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P61157 (ARP3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Actin-related protein 3
Alternative name(s):
Actin-2
Actin-like protein 3
Gene names
Name:ACTR3
Synonyms:ARP3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1 By similarity.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Cell projection By similarity.

Sequence similarities

Belongs to the actin family. ARP3 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 418417Actin-related protein 3
PRO_0000089078

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue161Phosphotyrosine By similarity
Modified residue2021Phosphotyrosine By similarity
Modified residue2311Phosphotyrosine By similarity
Modified residue2401N6-acetyllysine By similarity
Modified residue2441N6-acetyllysine By similarity
Modified residue2511N6-acetyllysine By similarity
Modified residue2541N6-acetyllysine By similarity
Modified residue4181Phosphoserine By similarity

Experimental info

Sequence conflict3441D → G in AAI23583. Ref.2

Secondary structure

1 .......................................................................... 418
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P61157 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 23E5564198B81C63

FASTA41847,371
        10         20         30         40         50         60 
MAGRLPACVV DCGTGYTKLG YAGNTEPQFI IPSCIAIKES AKVGDQAQRR VMKGVDDLDF 

        70         80         90        100        110        120 
FIGDEAIEKP TYATKWPIRH GIVEDWDLME RFMEQVIFKY LRAEPEDHYF LLTEPPLNTP 

       130        140        150        160        170        180 
ENREYTAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGTVIDS GDGVTHVIPV 

       190        200        210        220        230        240 
AEGYVIGSCI KHIPIAGRDI TYFIQQLLRD REVGIPPEQS LETAKAVKER YSYVCPDLVK 

       250        260        270        280        290        300 
EFNKYDTDGS KWIKQYTGIN AISKKEFSID VGYERFLGPE IFFHPEFANP DFTQPISEVV 

       310        320        330        340        350        360 
DEVIQNCPID VRRPLYKNIV LSGGSTMFRD FGRRLQRDLK RTVDARLKLS EELSGGRLKP 

       370        380        390        400        410 
KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKKDY EEIGPSICRH NPVFGVMS

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of bovine actin-like protein, actin2."
Tanaka T., Shibasaki F., Ishikawa M., Hirano N., Sakai R., Nishida J., Takenawa T., Hirai H.
Biochem. Biophys. Res. Commun. 187:1022-1028(1992) [PubMed: 1530599] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.
[3]"Crystal structure of Arp2/3 complex."
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N., Choe S., Pollard T.D.
Science 294:1679-1684(2001) [PubMed: 11721045] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
[4]"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
Nolen B.J., Littlefield R.S., Pollard T.D.
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed: 15505213] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D12816 mRNA. Translation: BAA02249.1.
BC123582 mRNA. Translation: AAI23583.1.
BC142009 mRNA. Translation: AAI42010.1.
IPIIPI00714052.
PIRJQ1616.
RefSeqNP_776651.1. NM_174226.2.
UniGeneBt.4292.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00A1-418[»]
1TYQX-ray2.55A1-418[»]
1U2VX-ray2.55A1-418[»]
2P9IX-ray2.46A1-418[»]
2P9KX-ray2.59A1-418[»]
2P9LX-ray2.65A1-418[»]
2P9NX-ray2.85A1-418[»]
2P9PX-ray2.90A1-418[»]
2P9SX-ray2.68A1-418[»]
2P9UX-ray2.75A1-418[»]
3DXKX-ray2.70A1-418[»]
3DXMX-ray2.85A1-418[»]
3RSEX-ray2.65A1-418[»]
ProteinModelPortalP61157.
SMRP61157. Positions 3-417.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29790N.
IntActP61157. 2 interactions.
STRINGP61157.

Proteomic databases

PRIDEP61157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281597.
KEGGbta:281597.

Organism-specific databases

CTD10096.

Phylogenomic databases

eggNOGmaNOG14110.
GeneTreeENSGT00550000074695.
HOVERGENHBG003771.
InParanoidP61157.
OrthoDBEOG4XKV6W.
PhylomeDBP61157.

Family and domain databases

InterProIPR004000. Actin-like.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3.
[Graphical view]
PANTHERPTHR11937. Actin_like. 1 hit.
PTHR11937:SF31. Arp3. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARP3_BOVIN
AccessionPrimary (citable) accession number: P61157
Secondary accession number(s): A5PJ90, P32391, Q08DS8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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