402 By similarity

Natural variations

Alternative sequence242 – 27029Missing in isoform Short.
VSP_001871

Experimental info

Mutagenesis1931S → A: Moderate decrease in ligand binding. 200-fold reduction of agonist-mediated cAMP inhibition. Ref.9
Mutagenesis1941S → A: Small decrease in agonist binding. Complete loss of agonist-mediated cAMP inhibition. Ref.9
Mutagenesis1971S → A: Small decrease in agonist binding. 18-fold reduction of agonist-mediated cAMP inhibition. Ref.9
Mutagenesis4201S → A: Moderate decrease in ligand binding. Ref.9
Sequence conflict991E → D in CAA37373. Ref.5
Sequence conflict1731G → R in CAA37373. Ref.5
Sequence conflict1801N → G in CAA37373. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified May 10, 2004. Version 1.
Checksum: 216E56CEE5CA32FB

FASTA44450,904
        10         20         30         40         50         60 
MDPLNLSWYD DDLERQNWSR PFNGSEGKAD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS 

        70         80         90        100        110        120 
REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 

       130        140        150        160        170        180 
SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN 

       190        200        210        220        230        240 
ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL 

       250        260        270        280        290        300 
KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 

       310        320        330        340        350        360 
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS 

       370        380        390        400        410        420 
RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS 

       430        440 
AVNPIIYTTF NIEFRKAFMK ILHC 

« Hide

Isoform Short [UniParc] [UniParc].

Checksum: 2923089F3EDAC911
Show »

FASTA41547,599

References

[1]"Cloning and expression of a rat D2 dopamine receptor cDNA."
Bunzow J.R., van Tol H.H.M., Grandy D.K., Albert P., Salon J., Christie M., Machida C.A., Neve K.A., Civelli O.
Nature 336:783-787(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Brain.
[2]"D2 receptor, a missing exon."
Eidne K.A., Taylor P.L., Zabavnik J., Saunders P.T.K., Inglis J.D.
Nature 342:865-865(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Alternative splicing directs the expression of two D2 dopamine receptor isoforms."
Giros B., Sokoloff P., Martres M.-P., Riou J.-F., Emorine L.J., Schwartz J.-C.
Nature 342:923-926(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Multiple D2 dopamine receptors produced by alternative RNA splicing."
Monsma F.J. Jr., McVittie L.D., Gerfen C.R., Mahan L.C., Sibley D.R.
Nature 342:926-929(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction."
Rao D.D., McKelvy J., Kebabian J., MacKenzie R.G.
FEBS Lett. 263:18-22(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"5'untranslated region of rat pituitary dopamine D2(B) receptor contains a putative CpG island."
Taylor P.L., Inglis J.D., Eidne K.A.
Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
Strain: Sprague-Dawley.
[7]"Identification by sequence analysis of a second rat brain cDNA encoding the dopamine (D2) receptor."
Miller J.C., Wang Y., Filer D.
Biochem. Biophys. Res. Commun. 166:109-112(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-270.
[8]"Cloning of two additional catecholamine receptors from rat brain."
O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P., Niznik H.B.
FEBS Lett. 262:8-12(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-270.
[9]"Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors."
Cox B.A., Henningsen R.A., Spanoyannis A., Neve R.L., Neve K.A.
J. Neurochem. 59:627-635(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF SER-193; SER-194; SER-197 AND SER-420.
[10]"Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein."
Smith F.D., Oxford G.S., Milgram S.L.
J. Biol. Chem. 274:19894-19900(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPP1R9B.
[11]"CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors."
Griffon N., Jeanneteau F., Prieur F., Diaz J., Sokoloff P.
Brain Res. Mol. Brain Res. 117:47-57(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CLIC6.
[12]"Dopamine responsiveness is regulated by targeted sorting of D2 receptors."
Bartlett S.E., Enquist J., Hopf F.W., Lee J.H., Gladher F., Kharazia V., Waldhoer M., Mailliard W.S., Armstrong R., Bonci A., Whistler J.L.
Proc. Natl. Acad. Sci. U.S.A. 102:11521-11526(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GPRASP1.
[13]"G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor."
Namkung Y., Dipace C., Javitch J.A., Sibley D.R.
J. Biol. Chem. 284:15038-15051(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARRB2.
[14]"Molecular modelling of D2-like dopamine receptors."
Livingstone C.D., Strange P.G., Naylor L.H.
Biochem. J. 287:277-282(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36831 mRNA. Translation: AAA41075.1.
X53278 mRNA. Translation: CAA37373.1.
X56065 mRNA. Translation: CAA39543.1.
M32241 mRNA. Translation: AAA41074.1.
PIRS08146.
RefSeqNP_036679.1. NM_012547.1.
XP_006243041.1. XM_006242979.1.
UniGeneRn.87299.

3D structure databases

ProteinModelPortalP61169.
SMRP61169. Positions 37-444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246498. 2 interactions.
DIPDIP-30883N.
IntActP61169. 3 interactions.
MINTMINT-4792453.

Chemistry

BindingDBP61169.
ChEMBLCHEMBL339.
GuidetoPHARMACOLOGY215.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP61169.

Proteomic databases

PRIDEP61169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000045944; ENSRNOP00000043759; ENSRNOG00000008428. [P61169-2]
GeneID24318.
KEGGrno:24318.
UCSCRGD:2520. rat.

Organism-specific databases

CTD1813.
RGD2520. Drd2.

Phylogenomic databases

eggNOGNOG309657.
GeneTreeENSGT00750000117240.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP61169.
KOK04145.
OMANSVKHSR.
OrthoDBEOG769ZMG.
PhylomeDBP61169.
TreeFamTF334382.

Gene expression databases

GenevestigatorP61169.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR002233. ADR_fam.
IPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248. PTHR24248. 1 hit.
PTHR24248:SF13. PTHR24248:SF13. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284001.
PROP61169.

Entry information

Entry nameDRD2_RAT
AccessionPrimary (citable) accession number: P61169
Secondary accession number(s): P13953
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries