ID   SYUA_LAGLA              Reviewed;         140 AA.
AC   P61141;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Alpha-synuclein;
GN   Name=SNCA;
OS   Lagothrix lagotricha (Common woolly monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Atelidae; Atelinae; Lagothrix.
OX   NCBI_TaxID=9519;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15028296; DOI=10.1016/j.ygeno.2003.09.016;
RA   Hamilton B.A.;
RT   "Alpha-synuclein A53T substitution associated with Parkinson disease
RT   also marks the divergence of Old World and New World primates.";
RL   Genomics 83:739-742(2004).
CC   -!- FUNCTION: May be involved in the regulation of dopamine release
CC       and transport (By similarity).
CC   -!- SUBUNIT: Interacts with UCHL1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- PTM: Phosphorylated, predominantly on serine residues.
CC       Phosphorylated on Tyr-125 upon osmotic stress (By similarity).
CC   -!- PTM: Ubiquitinated. The predominant conjugate is the
CC       diubiquitinated form (By similarity).
CC   -!- SIMILARITY: Belongs to the synuclein family.
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DR   EMBL; AY362334; AAQ85073.1; -; Genomic_DNA.
DR   EMBL; AY362330; AAQ85073.1; JOINED; Genomic_DNA.
DR   EMBL; AY362331; AAQ85073.1; JOINED; Genomic_DNA.
DR   EMBL; AY362332; AAQ85073.1; JOINED; Genomic_DNA.
DR   EMBL; AY362333; AAQ85073.1; JOINED; Genomic_DNA.
DR   SMR; P61141; 1-140.
DR   HOVERGEN; P61141; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IEA:InterPro.
DR   InterPro; IPR001058; Synuclein.
DR   InterPro; IPR002460; Synuclein_alpha.
DR   Gene3D; G3DSA:1.10.287.700; Synuclein; 1.
DR   PANTHER; PTHR13820; Synuclein; 1.
DR   Pfam; PF01387; Synuclein; 1.
DR   PRINTS; PR01212; ASYNUCLEIN.
DR   PRINTS; PR01211; SYNUCLEIN.
DR   ProDom; PD010631; Synuclein; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Repeat; Ubl conjugation.
FT   CHAIN         1    140       Alpha-synuclein.
FT                                /FTId=PRO_0000184023.
FT   MOD_RES     125    125       Phosphotyrosine (By similarity).
SQ   SEQUENCE   140 AA;  14446 MW;  89BDCDD1E2FB649E CRC64;
     MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK
     EQVTSVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDHS GKSEEGAPQE GILEDMPVDP
     DNEAYEMPSE EGYQDYEPEA
//