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Protein

Actin-related protein 2

Gene

Actr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162ATPBy similarity3
Nucleotide bindingi214 – 218ATPBy similarity5
Nucleotide bindingi305 – 310ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • Arp2/3 complex-mediated actin nucleation Source: MGI
  • asymmetric cell division Source: MGI
  • cilium assembly Source: MGI
  • cytosolic transport Source: MGI
  • establishment or maintenance of cell polarity Source: MGI
  • meiotic cell cycle Source: MGI
  • meiotic chromosome movement towards spindle pole Source: MGI
  • meiotic cytokinesis Source: MGI
  • spindle localization Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2
Alternative name(s):
Actin-like protein 2
Gene namesi
Name:Actr2
Synonyms:Arp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913963. Actr2.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projection By similarity

GO - Cellular componenti

  • actin cap Source: MGI
  • Arp2/3 protein complex Source: MGI
  • cell cortex Source: MGI
  • cell projection Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • cytosol Source: GOC
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890681 – 394Actin-related protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61161.
PaxDbiP61161.
PeptideAtlasiP61161.
PRIDEiP61161.

PTM databases

iPTMnetiP61161.
PhosphoSitePlusiP61161.
SwissPalmiP61161.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020152.
CleanExiMM_ACTR2.
ExpressionAtlasiP61161. baseline and differential.
GenevisibleiP61161. MM.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

Protein-protein interaction databases

BioGridi211665. 2 interactors.
IntActiP61161. 5 interactors.
MINTiMINT-1870062.
STRINGi10090.ENSMUSP00000000137.

Structurei

3D structure databases

ProteinModelPortaliP61161.
SMRiP61161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0677. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129873.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP61161.
KOiK17260.
OMAiSTYIAIQ.
OrthoDBiEOG091G08WH.
PhylomeDBiP61161.
TreeFamiTF300467.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027306. Arp2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF149. PTHR11937:SF149. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI
60 70 80 90 100
EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI
110 120 130 140 150
DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG
160 170 180 190 200
LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR
210 220 230 240 250
GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR
260 270 280 290 300
IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH
310 320 330 340 350
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR
360 370 380 390
KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR
Length:394
Mass (Da):44,761
Last modified:May 10, 2004 - v1
Checksum:i1BFA6B442ED1A797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032832 mRNA. Translation: BAC28048.1.
AK088216 mRNA. Translation: BAC40216.1.
BC027799 mRNA. Translation: AAH27799.1.
BC047530 mRNA. Translation: AAH47530.1.
CCDSiCCDS24455.1.
RefSeqiNP_666355.1. NM_146243.2.
UniGeneiMm.259045.

Genome annotation databases

EnsembliENSMUST00000000137; ENSMUSP00000000137; ENSMUSG00000020152.
GeneIDi66713.
KEGGimmu:66713.
UCSCiuc011xrw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032832 mRNA. Translation: BAC28048.1.
AK088216 mRNA. Translation: BAC40216.1.
BC027799 mRNA. Translation: AAH27799.1.
BC047530 mRNA. Translation: AAH47530.1.
CCDSiCCDS24455.1.
RefSeqiNP_666355.1. NM_146243.2.
UniGeneiMm.259045.

3D structure databases

ProteinModelPortaliP61161.
SMRiP61161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211665. 2 interactors.
IntActiP61161. 5 interactors.
MINTiMINT-1870062.
STRINGi10090.ENSMUSP00000000137.

PTM databases

iPTMnetiP61161.
PhosphoSitePlusiP61161.
SwissPalmiP61161.

Proteomic databases

EPDiP61161.
PaxDbiP61161.
PeptideAtlasiP61161.
PRIDEiP61161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000137; ENSMUSP00000000137; ENSMUSG00000020152.
GeneIDi66713.
KEGGimmu:66713.
UCSCiuc011xrw.1. mouse.

Organism-specific databases

CTDi10097.
MGIiMGI:1913963. Actr2.

Phylogenomic databases

eggNOGiKOG0677. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129873.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP61161.
KOiK17260.
OMAiSTYIAIQ.
OrthoDBiEOG091G08WH.
PhylomeDBiP61161.
TreeFamiTF300467.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiActr2. mouse.
PROiP61161.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020152.
CleanExiMM_ACTR2.
ExpressionAtlasiP61161. baseline and differential.
GenevisibleiP61161. MM.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027306. Arp2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF149. PTHR11937:SF149. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARP2_MOUSE
AccessioniPrimary (citable) accession number: P61161
Secondary accession number(s): O15142, Q6PI31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.