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P61148

- FGF1_MOUSE

UniProt

P61148 - FGF1_MOUSE

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Protein
Fibroblast growth factor 1
Gene
Fgf1, Fgf-1, Fgfa
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Heparin By similarity

GO - Molecular functioni

  1. S100 protein binding Source: UniProtKB
  2. fibroblast growth factor receptor binding Source: UniProtKB
  3. growth factor activity Source: UniProtKB
  4. heparin binding Source: UniProtKB
  5. protein binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. branch elongation involved in ureteric bud branching Source: UniProtKB
  3. cardiac muscle cell proliferation Source: DFLAT
  4. cellular response to heat Source: UniProtKB
  5. fibroblast growth factor receptor signaling pathway Source: UniProtKB
  6. lung development Source: MGI
  7. mesonephric epithelium development Source: UniProtKB
  8. organ induction Source: MGI
  9. positive regulation of angiogenesis Source: UniProtKB
  10. positive regulation of cell division Source: UniProtKB
  11. positive regulation of cell migration Source: UniProtKB
  12. positive regulation of cell proliferation Source: UniProtKB
  13. positive regulation of cholesterol biosynthetic process Source: UniProtKB
  14. positive regulation of epithelial cell proliferation Source: MGI
  15. positive regulation of intracellular signal transduction Source: UniProtKB
  16. positive regulation of protein phosphorylation Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. positive regulation of transcription, DNA-templated Source: DFLAT
  19. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_220836. FGFR1b ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 1
Short name:
FGF-1
Alternative name(s):
Acidic fibroblast growth factor
Short name:
aFGF
Heparin-binding growth factor 1
Short name:
HBGF-1
Gene namesi
Name:Fgf1
Synonyms:Fgf-1, Fgfa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:95515. Fgf1.

Subcellular locationi

Secreted. Cytoplasm By similarity. Cytoplasmcell cortex By similarity. Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu2+ ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 By similarity.

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: MGI
  5. nucleolus Source: Ensembl
  6. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Propeptidei2 – 1514 By similarity
PRO_0000008911Add
BLAST
Chaini16 – 155140Fibroblast growth factor 1
PRO_0000008912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Post-translational modificationi

In the nucleus, phosphorylated by PKC/PRKCD By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP61148.
PaxDbiP61148.
PRIDEiP61148.

Expressioni

Gene expression databases

ArrayExpressiP61148.
BgeeiP61148.
CleanExiMM_FGF1.
GenevestigatoriP61148.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu2+-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 By similarity. Interacts with LRRC59 By similarity. Interacts with CSNKA, CSNKB and FIBP By similarity. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1 By similarity.

Protein-protein interaction databases

BioGridi199638. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP61148.
SMRiP61148. Positions 22-155.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG246422.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP61148.
KOiK04358.
OMAiNGLLYGS.
OrthoDBiEOG7992S1.
PhylomeDBiP61148.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61148-1 [UniParc]FASTAAdd to Basket

« Hide

MAEGEITTFA ALTERFNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR    50
DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF 100
LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL 150
PVSSD 155
Length:155
Mass (Da):17,418
Last modified:May 10, 2004 - v1
Checksum:i8880E4FF0FBA4161
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30641 mRNA. Translation: AAA37618.1.
U36459, U36457, U36458 Genomic DNA. Translation: AAC52969.1.
U67610 mRNA. Translation: AAC52907.1.
BC037601 mRNA. Translation: AAH37601.1.
CCDSiCCDS29204.1.
PIRiD37360.
RefSeqiNP_034327.1. NM_010197.3.
XP_006525707.1. XM_006525644.1.
XP_006525708.1. XM_006525645.1.
XP_006525709.1. XM_006525646.1.
XP_006525710.1. XM_006525647.1.
XP_006525711.1. XM_006525648.1.
XP_006525712.1. XM_006525649.1.
UniGeneiMm.241282.

Genome annotation databases

EnsembliENSMUST00000040647; ENSMUSP00000045710; ENSMUSG00000036585.
ENSMUST00000115582; ENSMUSP00000111245; ENSMUSG00000036585.
GeneIDi14164.
KEGGimmu:14164.
UCSCiuc008esn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30641 mRNA. Translation: AAA37618.1 .
U36459 , U36457 , U36458 Genomic DNA. Translation: AAC52969.1 .
U67610 mRNA. Translation: AAC52907.1 .
BC037601 mRNA. Translation: AAH37601.1 .
CCDSi CCDS29204.1.
PIRi D37360.
RefSeqi NP_034327.1. NM_010197.3.
XP_006525707.1. XM_006525644.1.
XP_006525708.1. XM_006525645.1.
XP_006525709.1. XM_006525646.1.
XP_006525710.1. XM_006525647.1.
XP_006525711.1. XM_006525648.1.
XP_006525712.1. XM_006525649.1.
UniGenei Mm.241282.

3D structure databases

ProteinModelPortali P61148.
SMRi P61148. Positions 22-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199638. 1 interaction.

Protein family/group databases

TCDBi 9.A.48.1.1. the unconventional protein secretion (ups) system.

Proteomic databases

MaxQBi P61148.
PaxDbi P61148.
PRIDEi P61148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040647 ; ENSMUSP00000045710 ; ENSMUSG00000036585 .
ENSMUST00000115582 ; ENSMUSP00000111245 ; ENSMUSG00000036585 .
GeneIDi 14164.
KEGGi mmu:14164.
UCSCi uc008esn.1. mouse.

Organism-specific databases

CTDi 2246.
MGIi MGI:95515. Fgf1.

Phylogenomic databases

eggNOGi NOG246422.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P61148.
KOi K04358.
OMAi NGLLYGS.
OrthoDBi EOG7992S1.
PhylomeDBi P61148.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_220836. FGFR1b ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi FGF1. mouse.
NextBioi 285302.
PROi P61148.
SOURCEi Search...

Gene expression databases

ArrayExpressi P61148.
Bgeei P61148.
CleanExi MM_FGF1.
Genevestigatori P61148.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028210. FGF1.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF65. PTHR11486:SF65. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
    Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
    Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the mouse Fgf-1 gene."
    Madiai F., Hackshaw K.V., Chiu I.M.
    Gene 179:231-236(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain."
    Alam K.Y., Frostholm A., Hackshaw K.V., Evans J.E., Rotter A., Chiu I.M.
    J. Biol. Chem. 271:30263-30271(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiFGF1_MOUSE
AccessioniPrimary (citable) accession number: P61148
Secondary accession number(s): P10935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi