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P61168

- DRD2_MOUSE

UniProt

P61168 - DRD2_MOUSE

Protein

D(2) dopamine receptor

Gene

Drd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141AgonistBy similarity
    Sitei194 – 1941Important for receptor activation
    Sitei197 – 1971Important for receptor activation

    GO - Molecular functioni

    1. dopamine binding Source: MGI
    2. dopamine neurotransmitter receptor activity Source: MGI
    3. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGI
    4. drug binding Source: Ensembl
    5. G-protein coupled receptor activity Source: MGI

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. adenohypophysis development Source: MGI
    3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
    4. adult behavior Source: MGI
    5. adult walking behavior Source: MGI
    6. arachidonic acid secretion Source: Ensembl
    7. associative learning Source: MGI
    8. auditory behavior Source: Ensembl
    9. axonogenesis Source: MGI
    10. behavioral response to cocaine Source: MGI
    11. behavioral response to ethanol Source: MGI
    12. branching morphogenesis of a nerve Source: MGI
    13. cerebral cortex GABAergic interneuron migration Source: MGI
    14. circadian regulation of gene expression Source: MGI
    15. dopamine metabolic process Source: MGI
    16. dopamine receptor signaling pathway Source: MGI
    17. feeding behavior Source: MGI
    18. G-protein coupled receptor internalization Source: Ensembl
    19. G-protein coupled receptor signaling pathway Source: MGI
    20. grooming behavior Source: MGI
    21. intracellular signal transduction Source: Ensembl
    22. locomotory behavior Source: MGI
    23. long-term memory Source: Ensembl
    24. negative regulation of adenylate cyclase activity Source: Ensembl
    25. negative regulation of blood pressure Source: MGI
    26. negative regulation of cell migration Source: MGI
    27. negative regulation of cell proliferation Source: MGI
    28. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
    29. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    30. negative regulation of dopamine receptor signaling pathway Source: MGI
    31. negative regulation of dopamine secretion Source: Ensembl
    32. negative regulation of insulin secretion Source: Ensembl
    33. negative regulation of protein kinase B signaling Source: MGI
    34. negative regulation of protein secretion Source: Ensembl
    35. negative regulation of synaptic transmission, glutamatergic Source: MGI
    36. negative regulation of voltage-gated calcium channel activity Source: Ensembl
    37. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
    38. neuron-neuron synaptic transmission Source: MGI
    39. orbitofrontal cortex development Source: Ensembl
    40. peristalsis Source: MGI
    41. phosphatidylinositol metabolic process Source: Ensembl
    42. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
    43. pigmentation Source: MGI
    44. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    45. positive regulation of dopamine uptake involved in synaptic transmission Source: MGI
    46. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    47. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    48. positive regulation of growth hormone secretion Source: MGI
    49. positive regulation of long-term synaptic potentiation Source: Ensembl
    50. positive regulation of multicellular organism growth Source: MGI
    51. positive regulation of neuroblast proliferation Source: MGI
    52. positive regulation of receptor internalization Source: Ensembl
    53. positive regulation of renal sodium excretion Source: MGI
    54. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    55. positive regulation of urine volume Source: MGI
    56. prepulse inhibition Source: MGI
    57. protein localization Source: MGI
    58. regulation of dopamine secretion Source: MGI
    59. regulation of dopamine uptake involved in synaptic transmission Source: MGI
    60. regulation of heart rate Source: MGI
    61. regulation of locomotion involved in locomotory behavior Source: Ensembl
    62. regulation of long-term neuronal synaptic plasticity Source: MGI
    63. regulation of phosphoprotein phosphatase activity Source: Ensembl
    64. regulation of potassium ion transport Source: MGI
    65. regulation of sodium ion transport Source: MGI
    66. regulation of synapse structural plasticity Source: Ensembl
    67. regulation of synaptic transmission Source: MGI
    68. regulation of synaptic transmission, GABAergic Source: MGI
    69. release of sequestered calcium ion into cytosol Source: Ensembl
    70. response to amphetamine Source: MGI
    71. response to axon injury Source: Ensembl
    72. response to cocaine Source: MGI
    73. response to drug Source: MGI
    74. response to histamine Source: Ensembl
    75. response to hypoxia Source: Ensembl
    76. response to inactivity Source: Ensembl
    77. response to iron ion Source: Ensembl
    78. response to light stimulus Source: MGI
    79. response to morphine Source: MGI
    80. response to nicotine Source: Ensembl
    81. response to toxic substance Source: Ensembl
    82. sensory perception of smell Source: MGI
    83. startle response Source: MGI
    84. striatum development Source: Ensembl
    85. synapse assembly Source: Ensembl
    86. synaptic transmission, dopaminergic Source: Ensembl
    87. temperature homeostasis Source: MGI
    88. visual learning Source: MGI
    89. Wnt signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(2) dopamine receptor
    Alternative name(s):
    Dopamine D2 receptor
    Gene namesi
    Name:Drd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:94924. Drd2.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. axon Source: MGI
    3. axon terminus Source: Ensembl
    4. dendrite Source: MGI
    5. dendritic spine Source: Ensembl
    6. endocytic vesicle Source: Ensembl
    7. integral component of plasma membrane Source: InterPro
    8. lateral plasma membrane Source: Ensembl
    9. membrane Source: MGI
    10. perikaryon Source: Ensembl
    11. postsynaptic density Source: Ensembl
    12. sperm flagellum Source: Ensembl
    13. synaptic vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444D(2) dopamine receptorPRO_0000069388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 182PROSITE-ProRule annotation
    Disulfide bondi400 ↔ 402PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP61168.

    PTM databases

    PhosphoSiteiP61168.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are expressed in the pituitary and brain. Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.

    Gene expression databases

    BgeeiP61168.
    CleanExiMM_DRD2.
    GenevestigatoriP61168.

    Interactioni

    Subunit structurei

    Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B, CADPS, CADPS2 and CLIC6. Interacts with ARRB2, HTR2A and GNAI1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199306. 1 interaction.
    IntActiP61168. 4 interactions.
    MINTiMINT-5313868.
    STRINGi10090.ENSMUSP00000075170.

    Structurei

    3D structure databases

    ProteinModelPortaliP61168.
    SMRiP61168. Positions 37-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularBy similarityAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicBy similarity
    Topological domaini94 – 10815ExtracellularBy similarityAdd
    BLAST
    Topological domaini131 – 15121CytoplasmicBy similarityAdd
    BLAST
    Topological domaini173 – 18816ExtracellularBy similarityAdd
    BLAST
    Topological domaini214 – 374161CytoplasmicBy similarityAdd
    BLAST
    Topological domaini397 – 41014ExtracellularBy similarityAdd
    BLAST
    Topological domaini433 – 44412CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6023Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9323Helical; Name=2By similarityAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3By similarityAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4By similarityAdd
    BLAST
    Transmembranei189 – 21325Helical; Name=5By similarityAdd
    BLAST
    Transmembranei375 – 39622Helical; Name=6By similarityAdd
    BLAST
    Transmembranei411 – 43222Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1978Agonist bindingBy similarity
    Regioni211 – 374164Interaction with PPP1R9BBy similarityAdd
    BLAST
    Regioni387 – 3959Agonist bindingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309657.
    GeneTreeiENSGT00750000117240.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ0VGH9.
    KOiK04145.
    OMAiRNWSRPF.
    OrthoDBiEOG769ZMG.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001922. Dopamine_D2_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00567. DOPAMINED2R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P61168-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF    50
    GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 100
    KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 150
    RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV 200
    PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM 250
    KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP 300
    SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG 350
    KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC 400
    DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC 444
    Length:444
    Mass (Da):50,930
    Last modified:July 27, 2011 - v2
    Checksum:i2EC8460CA11FC7F0
    GO
    Isoform 2 (identifier: P61168-2) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         242-270: Missing.

    Show »
    Length:415
    Mass (Da):47,625
    Checksum:i645E7A47407FCFCD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291P → A in CAA39209. (PubMed:1991517)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei242 – 27029Missing in isoform 2. 1 PublicationVSP_010241Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55674 mRNA. Translation: CAA39209.1.
    CH466522 Genomic DNA. Translation: EDL25723.1.
    BC105663 mRNA. Translation: AAI05664.1.
    BC105664 mRNA. Translation: AAI05665.1.
    BC105665 mRNA. Translation: AAI05666.1.
    BC105666 mRNA. Translation: AAI05667.1.
    CCDSiCCDS40615.1.
    PIRiS13921. DYMSD2.
    RefSeqiNP_034207.2. NM_010077.2. [P61168-1]
    XP_006510059.1. XM_006509996.1. [P61168-2]
    UniGeneiMm.41970.

    Genome annotation databases

    EnsembliENSMUST00000075764; ENSMUSP00000075170; ENSMUSG00000032259. [P61168-1]
    GeneIDi13489.
    KEGGimmu:13489.
    UCSCiuc009pja.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55674 mRNA. Translation: CAA39209.1 .
    CH466522 Genomic DNA. Translation: EDL25723.1 .
    BC105663 mRNA. Translation: AAI05664.1 .
    BC105664 mRNA. Translation: AAI05665.1 .
    BC105665 mRNA. Translation: AAI05666.1 .
    BC105666 mRNA. Translation: AAI05667.1 .
    CCDSi CCDS40615.1.
    PIRi S13921. DYMSD2.
    RefSeqi NP_034207.2. NM_010077.2. [P61168-1 ]
    XP_006510059.1. XM_006509996.1. [P61168-2 ]
    UniGenei Mm.41970.

    3D structure databases

    ProteinModelPortali P61168.
    SMRi P61168. Positions 37-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199306. 1 interaction.
    IntActi P61168. 4 interactions.
    MINTi MINT-5313868.
    STRINGi 10090.ENSMUSP00000075170.

    Chemistry

    BindingDBi P61168.
    ChEMBLi CHEMBL3427.
    GuidetoPHARMACOLOGYi 215.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P61168.

    Proteomic databases

    PRIDEi P61168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075764 ; ENSMUSP00000075170 ; ENSMUSG00000032259 . [P61168-1 ]
    GeneIDi 13489.
    KEGGi mmu:13489.
    UCSCi uc009pja.1. mouse.

    Organism-specific databases

    CTDi 1813.
    MGIi MGI:94924. Drd2.

    Phylogenomic databases

    eggNOGi NOG309657.
    GeneTreei ENSGT00750000117240.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q0VGH9.
    KOi K04145.
    OMAi RNWSRPF.
    OrthoDBi EOG769ZMG.
    TreeFami TF334382.

    Miscellaneous databases

    NextBioi 284001.
    PROi P61168.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61168.
    CleanExi MM_DRD2.
    Genevestigatori P61168.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001922. Dopamine_D2_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00567. DOPAMINED2R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of the mouse D2 dopamine receptor isoforms."
      Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R., Borrelli E.
      FEBS Lett. 278:239-243(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus."
      Chio C.L., Hess G.F., Graham R.S., Huff R.M.
      Nature 343:266-269(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The dopamine D2 receptor: two molecular forms generated by alternative splicing."
      Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A., Shivers B.D., Seeburg P.H.
      EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-270 (ISOFORM 1).

    Entry informationi

    Entry nameiDRD2_MOUSE
    AccessioniPrimary (citable) accession number: P61168
    Secondary accession number(s): P13953, Q0VGH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3