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P61159

- FDHA_METJA

UniProt

P61159 - FDHA_METJA

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Protein
Formate dehydrogenase subunit alpha
Gene
fdhA, MJ1353
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of formate By similarity.

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.
Zinc By similarity.
FAD By similarity.
Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101Iron-sulfur (4Fe-4S) By similarity
Metal bindingi13 – 131Iron-sulfur (4Fe-4S) By similarity
Metal bindingi17 – 171Iron-sulfur (4Fe-4S) By similarity
Metal bindingi45 – 451Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: InterPro
  3. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  4. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase subunit alpha (EC:1.2.1.2)
Gene namesi
Name:fdhA
Ordered Locus Names:MJ1353
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Formate dehydrogenase subunit alpha
PRO_0000063226Add
BLAST

Interactioni

Subunit structurei

Dimer of an alpha and a beta subunit By similarity.

Protein-protein interaction databases

STRINGi243232.MJ1353m.

Structurei

3D structure databases

ProteinModelPortaliP61159.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 59574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0243.
OMAiCQGEDIL.
PhylomeDBiP61159.

Family and domain databases

InterProiIPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61159-1 [UniParc]FASTAAdd to Basket

« Hide

MEFKIVNTIC PYCGVGCGLG LVVKDGRVIG IHPNKRHPIN EGKLCAKGNY    50
CYQFIHSKDR LTKPLIKKES GFVETTWNKA LEVIAENLKT YKDEIGFFSS 100
ARCTNEDNYI LQKFARVALK TNNIDHCARL UHSATVTGMS ACFGSGAMTN 150
SIEDIELADC ILIIGSNTFE QHPLIARRIM RAKDKGAKII VIDPRRTITA 200
KNSDIYLQII PGTNVALINA MINVIIKENL IDKEFIKNRT EGFEKLKEII 250
KKYTPEYASK ICGVDKELII ESAKIYGNAE RASIIYCMGV TQFTHGVDAV 300
KALCNLAMIT GNIGKEGTGV NPLRGQNNVQ GACDMGALPN VFPGYQKVED 350
GYKLFEEYWK TDLNPNSGLT IPEMIDESGK NIKFLYIMGE NPIVSDPDVK 400
HVEKALKSLD FLVVQDIFLT ETAKLADVVL PAACWAEKDG TFTNTERRVQ 450
LIRKAVNPPG EALEDWIIIK KLAEKLGYGD KFNYNKVEDI FNEIRKVTPQ 500
YRGITYKRLK IDGIHWPCLD ENHSGTKILH KDKFLTDNGR GKIFPVEYRE 550
VAELPDKDYP FILTTGRIIF HYHTGTMTRR CKNLVEEINE PFIEINPDDA 600
KSLKIENGDL VKVISRRGEI TAKARITEDI KKGVVFMPFH FVEANPNVLT 650
NTALDELCKI PELKVCAVKI ERI 673
Length:673
Mass (Da):75,770
Last modified:February 26, 2008 - v2
Checksum:iB87A668BDF6B98D5
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei131 – 1311Selenocysteine Inferred

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P61159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1353m.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0243.
OMAi CQGEDIL.
PhylomeDBi P61159.

Family and domain databases

InterProi IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion."
    Wilting R., Schorling S., Persson B.C., Boeck A.
    J. Mol. Biol. 266:637-641(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE SELENOCYSTEINE AT SEC-131.

Entry informationi

Entry nameiFDHA_METJA
AccessioniPrimary (citable) accession number: P61159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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