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P61164

- ACTZ_MOUSE

UniProt

P61164 - ACTZ_MOUSE

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Protein
Alpha-centractin
Gene
Actr1a, Ctrn1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-centractin
Short name:
Centractin
Alternative name(s):
ARP1
Actin-RPV
Centrosome-associated actin homolog
Gene namesi
Name:Actr1a
Synonyms:Ctrn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1858964. Actr1a.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Alpha-centractin
PRO_0000089059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61164.
PaxDbiP61164.
PRIDEiP61164.

2D gel databases

REPRODUCTION-2DPAGEP61164.

PTM databases

PhosphoSiteiP61164.

Expressioni

Gene expression databases

BgeeiP61164.
CleanExiMM_ACTR1A.
GenevestigatoriP61164.

Interactioni

Protein-protein interaction databases

BioGridi207569. 15 interactions.
IntActiP61164. 16 interactions.
MINTiMINT-1865294.
STRINGi10090.ENSMUSP00000039844.

Structurei

3D structure databases

ProteinModelPortaliP61164.
SMRiP61164. Positions 10-374.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.

Phylogenomic databases

eggNOGiCOG5277.
GeneTreeiENSGT00660000095111.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP61164.
KOiK16575.
OMAiDMERIWS.
OrthoDBiEOG72G17C.
PhylomeDBiP61164.
TreeFamiTF300420.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61164-1 [UniParc]FASTAAdd to Basket

« Hide

MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG    50
ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ 100
TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT 150
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK 200
EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE 250
IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL 300
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL 350
DTFKKMWVSK KEYEEDGARS IHRKTF 376
Length:376
Mass (Da):42,614
Last modified:May 10, 2004 - v1
Checksum:i4A978E7AB3739436
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010297 mRNA. Translation: BAA24423.1.
AK010632 mRNA. Translation: BAB27076.1.
AK088062 mRNA. Translation: BAC40124.1.
AK167450 mRNA. Translation: BAE39536.1.
AK168889 mRNA. Translation: BAE40706.1.
BC007131 mRNA. Translation: AAH07131.1.
CCDSiCCDS29878.1.
RefSeqiNP_058556.1. NM_016860.1.
UniGeneiMm.3118.

Genome annotation databases

EnsembliENSMUST00000040270; ENSMUSP00000039844; ENSMUSG00000025228.
GeneIDi54130.
KEGGimmu:54130.
UCSCiuc008htm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010297 mRNA. Translation: BAA24423.1 .
AK010632 mRNA. Translation: BAB27076.1 .
AK088062 mRNA. Translation: BAC40124.1 .
AK167450 mRNA. Translation: BAE39536.1 .
AK168889 mRNA. Translation: BAE40706.1 .
BC007131 mRNA. Translation: AAH07131.1 .
CCDSi CCDS29878.1.
RefSeqi NP_058556.1. NM_016860.1.
UniGenei Mm.3118.

3D structure databases

ProteinModelPortali P61164.
SMRi P61164. Positions 10-374.
ModBasei Search...

Protein-protein interaction databases

BioGridi 207569. 15 interactions.
IntActi P61164. 16 interactions.
MINTi MINT-1865294.
STRINGi 10090.ENSMUSP00000039844.

PTM databases

PhosphoSitei P61164.

2D gel databases

REPRODUCTION-2DPAGE P61164.

Proteomic databases

MaxQBi P61164.
PaxDbi P61164.
PRIDEi P61164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040270 ; ENSMUSP00000039844 ; ENSMUSG00000025228 .
GeneIDi 54130.
KEGGi mmu:54130.
UCSCi uc008htm.1. mouse.

Organism-specific databases

CTDi 10121.
MGIi MGI:1858964. Actr1a.

Phylogenomic databases

eggNOGi COG5277.
GeneTreei ENSGT00660000095111.
HOGENOMi HOG000233340.
HOVERGENi HBG003771.
InParanoidi P61164.
KOi K16575.
OMAi DMERIWS.
OrthoDBi EOG72G17C.
PhylomeDBi P61164.
TreeFami TF300420.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

ChiTaRSi ACTR1A. mouse.
NextBioi 310933.
PROi P61164.
SOURCEi Search...

Gene expression databases

Bgeei P61164.
CleanExi MM_ACTR1A.
Genevestigatori P61164.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of mouse actin-related protein 1 (Arp1) and its tissue expression."
    Kusano K., Abe H., Obinata T.
    Zool. Sci. 14:77-82(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Diaphragm.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Liver, Placenta and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiACTZ_MOUSE
AccessioniPrimary (citable) accession number: P61164
Secondary accession number(s): P42024, Q3TJF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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