Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61159

- FDHA_METJA

UniProt

P61159 - FDHA_METJA

Protein

Formate dehydrogenase subunit alpha

Gene

fdhA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of formate.By similarity

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity
    Zinc.By similarity
    FAD.By similarity
    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi10 – 101Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi13 – 131Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi17 – 171Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi45 – 451Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: InterPro
    3. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    4. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. formate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase subunit alpha (EC:1.2.1.2)
    Gene namesi
    Name:fdhA
    Ordered Locus Names:MJ1353
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 673673Formate dehydrogenase subunit alphaPRO_0000063226Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi243232.MJ1353m.

    Structurei

    3D structure databases

    ProteinModelPortaliP61159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 59574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0243.
    OMAiCQGEDIL.
    PhylomeDBiP61159.

    Family and domain databases

    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    [Graphical view]
    PfamiPF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view]
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
    PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61159-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFKIVNTIC PYCGVGCGLG LVVKDGRVIG IHPNKRHPIN EGKLCAKGNY    50
    CYQFIHSKDR LTKPLIKKES GFVETTWNKA LEVIAENLKT YKDEIGFFSS 100
    ARCTNEDNYI LQKFARVALK TNNIDHCARL UHSATVTGMS ACFGSGAMTN 150
    SIEDIELADC ILIIGSNTFE QHPLIARRIM RAKDKGAKII VIDPRRTITA 200
    KNSDIYLQII PGTNVALINA MINVIIKENL IDKEFIKNRT EGFEKLKEII 250
    KKYTPEYASK ICGVDKELII ESAKIYGNAE RASIIYCMGV TQFTHGVDAV 300
    KALCNLAMIT GNIGKEGTGV NPLRGQNNVQ GACDMGALPN VFPGYQKVED 350
    GYKLFEEYWK TDLNPNSGLT IPEMIDESGK NIKFLYIMGE NPIVSDPDVK 400
    HVEKALKSLD FLVVQDIFLT ETAKLADVVL PAACWAEKDG TFTNTERRVQ 450
    LIRKAVNPPG EALEDWIIIK KLAEKLGYGD KFNYNKVEDI FNEIRKVTPQ 500
    YRGITYKRLK IDGIHWPCLD ENHSGTKILH KDKFLTDNGR GKIFPVEYRE 550
    VAELPDKDYP FILTTGRIIF HYHTGTMTRR CKNLVEEINE PFIEINPDDA 600
    KSLKIENGDL VKVISRRGEI TAKARITEDI KKGVVFMPFH FVEANPNVLT 650
    NTALDELCKI PELKVCAVKI ERI 673
    Length:673
    Mass (Da):75,770
    Last modified:February 26, 2008 - v2
    Checksum:iB87A668BDF6B98D5
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei131 – 1311SelenocysteineCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. No translation available.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali P61159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1353m.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0243.
    OMAi CQGEDIL.
    PhylomeDBi P61159.

    Family and domain databases

    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    [Graphical view ]
    Pfami PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
    PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00490. MOLYBDOPTERIN_PROK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion."
      Wilting R., Schorling S., Persson B.C., Boeck A.
      J. Mol. Biol. 266:637-641(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROBABLE SELENOCYSTEINE AT SEC-131.

    Entry informationi

    Entry nameiFDHA_METJA
    AccessioniPrimary (citable) accession number: P61159
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3