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P61168

- DRD2_MOUSE

UniProt

P61168 - DRD2_MOUSE

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Protein

D(2) dopamine receptor

Gene

Drd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141AgonistBy similarity
Sitei194 – 1941Important for receptor activation
Sitei197 – 1971Important for receptor activation

GO - Molecular functioni

  1. dopamine binding Source: MGI
  2. dopamine neurotransmitter receptor activity Source: MGI
  3. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: MGI
  4. drug binding Source: Ensembl
  5. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. activation of protein kinase activity Source: Ensembl
  2. adenohypophysis development Source: MGI
  3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
  4. adult behavior Source: MGI
  5. adult walking behavior Source: MGI
  6. arachidonic acid secretion Source: Ensembl
  7. associative learning Source: MGI
  8. auditory behavior Source: Ensembl
  9. axonogenesis Source: MGI
  10. behavioral response to cocaine Source: MGI
  11. behavioral response to ethanol Source: MGI
  12. branching morphogenesis of a nerve Source: MGI
  13. cerebral cortex GABAergic interneuron migration Source: MGI
  14. circadian regulation of gene expression Source: MGI
  15. dopamine metabolic process Source: MGI
  16. dopamine receptor signaling pathway Source: MGI
  17. feeding behavior Source: MGI
  18. G-protein coupled receptor internalization Source: Ensembl
  19. G-protein coupled receptor signaling pathway Source: MGI
  20. grooming behavior Source: MGI
  21. intracellular signal transduction Source: Ensembl
  22. locomotory behavior Source: MGI
  23. long-term memory Source: Ensembl
  24. negative regulation of adenylate cyclase activity Source: Ensembl
  25. negative regulation of blood pressure Source: MGI
  26. negative regulation of cell migration Source: MGI
  27. negative regulation of cell proliferation Source: MGI
  28. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
  29. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  30. negative regulation of dopamine receptor signaling pathway Source: MGI
  31. negative regulation of dopamine secretion Source: Ensembl
  32. negative regulation of insulin secretion Source: Ensembl
  33. negative regulation of protein kinase B signaling Source: MGI
  34. negative regulation of protein secretion Source: Ensembl
  35. negative regulation of synaptic transmission, glutamatergic Source: MGI
  36. negative regulation of voltage-gated calcium channel activity Source: Ensembl
  37. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  38. neuron-neuron synaptic transmission Source: MGI
  39. orbitofrontal cortex development Source: Ensembl
  40. peristalsis Source: MGI
  41. phosphatidylinositol metabolic process Source: Ensembl
  42. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  43. pigmentation Source: MGI
  44. positive regulation of cytokinesis Source: Ensembl
  45. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  46. positive regulation of dopamine uptake involved in synaptic transmission Source: MGI
  47. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  48. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  49. positive regulation of growth hormone secretion Source: MGI
  50. positive regulation of long-term synaptic potentiation Source: Ensembl
  51. positive regulation of multicellular organism growth Source: MGI
  52. positive regulation of neuroblast proliferation Source: MGI
  53. positive regulation of receptor internalization Source: Ensembl
  54. positive regulation of renal sodium excretion Source: MGI
  55. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  56. positive regulation of urine volume Source: MGI
  57. prepulse inhibition Source: MGI
  58. protein localization Source: MGI
  59. regulation of dopamine secretion Source: MGI
  60. regulation of dopamine uptake involved in synaptic transmission Source: MGI
  61. regulation of heart rate Source: MGI
  62. regulation of locomotion involved in locomotory behavior Source: Ensembl
  63. regulation of long-term neuronal synaptic plasticity Source: MGI
  64. regulation of phosphoprotein phosphatase activity Source: Ensembl
  65. regulation of potassium ion transport Source: MGI
  66. regulation of sodium ion transport Source: MGI
  67. regulation of synapse structural plasticity Source: Ensembl
  68. regulation of synaptic transmission Source: MGI
  69. regulation of synaptic transmission, GABAergic Source: MGI
  70. release of sequestered calcium ion into cytosol Source: Ensembl
  71. response to amphetamine Source: MGI
  72. response to axon injury Source: Ensembl
  73. response to cocaine Source: MGI
  74. response to drug Source: MGI
  75. response to histamine Source: Ensembl
  76. response to hypoxia Source: Ensembl
  77. response to inactivity Source: Ensembl
  78. response to iron ion Source: Ensembl
  79. response to light stimulus Source: MGI
  80. response to morphine Source: MGI
  81. response to nicotine Source: Ensembl
  82. response to toxic substance Source: Ensembl
  83. sensory perception of smell Source: MGI
  84. startle response Source: MGI
  85. striatum development Source: Ensembl
  86. synapse assembly Source: Ensembl
  87. synaptic transmission, dopaminergic Source: Ensembl
  88. temperature homeostasis Source: MGI
  89. visual learning Source: MGI
  90. Wnt signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_250376. G alpha (i) signalling events.
REACT_253535. Dopamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
Gene namesi
Name:Drd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:94924. Drd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularBy similarityAdd
BLAST
Transmembranei38 – 6023Helical; Name=1By similarityAdd
BLAST
Topological domaini61 – 7010CytoplasmicBy similarity
Transmembranei71 – 9323Helical; Name=2By similarityAdd
BLAST
Topological domaini94 – 10815ExtracellularBy similarityAdd
BLAST
Transmembranei109 – 13022Helical; Name=3By similarityAdd
BLAST
Topological domaini131 – 15121CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 18816ExtracellularBy similarityAdd
BLAST
Transmembranei189 – 21325Helical; Name=5By similarityAdd
BLAST
Topological domaini214 – 374161CytoplasmicBy similarityAdd
BLAST
Transmembranei375 – 39622Helical; Name=6By similarityAdd
BLAST
Topological domaini397 – 41014ExtracellularBy similarityAdd
BLAST
Transmembranei411 – 43222Helical; Name=7By similarityAdd
BLAST
Topological domaini433 – 44412CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axon Source: MGI
  3. axon terminus Source: Ensembl
  4. dendrite Source: MGI
  5. dendritic spine Source: Ensembl
  6. endocytic vesicle Source: Ensembl
  7. integral component of plasma membrane Source: InterPro
  8. lateral plasma membrane Source: Ensembl
  9. membrane Source: MGI
  10. perikaryon Source: Ensembl
  11. postsynaptic density Source: Ensembl
  12. sperm flagellum Source: Ensembl
  13. synaptic vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444D(2) dopamine receptorPRO_0000069388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 182PROSITE-ProRule annotation
Disulfide bondi400 ↔ 402PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP61168.

PTM databases

PhosphoSiteiP61168.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in the pituitary and brain. Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.

Gene expression databases

BgeeiP61168.
CleanExiMM_DRD2.
GenevestigatoriP61168.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B, CADPS, CADPS2 and CLIC6. Interacts with ARRB2, HTR2A and GNAI1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199306. 1 interaction.
IntActiP61168. 4 interactions.
MINTiMINT-5313868.
STRINGi10090.ENSMUSP00000075170.

Structurei

3D structure databases

ProteinModelPortaliP61168.
SMRiP61168. Positions 37-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1978Agonist bindingBy similarity
Regioni211 – 374164Interaction with PPP1R9BBy similarityAdd
BLAST
Regioni387 – 3959Agonist bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309657.
GeneTreeiENSGT00770000120457.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP61168.
KOiK04145.
OMAiRNWSRPF.
OrthoDBiEOG769ZMG.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61168-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSEGKPD RPHYNYYAML LTLLIFIIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMIAIVW VLSFTISCPL LFGLNNTDQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM
260 270 280 290 300
KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG
360 370 380 390 400
KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF FITHILNIHC
410 420 430 440
DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFMK ILHC
Length:444
Mass (Da):50,930
Last modified:July 27, 2011 - v2
Checksum:i2EC8460CA11FC7F0
GO
Isoform 2 (identifier: P61168-2) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Show »
Length:415
Mass (Da):47,625
Checksum:i645E7A47407FCFCD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291P → A in CAA39209. (PubMed:1991517)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 27029Missing in isoform 2. 1 PublicationVSP_010241Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55674 mRNA. Translation: CAA39209.1.
CH466522 Genomic DNA. Translation: EDL25723.1.
BC105663 mRNA. Translation: AAI05664.1.
BC105664 mRNA. Translation: AAI05665.1.
BC105665 mRNA. Translation: AAI05666.1.
BC105666 mRNA. Translation: AAI05667.1.
CCDSiCCDS40615.1.
PIRiS13921. DYMSD2.
RefSeqiNP_034207.2. NM_010077.2. [P61168-1]
XP_006510059.1. XM_006509996.1. [P61168-2]
UniGeneiMm.41970.

Genome annotation databases

EnsembliENSMUST00000075764; ENSMUSP00000075170; ENSMUSG00000032259. [P61168-1]
GeneIDi13489.
KEGGimmu:13489.
UCSCiuc009pja.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55674 mRNA. Translation: CAA39209.1 .
CH466522 Genomic DNA. Translation: EDL25723.1 .
BC105663 mRNA. Translation: AAI05664.1 .
BC105664 mRNA. Translation: AAI05665.1 .
BC105665 mRNA. Translation: AAI05666.1 .
BC105666 mRNA. Translation: AAI05667.1 .
CCDSi CCDS40615.1.
PIRi S13921. DYMSD2.
RefSeqi NP_034207.2. NM_010077.2. [P61168-1 ]
XP_006510059.1. XM_006509996.1. [P61168-2 ]
UniGenei Mm.41970.

3D structure databases

ProteinModelPortali P61168.
SMRi P61168. Positions 37-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199306. 1 interaction.
IntActi P61168. 4 interactions.
MINTi MINT-5313868.
STRINGi 10090.ENSMUSP00000075170.

Chemistry

BindingDBi P61168.
ChEMBLi CHEMBL2109245.
GuidetoPHARMACOLOGYi 215.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P61168.

Proteomic databases

PRIDEi P61168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075764 ; ENSMUSP00000075170 ; ENSMUSG00000032259 . [P61168-1 ]
GeneIDi 13489.
KEGGi mmu:13489.
UCSCi uc009pja.1. mouse.

Organism-specific databases

CTDi 1813.
MGIi MGI:94924. Drd2.

Phylogenomic databases

eggNOGi NOG309657.
GeneTreei ENSGT00770000120457.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P61168.
KOi K04145.
OMAi RNWSRPF.
OrthoDBi EOG769ZMG.
TreeFami TF334382.

Enzyme and pathway databases

Reactomei REACT_250376. G alpha (i) signalling events.
REACT_253535. Dopamine receptors.

Miscellaneous databases

NextBioi 284001.
PROi P61168.
SOURCEi Search...

Gene expression databases

Bgeei P61168.
CleanExi MM_DRD2.
Genevestigatori P61168.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of the mouse D2 dopamine receptor isoforms."
    Montmayeur J.P., Bausero P., Amlaiky N., Maroteaux L., Hen R., Borrelli E.
    FEBS Lett. 278:239-243(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus."
    Chio C.L., Hess G.F., Graham R.S., Huff R.M.
    Nature 343:266-269(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The dopamine D2 receptor: two molecular forms generated by alternative splicing."
    Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A., Shivers B.D., Seeburg P.H.
    EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-270 (ISOFORM 1).

Entry informationi

Entry nameiDRD2_MOUSE
AccessioniPrimary (citable) accession number: P61168
Secondary accession number(s): P13953, Q0VGH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3