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Protein

Fibroblast growth factor 1

Gene

Fgf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33HeparinBy similarity1

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: RGD
  • heparin binding Source: UniProtKB
  • Hsp70 protein binding Source: RGD
  • integrin binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-190322 FGFR4 ligand binding and activation
R-RNO-190370 FGFR1b ligand binding and activation
R-RNO-190371 FGFR3b ligand binding and activation
R-RNO-190372 FGFR3c ligand binding and activation
R-RNO-190373 FGFR1c ligand binding and activation
R-RNO-190375 FGFR2c ligand binding and activation
R-RNO-190377 FGFR2b ligand binding and activation
R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221 Phospholipase C-mediated cascade, FGFR2
R-RNO-5654227 Phospholipase C-mediated cascade, FGFR3
R-RNO-5654228 Phospholipase C-mediated cascade, FGFR4
R-RNO-5654687 Downstream signaling of activated FGFR1
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654719 SHC-mediated cascade:FGFR4
R-RNO-5654720 PI-3K cascade:FGFR4
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5654733 Negative regulation of FGFR4 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Gene namesi
Name:Fgf1
Synonyms:Fgf-1, Fgfa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2605 Fgf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
PropeptideiPRO_00000089162 – 15By similarityAdd BLAST14
ChainiPRO_000000891716 – 155Fibroblast growth factor 1Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP61149

Expressioni

Gene expression databases

BgeeiENSRNOG00000013867
GenevisibleiP61149 RN

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: RGD
  • Hsp70 protein binding Source: RGD
  • integrin binding Source: UniProtKB
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi247356, 1 interactor
IntActiP61149, 2 interactors
MINTiP61149
STRINGi10116.ENSRNOP00000018577

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Turni32 – 35Combined sources4
Beta strandi36 – 40Combined sources5
Beta strandi44 – 50Combined sources7
Helixi55 – 57Combined sources3
Beta strandi59 – 65Combined sources7
Beta strandi68 – 73Combined sources6
Turni74 – 76Combined sources3
Beta strandi79 – 82Combined sources4
Beta strandi88 – 93Combined sources6
Helixi96 – 98Combined sources3
Beta strandi100 – 104Combined sources5
Beta strandi110 – 115Combined sources6
Helixi118 – 120Combined sources3
Beta strandi130 – 132Combined sources3
Helixi135 – 137Combined sources3
Helixi143 – 145Combined sources3
Beta strandi147 – 151Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J3PX-ray1.40A/B22-155[»]
2UUSX-ray2.20A/B22-153[»]
ProteinModelPortaliP61149
SMRiP61149
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61149

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 143Heparin-bindingBy similarityAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP61149
KOiK18496
OMAiLGPRTHY
OrthoDBiEOG091G0NAY
PhylomeDBiP61149
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028210 FGF1
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF86 PTHR11486:SF86, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL

PVSSD
Length:155
Mass (Da):17,418
Last modified:May 10, 2004 - v1
Checksum:i8880E4FF0FBA4161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14232 mRNA Translation: CAA32448.1
PIRiS04147
RefSeqiNP_036978.1, NM_012846.1
XP_006254712.1, XM_006254650.3
XP_006254713.1, XM_006254651.3
XP_006254714.1, XM_006254652.3
UniGeneiRn.88013

Genome annotation databases

EnsembliENSRNOT00000018577; ENSRNOP00000018577; ENSRNOG00000013867
ENSRNOT00000087408; ENSRNOP00000070685; ENSRNOG00000013867
GeneIDi25317
KEGGirno:25317
UCSCiRGD:2605 rat

Similar proteinsi

Entry informationi

Entry nameiFGF1_RAT
AccessioniPrimary (citable) accession number: P61149
Secondary accession number(s): P10935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health