Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 1

Gene

Fgf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331HeparinBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_289551. FGFR1b ligand binding and activation.
REACT_297015. FGFR2b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_317910. FGFR3b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_354830. FGFR1c ligand binding and activation.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_357826. Negative regulation of FGFR3 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359386. Phospholipase C-mediated cascade, FGFR3.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_360961. PI-3K cascade:FGFR3.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Gene namesi
Name:Fgf1
Synonyms:Fgf-1, Fgfa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95515. Fgf1.

Subcellular locationi

  • Secreted
  • Cytoplasm By similarity
  • Cytoplasmcell cortex By similarity
  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

  • Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).By similarity

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: MGI
  • nucleolus Source: Ensembl
  • nucleoplasm Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Propeptidei2 – 1514By similarityPRO_0000008911Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1PRO_0000008912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP61148.
PaxDbiP61148.
PRIDEiP61148.

Expressioni

Gene expression databases

BgeeiP61148.
CleanExiMM_FGF1.
ExpressionAtlasiP61148. baseline and differential.
GenevisibleiP61148. MM.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199638. 1 interaction.
IntActiP61148. 1 interaction.
STRINGi10090.ENSMUSP00000045710.

Structurei

3D structure databases

ProteinModelPortaliP61148.
SMRiP61148. Positions 22-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG246422.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP61148.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG7992S1.
PhylomeDBiP61148.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR
60 70 80 90 100
DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF
110 120 130 140 150
LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL

PVSSD
Length:155
Mass (Da):17,418
Last modified:May 10, 2004 - v1
Checksum:i8880E4FF0FBA4161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30641 mRNA. Translation: AAA37618.1.
U36459, U36457, U36458 Genomic DNA. Translation: AAC52969.1.
U67610 mRNA. Translation: AAC52907.1.
BC037601 mRNA. Translation: AAH37601.1.
CCDSiCCDS29204.1.
PIRiD37360.
RefSeqiNP_034327.1. NM_010197.3.
XP_006525707.1. XM_006525644.2.
XP_006525708.1. XM_006525645.2.
XP_006525710.1. XM_006525647.2.
XP_006525711.1. XM_006525648.2.
XP_006525712.1. XM_006525649.1.
UniGeneiMm.241282.

Genome annotation databases

EnsembliENSMUST00000040647; ENSMUSP00000045710; ENSMUSG00000036585.
ENSMUST00000115582; ENSMUSP00000111245; ENSMUSG00000036585.
GeneIDi14164.
KEGGimmu:14164.
UCSCiuc008esn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30641 mRNA. Translation: AAA37618.1.
U36459, U36457, U36458 Genomic DNA. Translation: AAC52969.1.
U67610 mRNA. Translation: AAC52907.1.
BC037601 mRNA. Translation: AAH37601.1.
CCDSiCCDS29204.1.
PIRiD37360.
RefSeqiNP_034327.1. NM_010197.3.
XP_006525707.1. XM_006525644.2.
XP_006525708.1. XM_006525645.2.
XP_006525710.1. XM_006525647.2.
XP_006525711.1. XM_006525648.2.
XP_006525712.1. XM_006525649.1.
UniGeneiMm.241282.

3D structure databases

ProteinModelPortaliP61148.
SMRiP61148. Positions 22-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199638. 1 interaction.
IntActiP61148. 1 interaction.
STRINGi10090.ENSMUSP00000045710.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Proteomic databases

MaxQBiP61148.
PaxDbiP61148.
PRIDEiP61148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040647; ENSMUSP00000045710; ENSMUSG00000036585.
ENSMUST00000115582; ENSMUSP00000111245; ENSMUSG00000036585.
GeneIDi14164.
KEGGimmu:14164.
UCSCiuc008esn.1. mouse.

Organism-specific databases

CTDi2246.
MGIiMGI:95515. Fgf1.

Phylogenomic databases

eggNOGiNOG246422.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP61148.
KOiK18496.
OMAiLGPRTHY.
OrthoDBiEOG7992S1.
PhylomeDBiP61148.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_289551. FGFR1b ligand binding and activation.
REACT_297015. FGFR2b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_317910. FGFR3b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_354830. FGFR1c ligand binding and activation.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_357826. Negative regulation of FGFR3 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359386. Phospholipase C-mediated cascade, FGFR3.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_360961. PI-3K cascade:FGFR3.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Miscellaneous databases

ChiTaRSiFgf1. mouse.
NextBioi285302.
PROiP61148.
SOURCEiSearch...

Gene expression databases

BgeeiP61148.
CleanExiMM_FGF1.
ExpressionAtlasiP61148. baseline and differential.
GenevisibleiP61148. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
    Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
    Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the mouse Fgf-1 gene."
    Madiai F., Hackshaw K.V., Chiu I.M.
    Gene 179:231-236(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain."
    Alam K.Y., Frostholm A., Hackshaw K.V., Evans J.E., Rotter A., Chiu I.M.
    J. Biol. Chem. 271:30263-30271(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiFGF1_MOUSE
AccessioniPrimary (citable) accession number: P61148
Secondary accession number(s): P10935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.