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P61159 (FDHA_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Formate dehydrogenase subunit alpha

EC=1.2.1.2
Gene names
Name:fdhA
Ordered Locus Names:MJ1353
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of formate By similarity.

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Cofactor

Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Zinc By similarity.

FAD By similarity.

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Dimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 673673Formate dehydrogenase subunit alpha
PRO_0000063226

Regions

Domain3 – 59574Fe-4S Mo/W bis-MGD-type

Sites

Metal binding101Iron-sulfur (4Fe-4S) By similarity
Metal binding131Iron-sulfur (4Fe-4S) By similarity
Metal binding171Iron-sulfur (4Fe-4S) By similarity
Metal binding451Iron-sulfur (4Fe-4S) By similarity

Amino acid modifications

Non-standard residue1311Selenocysteine Probable

Sequences

Sequence LengthMass (Da)Tools
P61159 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: B87A668BDF6B98D5

FASTA67375,770
        10         20         30         40         50         60 
MEFKIVNTIC PYCGVGCGLG LVVKDGRVIG IHPNKRHPIN EGKLCAKGNY CYQFIHSKDR 

        70         80         90        100        110        120 
LTKPLIKKES GFVETTWNKA LEVIAENLKT YKDEIGFFSS ARCTNEDNYI LQKFARVALK 

       130        140        150        160        170        180 
TNNIDHCARL UHSATVTGMS ACFGSGAMTN SIEDIELADC ILIIGSNTFE QHPLIARRIM 

       190        200        210        220        230        240 
RAKDKGAKII VIDPRRTITA KNSDIYLQII PGTNVALINA MINVIIKENL IDKEFIKNRT 

       250        260        270        280        290        300 
EGFEKLKEII KKYTPEYASK ICGVDKELII ESAKIYGNAE RASIIYCMGV TQFTHGVDAV 

       310        320        330        340        350        360 
KALCNLAMIT GNIGKEGTGV NPLRGQNNVQ GACDMGALPN VFPGYQKVED GYKLFEEYWK 

       370        380        390        400        410        420 
TDLNPNSGLT IPEMIDESGK NIKFLYIMGE NPIVSDPDVK HVEKALKSLD FLVVQDIFLT 

       430        440        450        460        470        480 
ETAKLADVVL PAACWAEKDG TFTNTERRVQ LIRKAVNPPG EALEDWIIIK KLAEKLGYGD 

       490        500        510        520        530        540 
KFNYNKVEDI FNEIRKVTPQ YRGITYKRLK IDGIHWPCLD ENHSGTKILH KDKFLTDNGR 

       550        560        570        580        590        600 
GKIFPVEYRE VAELPDKDYP FILTTGRIIF HYHTGTMTRR CKNLVEEINE PFIEINPDDA 

       610        620        630        640        650        660 
KSLKIENGDL VKVISRRGEI TAKARITEDI KKGVVFMPFH FVEANPNVLT NTALDELCKI 

       670 
PELKVCAVKI ERI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP61159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1353m.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0243.
OMAIDEGKMK.

Family and domain databases

InterProIPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
[Graphical view]
PfamPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMSSF50692. SSF50692. 1 hit.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDHA_METJA
AccessionPrimary (citable) accession number: P61159
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names