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Protein

Actin-related protein 3

Gene

ACTR3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3
Alternative name(s):
Actin-2
Actin-like protein 3
Gene namesi
Name:ACTR3
Synonyms:ARP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000890782 – 418Actin-related protein 3Add BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei240N6-acetyllysineBy similarity1
Modified residuei244N6-acetyllysineBy similarity1
Modified residuei251N6-acetyllysineBy similarity1
Modified residuei254N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP61157.
PeptideAtlasiP61157.
PRIDEiP61157.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi158917. 1 interactor.
DIPiDIP-29790N.
IntActiP61157. 5 interactors.
STRINGi9913.ENSBTAP00000004410.

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Beta strandi14 – 21Combined sources8
Beta strandi28 – 33Combined sources6
Beta strandi35 – 37Combined sources3
Helixi56 – 58Combined sources3
Beta strandi60 – 62Combined sources3
Helixi63 – 66Combined sources4
Beta strandi72 – 75Combined sources4
Turni77 – 80Combined sources4
Beta strandi82 – 84Combined sources3
Helixi86 – 98Combined sources13
Turni99 – 101Combined sources3
Helixi105 – 107Combined sources3
Beta strandi110 – 114Combined sources5
Helixi120 – 132Combined sources13
Beta strandi137 – 143Combined sources7
Helixi144 – 151Combined sources8
Helixi152 – 154Combined sources3
Beta strandi155 – 157Combined sources3
Beta strandi165 – 173Combined sources9
Beta strandi175 – 181Combined sources7
Helixi187 – 189Combined sources3
Beta strandi191 – 194Combined sources4
Helixi197 – 209Combined sources13
Helixi217 – 219Combined sources3
Helixi220 – 231Combined sources12
Helixi238 – 247Combined sources10
Helixi249 – 251Combined sources3
Beta strandi254 – 259Combined sources6
Turni261 – 263Combined sources3
Beta strandi266 – 271Combined sources6
Helixi274 – 280Combined sources7
Turni281 – 283Combined sources3
Helixi285 – 287Combined sources3
Helixi296 – 306Combined sources11
Helixi309 – 311Combined sources3
Helixi314 – 317Combined sources4
Beta strandi319 – 323Combined sources5
Helixi324 – 326Combined sources3
Helixi331 – 353Combined sources23
Turni372 – 375Combined sources4
Helixi376 – 384Combined sources9
Helixi388 – 393Combined sources6
Beta strandi394 – 396Combined sources3
Helixi397 – 403Combined sources7
Helixi405 – 409Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00A1-418[»]
1TYQX-ray2.55A1-418[»]
1U2VX-ray2.55A1-418[»]
2P9IX-ray2.46A1-418[»]
2P9KX-ray2.59A1-418[»]
2P9LX-ray2.65A1-418[»]
2P9NX-ray2.85A1-418[»]
2P9PX-ray2.90A1-418[»]
2P9SX-ray2.68A1-418[»]
2P9UX-ray2.75A1-418[»]
3DXKX-ray2.70A1-418[»]
3DXMX-ray2.85A1-418[»]
3RSEX-ray2.65A1-418[»]
3UKRX-ray2.48A1-418[»]
3UKUX-ray2.75A1-418[»]
3ULEX-ray2.50A1-418[»]
4JD2X-ray3.08A1-418[»]
4XEIX-ray3.87A1-418[»]
4XF2X-ray5.00A/T1-418[»]
ProteinModelPortaliP61157.
SMRiP61157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61157.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP3 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0678. Eukaryota.
COG5277. LUCA.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiP61157.
KOiK18584.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3_met.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF284. PTHR11937:SF284. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 2 hits.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRLPACVV DCGTGYTKLG YAGNTEPQFI IPSCIAIKES AKVGDQAQRR
60 70 80 90 100
VMKGVDDLDF FIGDEAIEKP TYATKWPIRH GIVEDWDLME RFMEQVIFKY
110 120 130 140 150
LRAEPEDHYF LLTEPPLNTP ENREYTAEIM FESFNVPGLY IAVQAVLALA
160 170 180 190 200
ASWTSRQVGE RTLTGTVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI
210 220 230 240 250
TYFIQQLLRD REVGIPPEQS LETAKAVKER YSYVCPDLVK EFNKYDTDGS
260 270 280 290 300
KWIKQYTGIN AISKKEFSID VGYERFLGPE IFFHPEFANP DFTQPISEVV
310 320 330 340 350
DEVIQNCPID VRRPLYKNIV LSGGSTMFRD FGRRLQRDLK RTVDARLKLS
360 370 380 390 400
EELSGGRLKP KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKKDY
410
EEIGPSICRH NPVFGVMS
Length:418
Mass (Da):47,371
Last modified:January 23, 2007 - v3
Checksum:i23E5564198B81C63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344D → G in AAI23583 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12816 mRNA. Translation: BAA02249.1.
BC123582 mRNA. Translation: AAI23583.1.
BC142009 mRNA. Translation: AAI42010.1.
PIRiJQ1616.
RefSeqiNP_776651.1. NM_174226.2.
UniGeneiBt.4292.

Genome annotation databases

GeneIDi281597.
KEGGibta:281597.

Similar proteinsi

Entry informationi

Entry nameiARP3_BOVIN
AccessioniPrimary (citable) accession number: P61157
Secondary accession number(s): A5PJ90, P32391, Q08DS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families