Reviewed,
UniProtKB/Swiss-Prot P61163 (ACTZ_HUMAN)
Last modified
November 24, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alpha-centractin Short name=Centractin Alternative name(s): Centrosome-associated actin homolog Actin-RPV ARP1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| Subcellular location | Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › centrosome. |
| Sequence similarities | Belongs to the actin family. ARP1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Ligand | ATP-binding Nucleotide-binding |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | vesicle-mediated transport Ref.2 Traceable author statement. Source: ProtInc |
| Cellular component | centrosome Inferred from electronic annotation. Source: UniProtKB-SubCell cytosolInferred from Experiment. Source: Reactome dynactin complex Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins." Clark S.W., Staub O., Holzbaur E.L.F., Paschal B.M., Vallee R.B., Meyer D.I., Clark I.B. Mol. Biol. Cell 5:1301-1310(1994) [PubMed: 7696711] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility." Lees-Miller J.P., Helfman D.M., Schroer T.A. Nature 359:244-246(1992) [PubMed: 1528266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [4] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Muscle. |
| [7] | Bienvenut W.V., Glen H., Frame M.C. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-22; 239-255 AND 330-336, MASS SPECTROMETRY. Tissue: Osteosarcoma. |
| [8] | Lubec G., Vishwanath V. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 97-118; 201-215 AND 239-255, MASS SPECTROMETRY. Tissue: Brain and Cajal-Retzius cell. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [10] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X82206 mRNA. Translation: CAA57690.1. Z14978 mRNA. Translation: CAA78701.1. AK312506 mRNA. Translation: BAG35407.1. AL121928 Genomic DNA. Translation: CAC08404.1. CH471066 Genomic DNA. Translation: EAW49685.1. BC000693 mRNA. Translation: AAH00693.1. BC026016 mRNA. Translation: AAH26016.1. | |
| IPI | IPI00029468. |
| PIR | S29089. |
| RefSeq | NP_005727.1. |
| UniGene | Hs.153961 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P61163. 1 interaction. |
| STRING | P61163. |
PTM databases | |
| PhosphoSite | P61163. |
2-D gel databases | |
| OGP | P42024. |
| REPRODUCTION-2DPAGE | IPI00029468. |
Proteomic databases | |
| PeptideAtlas | P61163. |
| PRIDE | P61163. |
Genome annotation databases | |
| Ensembl | ENST00000369905; ENSP00000358921; ENSG00000138107; Homo sapiens. [Genome view] |
| GeneID | 10121. |
| KEGG | hsa:10121. |
| UCSC | uc001kvv.1. human. |
Organism-specific databases | |
| CTD | 10121. |
| GeneCards | GC10M104228. |
| H-InvDB | HIX0009162. |
| HGNC | HGNC:167. ACTR1A. |
| MIM | 605143. gene. |
| PharmGKB | PA24486. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P61163. |
| HOVERGEN | P61163. |
| OMA | IVTDWND |
Enzyme and pathway databases | |
| Reactome | REACT_152. Cell Cycle, Mitotic. |
Gene expression databases | |
| ArrayExpress | P61163. |
| Bgee | P61163. |
| CleanEx | HS_ACTR1A. |
| Genevestigator | P61163. |
| GermOnline | ENSG00000138107. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. IPR004001. Actin_CS. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| PRINTS | PR00190. ACTIN. |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| PROSITE | PS00432. ACTINS_2. 1 hit. PS01132. ACTINS_ACT_LIKE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38283. |
| SOURCE | Search... |
Entry information
| Entry name | ACTZ_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P61163 Secondary accession number(s): B2R6B0, P42024 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


