Formate dehydrogenase subunit alpha - Methanocaldococcus jannaschii

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Reviewed, UniProtKB/Swiss-Prot P61159 (FDHA_METJA)

Last modified November 3, 2009. Version 30. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Formate dehydrogenase subunit alpha
EC=1.2.1.2

Gene names

Name:	fdhA
Ordered Locus Names:	MJ1353

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the oxidation of formate By similarity.
Catalytic activity	Formate + NAD⁺ = CO₂ + NADH.
Cofactor	Molybdenum (molybdopterin) By similarity. Zinc By similarity. FAD By similarity. Binds 1 4Fe-4S cluster Potential.
Subunit structure	Dimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	4Fe-4S FAD Flavoprotein Iron Iron-sulfur Metal-binding Molybdenum NAD Selenium Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	formate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	formate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro formate dehydrogenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW selenium binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

673

Formate dehydrogenase subunit alpha

PRO_0000063226

Sites

Metal binding

1

Iron-sulfur (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur (4Fe-4S) By similarity

Amino acid modifications

Non-standard residue

1

Selenocysteine Probable

Sequences

Sequence

Length

Mass (Da)

Tools

P61159-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: B87A668BDF6B98D5
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673

75,770

        10         20         30         40         50         60 
MEFKIVNTIC PYCGVGCGLG LVVKDGRVIG IHPNKRHPIN EGKLCAKGNY CYQFIHSKDR 

        70         80         90        100        110        120 
LTKPLIKKES GFVETTWNKA LEVIAENLKT YKDEIGFFSS ARCTNEDNYI LQKFARVALK 

       130        140        150        160        170        180 
TNNIDHCARL UHSATVTGMS ACFGSGAMTN SIEDIELADC ILIIGSNTFE QHPLIARRIM 

       190        200        210        220        230        240 
RAKDKGAKII VIDPRRTITA KNSDIYLQII PGTNVALINA MINVIIKENL IDKEFIKNRT 

       250        260        270        280        290        300 
EGFEKLKEII KKYTPEYASK ICGVDKELII ESAKIYGNAE RASIIYCMGV TQFTHGVDAV 

       310        320        330        340        350        360 
KALCNLAMIT GNIGKEGTGV NPLRGQNNVQ GACDMGALPN VFPGYQKVED GYKLFEEYWK 

       370        380        390        400        410        420 
TDLNPNSGLT IPEMIDESGK NIKFLYIMGE NPIVSDPDVK HVEKALKSLD FLVVQDIFLT 

       430        440        450        460        470        480 
ETAKLADVVL PAACWAEKDG TFTNTERRVQ LIRKAVNPPG EALEDWIIIK KLAEKLGYGD 

       490        500        510        520        530        540 
KFNYNKVEDI FNEIRKVTPQ YRGITYKRLK IDGIHWPCLD ENHSGTKILH KDKFLTDNGR 

       550        560        570        580        590        600 
GKIFPVEYRE VAELPDKDYP FILTTGRIIF HYHTGTMTRR CKNLVEEINE PFIEINPDDA 

       610        620        630        640        650        660 
KSLKIENGDL VKVISRRGEI TAKARITEDI KKGVVFMPFH FVEANPNVLT NTALDELCKI 

       670 
PELKVCAVKI ERI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion." Wilting R., Schorling S., Persson B.C., Boeck A. J. Mol. Biol. 266:637-641(1997) [PubMed: 9102456] [Abstract] Cited for: PROBABLE SELENOCYSTEINE AT SEC-131.

Cross-references

Sequence databases
	L77117 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus MJ1353 in contig L77117_GR.
TIGR	MJ1353.
Phylogenomic databases
HOGENOM	P61159.
OMA	EIFDEMA.
Enzyme and pathway databases
BRENDA	1.2.1.2. 256362.
Family and domain databases
InterPro	IPR009010. Asp_de-COase-like_fold. IPR006478. Formate_DH_asu. IPR006656. Mopterin_OxRdtase. IPR006963. Mopterin_OxRdtase_Fe4S4. IPR006655. Mopterin_OxRdtase_prok_CS. IPR006657. MPT_dinuc_bd. [Graphical view]
Gene3D	G3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
Pfam	PF04879. Molybdop_Fe4S4. 1 hit. PF00384. Molybdopterin. 1 hit. PF01568. Molydop_binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01591. Fdh-alpha. 1 hit.
PROSITE	PS00551. MOLYBDOPTERIN_PROK_1. 1 hit. PS00490. MOLYBDOPTERIN_PROK_2. 1 hit. PS00932. MOLYBDOPTERIN_PROK_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FDHA_METJA

Accession

Primary (citable) accession number: P61159

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 30 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents