ID DRD2_MOUSE Reviewed; 444 AA. AC P61168; P13953; Q0VGH9; DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 24-JAN-2024, entry version 173. DE RecName: Full=D(2) dopamine receptor; DE AltName: Full=Dopamine D2 receptor; GN Name=Drd2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY. RX PubMed=1991517; DOI=10.1016/0014-5793(91)80125-m; RA Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R., Borrelli E.; RT "Differential expression of the mouse D2 dopamine receptor isoforms."; RL FEBS Lett. 278:239-243(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP INTERACTION WITH KCNA2. RX PubMed=21233214; DOI=10.1074/jbc.m110.153262; RA Fulton S., Thibault D., Mendez J.A., Lahaie N., Tirotta E., Borrelli E., RA Bouvier M., Tempel B.L., Trudeau L.E.; RT "Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor RT regulation of axonal dopamine overflow."; RL J. Biol. Chem. 286:9360-9372(2011). RN [5] RP INTERACTION WITH DRD1. RX PubMed=25865831; DOI=10.1111/jnc.13119; RA Jung G., Kim E.J., Cicvaric A., Sase S., Groeger M., Hoeger H., RA Sialana F.J., Berger J., Monje F.J., Lubec G.; RT "Drebrin depletion alters neurotransmitter receptor levels in protein RT complexes, dendritic spine morphogenesis and memory-related synaptic RT plasticity in the mouse hippocampus."; RL J. Neurochem. 134:327-339(2015). RN [6] RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE. RX PubMed=30936473; DOI=10.1038/s41556-019-0301-x; RA Nguyen M.T., Vemaraju S., Nayak G., Odaka Y., Buhr E.D., Alonzo N., RA Tran U., Batie M., Upton B.A., Darvas M., Kozmik Z., Rao S., Hegde R.S., RA Iuvone P.M., Van Gelder R.N., Lang R.A.; RT "An opsin 5-dopamine pathway mediates light-dependent vascular development RT in the eye."; RL Nat. Cell Biol. 21:420-429(2019). CC -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins CC which inhibit adenylyl cyclase (By similarity). Positively regulates CC postnatal regression of retinal hyaloid vessels via suppression of CC VEGFR2/KDR activity, downstream of OPN5 (PubMed:30936473). CC {ECO:0000250|UniProtKB:P14416, ECO:0000269|PubMed:30936473}. CC -!- SUBUNIT: Forms homo- and heterooligomers with DRD4 (By similarity). The CC interaction with DRD4 may modulate agonist-induced downstream signaling CC (By similarity). Interacts with CADPS and CADPS2 (By similarity). CC Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts CC with ARRB2 (By similarity). Interacts with HTR2A (By similarity). CC Interacts with DRD1 (PubMed:25865831). {ECO:0000250|UniProtKB:P14416, CC ECO:0000250|UniProtKB:P61169, ECO:0000269|PubMed:25865831}. CC -!- SUBUNIT: [Isoform 1]: Interacts with KCNA2. CC {ECO:0000269|PubMed:21233214}. CC -!- SUBUNIT: [Isoform 2]: Interacts with KCNA2. CC {ECO:0000269|PubMed:21233214}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14416}; CC Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane CC {ECO:0000250|UniProtKB:P14416}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=Long; CC IsoId=P61168-1, P13953-1; Sequence=Displayed; CC Name=2; Synonyms=Short; CC IsoId=P61168-2, P13953-2; Sequence=VSP_010241; CC -!- TISSUE SPECIFICITY: Expressed in retinal hyaloid vessels at postnatal CC day 6. {ECO:0000269|PubMed:30936473}. CC -!- TISSUE SPECIFICITY: [Isoform 1]: Expressed in the pituitary gland, CC stratum, brain stem and cortex. {ECO:0000269|PubMed:1991517}. CC -!- TISSUE SPECIFICITY: [Isoform 2]: Expressed in the brain stem. CC {ECO:0000269|PubMed:1991517}. CC -!- PTM: Palmitoylated. Palmitoylation which is required for proper CC localization to the plasma membrane and stability of the receptor could CC be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. CC {ECO:0000250|UniProtKB:P14416}. CC -!- DISRUPTION PHENOTYPE: Conditional knockouts in vascular endothelial CC cells show an increase in activated Vegfr2/Kdr in the retinal hyaloid CC at P6, and hyaloid vessels continue to persist at P8. CC {ECO:0000269|PubMed:30936473}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X55674; CAA39209.1; -; mRNA. DR EMBL; CH466522; EDL25723.1; -; Genomic_DNA. DR EMBL; BC105663; AAI05664.1; -; mRNA. DR EMBL; BC105664; AAI05665.1; -; mRNA. DR EMBL; BC105665; AAI05666.1; -; mRNA. DR EMBL; BC105666; AAI05667.1; -; mRNA. DR CCDS; CCDS40615.1; -. DR PIR; S13921; DYMSD2. DR RefSeq; NP_034207.2; NM_010077.2. [P61168-1] DR RefSeq; XP_006510059.1; XM_006509996.3. DR AlphaFoldDB; P61168; -. DR SMR; P61168; -. DR BioGRID; 199306; 7. DR IntAct; P61168; 7. DR MINT; P61168; -. DR STRING; 10090.ENSMUSP00000075170; -. DR BindingDB; P61168; -. DR ChEMBL; CHEMBL3427; -. DR DrugCentral; P61168; -. DR GuidetoPHARMACOLOGY; 215; -. DR GlyCosmos; P61168; 3 sites, No reported glycans. DR GlyGen; P61168; 3 sites. DR PhosphoSitePlus; P61168; -. DR PaxDb; 10090-ENSMUSP00000075170; -. DR ProteomicsDB; 277493; -. DR ProteomicsDB; 277494; -. [P61168-2] DR ABCD; P61168; 1 sequenced antibody. DR Antibodypedia; 2801; 457 antibodies from 40 providers. DR DNASU; 13489; -. DR Ensembl; ENSMUST00000075764.8; ENSMUSP00000075170.7; ENSMUSG00000032259.9. [P61168-1] DR GeneID; 13489; -. DR KEGG; mmu:13489; -. DR UCSC; uc009pja.1; mouse. DR AGR; MGI:94924; -. DR CTD; 1813; -. DR MGI; MGI:94924; Drd2. DR VEuPathDB; HostDB:ENSMUSG00000032259; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT00940000155539; -. DR HOGENOM; CLU_009579_11_1_1; -. DR InParanoid; P61168; -. DR OMA; APMDPLN; -. DR OrthoDB; 2999405at2759; -. DR PhylomeDB; P61168; -. DR TreeFam; TF334382; -. DR Reactome; R-MMU-390651; Dopamine receptors. DR BioGRID-ORCS; 13489; 1 hit in 78 CRISPR screens. DR PRO; PR:P61168; -. DR Proteomes; UP000000589; Chromosome 9. DR RNAct; P61168; Protein. DR Bgee; ENSMUSG00000032259; Expressed in superior frontal gyrus and 78 other cell types or tissues. DR GO; GO:0001669; C:acrosomal vesicle; ISO:MGI. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0043679; C:axon terminus; ISO:MGI. DR GO; GO:0060170; C:ciliary membrane; ISO:MGI. DR GO; GO:0005929; C:cilium; ISO:MGI. DR GO; GO:0030425; C:dendrite; IDA:MGI. DR GO; GO:0043197; C:dendritic spine; ISO:MGI. DR GO; GO:0098691; C:dopaminergic synapse; IDA:SynGO. DR GO; GO:0030139; C:endocytic vesicle; ISO:MGI. DR GO; GO:0097648; C:G protein-coupled receptor complex; ISO:MGI. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016328; C:lateral plasma membrane; ISO:MGI. DR GO; GO:0016020; C:membrane; ISO:MGI. DR GO; GO:0097730; C:non-motile cilium; ISO:MGI. DR GO; GO:0043204; C:perikaryon; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0045211; C:postsynaptic membrane; IDA:SynGO. DR GO; GO:0042734; C:presynaptic membrane; IDA:SynGO. DR GO; GO:0036126; C:sperm flagellum; ISO:MGI. DR GO; GO:0030672; C:synaptic vesicle membrane; ISO:MGI. DR GO; GO:0035240; F:dopamine binding; IDA:MGI. DR GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IDA:MGI. DR GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IDA:MGI. DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:MGI. DR GO; GO:0001965; F:G-protein alpha-subunit binding; ISO:MGI. DR GO; GO:1901363; F:heterocyclic compound binding; ISO:MGI. DR GO; GO:0032795; F:heterotrimeric G-protein binding; ISO:MGI. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0035255; F:ionotropic glutamate receptor binding; ISO:MGI. DR GO; GO:0097159; F:organic cyclic compound binding; ISO:MGI. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI. DR GO; GO:0046717; P:acid secretion; ISO:MGI. DR GO; GO:0021984; P:adenohypophysis development; IMP:MGI. DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IDA:MGI. DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:0030534; P:adult behavior; IMP:MGI. DR GO; GO:0007628; P:adult walking behavior; IMP:MGI. DR GO; GO:0050482; P:arachidonic acid secretion; ISO:MGI. DR GO; GO:0008306; P:associative learning; IMP:MGI. DR GO; GO:0031223; P:auditory behavior; ISO:MGI. DR GO; GO:0006914; P:autophagy; ISO:MGI. DR GO; GO:0007409; P:axonogenesis; IMP:MGI. DR GO; GO:0048148; P:behavioral response to cocaine; IMP:MGI. DR GO; GO:0048149; P:behavioral response to ethanol; IMP:MGI. DR GO; GO:0048755; P:branching morphogenesis of a nerve; IMP:MGI. DR GO; GO:0016477; P:cell migration; IMP:MGI. DR GO; GO:0008283; P:cell population proliferation; IMP:MGI. DR GO; GO:0021853; P:cerebral cortex GABAergic interneuron migration; IMP:MGI. DR GO; GO:0032922; P:circadian regulation of gene expression; IMP:MGI. DR GO; GO:0042417; P:dopamine metabolic process; IMP:MGI. DR GO; GO:0007212; P:dopamine receptor signaling pathway; IGI:MGI. DR GO; GO:0051583; P:dopamine uptake involved in synaptic transmission; IMP:MGI. DR GO; GO:0042756; P:drinking behavior; ISO:MGI. DR GO; GO:0050673; P:epithelial cell proliferation; IMP:MGI. DR GO; GO:0007631; P:feeding behavior; IGI:MGI. DR GO; GO:0030900; P:forebrain development; ISO:MGI. DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:MGI. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI. DR GO; GO:0007625; P:grooming behavior; IMP:MGI. DR GO; GO:1990384; P:hyaloid vascular plexus regression; IMP:UniProtKB. DR GO; GO:0035556; P:intracellular signal transduction; ISO:MGI. DR GO; GO:0007626; P:locomotory behavior; IMP:MGI. DR GO; GO:0007616; P:long-term memory; ISO:MGI. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IMP:MGI. DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI. DR GO; GO:1900038; P:negative regulation of cellular response to hypoxia; ISO:MGI. DR GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; ISO:MGI. DR GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; ISO:MGI. DR GO; GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IGI:MGI. DR GO; GO:0033602; P:negative regulation of dopamine secretion; ISO:MGI. DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI. DR GO; GO:0045824; P:negative regulation of innate immune response; IMP:CACAO. DR GO; GO:0046676; P:negative regulation of insulin secretion; ISO:MGI. DR GO; GO:2001223; P:negative regulation of neuron migration; IMP:MGI. DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IMP:MGI. DR GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:MGI. DR GO; GO:0050709; P:negative regulation of protein secretion; ISO:MGI. DR GO; GO:0050805; P:negative regulation of synaptic transmission; ISO:MGI. DR GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IMP:MGI. DR GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; IMP:MGI. DR GO; GO:0007405; P:neuroblast proliferation; IDA:MGI. DR GO; GO:0001764; P:neuron migration; IMP:MGI. DR GO; GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI. DR GO; GO:0021769; P:orbitofrontal cortex development; IEA:Ensembl. DR GO; GO:0030432; P:peristalsis; IMP:MGI. DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IMP:MGI. DR GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IDA:MGI. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:0043473; P:pigmentation; IMP:MGI. DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI. DR GO; GO:0051586; P:positive regulation of dopamine uptake involved in synaptic transmission; IMP:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:1900168; P:positive regulation of glial cell-derived neurotrophic factor production; ISO:MGI. DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IMP:MGI. DR GO; GO:1900273; P:positive regulation of long-term synaptic potentiation; ISO:MGI. DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IDA:MGI. DR GO; GO:0050769; P:positive regulation of neurogenesis; ISO:MGI. DR GO; GO:0002092; P:positive regulation of receptor internalization; ISO:MGI. DR GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0035810; P:positive regulation of urine volume; IMP:MGI. DR GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; ISO:MGI. DR GO; GO:0060134; P:prepulse inhibition; IMP:MGI. DR GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; IDA:SynGO. DR GO; GO:0008104; P:protein localization; IMP:MGI. DR GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central. DR GO; GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IMP:MGI. DR GO; GO:0002027; P:regulation of heart rate; IMP:MGI. DR GO; GO:0090325; P:regulation of locomotion involved in locomotory behavior; ISO:MGI. DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI. DR GO; GO:0043408; P:regulation of MAPK cascade; ISO:MGI. DR GO; GO:0051580; P:regulation of neurotransmitter uptake; IDA:SynGO. DR GO; GO:0043266; P:regulation of potassium ion transport; IMP:MGI. DR GO; GO:0002028; P:regulation of sodium ion transport; IMP:MGI. DR GO; GO:0051823; P:regulation of synapse structural plasticity; ISO:MGI. DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:MGI. DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:MGI. DR GO; GO:0001975; P:response to amphetamine; IMP:MGI. DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl. DR GO; GO:0042220; P:response to cocaine; IDA:MGI. DR GO; GO:0034776; P:response to histamine; ISO:MGI. DR GO; GO:0001666; P:response to hypoxia; ISO:MGI. DR GO; GO:0014854; P:response to inactivity; IEA:Ensembl. DR GO; GO:0010039; P:response to iron ion; IEA:Ensembl. DR GO; GO:0009416; P:response to light stimulus; IMP:MGI. DR GO; GO:0043278; P:response to morphine; IMP:MGI. DR GO; GO:0035094; P:response to nicotine; IEA:Ensembl. DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl. DR GO; GO:0009410; P:response to xenobiotic stimulus; IDA:MGI. DR GO; GO:0007608; P:sensory perception of smell; IMP:MGI. DR GO; GO:0001964; P:startle response; IMP:MGI. DR GO; GO:0021756; P:striatum development; IEA:Ensembl. DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl. DR GO; GO:0001659; P:temperature homeostasis; IMP:MGI. DR GO; GO:0008542; P:visual learning; IMP:MGI. DR GO; GO:0016055; P:Wnt signaling pathway; ISO:MGI. DR CDD; cd15309; 7tmA_D2_dopamine_R; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2. DR InterPro; IPR001922; Dopamine_D2_rcpt. DR InterPro; IPR000929; Dopamine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24248:SF87; D(2) DOPAMINE RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00567; DOPAMINED2R. DR PRINTS; PR00242; DOPAMINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Golgi apparatus; Lipoprotein; KW Membrane; Palmitate; Receptor; Reference proteome; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1..444 FT /note="D(2) dopamine receptor" FT /id="PRO_0000069388" FT TOPO_DOM 1..37 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 38..60 FT /note="Helical; Name=1" FT /evidence="ECO:0000250" FT TOPO_DOM 61..70 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 71..93 FT /note="Helical; Name=2" FT /evidence="ECO:0000250" FT TOPO_DOM 94..108 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 109..130 FT /note="Helical; Name=3" FT /evidence="ECO:0000250" FT TOPO_DOM 131..151 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 152..172 FT /note="Helical; Name=4" FT /evidence="ECO:0000250" FT TOPO_DOM 173..188 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 189..213 FT /note="Helical; Name=5" FT /evidence="ECO:0000250" FT TOPO_DOM 214..374 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 375..396 FT /note="Helical; Name=6" FT /evidence="ECO:0000250" FT TOPO_DOM 397..410 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 411..432 FT /note="Helical; Name=7" FT /evidence="ECO:0000250" FT TOPO_DOM 433..444 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT REGION 211..374 FT /note="Interaction with PPP1R9B" FT /evidence="ECO:0000250" FT REGION 282..329 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT SITE 194 FT /note="Important for receptor activation" FT SITE 197 FT /note="Important for receptor activation" FT LIPID 444 FT /note="S-palmitoyl cysteine" FT /evidence="ECO:0000250|UniProtKB:P14416" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 17 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 23 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 107..182 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT DISULFID 400..402 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VAR_SEQ 242..270 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:1991517" FT /id="VSP_010241" FT CONFLICT 29 FT /note="P -> A (in Ref. 1; CAA39209)" FT /evidence="ECO:0000305" SQ SEQUENCE 444 AA; 50930 MW; 2EC8460CA11FC7F0 CRC64; MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC //