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P61164

- ACTZ_MOUSE

UniProt

P61164 - ACTZ_MOUSE

Protein

Alpha-centractin

Gene

Actr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (10 May 2004)
      Previous versions | rss
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    Functioni

    Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-centractin
    Short name:
    Centractin
    Alternative name(s):
    ARP1
    Actin-RPV
    Centrosome-associated actin homolog
    Gene namesi
    Name:Actr1a
    Synonyms:Ctrn1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1858964. Actr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Alpha-centractinPRO_0000089059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP61164.
    PaxDbiP61164.
    PRIDEiP61164.

    2D gel databases

    REPRODUCTION-2DPAGEP61164.

    PTM databases

    PhosphoSiteiP61164.

    Expressioni

    Gene expression databases

    BgeeiP61164.
    CleanExiMM_ACTR1A.
    GenevestigatoriP61164.

    Interactioni

    Protein-protein interaction databases

    BioGridi207569. 15 interactions.
    IntActiP61164. 16 interactions.
    MINTiMINT-1865294.
    STRINGi10090.ENSMUSP00000039844.

    Structurei

    3D structure databases

    ProteinModelPortaliP61164.
    SMRiP61164. Positions 10-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the actin family. ARP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5277.
    GeneTreeiENSGT00660000095111.
    HOGENOMiHOG000233340.
    HOVERGENiHBG003771.
    InParanoidiP61164.
    KOiK16575.
    OMAiDMERIWS.
    OrthoDBiEOG72G17C.
    PhylomeDBiP61164.
    TreeFamiTF300420.

    Family and domain databases

    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view]
    PANTHERiPTHR11937. PTHR11937. 1 hit.
    PfamiPF00022. Actin. 1 hit.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    [Graphical view]
    PROSITEiPS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG    50
    ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ 100
    TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT 150
    GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK 200
    EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE 250
    IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL 300
    SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL 350
    DTFKKMWVSK KEYEEDGARS IHRKTF 376
    Length:376
    Mass (Da):42,614
    Last modified:May 10, 2004 - v1
    Checksum:i4A978E7AB3739436
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010297 mRNA. Translation: BAA24423.1.
    AK010632 mRNA. Translation: BAB27076.1.
    AK088062 mRNA. Translation: BAC40124.1.
    AK167450 mRNA. Translation: BAE39536.1.
    AK168889 mRNA. Translation: BAE40706.1.
    BC007131 mRNA. Translation: AAH07131.1.
    CCDSiCCDS29878.1.
    RefSeqiNP_058556.1. NM_016860.1.
    UniGeneiMm.3118.

    Genome annotation databases

    EnsembliENSMUST00000040270; ENSMUSP00000039844; ENSMUSG00000025228.
    GeneIDi54130.
    KEGGimmu:54130.
    UCSCiuc008htm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010297 mRNA. Translation: BAA24423.1 .
    AK010632 mRNA. Translation: BAB27076.1 .
    AK088062 mRNA. Translation: BAC40124.1 .
    AK167450 mRNA. Translation: BAE39536.1 .
    AK168889 mRNA. Translation: BAE40706.1 .
    BC007131 mRNA. Translation: AAH07131.1 .
    CCDSi CCDS29878.1.
    RefSeqi NP_058556.1. NM_016860.1.
    UniGenei Mm.3118.

    3D structure databases

    ProteinModelPortali P61164.
    SMRi P61164. Positions 10-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207569. 15 interactions.
    IntActi P61164. 16 interactions.
    MINTi MINT-1865294.
    STRINGi 10090.ENSMUSP00000039844.

    PTM databases

    PhosphoSitei P61164.

    2D gel databases

    REPRODUCTION-2DPAGE P61164.

    Proteomic databases

    MaxQBi P61164.
    PaxDbi P61164.
    PRIDEi P61164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040270 ; ENSMUSP00000039844 ; ENSMUSG00000025228 .
    GeneIDi 54130.
    KEGGi mmu:54130.
    UCSCi uc008htm.1. mouse.

    Organism-specific databases

    CTDi 10121.
    MGIi MGI:1858964. Actr1a.

    Phylogenomic databases

    eggNOGi COG5277.
    GeneTreei ENSGT00660000095111.
    HOGENOMi HOG000233340.
    HOVERGENi HBG003771.
    InParanoidi P61164.
    KOi K16575.
    OMAi DMERIWS.
    OrthoDBi EOG72G17C.
    PhylomeDBi P61164.
    TreeFami TF300420.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    ChiTaRSi ACTR1A. mouse.
    NextBioi 310933.
    PROi P61164.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61164.
    CleanExi MM_ACTR1A.
    Genevestigatori P61164.

    Family and domain databases

    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    [Graphical view ]
    PANTHERi PTHR11937. PTHR11937. 1 hit.
    Pfami PF00022. Actin. 1 hit.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of mouse actin-related protein 1 (Arp1) and its tissue expression."
      Kusano K., Abe H., Obinata T.
      Zool. Sci. 14:77-82(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Diaphragm.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Liver, Placenta and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiACTZ_MOUSE
    AccessioniPrimary (citable) accession number: P61164
    Secondary accession number(s): P42024, Q3TJF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3