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Protein

Alpha-centractin

Gene

Actr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-centractin
Short name:
Centractin
Alternative name(s):
ARP1
Actin-RPV
Centrosome-associated actin homolog
Gene namesi
Name:Actr1a
Synonyms:Ctrn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1858964 Actr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890591 – 376Alpha-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61164
MaxQBiP61164
PaxDbiP61164
PeptideAtlasiP61164
PRIDEiP61164

2D gel databases

REPRODUCTION-2DPAGEiP61164

PTM databases

iPTMnetiP61164
PhosphoSitePlusiP61164

Expressioni

Gene expression databases

BgeeiENSMUSG00000025228
CleanExiMM_ACTR1A
GenevisibleiP61164 MM

Interactioni

Subunit structurei

Interacts with BCCIP.By similarity

Protein-protein interaction databases

BioGridi207569, 19 interactors
IntActiP61164, 18 interactors
MINTiP61164
STRINGi10090.ENSMUSP00000039844

Structurei

3D structure databases

ProteinModelPortaliP61164
SMRiP61164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP61164
KOiK16575
OMAiKIKYPME
OrthoDBiEOG091G08LD
PhylomeDBiP61164
TreeFamiTF300420

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
IPR029909 Arp1
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF195 PTHR11937:SF195, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P61164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG
60 70 80 90 100
ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK
210 220 230 240 250
EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE
260 270 280 290 300
IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGARS IHRKTF
Length:376
Mass (Da):42,614
Last modified:May 10, 2004 - v1
Checksum:i4A978E7AB3739436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010297 mRNA Translation: BAA24423.1
AK010632 mRNA Translation: BAB27076.1
AK088062 mRNA Translation: BAC40124.1
AK167450 mRNA Translation: BAE39536.1
AK168889 mRNA Translation: BAE40706.1
BC007131 mRNA Translation: AAH07131.1
CCDSiCCDS29878.1
RefSeqiNP_058556.1, NM_016860.1
UniGeneiMm.3118

Genome annotation databases

EnsembliENSMUST00000040270; ENSMUSP00000039844; ENSMUSG00000025228
GeneIDi54130
KEGGimmu:54130
UCSCiuc008htm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACTZ_MOUSE
AccessioniPrimary (citable) accession number: P61164
Secondary accession number(s): P42024, Q3TJF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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